[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"age-related-muscle-weakness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:age-related-muscle-weakness":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100634372","effect-of-lactiplantibacillus-plantarum-lm1001-on-muscle-strength-in-older-adults-100634372",false,"NCT07538830","Effect of Lactiplantibacillus Plantarum LM1001 on Muscle Strength in Older Adults","A Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Effects of Lactiplantibacillus Plantarum LM1001 on Muscle Strength in Older Adults.","Inclusion Criteria:\n\n* Adults aged 50 to 84 years (male or female)\n* Body mass index (BMI) between 18.5 and 30.0 kg\u002Fm²\n* Reduced skeletal muscle mass (≤110% of standard value by BIA)\n* Decreased handgrip strength according to age- and sex-specific criteria\n* Short Physical Performance Battery (SPPB) score over 9\n* Able to perform normal physical activity and provide written informed consent\n\nExclusion Criteria:\n\n* Clinically significant acute or chronic diseases requiring treatment\n* Conditions affecting muscle function or physical performance (e.g., severe musculoskeletal, neurological, or cognitive disorders, including sarcopenia)\n* Significant gastrointestinal disorders or history of major gastrointestinal surgery\n* Severe psychiatric disorders or recent use of antipsychotic medications\n* Respiratory diseases affecting lung function\n* Excessive alcohol intake, substance abuse, or heavy smoking\n* Known hypersensitivity to the investigational product or its components\n* Recent use of medications or supplements affecting muscle function or gut microbiota (e.g., antibiotics, probiotics, steroids)\n* Regular high-intensity or resistance exercise\n* Clinically significant abnormal laboratory findings or uncontrolled medical conditions\n* Recent fractures within the past year\n* Participation in another clinical trial within 3 months prior to screening\n* Pregnant or breastfeeding women\n* Individuals unable to communicate or ambulate\n* Any other condition deemed unsuitable by the investigator",true,"ALL","50 Years","85 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","Purpose:\n\nThis clinical trial aims to evaluate the efficacy and safety of Lactiplantibacillus plantarum LM1001 in improving muscle strength in older adults. The study is designed to investigate its potential effects on muscle strength based on the gut-muscle axis.\n\nMethodology:\n\nThis study is a randomized, double-blind, placebo-controlled, single-center clinical trial. A total of 100 participants will be enrolled and randomly assigned to either the test group (n=50) or the placebo group (n=50). Participants in the test group will receive 500 mg of Lactiplantibacillus plantarum LM1001 (1.0 × 10¹⁰ CFU\u002Fday) once daily for 12 weeks, while those in the placebo group will receive a matching placebo.\n\nKey Outcome Measures:\n\nTo evaluate the effects on muscle strength, the following parameters will be assessed at baseline and after the 12-week intervention period:\n\n\\- Primary Outcome Measures: Changes in isokinetic knee extension and flexion strength.\n\n\\- Secondary Outcome Measures: Changes in muscle strength-related parameters, including muscle power, skeletal muscle mass (SMM), and skeletal muscle mass index (SMI), as well as physical performance measures such as handgrip strength, Short Physical Performance Battery (SPPB) score, Timed Up and Go (TUG) test, and health-related quality of life assessed by EQ-5D-5L.\n\n\\- Safety Assessments: Safety will be evaluated based on the incidence of adverse events, serum biochemical parameters, and clinical laboratory test results.",[28],"Age-Related Muscle Weakness",[30,31,32,33],"probiotics","Lactiplantibacillus plantarum","Age-related muscle weakness","Gut-muscle axis","RECRUITING","2026-04-22",{"date":37,"type":38},"2026-04-27","ACTUAL",{"date":40,"type":38},"2026-01-27",{"date":42,"type":22},"2026-12-31",{"name":44,"class":45},"Lactomason Co., Ltd.","INDUSTRY",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":46},"100620441","effects-of-rehabilitative-exergame-training-on-foot-muscle-activity-balance-and-mobility-in-older-adults-100620441","NCT07357662","Effects of Rehabilitative Exergame Training on Foot Muscle Activity, Balance, and Mobility in Older Adults","Evaluation of the Effects of Rehabilitative Exergame Exercises on Foot Muscle Activation, Balance, and Mobility in Older Adults Using Surface Electromyography and Postural Sway Measurements","EXG-FOOT","Inclusion Criteria:\n\n* Aged 65 to 80 years\n* Having a minimum of 5 years of formal education\n* Ability to walk independently for at least 10 meters, with or without a walking aid if necessary\n* Having sufficient cognitive function for communication and participation, defined as a Mini-Mental State Examination (MMSE) score ≥26\n\nExclusion Criteria:\n\n* Body mass index (BMI ≥30 kg\u002Fm²)\n* Presence of central or peripheral nervous system disorders or use of medications that may affect balance\n* History of vestibular pathology\n* Lower extremity amputation, prior lower extremity surgery, or malignancy affecting the lower extremities\n* Presence of moderate to severe congenital heart disease, coronary artery disease, or cerebrovascular disease\n* Presence of visual, psychiatric, or cognitive impairments that could interfere with study participation or assessment procedures","65 Years","80 Years",{"count":58,"type":22},40,[25],"This study is designed as a randomized controlled trial. A total of 40 healthy older adults residing in private and public nursing homes and rehabilitation centers in Mersin will be enrolled. Participants will be randomly assigned to either the intervention group (Group 1) or the control group (Group 2).\n\nThe intervention group will receive rehabilitative interactive game-based exercise training, while the control group will receive functional balance exercise training. Both groups will participate in exercise sessions three times per week, with each session lasting 40 minutes, over a period of 8 weeks.\n\nParticipants will undergo pre- and post-intervention assessments, including:\n\ni) clinical tests and measurements for cognitive, functional, and balance evaluation; ii) surface electromyography (sEMG) measurements recorded during the Functional Reach Test (FRT); and iii) biomechanical measurements obtained via integrated inertial measurement unit (IMU) sensors (accelerometer and gyroscope) and the Becure game board.\n\nElectrophysiological and biomechanical data will be analyzed using statistical comparisons, correlation analyses, and regression models. Variables derived from time, frequency, and time-frequency domain analyses will be examined to identify potential sEMG and biomechanical biomarkers.",[62,63,64,28],"Aging","Foot Muscle Dysfunction","Sarcopenia",[66,67,68,69],"older adults, physical activity, interactive computer games, biomarkers, electrophysiology, biomedical signal processing","Older adults","Biomedical signal processing","Physical activity","NOT_YET_RECRUITING","2026-01-20",{"date":73,"type":38},"2026-01-22",{"date":75,"type":22},"2026-01-01",{"date":77,"type":22},"2027-12-30",{"name":79,"class":80},"Tarsus University","OTHER"]