[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aged\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aged":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,25,0,[8,41,71,100,127,150,160,182,210,232,266,294,321,351,376,410,438,476,503,526,553,580,604,633,656],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100053824","aging-geriatric-syndromes-and-clonal-hematopoiesis-100053824",false,"NCT02604563","Aging, Geriatric Syndromes and Clonal Hematopoiesis","Inclusion Criteria:\n\n* At least 50 years of age.\n* Able to understand written and spoken English.\n* Able to understand and willing to sign an IRB-approved written informed consent document (or that of a legally authorized representative, if applicable for the trauma cohort)\n\nExclusion Criteria:\n\n* Inability or unwillingness to complete health questionnaire (with the exception of hip and knee replacement participants).\n* History of a recent (\\\u003C30 days) acute viral illness.\n* Current cancer diagnosis and currently receiving chemotherapy or undergoing radiation therapy. A prior history of cancer is allowed if the participant completed therapy \\> 1 year prior to enrollment; participants with a prior diagnosis of cancer will be asked to sign a release of information for the research team to obtain records regarding their prior cancer treatment.\n* Current use of drugs that cause DNA damage (e.g. Cytoxan, azathioprine, etc.) for the treatment of a non-malignant disease.\n* Vulnerable populations (e.g. prisoners).\n* Known infection with Hepatitis B or C, HTLV, or HIV.\n* Additional exclusion for optional bone marrow aspirate\u002Fbiopsy substudy:\n\n  * Use of medications for anticoagulation or \"blood thinning\" including warfarin, low molecular weight heparins (enoxaparin, daltaparin) or direct-acting oral anticoagulants (dabigatran, rivaroxaban, apixaban, edoxaban or betrixaban)\n  * allergy to lidocaine or other local anesthetics.",true,"ALL","50 Years",{"count":19,"type":20},2000,"ESTIMATED","OBSERVATIONAL","In this study the investigators will incorporate a wide range of clinical variables associated with aging and cardiovascular disease to determine whether they are associated with mutation status independent of chronologic age. Clinically, aging can be operationalized using geriatric assessment, which entails a comprehensive multi-dimensional assessment of the health of an older adult, including measures of comorbidity, polypharmacy, functional status, cognition, depression, falls, social activities and social support. Given that aging is heterogeneous, geriatric assessment allows greater specificity for aging than chronological age alone.",[24,25,26,27],"Geriatrics","Aged","Geriatric Syndromes","Cardiovascular Diseases","RECRUITING","2026-07-09",{"date":31,"type":32},"2026-07-13","ACTUAL",{"date":34,"type":32},"2016-03-10",{"date":36,"type":20},"2030-04-30",{"name":38,"class":39},"Washington University School of Medicine","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":40},"100500012","development-of-a-pharmacodynamic-model-for-propofol-in-older-adults-100500012","NCT05790720","Development of a Pharmacodynamic Model for Propofol in Older Adults","Development of a Pharmacodynamic Model for Propofol in Older Adults (Development phaRmacodynamic mOdel Propofol oLdEr adulTs: DROPLET)","DROPLET","Inclusion Criteria:\n\n* Patients undergoing non-cardiac elective surgery requiring general anesthesia\n* American Society of Anesthesiologists Physical Status I to III\n\nExclusion Criteria:\n\n* Patients undergoing emergency surgery\n* Neurosurgical patients\n* History of alcohol abuse or recreational drug use\n* Known allergie to Propofol\n* Body mass index ≥ 35 Kg m-2\n* Unstable heart failure","65 Years","99 Years",{"count":52,"type":20},36,"INTERVENTIONAL",[55],"NA","The goal of this pharmacodynamic study is to develop a model for Propofol administration for older adults (\\>65 years). The main objective is to create a model based on a new pharmacodynamic parameter, derived from frontal electroencephalogram (EEG), to admininster Propofol in older adults. With this new model, the investigators aim to:\n\n* Evaluate the relationship between the plasmatic concentration, described by the Eleveld pharmacokinetic model, versus the effect of the drug represented with a new parameter derived from the intraoperative frontal EEG.\n* To validate the predictive ability of Eleveld's pharmacokinetic-pharmacodynamic model, based on the bispectral index (BIS), compared to the new model based on a parameter derived from intraoperative frontal EEG.\n\nParticipants will be asked to answer preoperative questionnaires, receive a Propofol intravenous infusion concomitantly with continuous BIS and EEG monitoring, and to be evaluated for clinical sings of loss and return of consciousness.",[25],[59,60,61],"Propofol","TCI","TIVA","2026-06-23",{"date":64,"type":32},"2026-06-26",{"date":66,"type":32},"2024-06-01",{"date":68,"type":20},"2026-08-01",{"name":70,"class":39},"Pontificia Universidad Catolica de Chile",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":15,"sex":16,"minAge":78,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":53,"phases":81,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":40},"100641365","moderate-intensity-aerobic-calisthenics-for-rural-elderly-with-motoric-cognitive-risk-syndrome-100641365","NCT07658469","Moderate-Intensity Aerobic Calisthenics for Rural Elderly With Motoric Cognitive Risk Syndrome","A Study on the Application of Moderate-Intensity Aerobic Calisthenics in Rural Elderly With Motoric Cognitive Risk Syndrome","Inclusion Criteria:\n\n* Age ≥60 years;\n\n  * Meeting the diagnostic criteria for Motor Cognitive Risk Syndrome (MCR);\n\n    * Clear consciousness and ability to communicate clearly;\n\n      * Permanent residents of rural areas in nine prefecture-level cities of Fujian Province (with an annual residence of ≥9 months) and no plan to relocate within the next year; -⑤ Willing to voluntarily participate and sign the informed consent form.\n\nExclusion Criteria:\n\n* Presence of severe mental disorders, history of stroke, Parkinson's disease, or severe visual\u002Fauditory impairments;\n\n  * Physical disability that prevents independent walking;\n\n    * Comorbid severe systemic diseases, such as cardiopulmonary conditions; -④ Regular exercise habits within the past 6 months (≥30 minutes\u002Fday, ≥3 days\u002Fweek) or a long-term history of exercise; -⑤ Current participation in other interventional studies.","60 Years",{"count":80,"type":20},106,[55],"The aging of China's rural population is severe, with both the prevalence and mortality rates of dementia higher in rural areas than in urban areas. Motor Cognitive Risk Syndrome (MCR), as a novel pre-dementia syndrome characterized by both subjective cognitive decline and slow gait, represents a \"golden window of opportunity\" for the early prevention and treatment of dementia. Currently, there is no specific pharmacological treatment for MCR; non-pharmacological interventions, particularly exercise interventions, are key strategies. Moderate-intensity aerobic calisthenics, which integrates music, dance, and gymnastic elements, is economical, simple, highly engaging, safe, and has demonstrated potential for improving both cognitive and gait function, making it especially suitable for promotion in resource-limited rural settings. However, there is a lack of systematic, theory-guided exercise intervention protocols and effectiveness validation for rural older adults with MCR. Therefore, this study aims to develop and validate a moderate-intensity aerobic calisthenics intervention protocol tailored to this population.",[84,25],"Cognition Disorders",[86,87,88,89,25],"MCR","Motoric Cognitive Risk Syndrome","moderate-intensity aerobic exercise","rural areas","NOT_YET_RECRUITING","2026-06-14",{"date":93,"type":32},"2026-06-22",{"date":95,"type":20},"2026-07-01",{"date":97,"type":20},"2027-01-31",{"name":99,"class":39},"Fujian Provincial Hospital",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":53,"phases":109,"briefSummary":110,"conditions":111,"keywords":116,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":40},"100643642","clinical-study-of-a-new-treatment-model-for-elderly-lung-cancer-patients-100643642","NCT07632664","Clinical Study of a New Treatment Model for Elderly Lung Cancer Patients","A Multicenter Clinical Study on a New Treatment Model Combining New Surgical Techniques, Perioperative Comprehensive Treatment, and Postoperative Rehabilitation for Elderly Patients With Lung Cancer","Inclusion Criteria:\n\n1. Aged ≥65 years old\n2. Pathologically confirmed non-small cell lung cancer with clinical stage eligible for curative surgical resection\n3. Complete preoperative geriatric comprehensive assessment data available\n4. Capable of finishing planned surgery and long-term follow-up\n5. Voluntarily sign informed consent form\n\nExclusion Criteria:\n\n1. History of other malignant tumors within recent 5 years\n2. Severe organic dysfunction of heart, liver, renal or respiratory system that cannot tolerate thoracic surgery\n3. Preoperative confirmed distant metastasis preventing radical resection\n4. Uncontrolled active severe infection or obvious coagulation disorders\n5. Severe psychiatric disorder or cognitive dysfunction failing to cooperate with treatment and follow-up\n6. Refuse random grouping and postoperative regular monitoring",{"count":108,"type":20},1000,[55],"This multicenter prospective clinical study focuses on elderly patients with lung cancer. We will build a standardized clinical registry database, develop perioperative risk stratification and surgical early-warning models, optimize individualized surgical regimens, construct multidisciplinary perioperative comprehensive therapy, integrated Chinese-Western medicine full-cycle management and personalized postoperative rehabilitation systems, so as to form a whole-process optimized treatment model for elderly lung cancer.",[112,113,114,115,25],"Lung Neoplasm","Thoracic Surgical Procedures","Perioperative Care","Postoperative Rehabilitation",[117],"Elderly lung cancer, Risk stratification, Multimodality therapy, Integrated Chinese and Western Medicine, Enhanced recovery after surgery","2026-06-02",{"date":120,"type":32},"2026-06-08",{"date":122,"type":32},"2024-08-01",{"date":124,"type":20},"2028-08-31",{"name":126,"class":39},"Peking University People's Hospital",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":15,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":53,"phases":135,"briefSummary":136,"conditions":137,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":146,"leadSponsor":148,"locationsCount":40},"100640256","development-of-a-chatbot-supported-personalized-exercise-program-for-older-adults-and-evaluation-of-its-effects-on-cognitive-functions-100640256","NCT07596082","Development of a Chatbot-supported Personalized Exercise Program for Older Adults and Evaluation of Its Effects on Cognitive Functions","Inclusion Criteria:\n\n* Aged 65 years and older\n* Normal or mildly impaired cognitive status\n* Medical condition that does not prevent participation in physical activity\n* Ability to use a smartphone or tablet (for chatbot access)\n* Voluntary participation\n\nExclusion Criteria:\n\n* Moderate to severe dementia\n* Severe depression or serious psychiatric disorders\n* Acute cardiovascular risk\n* Communication difficulties due to significant hearing or visual impairment\n* Regular engagement in structured exercise within the past 6 months (participants in the maintenance phase of exercise behavior)",{"count":134,"type":20},90,[55],"The purpose of this study is to develop an artificial intelligence-based chatbot application to support exercise behavior in individuals aged 60 and over who do not regularly exercise, and to evaluate its effectiveness. In addition, the study aims to examine the effects of changes in exercise habits on the cognitive (mental) functions of older adults.\n\nIn this study, the impact of a chatbot-supported personalized exercise program on cognitive functions in older individuals will be evaluated. A total of 90 participants is planned for inclusion in this study.\n\nIf you agree to participate in this study, depending on the group you are assigned to, you may receive:\n\n* An artificial intelligence-based chatbot program, along with educational materials about the importance of exercise, or\n* Only educational materials (brochures) prepared by the researchers about the importance of exercise.\n\nAt the beginning of the study, you will be asked to complete a data collection form. The same form will also be administered at week 12 and week 24.\n\nThis form will include:\n\n* Basic information such as your age and gender,\n* Questions about your exercise habits,\n* A brief test to assess your cognitive (mental) functions,\n* Questions evaluating your level of physical activity. The study duration is 24 weeks, including 12 weeks of intervention and 12 weeks of follow-up.",[25,138,139,140,141],"Exercise","Cognition","Artificial Intelligence (AI)","Health Behavior","2026-05-12",{"date":144,"type":32},"2026-05-19",{"date":68,"type":20},{"date":147,"type":20},"2026-10-30",{"name":149,"class":39},"Dokuz Eylul University",{"id":151,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":154,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":157,"completionDateStruct":158,"leadSponsor":159,"locationsCount":40},"100255479","Inclusion Criteria:\n\n* At least 50 years of age.\n* Able to understand written and spoken English.\n* Able to understand and willing to sign an IRB-approved written informed consent document (or that of a legally authorized representative, if applicable for the trauma cohort)\n\nExclusion Criteria:\n\n* Inability or unwillingness to complete health questionnaire (with the exception of hip replacement participants).\n* History of a recent (\\\u003C30 days) acute viral illness.\n* Current cancer diagnosis and currently receiving chemotherapy or undergoing radiation therapy. A prior history of cancer is allowed if the participant completed therapy \\> 1 year prior to enrollment; participants with a prior diagnosis of cancer will be asked to sign a release of information for the research team to obtain records regarding their prior cancer treatment.\n* Current use of drugs that cause DNA damage (e.g. Cytoxan, azathioprine, etc.) for the treatment of a non-malignant disease.\n* Vulnerable populations (e.g. prisoners).\n* Known infection with Hepatitis B or C, HTLV, or HIV.\n* Additional exclusion for optional bone marrow aspirate\u002Fbiopsy substudy:\n\n  * Use of medications for anticoagulation or \"blood thinning\" including warfarin, low molecular weight heparins (enoxaparin, daltaparin) or direct-acting oral anticoagulants (dabigatran, rivaroxaban, apixaban, edoxaban or betrixaban)\n  * allergy to lidocaine or other local anesthetics.",{"count":19,"type":20},[24,25,26,27],"2026-05-07",{"date":142,"type":32},{"date":34,"type":32},{"date":36,"type":20},{"name":38,"class":39},{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":166,"targetDuration":4,"studyType":53,"phases":168,"briefSummary":169,"conditions":170,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":40},"100638334","quantitative-monitoring-of-disability-care-quality-for-long-term-care-facilities-2-100638334","NCT07579832","Quantitative Monitoring of Disability Care Quality for Long-Term Care Facilities 2","Inclusion Criteria:\n\n* Older adults with disabilities:\n\n  * Aged ≥ 65 years.\n  * Classified as CMS level 2-6 under Taiwan Long-Term Care Need Assessment.\n  * Currently receiving at least one Long-Term Care 2.0 service (e.g., home care, home-based rehabilitation, or respite care).\n  * Have normal cognitive function, or a Mini-Mental State Examination (MMSE) score ≥ 23 when cognitive screening is performed.\n  * Own and are able to use a smartphone.\n  * Willing to participate and provide written informed consent.\n* Family caregivers:\n\n  * Have normal cognitive function, or a Mini-Mental State Examination (MMSE) score ≥ 23 when cognitive screening is performed.\n  * Own and are able to use a smartphone.\n  * Willing to participate and provide written informed consent.\n* Multidisciplinary rehabilitation professionals:\n\n  * Employed or contracted by a home-based long-term care institution with at least three professional disciplines (e.g., physical therapists, occupational therapists, nurses, social workers).\n  * Own and are able to use a smartphone.\n  * Willing to participate and provide written informed consent.\n\nExclusion Criteria:\n\n* Older adults with disabilities:\n\n  * Severe acute medical conditions or unstable physiological status.\n  * Severe cognitive impairment without a caregiver capable of assisting with questionnaires.\n  * Not currently receiving any long-term care services.\n* Family caregivers:\n\n  * Severe acute medical conditions or unstable physiological status.\n  * Severe cognitive impairment without ability to complete questionnaires.\n  * Not currently involved in long-term care services.\n* Multidisciplinary rehabilitation professionals:\n\n  * Providing services exclusively in non-home-based settings (e.g., institutional or hospital-only care).",{"count":167,"type":20},1080,[55],"The goal of this clinical trial is to evaluate whether a smart wearable wristband-based care system can improve the quality of care and physical activity levels among older adults with disabilities receiving home-based care. The study population includes older adults with disabilities, their family caregivers, and multidisciplinary rehabilitation service providers.\n\nThe main questions it aims to answer are:\n\n1. Whether the use of a smart wearable wristband can improve functional performance, as measured by Activities of Daily Living (ADLs), Instrumental Activities of Daily Living (IADLs), and Integrated Care for Older People (ICOPE) assessments?\n2. Whether the intervention can increase physical activity levels and improve overall care quality, while reducing caregiver burden and enhancing satisfaction?\n\nParticipants will:\n\n1. Wear a smart wearable wristband continuously for 8 weeks to record physical activity data, including step count, activity level, heart rate, and fatigue index.\n2. Undergo assessments at baseline and after the 8-week intervention, including Activities of Daily Living (ADLs), Instrumental Activities of Daily Living (IADLs), Integrated Care for Older People (ICOPE), and the Chinese Version of the Physical Activity Scale for the Elderly (PASE-C).\n3. Provide data on caregiver stress, satisfaction, and service utilization for the analysis of care quality.",[171,172,25,173],"Disabled Persons","Activities of Daily Living","Motor Activity","2026-05-06",{"date":142,"type":32},{"date":177,"type":20},"2026-05-15",{"date":179,"type":20},"2027-12-31",{"name":181,"class":39},"National Health Research Institutes, Taiwan",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":188,"eligibilityCriteria":189,"healthyVolunteers":11,"sex":16,"minAge":78,"maxAge":4,"enrollmentInfo":190,"targetDuration":4,"studyType":53,"phases":192,"briefSummary":193,"conditions":194,"keywords":197,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":4},"100636145","comparative-effects-of-multicomponent-training-concerning-elastic-band-training-on-physical-fitness-postural-balance-and-health-related-quality-of-life-in-older-women-100636145","NCT07561879","Comparative Effects of Multicomponent Training Concerning Elastic Band Training on Physical Fitness, Postural Balance, and Health-related Quality of Life in Older Women","Comparative Effects of Multicomponent Training Concerning Elastic Band Training on Physicalfunctional Fitness, Postural Balance, and Health-related Quality of Life in Older Womean: a Randomized Controlled Trial.","RCT","Inclusion Criteria:\n\n* individuals over 70 - 75 years of age;\n* the ability to understand and follow contextually appropriate instructions through simple commands\n* independence, defined as a score of at least 43 points on the Preventive Medical Examination for Older People from the Chilean Ministry of Health (in Spanish, EMPAM) (MINSAL, 2012)\n* the ability to comply with at least 85% attendance of the scheduled intervention sessions.\n\nExclusion Criteria:\n\n* having any form of disability\n* having musculoskeletal injuries or being under physical rehabilitation that would prevent participation in usual physical activities\n* being permanently or temporarily unable to engage in physical activity.",{"count":191,"type":20},40,[55],"Objective: To compare the effects of MCT versus EBT on functional fitness, postural balance, and HRQoL in older women. Methods: Single-blind, parallel-group randomized controlled trial lasting 16 weeks (2 sessions\u002Fweek, 60 min). Twenty",[25,195,196],"Exercise Therapy","Physical Performance",[198,199,200],"Postural Balance","cognitive function","Quality of Life","2026-04-24",{"date":203,"type":32},"2026-05-01",{"date":205,"type":20},"2026-04-01",{"date":207,"type":20},"2026-06-01",{"name":209,"class":39},"Universidad Católica del Maule",{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":4,"eligibilityCriteria":216,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":217,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":219,"conditions":220,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":230,"locationsCount":40},"100629990","skin-conductance-for-predicting-spinal-anesthesia-induced-hypotension-in-geriatric-urologic-oncology-patients-100629990","NCT07481851","Skin Conductance for Predicting Spinal Anesthesia-Induced Hypotension in Geriatric Urologic Oncology Patients","Skin Conductance as a Predictor of Spinal Anesthesia-Induced Hypotension in Geriatric Oncology Patients","Inclusion Criteria:\n\n* Patients aged 65 years and older\n* Patients scheduled for elective urologic oncology surgery under spinal anesthesia\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Patients who provide written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Refusal to participate or inability to provide informed consent\n* Contraindication to spinal anesthesia (e.g., infection at puncture site, coagulopathy)\n* Severe cardiac conduction abnormalities or presence of a cardiac pacemaker\n* Severe autonomic dysfunction or known neuropathy affecting autonomic responses\n* Use of medications that significantly affect autonomic nervous system activity\n* Baseline hypotension or hemodynamic instability before spinal anesthesia\n* Inability to obtain reliable skin conductance measurements (e.g., severe skin lesions at electrode placement site)",{"count":218,"type":20},102,"Spinal anesthesia-induced hypotension is a common and clinically significant complication in elderly patients undergoing oncologic surgery. Early identification of patients at risk for hemodynamic instability remains a major challenge in perioperative management. Skin conductance reflects sympathetic nervous system activity and may provide a noninvasive indicator of autonomic responses. This prospective observational study aims to evaluate whether skin conductance measurements can predict the development of hypotension following spinal anesthesia in geriatric oncology patients undergoing urologic surgery. The findings may contribute to improved perioperative monitoring and early risk stratification in this vulnerable patient population.",[221,222,25,223],"Hypotension","Urologic Neoplasms","Spinal Anesthesia","2026-03-23",{"date":226,"type":32},"2026-03-25",{"date":228,"type":32},"2025-12-22",{"date":203,"type":20},{"name":231,"class":39},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital",{"id":233,"slug":234,"hasResults":11,"nctId":235,"briefTitle":236,"officialTitle":237,"acronym":238,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":16,"minAge":240,"maxAge":4,"enrollmentInfo":241,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":243,"conditions":244,"keywords":247,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":40},"100630409","g8-screening-tool-validation-in-older-adults-with-cancer-in-portugal-100630409","NCT07487298","G8 Screening Tool Validation in Older Adults With Cancer in Portugal","Prospective Validation of the G8 Geriatric Screening Tool in Older Adults With Cancer in Portugal (G8-PT Study)","G8-PT","Inclusion Criteria:\n\n* Age ≥70 years;\n* Histologically confirmed solid malignancy, regardless of tumor site or stage;\n* Referral to a multidisciplinary geriatric oncology consultation;\n* Consideration for or planned systemic anticancer treatment;\n* Ability to understand and respond to assessment tools (G8 and comprehensive geriatric assessment), with or without caregiver assistance;\n* Provision of written informed consent by the patient or legal representative.\n\nExclusion Criteria:\n\n* Age \\\u003C70 years;\n* Diagnosis of hematological malignancy (e.g., leukemia, lymphoma, multiple myeloma);\n* Severe cognitive impairment precluding completion of assessment tools without available caregiver support;\n* Clinical instability or acute condition preventing data collection (e.g., hospitalization for acute complication);\n* Refusal to participate or inability to provide informed consent.","70 Years",{"count":242,"type":20},150,"The G8 screening tool is widely recommended for the identification of frailty in older adults with cancer. However, prospective validation data in the Portuguese population are currently lacking.\n\nThis prospective observational study aims to evaluate the diagnostic performance of the G8 screening tool compared with a Comprehensive Geriatric Assessment (CGA) in older adults with cancer. Patients aged ≥70 years with solid tumors will be assessed using both the G8 screening tool and a multidimensional CGA. Frailty will be defined as impairment in at least one CGA domain. The performance of the G8 will be evaluated in terms of sensitivity, specificity, and area under the receiver operating characteristic curve.\n\nThis study aims to provide the first prospective validation of the G8 screening tool in Portuguese older adults with cancer and to support its implementation in clinical practice.",[245,246,25],"Cancer","Frailty",[248,249,250,251,252,253,254,255,256,257],"G8 screening tool","geriatric screening","oncogeriatrics","frailty","comprehensive geriatric assessment","CGA","older adults with cancer","geriatric oncology","frailty screening","G8 validation","2026-03-17",{"date":224,"type":32},{"date":261,"type":20},"2026-03-20",{"date":263,"type":20},"2027-12-15",{"name":265,"class":39},"Hospital de Braga",{"id":267,"slug":268,"hasResults":11,"nctId":269,"briefTitle":270,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":11,"sex":16,"minAge":272,"maxAge":4,"enrollmentInfo":273,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":275,"conditions":276,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":289,"completionDateStruct":290,"leadSponsor":291,"locationsCount":40},"100629258","home-based-acute-care-for-older-persons-initiated-by-the-emergency-medical-and-ambulance-services---a-retrospective-observation-of-effects-on-healthcare-utilisation-and-mortality-100629258","NCT07472335","Home-based Acute Care for Older Persons Initiated by the Emergency Medical and Ambulance Services - a Retrospective Observation of Effects on Healthcare Utilisation and Mortality","Inclusion Criteria:\n\n* Contact with the emergency number (112), followed by either a telephone assessment by the Emergency Medical Dispatch Centre or an in-home assessment by an ambulance nurse\n* Home-based acute care a weekday between 8 AM - 4 PM\n* Emergency-department care weeknight 4 PM - 8 AM or weekends\n* Registered residence in one of the municipalities of Gothenburg, Mölndal, Partille, or Härryda\n\nExclusion Criteria:\n\n* Immediate conditions requiring hospital care\n* Care at the emergency department or by a mobile primary care team occurring more than 24 hours after assessment by the Emergency Medical Dispatch Centre or ambulance services\n* Individuals who have already been assessed by a physician and\u002For have a written referral to the emergency department","75 Years",{"count":274,"type":20},5000,"This observational study aims to examine outcomes of home-based acute care delivered by a mobile healthcare team in persons aged 75 years and older following an episode of acute illness.\n\nThe study will assess whether home-based acute care initiated by the emergency medical dispatch centre or ambulance services is non-inferior to emergency department care with regard to care needs and mortality.",[25,277,278,279,280,281,282,283,284,285],"Home Care, Hospital-Based","Home Care Services","Emergency Medical Dispatch Centre","Emergency Medical Services","Ambulances","Emergency Service, Hospital","Acute Disease","Mortality","Treatment Outcome","2026-03-10",{"date":288,"type":32},"2026-03-16",{"date":205,"type":20},{"date":179,"type":20},{"name":292,"class":293},"Vastra Gotaland Region","OTHER_GOV",{"id":295,"slug":296,"hasResults":11,"nctId":297,"briefTitle":298,"officialTitle":299,"acronym":300,"eligibilityCriteria":301,"healthyVolunteers":11,"sex":16,"minAge":302,"maxAge":303,"enrollmentInfo":304,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":305,"conditions":306,"keywords":313,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":318,"leadSponsor":319,"locationsCount":40},"100621551","complications-of-surgical-geriatrics-hospitalized-in-the-orinoco-region-100621551","NCT07372092","Complications of Surgical Geriatrics Hospitalized in the Orinoco Region","Surgical Geriatrics o Geriatric Surgery? Outcomes in a Novel Hospital Model of Attention. A Comparative Cohort Study.","SURGER","Inclusion Criteria:\n\n* Adults\n* Hospitalized in the surgical ward\n* Surgical procedures\n\nExclusion Criteria:\n\n* Derived to other institution\n* Operated previously in other institution","18 Years","100 Years",{"count":242,"type":20},"The life expectancy of the Colombian population is increasing. Older patients are frequently hospitalized and treated in surgical wards, and are treated as the general surgical population. However, geriatric patients are frequently found with additional comorbidities, besides the primary surgical diagnosis. Some diseases, like hip fractures, diverticulitis, and cancer, are common in this age range. The preoperative, intraoperative, and postoperative period requires a special care and planning to avoid complications related to the physical status, medications, and comorbidities. Studies about the geriatric surgical population are limited in the Orinoco region. The implementation of a comprehensive geriatric assesment in surgical services requires follow-up of outcomes.",[307,25,308,309,310,311,312],"Operative Surgical Procedures","Aged 65 Years or Older","Geriatric","Geriatric Assessment","Postoperative Care","Postoperative Complications",[307,25,24,310,311,312],"2026-01-20",{"date":316,"type":32},"2026-01-28",{"date":68,"type":20},{"date":179,"type":20},{"name":320,"class":39},"Hospital Departamental de Villavicencio",{"id":322,"slug":323,"hasResults":11,"nctId":324,"briefTitle":325,"officialTitle":325,"acronym":326,"eligibilityCriteria":327,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":328,"targetDuration":4,"studyType":53,"phases":330,"briefSummary":331,"conditions":332,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":40},"100447554","light-in-frail-elderly---the-effect-of-a-dynamic-light-for-sleep-and-circadian-rhythm-100447554","NCT05107947","Light in Frail Elderly - the Effect of a Dynamic Light for Sleep and Circadian Rhythm","LIFE","Inclusion Criteria:\n\n* Over the age of 65 years\n* Admitted to one of the included study rooms\n\nExclusion Criteria:\n\n* Overdose addictive substance\n* Acute neurological disease\n* Melatonin treatment\n* Probable survival \\\u003C5 days\n* Severe visual impairment that makes reading impossible\n* Age \\\u003C65 years\n* Inability to understand Swedish in speech and writing\n* Inability to consent to participate in the study\n* The patient is on any of the following medicines:\n\n  * Medications for Parkinson's disease\n  * Neuroleptics (including lithium)\n  * Dementia",{"count":329,"type":20},300,[55],"The aim of this project is to evaluate the effect of a dynamic light in order to improve the circadian rhythm, provide a better sleep and well-being, and in the long run an improved recovery. The primary question is whether dynamic artificial light with circadian stimulus can affect the circadian rhythm. The secondary question is whether this also provides better sleep and well-being.\n\nThe group that is particularly interesting to study is a geriatric population that is more sensitive to circadian rhythm disorders, sleep disorders and confusion in connection with hospitalization and that can be of particular benefit from this intervention.",[25,333,139,334,335,336,337,338,339,246,340,341],"Circadian Rhythm","Fatigue","Humans","Light","Melatonin","Sleep","Biocentric","Karolinska Sleepiness Score","Inflammation","2026-01-09",{"date":344,"type":32},"2026-01-12",{"date":346,"type":32},"2022-10-31",{"date":348,"type":20},"2028-09",{"name":350,"class":39},"Region Skane",{"id":352,"slug":353,"hasResults":11,"nctId":354,"briefTitle":355,"officialTitle":356,"acronym":4,"eligibilityCriteria":357,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":358,"targetDuration":4,"studyType":53,"phases":359,"briefSummary":361,"conditions":362,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":40},"100613326","phase-4-remimazolam-vs-midazolam-to-reduce-delirium-in-adults-65-undergoing-cpb-valve-surgery-100613326","NCT07265128","Remimazolam vs Midazolam to Reduce Delirium in Adults ≥65 Undergoing CPB Valve Surgery","Effect of Remimazolam on Delirium After Cardiac Surgery: Randomized Controlled Trial With Midazolam","Inclusion Criteria:\n\n* Patients aged 65 years or older undergoing heart valve surgery involving cardiopulmonary bypass.\n\nExclusion Criteria:\n\n* Emergency surgery, Surgery involving total arch replacement, History of remimazolam anaphylaxis, History of major neurocognitive disorder, Alcohol or substance dependence\u002Fabuse, Major depressive disorder, Schizophrenia, Participation in other clinical studies that may affect outcomes, Inability to provide informed consent due to illiteracy, foreign language barrier, or cognitive impairment.",{"count":329,"type":20},[360],"PHASE4","\"Postoperative delirium is a common and serious complication following cardiac surgery, particularly among older adults who require intensive care. Its incidence is reported to range between 20% and 70% after cardiopulmonary bypass (CPB), and has been associated with prolonged hospitalization, increased medical costs, higher morbidity and mortality, and long-term cognitive decline. Benzodiazepines are frequently used during anesthetic induction in cardiac surgery due to favorable hemodynamic stability, although multiple clinical guidelines have recommended limitation of benzodiazepine exposure because of concerns for delirium. However, robust clinical evidence in cardiac surgery remains limited.\n\nMidazolam is currently the most commonly administered benzodiazepine in this setting, though metabolism through hepatic pathways and accumulation of active metabolites may increase the risk of postoperative delirium, especially in older patients and those with organ dysfunction. Remimazolam, a recently approved benzodiazepine, undergoes rapid hydrolysis by plasma esterases and demonstrates predictable pharmacokinetic properties with a markedly shorter context-sensitive half-time compared to midazolam. These pharmacologic features suggest a potentially reduced impact on postoperative delirium risk. Despite this rationale, no randomized controlled trial has evaluated the effect of remimazolam versus midazolam on delirium after CPB-assisted valve surgery.\n\nThis randomized double-blind controlled trial aims to determine whether remimazolam reduces the incidence of postoperative delirium compared with midazolam in patients aged ≥65 years undergoing valve surgery with CPB. Eligible participants will be randomized in a 1:1 ratio to receive either remimazolam or midazolam for anesthetic induction according to a computer-generated allocation sequence. All other anesthetic management will follow standardized institutional protocols, including depth of anesthesia monitoring. Delirium assessment will be performed three times daily in the intensive care unit using Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) or Intensive Care Delirium Screening Checklist (ICDSC) and twice daily on the ward using 3-Minute Diagnostic Interview for CAM (3D-CAM) for four postoperative days.\n\nThe primary endpoint is the incidence of delirium within four postoperative days. Key secondary outcomes include in-hospital or 30-day mortality and a composite of major postoperative complications. A total of 300 patients (150 per group) will be enrolled to provide 90% statistical power to detect the hypothesized difference in delirium risk between groups, accounting for a 10% dropout rate. Findings from this study are expected to provide high-quality evidence regarding the comparative impact of remimazolam and midazolam on postoperative delirium and may inform anesthetic strategy selection in high-risk cardiac surgical populations.\"",[363,364,25,365,366],"Delirium","Critical Illness","Cardiopulmonary Bypass","Benzodiazepines","2025-11-23",{"date":369,"type":32},"2025-12-04",{"date":371,"type":20},"2025-12",{"date":373,"type":20},"2027-09",{"name":375,"class":39},"Yonsei University",{"id":377,"slug":378,"hasResults":11,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":4,"eligibilityCriteria":382,"healthyVolunteers":15,"sex":16,"minAge":78,"maxAge":4,"enrollmentInfo":383,"targetDuration":4,"studyType":53,"phases":385,"briefSummary":386,"conditions":387,"keywords":389,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":402,"startDateStruct":404,"completionDateStruct":406,"leadSponsor":408,"locationsCount":40},"100605373","whatsapp-intervention-for-seniors-digital-and-cognitive-management-wisdom-100605373","NCT07161674","WhatsApp Intervention for Seniors' Digital and Cognitive Management (WISDOM)","WhatsApp Intervention for Seniors' Digital and Cognitive Management (WISDOM): a Mixed-methods Pilot Study","Inclusion Criteria:\n\n* Age 60 years and above\n* Own a smartphone\n* Received up to primary school education or lesser\n* Able to converse and read English or Mandarin\n\nExclusion Criteria:\n\n* Diagnosed with dementia or at risk of dementia (MoCA) ≤ 23\u002F24",{"count":384,"type":20},140,[55],"The goal of this clinical trial is to learn if a digital health literacy program using mobile phone chat-based application called WISDOM (WhatsApp Intervention for Seniors' Digital and cOgnitive Management) can help older adults in Singapore with fewer resources improve their digital health skills and support brain health.\n\nThe main questions it aims to answer are:\n\n* Is it feasible to run WISDOM in senior centres, and will participants join and stay in the program?\n* Does WISDOM help older adults find and use online health information?\n* Does WISDOM help older adults make health decisions and impact brain functions?\n* What do participants think about WISDOM, and how can it be improved?\n\nResearchers will compare two groups:\n\n* WISDOM group: Participants will join a 6-week program with face-to-face learning sessions and WhatsApp activities about digital health skills. Extra support will be given if needed.\n* Control group: Participants will continue with their usual activities at the senior centres.\n\nParticipants in the WISDOM group will:\n\n* Join weekly face-to-face sessions for 6 weeks\n* Use WhatsApp to complete learning activities",[139,25,388],"Digital Health Literacy",[390,391,392,393,394,395,396,397,398,399,400],"Digital health literacy","Cognitive health","Cognitive function","Older adults","Aging population","Community-based intervention","Health information seeking","Singapore","Feasibility study","Mixed methods study","WhatsApp intervention","2025-09-02",{"date":403,"type":32},"2025-09-09",{"date":405,"type":20},"2025-09-15",{"date":407,"type":20},"2027-02-28",{"name":409,"class":39},"National University of Singapore",{"id":411,"slug":412,"hasResults":11,"nctId":413,"briefTitle":414,"officialTitle":415,"acronym":416,"eligibilityCriteria":417,"healthyVolunteers":11,"sex":16,"minAge":302,"maxAge":4,"enrollmentInfo":418,"targetDuration":4,"studyType":53,"phases":420,"briefSummary":421,"conditions":422,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":429,"lastUpdatePostDateStruct":430,"startDateStruct":432,"completionDateStruct":434,"leadSponsor":436,"locationsCount":4},"100603377","online-access-to-clinical-treatment-notes-for-outpatients-100603377","NCT07135726","Online Access to Clinical Treatment Notes for Outpatients","OpenNOTES: Online Access to Clinical Treatment Notes for Outpatients - an Interventional, Prospective, Controlled Mixed-methods Study","OpenNOTES","Inclusion Criteria:\n\nPatients (General, Module A \\& D):\n\n* Aged 18 years or older\n* Outpatient treatment at one of the four study centers\n* For intervention group: access to an internet-enabled device (e.g. smartphone, tablet, computer) and ability to receive text messages\n\nFor Module D:\n\n* Experience with the respective disease or medical field (e.g. via prior treatment experience or basic medical understanding)\n* At least one documented clinical treatment in the internal system of a participating center within the 12 months prior to intervention start\n* Availability of clinically relevant treatment notes (e.g. physician letters, progress notes, discharge summaries, consultation notes) suitable for anonymized analysis\n\nPatients (Control Group - Module A):\n\n•No requirement for access to an internet-enabled device\n\nHealthcare Practitioners (Modules A \\& D):\n\n* Aged 18 years or older\n* Employed at one of the study centers\n* Ability to give informed consent\n* For Module D: experience in relevant clinical field and familiarity with medical terminology and treatment standards\n\nRelatives (Module B):\n\n* Aged 18 years or older\n* Ability to give informed consent\n* Identified as family member, friend, or legal representative of a participating patient\n\nExperts (Module E):\n\n* Demonstrated expertise or professional experience in digital health Relevant experience with telematics infrastructure (TI), HL7 FHIR®, ePA, KIM, TIM, or affiliation with relevant institutions (e.g. gematik GmbH, HL7 Deutschland e.V., mio42 GmbH)\n* Participation in or co-design of health IT interoperability projects\n\nPatients and Physicians (Module E):\n\n* Good proficiency in German (workshops conducted in German)\n* Basic digital literacy and experience with digital technologies in healthcare\n\nExclusion Criteria:\n\nGeneral:\n\n* Insufficient German language skills\n* Severe organic brain disorders with cognitive impairment\n* Intellectual disability\n* Acute self-endangerment or danger to others at time of inclusion\n* Lack of capacity to provide informed consent\n* Lack of access to an internet-enabled device and inability to receive text messages (except in control group of Module A)\n\nModule D:\n\n* Clinical notes that cannot be anonymized due to legal, ethical, or technical restrictions\n* Presence of rare diagnoses or unique treatment histories that hinder effective anonymization",{"count":419,"type":20},1092,[55],"This study investigates the feasibility and impact of patient access to clinical notes written by their healthcare providers-a concept known as Open Notes. While international research has already demonstrated positive effects of Open Notes on patient empowerment and treatment outcomes, there is a lack of corresponding evidence for the German healthcare context. The quasi-experimental study therefore combines quantitative and qualitative methods to evaluate the effects of Open Notes on patient-reported outcomes as well as clinical practice.\n\nThe study is structured into five modules, each addressing specific research questions:\n\nModule A - Summative Outcome Evaluation in Patients: Does the use of Open Notes lead to a significant increase in patient-reported outcomes such as empowerment and self-efficacy? Module B - Formative Process Evaluation with Stakeholders: What experiences do patients, relatives and clinicians have with Open Notes and what challenges and barriers arise in their use? Module C - Changes in Clinical Documentation: How do language style and content of clinical notes change when they are shared with patients as Open Notes? Module D - Optimization through Artificial Intelligence: Can clinical notes be processed using artificial intelligence in a way that makes them easier for patients to understand compared to conventional medical documentation? Module E - Integration into National Data Infrastructure: What technical, organizational and legal requirements must be met to successfully integrate Open Notes into the national telematics infrastructure and the electronic health record or routine care? The overall goal is to identify both patient-related outcomes and structural conditions for the sustainable implementation of Open Notes in the German healthcare system. The use of artificial intelligence is intended to further enhance patient-centeredness while reducing the burden on clinical staff.",[423,424,425,426,427,25,428],"Mental Disorders","Chronic Disease","Primary Health Care","Outpatients","Internal Medicine","Comorbidity","2025-08-20",{"date":431,"type":32},"2025-08-22",{"date":433,"type":20},"2025-09-01",{"date":435,"type":20},"2028-02-29",{"name":437,"class":39},"Julian Schwarz",{"id":439,"slug":440,"hasResults":11,"nctId":441,"briefTitle":442,"officialTitle":443,"acronym":4,"eligibilityCriteria":444,"healthyVolunteers":11,"sex":16,"minAge":78,"maxAge":4,"enrollmentInfo":445,"targetDuration":4,"studyType":53,"phases":447,"briefSummary":448,"conditions":449,"keywords":456,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":467,"lastUpdatePostDateStruct":468,"startDateStruct":470,"completionDateStruct":472,"leadSponsor":474,"locationsCount":40},"100602937","phase-4-preoperative-use-of-peripheral-nerve-blocks-in-elderly-patients-with-hip-fractures-100602937","NCT07130006","Preoperative Use of Peripheral Nerve Blocks in Elderly Patients With Hip Fractures","Preoperative Use of Peripheral Nerve Blocks in Elderly Patients With Hip Fractures: a Factorial Randomized Clinical Trial","Inclusion Criteria:\n\n* both sexes\n* 60 years old and older\n* diagnosed with a hip fracture resulting from low-energy trauma\n* scheduled surgery.\n\nExclusion Criteria:\n\n* polytraumatized patients\n* dementia and acute psychosis patients\n* patients for whom spinal anesthesia is contraindicated\n* patients with severe renal failure\n* patients for whom intravenous administration of tranexamic acid is contraindicated\n* patients with proven allergy and contraindications to dexamethasone, non-steroidal anti-rheumatic drugs, opioid analgesics, magnesium sulfate.",{"count":446,"type":20},256,[360],"The goal of this clinical trial is to explore the effects of different peripheral nerve blocks in older adults with hip fractures. It will also explore the safety of preoperative administration of peripheral nerve blocks. The main questions this trial aims to answer are:\n\n* which peripheral nerve block is the best regarding analgesia\n* which peripheral nerve block eases positioning and decrease time necessary for applying spinal anesthesia?\n* which peripheral nerve block is associated with reduced intake of analgesics, both oral and intravenous?\n* which peripheral nerve block lasts long enough but does not interfere with the start of physical therapy?\n* what medical problems do respondents have during their hospitalization, after administration of peripheral nerve blocks, spinal anesthesia and surgery?\n* what medical problems arise as a consequence of their complex medical history? Researchers will compare respondents who receive peripheral nerve blocks to those who do not. Those who do not receive blocks will be given fentanyl preoperatively, which was until recently standard at our institution.\n\nAll respondents will, in addition to obligatory intraoperative monitoring,:\n\n* be thoroughly examined by anesthesiologists before surgery\n* be closely monitored after surgery, until their hospital discharge.",[450,451,452,453,25,454,455],"Fractures, Hip","Femoral Neck Fractures","Intertrochanteric Fractures","Subtrochanteric Fractures","Frail Older Adults","Elderly",[457,458,459,460,461,462,463,464,465,466],"elderly","ultrasound-guided","peripheral nerve blocks","intravenous fentanyl","spinal anaesthesia","EQ-5D-5L","visual analog scale","pain at rest","dynamic pain","hip fracture surgery","2025-08-11",{"date":469,"type":32},"2025-08-19",{"date":471,"type":20},"2025-08-30",{"date":473,"type":20},"2026-03-31",{"name":475,"class":39},"University Hospital of Split",{"id":477,"slug":478,"hasResults":11,"nctId":479,"briefTitle":480,"officialTitle":481,"acronym":4,"eligibilityCriteria":482,"healthyVolunteers":11,"sex":16,"minAge":302,"maxAge":4,"enrollmentInfo":483,"targetDuration":4,"studyType":53,"phases":485,"briefSummary":486,"conditions":487,"keywords":492,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":493,"lastUpdatePostDateStruct":494,"startDateStruct":496,"completionDateStruct":498,"leadSponsor":500,"locationsCount":502},"100552080","dexmedetomidine-esketamine-combination-for-sedation-and-analgesia-in-icu-patients-100552080","NCT06468436","Dexmedetomidine-Esketamine Combination for Sedation and Analgesia in ICU Patients","Effect of Dexmedetomidine-Esketamine Combination for Sedation and Analgesia on Delirium in ICU Patients With Mechanical Ventilation: A Multicenter Randomized Trial","Inclusion Criteria:\n\n1. Aged ≥18 years;\n2. Receiving invasive or non-invasive mechanical ventilation in the ICU, with an expected duration ≥24 hours;\n3. Require sedation as judged by ICU physicians.\n\nExclusion Criteria:\n\n1. Pregnant or lactating women;\n2. History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis;\n3. Unable to communicate due to coma, severe dementia, or language barrier prior to invasive\u002Fnon-invasive mechanical ventilation;\n4. After stroke, hypoxic encephalopathy, traumatic brain injury, or neurosurgery;\n5. Comorbid with hyperthyroidism or pheochromocytoma;\n6. Left ventricular ejection fraction \\\u003C30%, sick sinus syndrome, severe sinus bradycardia (heart rate \\\u003C50 bpm), second-degree or higher atrioventricular block without a pacemaker, or systolic blood pressure \\\u003C90 mmHg despite use of vasopressors;\n7. Severe liver dysfunction (Child-Pugh Class C), severe renal dysfunction (requiring dialysis), or expected survival ≤24 hours;\n8. Allergy to dexmedetomidine and\u002For esketamine, or any other conditions that are considered unsuitable for study participation.",{"count":484,"type":20},1508,[55],"Patients with mechanical ventilation in the intensive care unit (ICU) often develop anxiety and agitation, sleep distuebances, and delirium. Delirium occurrence is associated with worse early and long-term outcomes. Dexmedetomidine and ketamine are recommended for sedation and analgesia in ICU patients, but each may induce side effects. The sedative effects of dexmedetomidine can help mitigate the psychiatric side effects of esketamine. Recent studies showed that dexmedetomidine-esketamine combination improved analgesia and sleep quality without increasing psychiatric side effects. This trial is designed to test the hypothesis that dexmedetomidine-esketamine combination for sedation and analgesia in ICU patients with mechanical ventilation may reduce delirium and improve respiratory recovery.",[25,488,489,490,491,363],"Intensive Care Units","Ventilators, Mechanical","Dexmedetomidine","Esketamine",[25,488,489,490,491,363],"2025-07-28",{"date":495,"type":32},"2025-07-31",{"date":497,"type":20},"2025-11",{"date":499,"type":20},"2030-12-01",{"name":501,"class":39},"Peking University First Hospital",3,{"id":504,"slug":505,"hasResults":11,"nctId":506,"briefTitle":507,"officialTitle":508,"acronym":4,"eligibilityCriteria":509,"healthyVolunteers":15,"sex":16,"minAge":302,"maxAge":4,"enrollmentInfo":510,"targetDuration":4,"studyType":53,"phases":512,"briefSummary":513,"conditions":514,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":524,"locationsCount":40},"100597061","community-beauty-and-health-program-for-older-adults-an-experiential-learning-trial-100597061","NCT07053592","Community Beauty and Health Program for Older Adults: An Experiential Learning Trial","Enhancing Well-being Through Beauty: Applying Experiential Learning in Senior Beauty and Health Care Courses for Community Practice and Effectiveness Evaluation","Inclusion Criteria:\n\n* At least 18 years old. Conscious and able to communicate in Mandarin or Taiwanese. Provided informed consent after being informed of the study purpose.\n\nExclusion Criteria:\n\n* Refusal to provide consent or students currently on leave of absence will not be enrolled.\n\nDiagnosed by a physician with severe mental illness or otherwise deemed unsuitable for participation.",{"count":511,"type":20},65,[55],"This study develops and evaluates a \"Senior Beauty and Health Care\" course designed to improve students' awareness, attitudes, and skills in caring for older adults' appearance and well-being. Using experiential learning and community practice, the course aims to reduce negative stereotypes and boost students' motivation and competence. A mixed-methods approach, including pretest-posttest surveys and focus group interviews, will assess the course's effectiveness and provide insights for future geriatric care education.",[25,515,516],"Experiential Learning","Health Education","2025-07-07",{"date":519,"type":32},"2025-07-08",{"date":521,"type":20},"2025-09-18",{"date":523,"type":20},"2026-01-23",{"name":525,"class":39},"Chang Gung University of Science and Technology",{"id":527,"slug":528,"hasResults":11,"nctId":529,"briefTitle":530,"officialTitle":531,"acronym":4,"eligibilityCriteria":532,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":533,"targetDuration":4,"studyType":53,"phases":535,"briefSummary":536,"conditions":537,"keywords":538,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":543,"lastUpdatePostDateStruct":544,"startDateStruct":546,"completionDateStruct":548,"leadSponsor":550,"locationsCount":552},"100585346","evaluation-of-a-residential-in-reach-program-in-regional-and-rural-australia-100585346","NCT06901167","Evaluation of a Residential In-Reach Program in Regional and Rural Australia","Evaluation of a Region-wide Residential In-Reach (RIR) Program in Regional and Rural Health Services: A Stepped-wedge Trial","Inclusion Criteria:\n\n* Health services that have emergency departments and\u002For emergency care centres that admit residents from residential aged care homes (RACH)\n* RACHs that do not currently have access to RIR programs\n* health service staff who have been involved with the set-up and delivery of the RIR program,\n* RACH staff who have experience of or accessing the RIR service for residents at least once,\n* residents living at a RACH who has experienced receiving medical care from the RIR program and can provide informed consent, or a family member of the resident,\n* general practitioners whose case load includes residents from RACHs.\n\nExclusion Criteria:\n\n• RACHs that already have access to a RIR program will be excluded",{"count":534,"type":20},100,[55],"Residential In-Reach (RIR) programs are designed to provide responsive care for residents in residential aged care homes (RACH) with the aim of avoiding unnecessary hospital transfers. The evidence for their clinical and cost-effectiveness and implementation has been established in urban settings, but there is a small amount of low-quality evidence for rural and regional settings. The Grampians Region Health Service Partnership Resi-In-Reach Redesign Committee will be implementing a new RIR program to be offered to all RACHs in the Grampians region, this project aims to evaluate the clinical and cost-effectiveness of this program, and its implementation in the rural and regional setting. A stepped-wedge trial will be conducted so that as the RIR program is gradually rolled-out across the region, outcomes can be compared in the same facilities across time and between different facilities. The primary outcome measure will be presentation to emergency departments and urgent care centres, and data will also be collected on other clinical outcomes and barriers and enablers of implementing the program. It is anticipated that there will be a reduction in hospital presentations, and a range of barriers and enablers unique to the rural and regional setting will emerge.",[25,283],[539,540,541,542],"stepped-wedge trial","residential aged care home","residential in reach","hospital avoidance","2025-05-25",{"date":545,"type":32},"2025-05-30",{"date":547,"type":32},"2025-05-01",{"date":549,"type":20},"2026-06-30",{"name":551,"class":39},"Monash University",8,{"id":554,"slug":555,"hasResults":11,"nctId":556,"briefTitle":557,"officialTitle":558,"acronym":4,"eligibilityCriteria":559,"healthyVolunteers":15,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":560,"targetDuration":4,"studyType":53,"phases":562,"briefSummary":563,"conditions":564,"keywords":567,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":572,"lastUpdatePostDateStruct":573,"startDateStruct":575,"completionDateStruct":577,"leadSponsor":578,"locationsCount":4},"100447544","aquatic-exercise-and-reactive-balance-100447544","NCT05107817","Aquatic Exercise and Reactive Balance","Catching and Throwing Exercises to Improve Reactive Balance: A Randomized Controlled Trial Protocol for the Comparison of Aquatic and Dry-land Training Environments","Inclusion Criteria:\n\n* Ability to stand using a double-leg stance for one minute of time\n* Ability to walk independently\n* Normal or corrected to normal vision\n* Normal or corrected to normal hearing based on a qualitative assessment\n\nExclusion Criteria:\n\n* Any neurological or musculoskeletal disorders that may inhibit the participation in the training and testing protocols\n* A concussion within the past one year before the participation\n* Any cognitive deficiencies (e.g., memory, concentration, or attention disorder)\n* One or more 'yes' answered on the Physical Activity Readiness Questionnaire (PAR-Q)\n* Fear of water",{"count":561,"type":20},44,[55],"The present clinical trial aims to identify if skills acquired during aquatic exercise are more effectively transferred to a reactive balance task than land exercise. This study is designed as a double-blinded, randomized controlled clinical trial. Forty-four older adults aged 60 years or above who meet the eligibility criteria will be recruited and randomized into an aquatic exercise group or land exercise group. Each group will participate in the same balance training exercise during a single session that includes a ball throwing and catching task. A modified lean-and-release test will be implemented on land immediately before, after, and one week after the training session. The outcomes will include reaction time, rapid response accuracy, and mini-BESTest scores obtained from stepping and grasping reactions.",[565,25,566,198,138,195],"Aging","Accidental Falls",[568,569,570,571],"Reactive balance","Aquatic exercise","Aquatic therapy","Fall prevention","2025-04-03",{"date":574,"type":32},"2025-04-08",{"date":576,"type":20},"2026-01",{"date":373,"type":20},{"name":579,"class":39},"Eadric Bressel",{"id":581,"slug":582,"hasResults":11,"nctId":583,"briefTitle":584,"officialTitle":585,"acronym":586,"eligibilityCriteria":587,"healthyVolunteers":11,"sex":16,"minAge":240,"maxAge":303,"enrollmentInfo":588,"targetDuration":4,"studyType":53,"phases":590,"briefSummary":591,"conditions":592,"keywords":593,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":595,"lastUpdatePostDateStruct":596,"startDateStruct":598,"completionDateStruct":600,"leadSponsor":602,"locationsCount":40},"100439449","rct-to-analyze-the-efficacy-of-a-spanish-healthcare-ministry-based-in-intervention-to-reduce-frailty-status-in-prefrail-older-adults-100439449","NCT05002439","RCT to Analyze the Efficacy of a Spanish Healthcare ministRy Based In InTervention to Reduce Frailty Status in Prefrail Older Adults","Multicenter Randomized Clinical Trial to Analyze the Efficacy of a Spanish Healthcare ministRy Based In InTervention to Reduce Frailty Status in Prefrail Older Adults (FRAILMERIT)","FRAILMERIT","Inclusion Criteria:\n\n* Community-dwelling adults with age equal or greater than 70 years.\n* Barthel index \\> 85\n* Gait speed \\\u003C 0.8 m\u002Fs OR frailty \u002Fprefrailty using the frailty phenotype\n* Ability to realize the physical exercise program\n* Capacity to understand the procedures and interventions of the trial\n* Capacity to understand and sign the informed consent\n\nExclusion Criteria:\n\n* Major contraindications for exercise: Severe aortic valve stenosis, myocardial infarction in the previous 6 weeks, Venous thromboembolic disease in the previous 6 weeks.\n* Inability to conduct the physical tests of the trial\n* Inability to understand the procedures of the trial\n* Active solid organ or hematologic neoplasm other than basocellular skin neoplasm, or life expectancy lower than one year.\n* Surgical intervention programmed that could interfere with the physical exercise program.",{"count":589,"type":20},273,[55],"Objectives: The main objective is to analyze the efficacy of an intervention based on the algorithm proposed by the Spanish Healtcare Ministry (see figure in annex 1) at Primary Care level to reduce Frailty status or Physical Function in community-dwelling older adults. Secondary objectives are: 1. To analyze if the intervention is cost-effective; 2. To analyze if the intervention reduces hospitalizations and emergency department visits, incident disability, falls, institutionalization, mortality, Primary Care visits and Drug use, and improves quality of life.\n\nMethodology: Multicentric Randomized Clinical Trial in 273 Prefrail or Frail or with a gait speed lower that 0.8 m\u002Fs community-dwelling women and men with an age equal or greater to 70 years, attended in selected Primary Care centers of Spain (Albacete, Hellín, Barcelona, Madrid, La Carlota, and Tacoronte). Randomization will be made by clusters, being every cluster a different Primary Care center in order to avoid contamination. Randomization on a 1:1 relationship between groups. The main outcome variable will be Frailty status or Physical function change (main composite outcome) at 8-month follow-up measured with the Frailty Phenotype and the Short Physical Performance Battery (SPPB) respectively. All instrumentation will follow the guidelines of the Spanish Healthcare Ministry algorithm for frailty updated 2022. Intervention will consist on a groupal multicomponent physical exercise program, a nutritional intervention program and a training in Frailty to Primary Care centers. The intervention will be delivered by trained experts in groups of 6 participants, and will be based on the recommendations of the Spanish Healthcare Ministry document, updated in 2022.",[246,25,138],[246,25,594],"Multimodal training","2025-03-14",{"date":597,"type":32},"2025-03-18",{"date":599,"type":32},"2020-01-01",{"date":601,"type":20},"2025-03-31",{"name":603,"class":39},"Complejo Hospitalario Universitario de Albacete",{"id":605,"slug":606,"hasResults":11,"nctId":607,"briefTitle":608,"officialTitle":609,"acronym":610,"eligibilityCriteria":611,"healthyVolunteers":15,"sex":16,"minAge":78,"maxAge":4,"enrollmentInfo":612,"targetDuration":4,"studyType":53,"phases":614,"briefSummary":615,"conditions":616,"keywords":618,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":624,"lastUpdatePostDateStruct":625,"startDateStruct":627,"completionDateStruct":629,"leadSponsor":631,"locationsCount":4},"100565170","crem---clinical-and-functional-outcomes-in-a-controlled-clinical-trial-with-older-adults-100565170","NCT06638697","CREM - Clinical and Functional Outcomes in a Controlled Clinical Trial with Older Adults","CREM - Reference Center for Aging and Movement: Clinical and Functional Outcomes in a Controlled Clinical Trial with Older Adults","CREM","Inclusion Criteria:\n\n* elderly people over 60 years old,\n* sex female our male,\n* presenting medical authorization to practice exercises,\n* being able to understand verbal instructions for carrying out the tests,\n* having accessibility to carry out the training,\n* coming from local Health Units and the community,\n* presenting independent walking and not having participated in any physical activity for at least three months before starting the research.\n\nExclusion Criteria:\n\n* not having a medical certificate indicating that they are fit to perform physical activity,\n* presenting medical comorbidities and\u002For a medical condition that contraindicates participation in the study, severe heart disease, uncontrolled arterial hypertension, myocardial infarction within a period of less than one year or history of physical-cognitive impairment, sequelae of a stroke,\n* having a pacemaker,\n* having undergone recent surgery,\n* prosthetics in the lower limbs or neuropathic pain in the lower limbs.",{"count":613,"type":20},240,[55],"To evaluate and compare the effects of different types of physical exercise on clinical and functional outcomes in the elderly. 240 community-dwelling elderly individuals of both sexes, sedentary, will be recruited for twelve groups of elderly individuals who will receive intervention for 32 weeks of different types of physical exercise (free walking, Nordic walking, dancing, physical exercise for cognition, balance, aquatic physiotherapy, multicomponent gymnastics, water aerobics, hydro-postural exercises, aquatic jogging, weight training, and Pilates mat). The training programs will have a frequency of two sessions per week and will last 50 minutes and will be periodized so that the duration of the sessions is equal among them. In order to evaluate the effects of the training, evaluations will be carried out before, during and after the training period of functional fitness, clinical-functional and biomechanical parameters. It is expected that the intervention groups will present results according to the nature of the modality and that they will be more effective when compared to the control group. As well as improvements in the variables of gait speed, muscle strength, balance and cognition.",[25,617],"Aged Subject",[457,619,620,621,622,623],"functionality","physical exercise","cognition","physical fragility","physical fitness","2024-10-11",{"date":626,"type":32},"2024-10-16",{"date":628,"type":20},"2025-01-01",{"date":630,"type":20},"2026-12",{"name":632,"class":39},"Federal University of Rio Grande do Sul",{"id":634,"slug":635,"hasResults":11,"nctId":636,"briefTitle":637,"officialTitle":638,"acronym":639,"eligibilityCriteria":640,"healthyVolunteers":11,"sex":16,"minAge":272,"maxAge":4,"enrollmentInfo":641,"targetDuration":4,"studyType":53,"phases":643,"briefSummary":644,"conditions":645,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":647,"lastUpdatePostDateStruct":648,"startDateStruct":650,"completionDateStruct":652,"leadSponsor":654,"locationsCount":40},"100387621","study-of-an-physical-exercise-program-on-older-people-of-75-years-old-and-more-hospitalized-in-geriatric-short-stay-100387621","NCT04327115","Study of an Physical Exercise Program on Older People of 75 Years Old and More, Hospitalized in Geriatric Short Stay","ACTI-PACT : Programme d'ACcompagnement à l'acTIvité Physique Chez la Personne Âgée de 75 Ans et Plus, hospitalisée en CourT séjour gériatrique","ACTI-PACT","Inclusion Criteria:\n\n* Men or women ≥ 75 years old\n* Hospitalization in geriatric short stay\n* Informed and express (oral) consent to participate in the study by the patient or the patient's representative\n* Affiliation to French Social Security.\n\nExclusion Criteria:\n\n* Neurological or orthopedic pathology that prevents the performance of one or more exercises corresponding to the patient's level of risk of falling\n* Short expected hospital stay\n* Contraindication to physical activity\n* Person subject to a safeguard of justice measure\n* Patient who previously participated to the study.",{"count":642,"type":20},864,[55],"The main objective is to assess the effect, compared to usual care, of a nursing accompaniment or nursing assistant intervention in the physical activity of patients hospitalized in the geriatric stay, on the daily number of steps.\n\nThe secondary objectives consist in evaluating the effect, compared to usual care, of a nursing or nursing assistant's intervention in physical activity of elderly patients hospitalized on a short geriatric stay in terms of:\n\n* The change of the daily physical exertion in metabolic equivalent\n* The change of the daily number of steps\n* The change of care course\n* The change of in falls occurrence\n* The change of autonomy patient\n* The change of travels habits",[646,25],"Physical Activity","2024-06-10",{"date":649,"type":32},"2024-06-11",{"date":651,"type":32},"2021-10-21",{"date":653,"type":20},"2025-12-20",{"name":655,"class":293},"University Hospital, Angers",{"id":657,"slug":658,"hasResults":11,"nctId":659,"briefTitle":660,"officialTitle":661,"acronym":662,"eligibilityCriteria":663,"healthyVolunteers":15,"sex":16,"minAge":49,"maxAge":303,"enrollmentInfo":664,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":665,"conditions":666,"keywords":669,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":673,"lastUpdatePostDateStruct":674,"startDateStruct":676,"completionDateStruct":678,"leadSponsor":680,"locationsCount":40},"100542650","gait-and-postural-balance-analysis-during-head-motion-perturbed-standing-and-walking-in-older-adults-100542650","NCT06345625","Gait and Postural Balance Analysis During Head-motion Perturbed Standing and Walking in Older Adults","Gait and Postural Balance Analysis During Head-motion Perturbed Standing and Walking in Older Adults - a Multisensory Approach by Use of Mixed-reality","BALANCAR","Inclusion Criteria:\n\n* Community dwelling\n* an age of 65 years or above\n\nExclusion Criteria:\n\n* age \\\u003C 65 years\n* medical history encompassing diagnosed vestibulopathy, orthostatic hypotension, peripheral neuropathy, limb amputation, neurological or neuromuscular disorders affecting balance, diagnosed neck disorders affecting sensorimotor control, blindness, deafness\n* a full-time walking aid is indispensable.",{"count":534,"type":20},"The main aim of this study is to unravel the biomechanics of postural balance reactions during head-motion perturbed standing and walking in older adults who fall, while integrating the influence of frailty, sensory functioning and cognitive processing.",[25,667,198,668],"Accidental Fall","Gait",[670,671,672],"older adults","Sensorimotor integration","visual tracking while walking","2024-05-08",{"date":675,"type":32},"2024-05-09",{"date":677,"type":32},"2024-05-07",{"date":679,"type":20},"2028-01",{"name":681,"class":39},"Universiteit Antwerpen"]