[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aggression\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aggression":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,25,0,[8,42,73,101,130,175,228,247,267,294,313,346,371,409,435,456,488,509,533,575,603,630,651,674,696],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100366002","refinements-of-functional-communication-training-100366002",false,"NCT04045600","Refinements of Functional Communication Training","Stimulus Control Refinements of Functional Communication Training","Inclusion Criteria:\n\n* Boys and girls from ages 3 to 17\n* Destructive behavior that occurs at least 10 times a day despite previous treatment\n* Destructive behavior reinforced by social consequences like attention (FCT is not appropriate for automatically reinforced destructive behavior)\n* On a stable psychoactive drug regimen for at least 10 half-lives per drug or drug free\n* Stable educational plan and placement with no anticipated changes during the child's treatment\n\nExclusion Criteria:\n\n* Patients who do not meet the inclusion criteria\n* Patients currently receiving 15 or more hours per week of treatment for their destructive behavior\n* DSM-5 diagnosis of Rett syndrome or other degenerative conditions (e.g., inborn error of metabolism)\n* A comorbid health condition or major mental disorder that would interfere with study participation\n* Occurrence of SIB during study assessments that presents a risk of serious or permanent harm (e.g., detached retinas) based on our routine clinical-risk assessment\n* Patients requiring drug-treatment changes, but the experimenters will invite these patients to participate if they meet inclusion criteria after drug regimen is stable.","ALL","3 Years","17 Years",{"count":20,"type":21},24,"ESTIMATED","INTERVENTIONAL",[24],"NA","Although treatments for problem behavior, like functional communication training (FCT), can be highly effective in the clinic, changes in the way the FCT is implemented (e.g., when transferring treatment to the home, when teachers implement treatment with poor fidelity) can result in treatment relapse. The goal of this study is to evaluate whether using treatment signals and gradually introducing materials from natural contexts can help mitigate treatment relapse during context changes and poor treatment-integrity scenarios.",[27,28],"Aggression","Self-injurious Behavior","RECRUITING","2026-06-15",{"date":32,"type":33},"2026-06-17","ACTUAL",{"date":35,"type":33},"2021-05-03",{"date":37,"type":21},"2026-12-31",{"name":39,"class":40},"Rutgers, The State University of New Jersey","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100626349","a-virtual-reality-mindfulness-application-for-aggression-in-schizophrenia-100626349","NCT07434479","A Virtual Reality Mindfulness Application for Aggression in Schizophrenia","Inclusion Criteria:\n\nTRIPP MBI VR and TAU Distraction Groups have the same inclusion criteria. Participants will:\n\n1. Is willing and able to provide written informed consent to participate in the study, attend study visits, and comply with study-related requirements and assessments.\n2. Fluent in written and spoken English, confirmed by ability to read and understand the informed consent form.\n3. Be on optimized and stable atypical antipsychotic treatment as indicated by no antipsychotic changes in 2 weeks prior to enrollment.\n4. Demonstrate documented evidence of good medication adherence for the 2 weeks prior to enrollment, as determined by electronic medication records review and prescriber reported adherence to prescribed schedule as documented in the participant's medical records.\n5. Have a history of impulsive aggression as assessed by a score of ≥ 4 on any item on Impulsive Aggression Factor (IA) on the Impulsive- Premeditated Aggression Scale (IPAS; Stanford et al., 2003).\n6. Have adequate visual and auditory abilities to complete assessments, see and hear stimuli in the VR\n7. Has a primary diagnosis of schizophrenia using the diagnostic criteria for schizophrenia or schizoaffective disorder, as defined in the SCID-5-RV at the Screening Visit.\n8. Adult or late adolescent, between 18 and 64 years of age at the time of informed consent.\n\nExclusion Criteria:\n\nParticipants will be excluded if they:\n\n1. Have past head trauma\n2. Diagnosed with a neurological disorder\n3. Are pregnant or breastfeeding women as evidenced by the participant's medical record.\n4. Have unstable medical illness that compromises the safety of the patient\n5. Have significant suicidal ideation at screening (as assessed by the Columbia - Suicide Severity Rating Scale (C-SSRS; participant answers \"Yes\" to \"suicidal ideation\" Item 4 (active suicidal ideation with some intent to act, without a specific plan) or Item 5 (active suicidal ideation with a specific plan and intent) on the C-SSRS; Non-suicidal self-injurious behavior is not exclusionary)\n6. Are on Electroconvulsive therapy (ECT) within 6 months of the study, participants with metal in their bodies or who have claustrophobia or who do not pass the criteria in NKI's Magnetic Resonance Safety Questionnaire (MRSQ)\n7. Score \\\u003C 4 on all items on Impulsive Aggression Factor (IA) on the IPAS (Stanford et al., 2003)\n8. Have a violent episode requiring seclusion, restraints, or a prn within the week before screening\n9. Evidence of suboptimal medication adherence in the 2 weeks prior to enrollment, as determined by electronic medication records review, and demonstrated by prescriber reported non- adherence to prescribed schedule. Suboptimal adherence includes missed doses (two of more missed doses within the past 2 weeks) or plasma levels indicating that the participant is not receiving the intended therapeutic dose.","18 Years","64 Years",{"count":51,"type":21},58,[24],"The study investigates whether a virtual reality-based mindfulness based intervention can reduce impulsive aggression in individuals with schizophrenia or schizoaffective disorder. The primary goal is to evaluate whether mindfulness delivered via VR (MBI-VR) improves emotion regulation and engages the dorsomedial prefrontal cortex (dmPFC), a brain region involved in cognitive control and regulation of emotional responses. The study also examines whether these effects show a dose-related relationship.\n\nParticipants will be randomized to receive different doses of MBI-VR intervention or distraction tasks and will complete repeated mindfulness VR sessions. Brain activity will be measured using functional magnetic resonance imaging (fMRI) during an emotion regulation task, along with clinical assessments of impulsive aggression related symptoms.",[55,56,27],"Schizophrenia Disorder","Schizoaffecitve Disorder",[58,59,60,61,62],"mindfulness based intervention","schizophrenia","dmPFC","emotion regulation","impulsive aggression","2026-06-09",{"date":65,"type":33},"2026-06-10",{"date":67,"type":21},"2026-06-05",{"date":69,"type":21},"2027-12-31",{"name":71,"class":40},"Manhattan Psychiatric Center",2,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":72},"100423432","manage-emotions-to-reduce-aggression-mera-100423432","NCT04793776","Manage Emotions to Reduce Aggression (MERA)","Manage Emotions to Reduce Aggression - MERA: A Brief Aggression Treatment for Veterans With PTSD Symptoms","MERA","Inclusion Criteria:\n\n1. Male and female Veterans who deployed to combat zones since 9\u002F11.\n2. Currently meets criteria for full or subthreshold PTSD, determined by the Clinician-Administered PTSD Scale for DSM-5\n3. Engaged in at least 3 self-reported aggressive acts (e.g., yelling, throwing objects, hitting objects\u002Fpeople) in the last month, measured by the Overt Aggression Scale\n4. Impulsive aggression is his\u002Fher primary form of aggression, determined by the Impulsive Premeditated Aggression Scale\n5. Each Veteran must allow an independent aggression rater (live-in partner, family member, or roommate above 18 years of age)\\] verify the number of aggressive acts, using the Overt Aggression Scale.\n6. Agreement not to change psychotropic medications through the duration of the study.\n\nExclusion Criteria:\n\n1. Currently suicidal with intent of self-harm in the last week.\n2. Currently homicidal with plans to hurt a specific person.\n3. Unable to complete self-report measures.\n4. Meets diagnostic criteria for bipolar disorder or psychotic disorder.\n5. Had a psychotropic medication change within 4 weeks prior to the baseline assessment. Veterans receiving general mental health services or engaging in usual care will be allowed to participate.",{"count":82,"type":21},204,[24],"PTSD is one of the most prevalent mental health conditions affecting Veterans who have served since 9\u002F11. Veterans with posttraumatic stress disorder (PTSD) report difficulty controlling impulsive aggression (IA). An inability to manage one's emotions (emotion dysregulation) is an underlying mechanism of IA. Reducing IA and increasing use of PTSD evidence-based psychotherapies are two critical missions for the Veterans Health Administration. The proposed research supports these missions by comparing a 3- session emotion regulation treatment (Manage Emotions to Reduce Aggression) to a control group in order to determine if MERA can reduce IA and prepare Veterans for PTSD treatment. By enhancing Veterans' abilities to cope with trauma-related emotions and feel equipped to initiate PTSD treatments, this research aims to help Veterans decrease IA and ultimately recover from PTSD.",[86,27,87],"Stress Disorders, Post-Traumatic","Emotion Regulation",[86,27,87,89,90],"Veterans","Psychotherapy","2026-06-04",{"date":93,"type":33},"2026-06-08",{"date":95,"type":33},"2022-01-03",{"date":97,"type":21},"2026-12-30",{"name":99,"class":100},"VA Office of Research and Development","FED",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":109,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":22,"phases":112,"briefSummary":113,"conditions":114,"keywords":117,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":4},"100639972","intensive-care-unit-conflict-mediation-study-100639972","NCT07621874","Intensive Care Unit Conflict Mediation Study","A Multidisciplinary Framework for ICU Conflict Mediation: Rationale and Methodological Approach to Enhancing Safety and Care Quality","\"GIRAFFE\"","-family members of patients or intensive care unit staff",true,{"count":111,"type":21},100,[24],"To evaluate the impact of a structured, multidisciplinary conflict management program incorporating an interprofessional Singular Care Plan \\*PAS\\* Committee and a Conflict Mediation Team on the incidence and severity of conflicts, family satisfaction, and staff well-being in an adult intensive care unit \\*ICU\\*",[27,115,116],"Critical Care Staff","Workplace Violence",[27,118,119],"critical care","Workplace violence","NOT_YET_RECRUITING","2026-06-01",{"date":123,"type":33},"2026-06-02",{"date":125,"type":21},"2026-10-01",{"date":127,"type":21},"2027-08-01",{"name":129,"class":40},"Hospital Israelita Albert Einstein",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":16,"minAge":138,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":22,"phases":141,"briefSummary":143,"conditions":144,"keywords":149,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":174},"100481029","phase-2-clinical-trial-on-agitation-in-alzheimers-dementia-100481029","NCT05543681","Clinical Trial on Agitation in Alzheimer's Dementia","A Phase 2, Multicenter, Double-Blind, Randomized, Placebo-Controlled, Trial of the Safety and Efficacy of IGC-AD1 on Agitation in Participants With Dementia Due to Alzheimer's Disease","CALMA","To be eligible to participate in this study, the participant must meet all the following criteria:\n\nInclusion Criteria\n\n1. Participant and\u002For Caregiver must provide a signed and dated ICF prior to any study procedures.\n2. Must have a Caregiver who is able and willing to comply with all required study procedures.\n3. The Caregiver must be known to the Participant and must be able to use electronic devices such as a cell phone, video conference over a laptop or cell phone, weighing scale, and be able to learn to take blood pressure, among others.\n4. Based on local practice, Participants that cannot consent may have Caregiver's consent provided the Caregiver has among others a) Power of Attorney, b) is a spouse, or c) a sibling or d) a child or e) a close relation. The practice of accepting consent must be consistent with established practice at the site and jurisdiction.\n5. Participants must consent to CYP450 and apolipoprotein E (ApoE) genotyping, and pharmacokinetics.\n6. Diagnosis of AD by NIA-AA criteria\n7. Clinically significant Agitation assessed by:\n\n   1. NPI (Agitation) ≥ 4\n   2. The presence of clinically significant, persistent Agitation based on the IPA definition (Appendix C) rather than those with recent onset and occasional symptoms, and\n   3. Agitation not attributable to another psychiatric disorder, suboptimal care conditions, other underlining medical condition, or the physiological effects of a substance.\n8. Negative drug screen, except for benzodiazepines if Participant has been using them in stable doses for at least 3 months before screening.\n9. All medications used for behavioral symptoms should be consistent for at least 6 weeks before screening, with allowance for dose changes up to 25%.\n10. Women must be of no childbearing potential (postmenopausal, defined as cessation of menses for at least 12 months, without an alternative medical cause for amenorrhea) or surgically sterile (hysterectomy, bilateral oophorectomy, or bilateral tubal ligation)).\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\nExclusion Criteria\n\n1. Prior adverse reaction to cannabinoids or to any component of Study Drug (IGC-AD1 and placebo).\n2. Serious or unstable medical illness, including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic, or hematologic disease, which might confound assessment of safety outcomes.\n3. History of seizures, schizophrenia, or bipolar disorder.\n4. Has participated in an investigational drug or device study within 30 days prior to study start.\n5. Urine drug screen positive for drug use, except for benzodiazepines if Participant was using them previously and their dose had remained stable for at least six weeks before screening.\n6. History of Alcohol and Drug use disorder, within one year prior to enrollment.\n7. Hypertension: Participants with a history of uncontrolled hypertension as determined by the PI and Participants with a hypertensive crisis in the six months prior to enrollment.\n8. Falls: Participants with a history of recurrent falls defined as more than two falls in the six-month period prior to enrollment and a history of falls resulting in injuries or associated with a new acute illness, loss of consciousness, fever, or abnormal blood pressure (Fuller et al., 2000).","60 Years",{"count":140,"type":21},164,[142],"PHASE2","The purpose of this study is to assess the efficacy of the oral medication IGC-AD1, a THC-based (Delta-9-Tetrahydrocannabinol) formulation administered twice a day on Agitation in patients with mild to severe dementia from Alzheimer's.",[145,146,147,148,27],"Alzheimer Disease","Agitation,Psychomotor","Care Giving Burden","NPS",[150,151,152,153,154,155,156,157,158,159,160,161,162,163],"Cannabis","Tetrahydrocannabinol","THC","Melatonin","Alzheimer's","Marijuana","Hemp","Agitation","Dementia","Depression","Anxiety","NPI","CMAI","Dronabinol","2026-05-18",{"date":166,"type":33},"2026-05-20",{"date":168,"type":33},"2022-10-11",{"date":170,"type":21},"2026-08",{"name":172,"class":173},"IGC Pharma, LLC","INDUSTRY",31,{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":4,"eligibilityCriteria":181,"healthyVolunteers":109,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":182,"targetDuration":4,"studyType":22,"phases":184,"briefSummary":185,"conditions":186,"keywords":210,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":223,"completionDateStruct":224,"leadSponsor":226,"locationsCount":41},"100637694","assessing-the-effects-of-cool-roofs-on-indoor-environments-and-health-in-tavua-fiji-100637694","NCT07592117","Assessing the Effects of Cool Roofs on Indoor Environments and Health in Tavua, Fiji","A Cluster Randomised Controlled Trial (cRCT) Evaluating the Effects of Cool Roofs on Health, Environmental and Economic Outcomes in Tavua, Fiji","Inclusion Criteria:\n\n* Permanent household resident.\n\nExclusion Criteria:\n\n* Roof damage, inaccessible or instability of roof adversely affecting cool roof coating application.\n* Participant unable to provide written\u002Fverbal informed consent.",{"count":183,"type":21},800,[24],"Ambient air temperatures in Fiji are increasing due to climate change. Solutions are needed to build heat resilience in communities and adapt. Sunlight-reflecting cool roof coatings may passively reduce indoor temperatures and energy use to protect home occupants from extreme heat. Occupants living in poor housing conditions in Fiji are susceptible to increased heat exposure.\n\nHeat exposure can instigate and worsen numerous physical, mental and social health conditions. The worst adverse health effects are experienced in communities that are least able to adapt to heat exposure. By reducing indoor temperatures, cool roof use can promote physical, mental and social wellbeing in household occupants.\n\nThe long-term research goal of the investigators is to identify viable passive housing adaptation technologies with proven health benefits to reduce the burden of heat stress in communities affected by heat in Fiji. To meet this goal, the investigators will conduct a cluster-randomized controlled trial to establish the effects of cool roof use on health, indoor environment and economic outcomes in Tavua, Fiji.",[187,188,159,189,190,191,192,193,194,195,196,197,198,199,200,201,202,203,204,205,27,206,207,208,209],"Resting Heart Rate","Blood Glucose Control","Heat-related Symptoms","Physician Diagnosed Heat-related Illnesses","Food Insecurity","Diet Quality","Health-Related Quality-of-Life","Indoor Thermal Comfort","Coping Ability","Life Satisfaction","Healthcare Provider Utilization","Hospitalization","Systolic Blood Pressure","Diastolic Blood Pressure","Inner Ear Canal Temperature","Dehydration","Sleep Quality","Cognition","Productivity","Indoor Air Temperature","Indoor Relative Humidity","Indoor Heat Index","Household Energy Expenditure",[211,212,213,214,215,159,216,217,218,219,220],"Hot temperature","Humidity","Housing","Heart rate","Cardiovascular","Mental health","Blood glucose","Diabetes","Cool roof","Heat stress","2026-05-11",{"date":164,"type":33},{"date":164,"type":21},{"date":225,"type":21},"2027-09-01",{"name":227,"class":40},"Aditi Bunker",{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":232,"acronym":4,"eligibilityCriteria":233,"healthyVolunteers":109,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":234,"targetDuration":4,"studyType":22,"phases":236,"briefSummary":237,"conditions":238,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":244,"completionDateStruct":245,"leadSponsor":246,"locationsCount":41},"100510577","manualized-assessment-and-treatment-model-of-challenging-behavior-100510577","NCT05928247","Manualized Assessment and Treatment Model of Challenging Behavior","Inclusion Criteria:\n\n1. children from ages 3 to 17;\n2. challenging behavior that occurs at least 10 times a day, despite previous treatment;\n3. challenging behavior maintained by social positive or automatic reinforcement;\n4. stable protective supports for self-injurious behavior (e.g., helmet) with no anticipated changes during enrollment;\n5. on a stable psychoactive drug regimen for at least 10 half-lives per drug or drug free;\n6. stable educational plan and placement with no anticipated changes during the child's treatment.\n\nExclusion Criteria:\n\n1. patients who do not meet the inclusion criteria;\n2. patients currently receiving 15 or more hours per week of treatment for their challenging behavior;\n3. DSM-5 diagnosis of Rett syndrome or other degenerative conditions (e.g., inborn error of metabolism);\n4. a comorbid health condition or major mental disorder that would interfere with study participation;\n5. occurrence of self-injury during study assessments that presents a risk of serious or permanent harm (e.g., detached retinas) based on our routine clinical-risk assessment (Betz, 2011);\n6. patients requiring changes to protective supports for self-injury or drug treatment, but the investigators will invite these patients to participate when protective supports and drug regimen are stable.",{"count":235,"type":21},30,[24],"Despite decades of mounting single-case-design evidence for the efficacy of applied behavior analysis (ABA) and other approaches for the assessment and treatment of challenging behavior, an evidence-based comprehensive approach remains to exist. The current study will collect test the efficacy of a standardized manual for assessing and treating challenging behavior for individuals with severe and mild challenging behavior.",[239,27,240],"Problem Behavior","Self-Injury","2026-05-04",{"date":243,"type":33},"2026-05-08",{"date":37,"type":21},{"date":69,"type":21},{"name":39,"class":40},{"id":248,"slug":249,"hasResults":11,"nctId":250,"briefTitle":251,"officialTitle":251,"acronym":4,"eligibilityCriteria":252,"healthyVolunteers":109,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":253,"targetDuration":4,"studyType":22,"phases":255,"briefSummary":256,"conditions":257,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":41},"100510335","basic-and-applied-research-on-extinction-bursts-100510335","NCT05925101","Basic and Applied Research on Extinction Bursts","Inclusion Criteria:\n\n1. children aged 3 to 17;\n2. problem behavior that occurs at least 10 times a day, despite previous treatment;\n3. problem behavior maintained by social positive reinforcement;\n4. stable protective supports for self-injurious behavior (e.g., helmet) with no anticipated changes during enrollment;\n5. on a stable psychoactive drug regimen for at least 10 half-lives per drug or drug free;\n6. stable educational plan and placement with no anticipated changes during the child's treatment.\n\nExclusion Criteria:\n\n1. patients currently receiving 15 or more hours per week of treatment for their problem behavior;\n2. DSM-5 diagnosis of Rett syndrome or other degenerative conditions (e.g., inborn error of metabolism);\n3. a comorbid health condition or major mental disorder that would interfere with study participation;\n4. occurrence of self-injury during study assessments that presents a risk of serious or permanent harm (e.g., detached retinas) based on our routine clinical-risk assessment;\n5. patients requiring changes to protective supports for self-injury or drug treatment, but we will invite these patients to participate when protective supports and drug regimen are stable.",{"count":254,"type":21},40,[24],"Although highly effective, treatments like FCT include extinction, which can have adverse side effects. The extinction burst, an increase in the frequency or intensity of destructive behavior at the start of treatment, is the most common side effect of extinction, and can increase the risk of harm to the patient and others. The goal of the current study is to evaluate the prevalence of extinction bursts when various parameters of reinforcement (i.e., rate, magnitude, quality) are manipulated.",[239,27,258],"Self Injury","2026-04-28",{"date":261,"type":33},"2026-04-29",{"date":263,"type":33},"2023-07-07",{"date":265,"type":21},"2028-05-31",{"name":39,"class":40},{"id":268,"slug":269,"hasResults":11,"nctId":270,"briefTitle":271,"officialTitle":271,"acronym":272,"eligibilityCriteria":273,"healthyVolunteers":109,"sex":16,"minAge":274,"maxAge":48,"enrollmentInfo":275,"targetDuration":4,"studyType":22,"phases":277,"briefSummary":278,"conditions":279,"keywords":281,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":41},"100609262","wise-intervention-for-reducing-aggressive-behaviors-and-promoting-prosocial-behaviors-toward-lgb-tnb-individuals-100609262","NCT07212283","Wise Intervention for Reducing Aggressive Behaviors and Promoting Prosocial Behaviors Toward LGB-TNB Individuals","LGB-TNB","Inclusion Criteria:\n\n* Informed consent by the adolescents and their families.\n* To be fluent in Spanish and\u002For Euskera.\n\nExclusion Criteria:\n\n* Lack of permission by families and the adolescent.\n* Lack of understanding of the instructions.","14 Years",{"count":276,"type":21},1000,[24],"This study evaluates the effectiveness of a wise Intervention to reduce aggressive behaviors and promote prosocial behaviors toward LGB-TNB individuals among Spanish adolescents. Half of the participants will receive the experimental intervention, while the other half will receive a control intervention.",[27,280],"Adolescence",[280,282,27,283,284],"LGBTQ","Prosocial Behavior","Wise Intervention","2026-04-27",{"date":287,"type":33},"2026-05-01",{"date":289,"type":33},"2025-09-18",{"date":291,"type":21},"2026-06",{"name":293,"class":40},"University of Deusto",{"id":295,"slug":296,"hasResults":11,"nctId":297,"briefTitle":298,"officialTitle":299,"acronym":4,"eligibilityCriteria":300,"healthyVolunteers":109,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":301,"targetDuration":4,"studyType":22,"phases":302,"briefSummary":303,"conditions":304,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":41},"100480563","extensions-of-resurgence-as-choice-100480563","NCT05537610","Extensions of Resurgence as Choice","Extensions of Resurgence as Choice: Basic and Clinical Studies","Inclusion Criteria:\n\n1. boys and girls from ages 3 to 17;\n2. problem behavior that occurs at least 10 times a day, despite previous treatment;\n3. problem behavior maintained by social positive reinforcement;\n4. stable protective supports for self-injurious behavior (e.g., helmet) with no anticipated changes during enrollment;\n5. on a stable psychoactive drug regimen for at least 10 half-lives per drug or drug free;\n6. stable educational plan and placement with no anticipated changes during the child's treatment.\n\nExclusion Criteria:\n\n1. patients who do not meet the inclusion criteria;\n2. patients currently receiving 15 or more hours per week of treatment for their problem behavior;\n3. DSM-5 diagnosis of Rett syndrome or other degenerative conditions (e.g., inborn error of metabolism);\n4. a comorbid health condition or major mental disorder that would interfere with study participation;\n5. occurrence of self-injury during study assessments that presents a risk of serious or permanent harm (e.g., detached retinas) based on our routine clinical-risk assessment;\n6. patients requiring changes to protective supports for self-injury or drug treatment, but we will invite these patients to participate when protective supports and drug regimen are stable.",{"count":235,"type":21},[24],"Although behavioral treatments for decreasing destructive behavior, such as differential reinforcement of alternative behavior (DRA), are effective in the clinic, problem behavior often returns when a caregiver does not give the child their way in the natural environment (e.g., caregiver is busy with an infant sibling). This form of treatment relapse is known as resurgence. The goal of the current study is to evaluate whether alternating sessions in which the child can have their way (i.e., \"on\" sessions) with sessions in which the child can not have their way (i.e., \"off\" sessions) helps to mitigate resurgence.",[239,27,240],"2026-04-14",{"date":307,"type":33},"2026-04-17",{"date":309,"type":33},"2023-02-01",{"date":311,"type":21},"2028-01-31",{"name":39,"class":40},{"id":314,"slug":315,"hasResults":11,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":4,"eligibilityCriteria":319,"healthyVolunteers":109,"sex":320,"minAge":48,"maxAge":321,"enrollmentInfo":322,"targetDuration":4,"studyType":22,"phases":324,"briefSummary":325,"conditions":326,"keywords":329,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":338,"lastUpdatePostDateStruct":339,"startDateStruct":341,"completionDateStruct":343,"leadSponsor":344,"locationsCount":4},"100611482","creative-drama-on-gender-role-stress-attitudes-toward-violence-against-women-and-aggression-100611482","NCT07241156","Creative Drama on Gender Role Stress, Attitudes Toward Violence Against Women, and Aggression","Determining the Impact of Creative Drama on Gender Role Stress, Attitudes Toward Violence Against Women, and Aggression Among Men Affected by an Earthquake:A Randomized Controlled Trial","Inclusion Criteria:\n\nMale individuals who experienced the 2023 Türkiye earthquake (centered in Kahramanmaraş) and currently live in Malatya.\n\nMarried during the earthquake and currently married.\n\nVolunteer to participate in the study.\n\nAged between 18 and 65 years.\n\nNo hearing or visual impairments.\n\nNo intellectual disability.\n\nAt least primary school graduate.\n\nNo diagnosed psychiatric disorder.\n\nHave not received creative drama training.\n\nHave not received psychosocial support after the earthquake.\n\nHave not participated in previous studies involving creative drama related to gender role stress, attitudes toward violence against women, or aggression.\n\nAgree to attend weekly sessions and comply with the study program.\n\nExclusion Criteria:\n\nVoluntary withdrawal from the study.\n\nFailure to attend sessions regularly.\n\nChanging residence to another city during the study period.\n\nDivorce during the study period.\n\nBeginning to receive psychosocial support during the study period.","MALE","65 Years",{"count":323,"type":21},75,[24],"This study aims to examine the effect of Creative Drama on gender role stress, attitudes toward violence against women, and aggression among men who experienced the February 6, 2023 earthquake in Türkiye (centered in Kahramanmaraş).\n\nA total of 75 men (25 experimental, 25 placebo, and 25 control) will participate in the study. The experimental group will take part in a creative drama program, the placebo group will watch films focusing on masculinity roles and violence for 10 weeks, and no intervention will be applied to the control group.\n\nData will be collected using the Gender Role Stress Scale for Men, the Attitudes Toward Violence Against Women Scale, and the Buss-Perry Aggression Questionnaire - Short Form, and will be analyzed by an independent statistician.\n\nThe study aims to enhance the psychological well-being of men affected by the earthquake in Türkiye, reduce violence against women, and contribute to gender equality.",[327,27,328],"Gender Role","Violence",[330,331,332,333,334,335,336,337],"Creative Drama","Gender Role Stress","Attitudes Toward Violence Against Women","Earthquake Survivors","Men's Mental Health","Post-Disaster Psychosocial Support","Türkiye Earthquake 2023","Non-Pharmacological Intervention","2026-04-07",{"date":340,"type":33},"2026-04-09",{"date":342,"type":21},"2026-03-30",{"date":97,"type":21},{"name":345,"class":40},"Ataturk University",{"id":347,"slug":348,"hasResults":11,"nctId":349,"briefTitle":350,"officialTitle":351,"acronym":352,"eligibilityCriteria":353,"healthyVolunteers":109,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":354,"targetDuration":4,"studyType":22,"phases":355,"briefSummary":356,"conditions":357,"keywords":359,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":363,"startDateStruct":365,"completionDateStruct":367,"leadSponsor":369,"locationsCount":41},"100562912","treatment-of-chronic-anger-and-aggression-following-military-related-betrayal-100562912","NCT06609330","Treatment of Chronic Anger and Aggression Following Military-Related Betrayal","Assessment and Treatment of Chronic Anger and Aggression Following Military-Related Interpersonal and Institutional Betrayal: A Pilot Investigation","CART","Inclusion Criteria:\n\n* Adult active duty military service members and veterans aged 18 or older.\n* Endorses a history of military-related betrayal (on the Modified Moral Injury Questionnaire)\n* Endorses problematic anger in the past month (as evidenced by a score of 12 or above on the Dimensions of Anger Reactions; DAR-5)\n* Engaged in at least 1 self-reported act of aggression in the past 1 month (on the Overt Aggression Scale-Modified; OAS-M)\n\nExclusion Criteria:\n\n* Participated in an anger management or trauma-focused intervention within the past 3 months as assessed by self-report.\n* Acute suicidality requiring immediate intervention, such as hospitalization as assessed by the Depressive Symptoms Index-Suicidality Subscale (DSI-SS) combined with follow up clinical interview for elevated scores.\n* Is currently homicidal with plans and intent to hurt a specific person and requiring immediate intervention as measured by self-report and follow-up with clinician if screened positive.\n* Moderate to severe brain injury as measured by inability to comprehend the informed consent document or baseline assessments.\n* Has severe alcohol consumption patterns as evidenced by a score of 19 or above on the Alcohol Use Disorders Identification Test (AUDIT).\n* Experiencing active psychosis or mania as measured by the Prodromal Questionnaire-Brief Version and the Mood Disorders Questionnaire.",{"count":254,"type":21},[24],"The goal of this clinical trial is to learn if a treatment designed to deal with anger and aggression from a past betrayal will work. The study will be done on active duty military service members and veterans aged 18 or older. The main questions it aims to answer are:\n\n* Will participants be satisfied with the treatment, and is the treatment feasible to do in a military outpatient setting\n* Will the treatment help with anger and aggression issues.\n\nResearchers will compare differences in groups that have different wait times (2-, 3-, or 4-weeks).\n\nParticipants will complete surveys before, during and after the treatment. The treatment will be 14 modules given twice a week. About 1 month after treatment ends, surveys will be taken again.",[358,27],"Anger Problems",[360,361,362],"Anger management","Military-related betrayal","Deficit of trust",{"date":364,"type":33},"2026-04-01",{"date":366,"type":33},"2025-03-17",{"date":368,"type":21},"2027-01",{"name":370,"class":40},"The University of Texas Health Science Center at San Antonio",{"id":372,"slug":373,"hasResults":11,"nctId":374,"briefTitle":375,"officialTitle":376,"acronym":4,"eligibilityCriteria":377,"healthyVolunteers":11,"sex":16,"minAge":378,"maxAge":379,"enrollmentInfo":380,"targetDuration":4,"studyType":22,"phases":382,"briefSummary":383,"conditions":384,"keywords":389,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":402,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":407,"locationsCount":72},"100599960","phase-2-propranolol-for-aggression-self-injury-and-severe-disruptive-behavior-in-adolescents-and-adults-with-autism-100599960","NCT07091279","Propranolol for Aggression, Self-Injury, and Severe Disruptive Behavior in Adolescents and Adults With Autism","Randomized Controlled Trial of Propranolol for Aggression, Self-Injury, and Severe Disruptive Behavior in Adolescents and Adults With Autism","Inclusion Criteria:\n\n* Age between 12-40 years.\n* Clinical best-estimate diagnosis of autism spectrum disorder\n* Occurrence of severe challenging behaviors, such as aggression, self-injury, and\u002For severely disruptive or destructive behavior, leading to safety concerns or serious impact of the quality of life, at least weekly over the past 2 months before screening.\n* Score in the ASD range on the Autism Diagnostic Observation Schedule conducted at the time of study entry or in the past 5 years\n* Clinical Global Impression Severity scale (CGI-S) score of 4 or above at Baseline\n* Aberrant Behavior Checklist-2 Irritability\u002FAgitation Subscale Score of 18 or above at Screening.\n* A resting pulse of greater than 60 and a resting blood pressure of greater than 100\u002F60.\n* Participant must have a designated study partner who spends a minimum of 5 hours\u002Fweek with the participant, and can, in the opinion of the investigator, provide a reliable report on the participant's behaviors, symptoms, and complete or supervise at-home safety monitoring and other assessments required during the study\n* Participants of childbearing potential who are sexually active must agree to practice effective contraception from time of screening through 30 days after their last dose of study drug. Effective contraception is the use of two methods of contraception: hormonal contraceptives or intrauterine device and barrier (i.e., condoms, diaphragm, or cervical cap).\n* Participant must be able to fully swallow study medication capsule.\n* English must be primary language for participant. Study partner must be able to consent in English and complete study related form in English.\n\nExclusion Criteria:\n\n* Those who are unable to provide informed consent and have no parent\u002Fguardian\u002Flegally authorized representative to provide informed consent for study enrollment\n* Change in psychotropic medication or behavioral intervention (except when caused by vocational, habilitation, or school schedule) within two months before randomization.\n* Asthma or history of any disorder involving bronchoconstriction in the past 5 years.\n* Cardiovascular history in which the use of propranolol at high doses would be contraindicated, as determined by consulting cardiologist (such as AV block, sick sinus syndrome, valvular pathologies, cardiomyopathies, or vascular disease).\n* Uncontrolled seizure disorder (a seizure within the past year and\u002For changes in seizure medication in the previous six months).\n* Diabetes mellitus\n* History of lactose intolerance that requires the potential participant to abstain from all dairy products or to take lactase supplements.\n* Medical history of renal or hepatic impairment.\n* Medical history of hypoglycemia\n* Inability to provide blood testing when there is a medical indication for blood testing to allow clinical safety determination by the study safety physician\n* Depressive episode currently or within the previous six months\n* History of allergy or adverse reaction to propranolol or another beta-blocker\n* Current use of any of the following: propafenone, quinidine, amiodarone, lidocaine, digitalis glycosides, calcium channel blockers, ACE inhibitors, clonidine, alpha blockers, reserpine, inotropic agents (epinephrine), isoproterenol and dobutamine, nonsteroidal anti-inflammatory drugs (indomethacin), antidepressants (MAO inhibitors, tricyclics), anesthetic agents (methoxyflurane, trichloroethylene), warfarin, neuroleptics (haloperidol), thyroxine, alcohol\n* Any other medical disorder or medication which would contraindicate the use of propranolol.\n* Is judged to be inappropriate for the study for any reason by the Investigator\n* Has recently participated in another investigational medication study or device study within last 3 months\n* Participant is unable to complete blood pressure or ECG safety assessments\n* If female, is pregnant or breastfeeding.","12 Years","40 Years",{"count":381,"type":21},60,[142],"The goal of this clinical trial is to learn if propranolol can help reduce challenging behaviors associated with Autism Spectrum Disorder, including aggression, self-injury, and severe disruptive behaviors. Participants will be randomly assigned to receive either propranolol or a placebo (a look-alike substance that contains no drug) daily for 12 weeks. After the 12 weeks, all participants will have the opportunity to receive propranolol for an additional 12 weeks.",[385,386,27,387,388],"Autism Spectrum Disorder","Challenging Behaviour","Severe Disruptive Behaviour Disorders","Self-injury",[390,391,392,393,394,395,396,397,398,399,400],"autism","autism spectrum disorder","propranolol","severe disruptive behavior","aggression","challenging behavior","self-injury","randomized clinical trial","RCT","high dose propranolol","open label","2026-03-26",{"date":342,"type":33},{"date":404,"type":33},"2026-01-30",{"date":406,"type":21},"2028-12",{"name":408,"class":40},"Jeremy Veenstra-vanderweele",{"id":410,"slug":411,"hasResults":11,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":415,"eligibilityCriteria":416,"healthyVolunteers":11,"sex":16,"minAge":378,"maxAge":48,"enrollmentInfo":417,"targetDuration":4,"studyType":22,"phases":419,"briefSummary":420,"conditions":421,"keywords":422,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":426,"lastUpdatePostDateStruct":427,"startDateStruct":429,"completionDateStruct":431,"leadSponsor":433,"locationsCount":41},"100630226","virtual-reality-intervention-vr-ginso-for-reducing-aggression-in-young-offenders-100630226","NCT07484919","Virtual Reality Intervention (VR-GINSO) for Reducing Aggression in Young Offenders","Virtual Reality Intervention (VR--GINSO) for Reducing Aggression in Young Offenders","VR-GINSO","Inclusion Criteria:\n\n* 12-18 years old at the moment of recruitment and allocation.\n* Minimum facility stay of 6 months since the begining of the study.\n* Documented records of recent aggresive behavior.\n\nExclusion Criteria:\n\n* Neurological disorder, brain injury, or psyquiatric pathology that affects cognitive functions or advises against use of virtual reality.\n* Not being fluent in Spanish.",{"count":418,"type":21},110,[24],"The goal of this clinical trial is to see if a specific intervention program that uses virtual reality (VR) helps young people reduce aggressive behavior more than the same program without VR or their usual treatment. The study will also look at how the program affects anger, impulsivity, emotional control, and how participants understand and handle conflicts with others.\n\nThe main questions the study wants to answer are:\n\n* Does the intervention program with VR help young people reduce aggressive behavior more than the same program without VR or just their usual treatment?\n* What changes in the mind and body are linked to improvements in aggressive behavior and emotional control?\n\nThe researchers will compare three groups of young people:\n\n* Usual treatment plus the 4-session intervention program with VR.\n* Usual treatment plus the 4-session intervention program without VR.\n* Usual treatment only.\n\nParticipants will:\n\n* Attend 4 individual sessions lasting 1 to 1.5 hours, once a week.\n* Take part in activities to learn how to recognize emotions, understand conflict situations, and manage anger and impulsivity.\n* Complete questionnaires about aggressive behavior, anger, impulsivity, emotional control, and how they interpret conflicts.\n* Have their aggressive behavior recorded through disciplinary reports at the center.\n* Provide saliva samples before and after sessions to measure hormones related to stress and aggression.\n* Wear a chest band that measures heart rate and a headset that records brain activity during the VR activities.\n\nAll data will be kept confidential, and the identities of participants will be protected at all times.",[27],[423,424,425],"youth violence","virtual reality","juvenile offenders","2026-03-17",{"date":428,"type":33},"2026-03-20",{"date":430,"type":33},"2025-12-15",{"date":432,"type":21},"2026-10",{"name":434,"class":40},"Universidad Francisco de Vitoria",{"id":436,"slug":437,"hasResults":11,"nctId":438,"briefTitle":439,"officialTitle":440,"acronym":441,"eligibilityCriteria":181,"healthyVolunteers":109,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":442,"targetDuration":4,"studyType":22,"phases":443,"briefSummary":444,"conditions":445,"keywords":447,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":450,"lastUpdatePostDateStruct":451,"startDateStruct":453,"completionDateStruct":454,"leadSponsor":455,"locationsCount":41},"100580253","assessing-the-effects-of-cool-roofs-on-indoor-environments-and-health-in-colima-mexico-100580253","NCT06834893","Assessing the Effects of Cool Roofs on Indoor Environments and Health in Colima, Mexico","A Cluster Randomised Controlled Trial (cRCT) Evaluating the Effects of Cool Roofs on Health, Environmental and Economic Outcomes in Colima, Mexico","REFLECT",{"count":183,"type":21},[24],"Ambient air temperatures in Mexico have broken record highs in 2024. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate change. Sunlight-reflecting cool roof coatings may passively reduce indoor temperatures and energy use to protect home occupants from extreme heat. Occupants living in poor housing conditions in the northern zone of Mexico are susceptible to increased heat exposure.\n\nHeat exposure can instigate and worsen numerous physical, mental and social health conditions. The worst adverse health effects are experienced in communities that are least able to adapt to heat exposure. By reducing indoor temperatures, cool roof use can promote physical, mental and social wellbeing in household occupants.\n\nThe long-term research goal of the investigators is to identify viable passive housing adaptation technologies with proven health benefits to reduce the burden of heat stress in communities affected by heat in Mexico. To meet this goal, the investigators will conduct a cluster-randomized controlled trial to establish the effects of cool roof use on health, indoor environment and economic outcomes in Colima, Mexico.",[187,188,159,189,190,191,192,446,194,195,196,197,198,199,200,201,202,203,204,205,27,206,207,208,209],"Health-related Quality of Life",[448,212,213,214,215,159,216,217,218,219,449],"Hot Temperature","Heat Stress","2026-03-10",{"date":452,"type":33},"2026-03-12",{"date":364,"type":21},{"date":225,"type":21},{"name":227,"class":40},{"id":457,"slug":458,"hasResults":11,"nctId":459,"briefTitle":460,"officialTitle":461,"acronym":4,"eligibilityCriteria":462,"healthyVolunteers":11,"sex":16,"minAge":463,"maxAge":464,"enrollmentInfo":465,"targetDuration":4,"studyType":22,"phases":467,"briefSummary":468,"conditions":469,"keywords":475,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":482,"completionDateStruct":484,"leadSponsor":486,"locationsCount":41},"100585460","step-by-step-evaluation-of-a-stepped-care-model-100585460","NCT06902649","Step-by-Step: Evaluation of a Stepped Care Model","Step-by-Step: Evaluation of a Stepped Care Model for Anger, Defiant, or Aggressive Behavior in Children and Adolescents","Inclusion Criteria:\n\n* Families with children aged 8-16 years who have difficulty controlling anger or exhibit defiant or aggressive behavior. The child\u002Fadolescent meets 3 of the diagnostic criteria for Oppositional Defiant Disorder or 2 criteria for Conduct Disorder indicating aggressive behavior.\n* Medication for the child can remain stable.\n* Parents need to be able to read and engage with materials in Swedish\n\nExclusion Criteria:\n\n* Families with children younger than 8 years old or who have already turned 17, or who do not exhibit defiant or aggressive behaviors according to the first inclusion criterion.\n* Children with severe depression, suicidal behavior, bipolar disorder, psychosis, eating disorders, severe autism (level 2 and 3), diagnosed intellectual disability, or ongoing criminal behavior assessed to require interventions other than the study's interventions are excluded.\n* Children\u002Fadolescents with other ongoing psychological treatments for the same condition or assessed by the clinician in need of other interventions\n* Parents and children with epilepsy or migraines","8 Years","16 Years",{"count":466,"type":21},210,[24],"The primary aim of this project is to examine the effectiveness of a stepped care model of interventions for children's defiant or aggressive behavior problems. The stepped model consists of a brief internet-based parenting support program (Step 1). For those with continued need of additional interventions, Step 2 includes access to one of following interventions: b) a Cognitive Behavior Therapy (CBT) -Virtual Reality (VR)-assisted parenting support program, b) a Cognitive Behavior Therapy -Virtual Reality-assisted child intervention, or c) standard interventions\u002Fsupport at the family's unit\u002Fclinic and continued access to the study's internet-based parenting support program, after which the family may choose CBT-VR for the child or the parent.",[470,471,472,473,27,474],"Child Behavior Problem","Disruptive Behavior","Oppositional Defiant Disorder","Conduct Problems","Anger",[471,470,476,477,478],"Cognitive behavior therapy","Virtual Reality","Parenting support program","2026-03-04",{"date":481,"type":33},"2026-03-06",{"date":483,"type":33},"2025-04-02",{"date":485,"type":21},"2027-08-31",{"name":487,"class":40},"Karolinska Institutet",{"id":489,"slug":490,"hasResults":11,"nctId":491,"briefTitle":492,"officialTitle":493,"acronym":441,"eligibilityCriteria":181,"healthyVolunteers":109,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":494,"targetDuration":4,"studyType":22,"phases":496,"briefSummary":497,"conditions":498,"keywords":499,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":500,"lastUpdatePostDateStruct":501,"startDateStruct":503,"completionDateStruct":505,"leadSponsor":507,"locationsCount":508},"100560653","assessing-the-effects-of-cool-roofs-on-indoor-environments-and-health-100560653","NCT06579950","Assessing the Effects of Cool Roofs on Indoor Environments and Health","The Effects of Cool Roofs on Health, Environmental, and Economic Outcomes: a Global Multi-center Cluster-randomized Controlled Trial",{"count":495,"type":21},3200,[24],"Ambient air temperatures in Asian, Latin American, African, and Pacific climate hotspots have broken record highs in 2024, driven by man-made climate change. Solutions are needed to reduce heat exposure in communities. Sunlight-reflecting cool roof coatings passively reduce indoor temperatures and energy use to protect home occupants from extreme heat. Occupants living in poor housing conditions globally - for example in informal settlements, slums, and low-socioeconomic households - are especially vulnerable to increased indoor heat exposure.\n\nHeat exposure can instigate and worsen numerous physical, mental and social health conditions. The worst adverse health effects are being experienced in communities least able to adapt to heat exposure. By reducing indoor temperatures, cool roof use can promote physical, mental and social wellbeing in occupants.\n\nThe long-term research goal is to identify viable passive housing adaptation technologies with proven health and environmental benefits to reduce the burden of heat stress in communities affected by heat globally. To meet this goal, the investigators will conduct a cluster-randomized controlled trial to establish the effects of cool roof use on health, indoor environment and economic outcomes in five urban climate hotspots: Ouagadougou, Burkina Faso; Colima, Mexico; Ahmedabad, India; Niue; and Tavua, Fiji.",[187,188,159,189,190,191,192,446,194,195,196,197,198,199,200,201,202,203,204,205,27,206,207,208,209],[448,212,213,214,215,159,216,217,218,219,449],"2026-02-25",{"date":502,"type":33},"2026-02-27",{"date":504,"type":33},"2024-09-04",{"date":506,"type":21},"2027-09-30",{"name":227,"class":40},5,{"id":510,"slug":511,"hasResults":11,"nctId":512,"briefTitle":513,"officialTitle":514,"acronym":4,"eligibilityCriteria":515,"healthyVolunteers":109,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":516,"targetDuration":4,"studyType":22,"phases":518,"briefSummary":519,"conditions":520,"keywords":521,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":526,"lastUpdatePostDateStruct":527,"startDateStruct":528,"completionDateStruct":530,"leadSponsor":531,"locationsCount":41},"100626646","managing-aggression-effectiveness-of-model-based-standardized-patient-simulation-100626646","NCT07438340","Managing Aggression: Effectiveness of Model-Based Standardized Patient Simulation","Managing Aggression! Evaluating the Effectiveness of Model-Based Standardized Patient Simulation: A Parallel Mixed-Methods Randomized Controlled Trial","Inclusion Criteria:\n\n* being 18 years of age\n* having taken and successfully passed the Mental Health and Psychiatric Nursing course\n* agreeing to participate in the study\n\nExclusion Criteria:\n\n* refusing to participate in the study",{"count":517,"type":21},56,[24],"This study aims to evaluate the effectiveness of standardized patient simulation based on \"The De-Escalation Model in Simple Form\" on nursing students' perceptions of aggression and perceived learning outcomes. Encountering aggressive and violent patient behavior is a common and challenging experience for nursing students. Simulation-based education offers experiential learning opportunities that can enhance students' confidence and clinical decision-making skills.\n\nThe study was designed using a convergent parallel mixed-methods approach. The quantitative component consists of a randomized controlled trial design in which participants will be randomly assigned to either the intervention group or the control group. Primary and secondary outcome measures related to aggression perception and perceived learning will be assessed post-test in both groups.\n\nThe intervention group will receive training based on the De-Escalation Model in Simple Form, followed by participation in an aggression management simulation with a standard patient. After the simulation, qualitative data will be collected from participants in the intervention group to examine their experiences, perceptions, and reactions to the intervention and simulation process.\n\nQuantitative and qualitative findings will be analyzed to provide a comprehensive understanding of the intervention's effectiveness and implementation process. The results of this study are expected to contribute to evidence-based educational practices aimed at improving nursing students' skills in managing aggressive patient behavior.",[27],[27,522,523,524,525],"Aggressive Patient","Aggression Management","De-Escalation Model in The Simple Form","Standardized Patient Simulation","2026-02-22",{"date":502,"type":33},{"date":529,"type":21},"2026-02",{"date":529,"type":21},{"name":532,"class":40},"Yuksek Ihtisas University",{"id":534,"slug":535,"hasResults":11,"nctId":536,"briefTitle":537,"officialTitle":537,"acronym":538,"eligibilityCriteria":539,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":540,"enrollmentInfo":541,"targetDuration":4,"studyType":22,"phases":542,"briefSummary":543,"conditions":544,"keywords":553,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":566,"lastUpdatePostDateStruct":567,"startDateStruct":569,"completionDateStruct":571,"leadSponsor":573,"locationsCount":41},"100409377","cognitive-remediation-in-forensic-mental-health-care-100409377","NCT04610697","Cognitive Remediation in Forensic Mental Health Care","CRFMHC","Inclusion Criteria:\n\ni1. Age 18 - 55; i2. Ability to read and speak in fluent English; i3. Current status as inpatient on the Forensic Treatment Unit.\n\nExclusion Criteria:\n\ne1. Intellectual disability; e2. TBI with loss of consciousness followed by known severe neurological sequelae requiring hospitalisation and rehabilitation.","55 Years",{"count":235,"type":21},[24],"Forensic patients often display cognitive deficits, particularly in the domain of executive functions, that represent a challenge to forensic rehabilitation.\n\nOne empirically-validated method to train executive functions is cognitive remediation, which consists of cognitive exercises combined with coaching.\n\nThis trial investigates whether cognitive remediation can improve cognitive, functional, and clinical outcomes in forensic inpatients.",[545,546,547,27,548,328,549,160,159,550,551,552],"Psychotic Disorders","ADHD","TBI (Traumatic Brain Injury)","Substance Use Disorders","Cognitive Dysfunction","Schizophrenia","Offenders","Antisocial",[554,555,556,557,558,559,560,561,562,563,564,204,565],"Cognitive Remediation","Cognitive Training","Cognitive Enhancement","Cognitive Rehabilitation","Neuropsychological Rehabilitation","Executive Function","Forensic Mental Health","Forensic Psychology","Forensic Neuropsychology","Forensic Neuroscience","Forensic Rehabilitation","Executive Functioning","2025-12-04",{"date":568,"type":33},"2025-12-12",{"date":570,"type":33},"2020-02-10",{"date":572,"type":21},"2026-02-10",{"name":574,"class":40},"The Royal Ottawa Mental Health Centre",{"id":576,"slug":577,"hasResults":11,"nctId":578,"briefTitle":579,"officialTitle":580,"acronym":4,"eligibilityCriteria":581,"healthyVolunteers":109,"sex":16,"minAge":274,"maxAge":582,"enrollmentInfo":583,"targetDuration":4,"studyType":585,"phases":4,"briefSummary":586,"conditions":587,"keywords":590,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":594,"lastUpdatePostDateStruct":595,"startDateStruct":597,"completionDateStruct":599,"leadSponsor":601,"locationsCount":41},"100507483","addressing-root-causes-for-gun-violence-prevention-arc-gvp-100507483","NCT05887973","Addressing Root Causes for Gun Violence Prevention (ARC-GVP)","Addressing Root Causes for Gun Violence Prevention (ARC-GVP) Outcomes Study","Inclusion Criteria:\n\n* Youth in Washington D.C. who are participating in The T.R.I.G.G.E.R Project, a grassroots youth firearm violence prevention program\n\nExclusion Criteria:\n\n* Emancipated minors","24 Years",{"count":584,"type":21},250,"OBSERVATIONAL","The goal of this study is to help build the evidence base for a locally-relevant youth firearm violence prevention program in Washington D.C., a city experiencing disparities in youth firearm violence outcomes.\n\nThe main question it aims to answer is:\n\nHow is youth participation in the summer youth employment program, the True Reasons I Grabbed the Gun Evolved from Risk (The T.R.I.G.G.E.R Project), which is designed to address root causes of gun violence, associated with individual youth behavioral outcomes, including pro-social involvement, aggression, and firearm-related attitudes and behaviors?",[328,588,589,27],"Adolescent","Firearm Injury",[591,592,593],"Youth Violence Prevention","Gun Violence Prevention","Positive Youth Development","2025-08-12",{"date":596,"type":33},"2025-08-14",{"date":598,"type":33},"2022-06-27",{"date":600,"type":21},"2026-07",{"name":602,"class":40},"University of Michigan",{"id":604,"slug":605,"hasResults":11,"nctId":606,"briefTitle":607,"officialTitle":608,"acronym":4,"eligibilityCriteria":609,"healthyVolunteers":11,"sex":16,"minAge":378,"maxAge":610,"enrollmentInfo":611,"targetDuration":4,"studyType":22,"phases":613,"briefSummary":614,"conditions":615,"keywords":618,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":622,"lastUpdatePostDateStruct":623,"startDateStruct":625,"completionDateStruct":627,"leadSponsor":628,"locationsCount":41},"100590792","motivational-interviewing-based-training-100590792","NCT06972030","Motivational Interviewing-Based Training","The Effect of Motivational Interviewing-Based Training on Peer Bullying, Social Exclusion and Aggression in Secondary School Students","Inclusion Criteria:\n\n* Being 12-13 years old\n* Being in one of the 6th and 7th grades of middle school\n* Having a high score on the ''Peer Bullying Determination Scale''\n* Being willing to participate in the research\n* Not having a communication barrier\n* The student and their parents having signed the informed consent form.\n\nExclusion Criteria:\n\n* Having a low score on the ''Peer Bullying Determination Scale''\n* The volunteer not wanting to continue during the research\n* Encountering any communication barriers during the research\n* Answering the data collection forms incompletely or incorrectly","13 Years",{"count":612,"type":21},80,[24],"The middle school period is the period when children begin to experience physical, emotional and social development and try to adapt to psychological changes. In this age group, which is seen as a transition period, the child's academic success and acceptance by peers and friends are also important. The problems experienced during this period can continue in adulthood and children are more likely to experience loneliness, sleep disorders, depression, anxiety, eating disorders, low self-esteem, suicidal thoughts, absenteeism and a decrease in academic success. For this reason, early detection of risky behaviors that threaten children's health and evaluation of health promotion practices are very important issues for child health nursing.\n\nIn recent years, peer bullying, aggression and social exclusion have increased and continue to increase in the middle school period, also called early adolescence. For this purpose, a study was needed to identify the situation in middle school students and reduce this negativity. In this respect, it is thought that the study will contribute to the literature. In addition, if the hypotheses of the study are confirmed, it is expected that similar training will be provided in other schools and contribute to the reduction of risky behaviors.\n\nThe aim of this study is to determine the effects of motivational interviewing-based education on peer bullying, social exclusion and aggression in secondary school students and to offer suggestions for situations where deficiencies are observed based on the findings obtained.",[616,27,617],"Social Exclusion","Bullying of Child",[619,27,620,621],"Peer bullying","Social exclusion","Motivational interviewing","2025-05-16",{"date":624,"type":33},"2025-05-21",{"date":626,"type":21},"2025-09-01",{"date":30,"type":21},{"name":629,"class":40},"Muş Alparslan University",{"id":631,"slug":632,"hasResults":11,"nctId":633,"briefTitle":634,"officialTitle":635,"acronym":636,"eligibilityCriteria":637,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":321,"enrollmentInfo":638,"targetDuration":4,"studyType":22,"phases":639,"briefSummary":640,"conditions":641,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":642,"lastUpdatePostDateStruct":643,"startDateStruct":645,"completionDateStruct":647,"leadSponsor":649,"locationsCount":41},"100418694","the-use-of-transcranial-direct-current-stimulation-tdcs-in-adults-with-developmental-disabilities-100418694","NCT04732052","The Use of Transcranial Direct Current Stimulation (tDCS) in Adults With Developmental Disabilities","The Use of Transcranial Direct Current Stimulation (tDCS) to Reduce Impulsivity and Aggression in Adults With Developmental Disabilities: The tDCS-RIADD Randomized Controlled Trial Protocol","tDCS-RIADD","Inclusion Criteria:\n\n* Adults aged 18-64 years\n* Diagnosis of a developmental disability\n* History of one or more incidents of aggression in the last month\n* Consent to participate in the trial by the individual or their Substitute Decision Maker\n\nExclusion Criteria:\n\n* History of epilepsy or seizures\n* History of acquired brain injury\n* Having metal in the brain\u002Fskull, e.g. splinters, fragments or clips\n* Having a cochlear implant\n* Having an implanted neuro-stimulator (e.g. direct brain stimulation, epidural\u002Fsubdural stimulation, vagal nerve stimulation)\n* History of brain surgery of procedure\n* History of severe adverse reaction to tDCS\n* Having a cardiac pacemaker or intracardiac lines\n* Current alcohol or drug misuse\n* Having a sensitive scalp",{"count":381,"type":21},[24],"Aggressive behaviours are highly prevalent among people with developmental disabilities, both in community and inpatient or residential settings, with adverse consequences for the individuals involved and others. Some predictive factors, particularly impulsivity, are dynamic with neurobiological underpinnings, and as such amenable to change or neuromodulation using non-invasive brain stimulation techniques. With this in mind, we designed an experimental protocol to determine the efficacy of transcranial Direct Current Stimulation (tDCS) as a non-invasive brain stimulation technique to reduce impulsivity and aggression associated with developmental disability.",[27],"2025-03-21",{"date":644,"type":33},"2025-03-25",{"date":646,"type":33},"2022-09-01",{"date":648,"type":21},"2028-12-31",{"name":650,"class":40},"Dr. Najat Khalifa",{"id":652,"slug":653,"hasResults":11,"nctId":654,"briefTitle":655,"officialTitle":656,"acronym":4,"eligibilityCriteria":657,"healthyVolunteers":109,"sex":16,"minAge":48,"maxAge":658,"enrollmentInfo":659,"targetDuration":4,"studyType":22,"phases":661,"briefSummary":662,"conditions":663,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":665,"lastUpdatePostDateStruct":666,"startDateStruct":668,"completionDateStruct":670,"leadSponsor":672,"locationsCount":41},"100450467","just-in-time-intervention-to-reduce-alcohol-facilitated-intimate-partner-violence-perpetration-100450467","NCT05145868","Just-In-Time Intervention to Reduce Alcohol-Facilitated Intimate Partner Violence Perpetration","Evaluation and Optimization of a Just-in-Time Messaging Intervention to Reduce Alcohol-Facilitated Intimate Partner Violence Perpetration Among At-Risk Young Adult Men and Women","Inclusion Criteria:\n\n* 18-30 years old\n* Consumed alcohol an average of 2 times per week in last 3 months\n* At least two instances of heavy episodic drinking in last month\n* Currently in a romantic relationship\n* History of IPV perpetration within last 3 months\n* Willing to provide cell phone number and carrier and receive text messages for 30 days\n\nExclusion Criteria:\n\n* None","30 Years",{"count":660,"type":21},400,[24],"Acute alcohol intoxication is a robust predictor of intimate partner violence (IPV) perpetration for young adult men and women; therefore, interventions delivered proximally to drinking episodes - a period of high risk - are needed to reduce alcohol-facilitated IPV. This project seeks to improve public health by delivering a just-in-time text messaging intervention proximally to drinking episodes and evaluating the impact of the intervention on alcohol-facilitated IPV in a sample of at-risk young adult men and women. Additionally, through an innovative design this project is poised to answer these important questions: whether receiving a message, when, for whom, what type, and under what conditions this just-in-time messaging intervention leads to reductions in alcohol use and IPV perpetration.",[664,27,87],"Alcohol Drinking","2025-03-12",{"date":667,"type":33},"2025-03-14",{"date":669,"type":33},"2023-01-03",{"date":671,"type":21},"2026-04-30",{"name":673,"class":40},"Georgia State University",{"id":675,"slug":676,"hasResults":11,"nctId":677,"briefTitle":678,"officialTitle":679,"acronym":4,"eligibilityCriteria":680,"healthyVolunteers":11,"sex":16,"minAge":463,"maxAge":464,"enrollmentInfo":681,"targetDuration":4,"studyType":22,"phases":683,"briefSummary":684,"conditions":685,"keywords":687,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":689,"lastUpdatePostDateStruct":690,"startDateStruct":692,"completionDateStruct":693,"leadSponsor":695,"locationsCount":4},"100559106","pilot-study-of-parent-training-with-role-plays-in-virtual-reality-for-parents-of-children-with-behavior-problems-100559106","NCT06559813","Pilot Study of Parent Training With Role-plays in Virtual Reality for Parents of Children With Behavior Problems","Step by Step - Pilot Study of Cognitive Behavior Therapy With Role-plays in Virtual Reality for Parents of Children With Anger, Oppositional or Aggressive Behaviors","INCLUSION CRITERIA:\n\nParents:\n\n* Parent of a child aged 8-16 years\n* The parent perceives that the child has oppositional, angry or aggressive behaviors, and\u002For that there are parent-child conflicts at home.\n* The child's behavior is elevated on a measure targeting behavioral problems (SDQ conduct problems subscale)\n\nEXCLUSION CRITERIA\n\nParent treatment:\n\n* Parent of a child under 8 years or over 16 years of age\n* The child does not currently exhibit oppositional, angry or aggressive behaviors\n* Child diagnosed with autism, serious depression, psychosis, eating disorder, or self-harm behaviors\n* Parent has epilepsy or migraine",{"count":682,"type":21},10,[24],"The main aim of this pilot trial is to evaluate preliminary effects and feasibility of a new parent training program for parents of children aged 8-16 years with disruptive behavior (e.g., angry, aggressive or defiant behavior). The parent training program is based on cognitive behavioral therapy (CBT) and includes practicing of skills in virtual reality (VR).\n\nThe main questions the project aims to answer are:\n\n* What are the preliminary effects of the CBT-VR parent training program?\n* What is the level of parent engagement in the CBT-VR parent training program?\n* What are the experiences of parents and therapists of the CBT-VR parent training program?\n\nThe CBT-VR parenting program is delivered at clinics during individual sessions. Parents will answer quantitative measurements before, during, and after treatment. Within-group analyses will be conducted to examine experiences and preliminary effects of the program. Parents and clinicians are also asked to participate in a qualitative interview after the program has ended.",[470,471,472,473,27,686],"Parent-Child Relations",[471,470,688,477],"Parenting","2024-08-15",{"date":691,"type":33},"2024-08-19",{"date":691,"type":21},{"date":694,"type":21},"2024-11-30",{"name":487,"class":40},{"id":697,"slug":698,"hasResults":11,"nctId":699,"briefTitle":700,"officialTitle":701,"acronym":4,"eligibilityCriteria":702,"healthyVolunteers":11,"sex":16,"minAge":703,"maxAge":464,"enrollmentInfo":704,"targetDuration":4,"studyType":22,"phases":705,"briefSummary":706,"conditions":707,"keywords":708,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":689,"lastUpdatePostDateStruct":712,"startDateStruct":713,"completionDateStruct":714,"leadSponsor":715,"locationsCount":4},"100559105","pilot-study-of-cognitive-behavior-therapy-with-role-plays-in-virtual-reality-for-children-with-behavior-problems-100559105","NCT06559800","Pilot Study of Cognitive Behavior Therapy With Role-plays in Virtual Reality for Children With Behavior Problems","Step by Step - Pilot Study of Cognitive Behavior Therapy With Role-plays in Virtual Reality for Children With Anger, Oppositional or Aggressive Behaviors","Inclusion Criteria:\n\n* Child\u002Fyouth aged between 10-16 years with increased levels of anger or disruptive behaviors,\n* The child's behavior problems is elevated on questions targeting behavioral problems (SDQ conduct problems subscale).\n\nExclusion Criteria:\n\n* Child\u002Fyouth is below 10 years or above 16 years of age\n* No increased levels of anger or disruptive behaviors\n* Child\u002Fyouth is diagnosed with autism, serious depression, psychosis, eating disorder, or self-harm behaviors\n* Child\u002Fyouth has epilepsy or migraine","10 Years",{"count":682,"type":21},[24],"The main aim of this small pilot trial is to evaluate preliminary effects and feasibility of the child intervention YourSkills for child disruptive behavior (e.g., enhanced anger or aggressive behavior) when evaluated in Sweden for children\u002Fyouth aged 10-16 years. YourSkills is based on cognitive behavioral therapy (CBT) and includes practicing of skills in virtual reality (VR).\n\nThe main questions the project aims to answer are:\n\n* What are the preliminary effects of the child\u002Fyouth CBT-VR-program?\n* What is the level of child\u002Fyouth engagement in the CBT-VR program?\n* What are the experiences of parents, children\u002Fyouth and therapists of the program?\n\nThe CBT-VR program is delivered at clinics during ten individual sessions. Parents will answer quantitative measurements before and after treatment, children will answer quantitative measurements before, during and after treatment. Within- group analyses will be conducted to examine experiences and preliminary effects of the program. Parents, children and clinicians are also asked to participate in a qualitative interview after the program has ended.",[470,471,472,473,27,474],[709,710,476,711],"Disruptive behavior","Child behavior problems","Virtual reality",{"date":691,"type":33},{"date":691,"type":21},{"date":694,"type":21},{"name":487,"class":40}]