[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aging-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aging-disorder":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,41,68,99,127,152,186],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100645061","exposome-pollutants-biology-in-the-older-subject-exposage-100645061",false,"NCT07678528","Exposome, Pollutants, Biology in the Older Subject: EXPOSAGE","EXPOSAGE","Inclusion Criteria:\n\n* Aged 55 or over\n* Affiliated with or beneficiaries of a social security scheme\n* Signed the informed consent form •-Persons residing in one of the following municipalities : Antibes, Le Bar-sur-Loup, Berre-les-Alpes, Beuil, Blausasc, Breil-sur-Roya, Cabris, Cannes, Carros, Clans, Contes, Drap, L'Escarène, Escragnolles, Fontan, La Gaude, Gilette, Grasse, Lantosque, Levens, Nice, Peillon, Peymeinade, Saint-André-de-la-Roche, Saint-Etienne-de-Tinée, Sospel, Tourrettes-sur-Loup, Vence, Tende\n\nExclusion Criteria:\n\n* patients currently undergoing intensive drug treatment, including chemotherapy",true,"ALL","55 Years",{"count":20,"type":21},400,"ESTIMATED","INTERVENTIONAL",[24],"NA","Numerous factors, both individual and environmental, can influence aging, an individual's health, and their functional status. However, the understanding of the combined impact of lifestyle-related exposures (e.g., physical activity, diet, sleep) (personal external exposome), exposures to pollutants (environmental external exposome), and their biological responses (internal exposome)-in other words, the impact of the \"exposome\" on healthy aging-remains limited, particularly in characterizing the molecular mechanisms associated with these interactions. Exposome approaches identifying key exposures and molecular mechanisms could lead to a better understanding of how the environment, interacting with health behaviors, can affect functional status. Thus, the objective of this study is i) to evaluate the links between the external exposome, the internal exposome and the health of older and aging individuals, and ii) to identify biological markers associated with a vulnerable health status in older and aging individuals.",[27],"Aging Disorder","NOT_YET_RECRUITING","2026-06-24",{"date":31,"type":32},"2026-07-01","ACTUAL",{"date":34,"type":21},"2030-09",{"date":36,"type":21},"2031-09",{"name":38,"class":39},"Centre Hospitalier Universitaire de Nice","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":67,"locationsCount":40},"100641643","aging-well-together---getting-to-know-you-better-characterization-of-health-factors-in-people-advancing-in-age-100641643","NCT07651527","Aging Well Together - 'Getting to Know You Better': Characterization of Health FACTors in People Advancing in AGE","BVE-FACTAGE: Aging Well Together - 'Getting to Know You Better': Characterization of Health FACTors in People Advancing in AGE","BVE-FACTAGE","Inclusion Criteria:\n\n* Age 55 or older\n* Affiliation with, or beneficiary of, a social security system\n* No objection to the study\n\nExclusion Criteria:\n\n* Individuals protected by law\n* unable to participate in a clinical trial\n* deprived of liberty",{"count":50,"type":21},4500,[24],"In order to implement effective actions to prevent the loss of autonomy in older adults, which has become a major issue, a crucial first step is to identify the conditions that influence it. Current approaches to health increasingly rely on a comprehensive and multidisciplinary vision, in line with so-called \"socio-ecological\" approaches, which argue that health is influenced by a wide range of interacting factors. However, these interdependencies and interactions are still poorly understood. It therefore seems necessary to move beyond the isolated analyses of risk factors carried out to date and adopt a holistic\u002Fsystemic vision by examining both individual and environmental factors, as well as their interactions, which together can contribute to functional decline or the development of pathologies in older adults and those aging.\n\nThe aim of this study is to identify the relationships between intrapersonal and environmental factors, and their cumulative, moderating, and mediating effects on the health of older adults and those experiencing aging.\n\nTo this end, participants will be asked to complete a series of questionnaires and perform tests on various health-related dimensions. The evaluation criteria are: health, autonomy and quality of life, individual factors (health practices (e.g., physical activity), psychological characteristics (e.g., personal beliefs), socioeconomic status, etc.) and environmental factors (accessibility, living environment).",[54,27,55],"Aging","Aging, Healthy",[57,58,59,60],"aging","physical activity","diet","environmental factors","2026-06-11",{"date":63,"type":32},"2026-06-16",{"date":65,"type":21},"2026-09",{"date":36,"type":21},{"name":38,"class":39},{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":17,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":40},"100572862","evaluation-of-the-efficiency-of-the-prpp-perceive-recall-plan-and-perform-task-analysis-system-on-support-and-orientation-decisions-for-people-with-aging-psychiatric-disorders-patpv-living-in-independent-housing-100572862","NCT06738784","Evaluation of the Efficiency of the PRPP (Perceive, Recall, Plan and Perform) Task Analysis System on Support and Orientation Decisions for People With Aging Psychiatric Disorders (PATPV) Living in Independent Housing.","ECO2PSY","Inclusion Criteria:\n\n* Be at least 40 years old\n* Reside within the PGU sector (Mérignac, Pessac, Talence and Gradignan)\n* Receive support from the PGU - CHCP \"pathologies, disability and aging\" department.\n* Fluency in French\n\nExclusion Criteria:\n\n* Being hospitalized for more than 18 months\n* Refuse inclusion in the research project","40 Years","65 Years",{"count":78,"type":21},66,[24],"Over the past 30 years, mental health policy has been geared towards increasing the number of people receiving care in the community, with a reduction of over 50% in the number of general psychiatric beds. The WHO recommends the implementation of alternatives to hospitalization, through the development of outpatient and home-based psychiatric care programs that support independent living.\n\nPeople suffering from psychiatric disorders show cognitive decline as they age, including deficits in perception, attention, memory and problem-solving. These cognitive problems affect the ability to carry out the tasks of daily life, and make it more difficult to remain at home. In order to avoid hospitalization for these psychiatrically-stabilized patients who are losing their autonomy, it is necessary to take into account their mental and cognitive handicap, and to provide them with appropriate compensation.\n\nOccupational therapy is a discipline concerned with the assessment, rehabilitation and integration of people with disabilities. Occupational therapists provide ecological assessments to support personalized care plans. The PRPP (Perceive, Recall, Plan and Perform) task analysis system is a validated, ecological tool that integrates an occupational therapy assessment and intervention model. The PRPP assessment measures occupational performance and the impact of cognitive impairments on information processing and on the cognitive strategies required to carry out activities. Research conducted in Canada illustrates the value of PRPP in supporting people with schizophrenia. To the best of our knowledge, no team has studied the use of PRPP in the decision-making process for maintaining people with aging psychiatric disorders (PATPV) at home.",[82,27,83],"Mental Health","Psychiatric Disorder",[85,86,87],"mental health","geriatric psychiatry","ergotherapy","RECRUITING","2026-03-13",{"date":91,"type":32},"2026-03-16",{"date":93,"type":32},"2024-12-09",{"date":95,"type":21},"2027-12-31",{"name":97,"class":98},"Centre Hospitalier Charles Perrens, Bordeaux","OTHER_GOV",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":16,"sex":17,"minAge":107,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":116,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":40},"100620397","carbon-dioxide-administration-and-brain-waste-clearance-100620397","NCT07357090","Carbon Dioxide Administration and Brain Waste Clearance","Mechanisms Underlying Carbon Dioxide Induced Protein Efflux in Health and Traumatic Brain Injury","COPETBI","Inclusion criteria for TBI cohort: 1) Able to give valid informed consent, 2) 18-82 years old, 3) history of TBI of any severity level (mild, moderate or severe) that was sustained in adulthood (age 18 and older), which will be confirmed using a semi-structured identification method (includes asking about loss of consciousness, posttraumatic amnesia, and feeling dazed\u002Fconfused).\n\nInclusion criteria for Healthy Subjects cohort: 1) Able to give valid informed consent and 2) 18-82 years old years old.\n\nExclusion criteria for TBI cohort: 1) contraindications to MRI scanning including pregnancy or claustrophobia, 2) unable to give valid informed consent, incarcerated, 3) diagnosed with Alzheimer's, ADRD or mild cognitive impairment, 4) pre-existing history of autism spectrum disorders, intellectual disability, serious neurological (e.g., epilepsy, tumors, other conditions requiring neurosurgery) or psychiatric disorders (requiring hospitalization) prior to TBI onset, 5) current or previous diagnosis of a psychosis spectrum disorder or bipolar disorder, 6) respiratory diseases or pulmonary conditions that may increase the risk of study procedures (e.g., severe asthma, chronic obstructive pulmonary disease or other significant respiratory disorders), 7) a history of cardiac arrythmias 8) history of a current substance use disorder, 9) non-English fluency (based on screener), 10) Weigh under 110 pounds for blood draw.\n\nExclusion criteria for Healthy Subjects cohort: 1) contraindications to MRI scanning including pregnancy or claustrophobia, 2) unable to give valid informed consent, incarcerated, 3) diagnosed with Alzheimer's, ADRD or mild cognitive impairment, 4) history of developmental, neurological, or psychiatric disorders requiring hospitalization, 5) regular use of any substance in the past six months (i.e., no current use confirmed with urine screening), 6) previous head injury with greater than 30 minutes loss of consciousness, 7) respiratory diseases or pulmonary conditions that may increase the risk of study procedures (e.g., severe asthma, chronic obstructive pulmonary disease or other significant respiratory disorders), 8) a history of cardiac arrythmias, 9) non-English fluency (based on screener), 10) Weigh under 110 pounds for blood draw.","18 Years","82 Years",{"count":110,"type":21},200,[24],"The current study tests whether different exposures to carbon dioxide (CO2) can safely result in the increased movement of proteins from the brain into the blood. The investigators believe that this would be a proxy for the brain clearing waste products more effectively. The current study will use a counter-balanced design, in which individuals with and without a history of traumatic brain injury (TBI) will receive different levels of CO2 (targeted changes of approximately 5 or 10 mmHG in end-tidal CO2) approximately one week apart. The counter-balanced design means that each participant receives a single dose of CO2 at each visit, and different doses of CO2 at each visit. The order in which participants receive the dose is randomized, and the participant will not be informed of the dose.",[114,27,115],"Traumatic Brain Injury","Magnetic Resonance Imaging (MRI)",[114,117],"Magnetic Resonance Imaging","2026-02-19",{"date":120,"type":32},"2026-02-23",{"date":122,"type":21},"2026-04",{"date":124,"type":21},"2032-02",{"name":126,"class":39},"Andrew Mayer",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":17,"minAge":107,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":136,"phases":4,"briefSummary":137,"conditions":138,"keywords":140,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":40},"100602355","aging-of-the-vascular-wall-100602355","NCT07122427","Aging of the Vascular Wall","VITAL","Inclusion Criteria:\n\n* Major patients requiring coronary artery bypass grafting (CABG).\n\nExclusion Criteria:\n\n* Hypertension, diabetes, systemic inflammatory disease.",{"count":135,"type":21},30,"OBSERVATIONAL","Demographic aging is predicted to be one of the most significant social changes of the 21st century. Aging is a slow, multifactorial process that progressively impacts the integrity of cells, tissues, and organs. This decline in function increases the risk of numerous diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases (CVD). CVD, the leading global cause of death, becomes more prevalent with age. Aging contributes to endothelial dysfunction, vessel stiffness, thickening, and impaired platelet function. These changes disrupt hemostatic processes and increase the risk of cardiovascular complications. Despite preventive strategies CVD remain a major public health challenge. Cellular aging, or senescence, affects all cell types, particularly endothelial cells and platelets. However, little research has compared the aging rates of different blood vessel types, such as arteries and veins. Given their distinct compositions and developmental origins, it is likely that their aging processes differ at molecular, cellular, and physiological levels.",[139,27],"Vascular Risk",[141,54,142],"Cardiovascular diseases","Eendothelial dysfunction","2025-08-15",{"date":145,"type":32},"2025-08-20",{"date":147,"type":32},"2025-07-17",{"date":149,"type":21},"2026-12",{"name":151,"class":39},"Centre Hospitalier Universitaire de Saint Etienne",{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":16,"sex":17,"minAge":76,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":136,"phases":4,"briefSummary":162,"conditions":163,"keywords":170,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":184,"locationsCount":40},"100402297","prevalence-determinants-and-natural-history-of-frailty-and-pre-frailty-in-elderly-people-100402297","NCT04518423","Prevalence, Determinants and Natural History of Frailty and Pre-frailty in Elderly People","Prevalence, Determinants and Natural History of Frailty and Pre-frailty in People Over the Age of 65 Years in a Prospective 5-year Observation","FRAILPOL","Inclusion Criteria:\n\n* Community dwelling elderly individuals over the age of 65 years who get around by themselves.\n\nExclusion Criteria:\n\n* Institutionalization\n* Inability to move around\n* Terminal diseases with an anticipated survival of less than 1 year.",{"count":161,"type":21},1093,"Frailty syndrome (i.e. frailty) is a geriatric syndrome which relies on the reduction of multisystem reserve capacity. Frail people have a lower potential to respond to external stressors and various life incidents as well as they present a weak prognosis particularly in cardiovascular diseases. Yet, frailty is not only a set of physical deficits, but it also concerns psychological and social dimensions of human functioning. Hence, an approach to frailty should be multidimensional because such a concept more adequately reflects a functional degradation in the elderly. Frailty is usually associated with the impaired condition of circulatory system, and therefore, an identification of subclinical cardiovascular abnormalities is paramount in the frailty prevention and treatment. Another potential mechanism which may predispose to frailty is a dysfunction of the autonomic nervous system. This system plays a crucial role in the response to internal or external stressors such as diseases and activities of daily living. An impairment of the autonomic nervous system function may maintain or accelerate the frailty process.\n\nIn this scientific project, a comprehensive echocardiography will investigate cardiac function with a particular attention to features which typically change with age, like flow parameters and chambers sizes. The activity of the autonomic nervous system will be explored with the analysis of heart rate, blood pressure and respiratory signals. The study participants will also undergo routine medical examination and a number of additional tests, including: assessment of cognitive function, psychological condition, nutrition status, activities of daily living, and risk of falls. The study group will comprise community dwelling elderly individuals over the age of 65 years who get around by themselves. After 2 years, the participants will be re-examined for their frailty and independence status, as well as their survival will be checked with the National Health Found electronic system. The aim of this project is to seek for factors determining frailty and to explore the frailty impact on the elderly people survival. Particular attention will be paid to the multidimensional frailty which is a new concept of the functional decline in the elderly. In addition, the prevalence of different modes of frailty in Polish community will be investigated. The results of this research should help to establish preventative and therapeutic strategies against frailty.",[164,165,166,167,54,168,27,169],"Frailty","Frailty Syndrome","Frail Elderly Syndrome","Fragility","Aging Problems","Aging Well",[164,171,172,173,174,175,54,176,177],"Physical Frailty","Cognitive Frailty","Social Frailty","Multidimensional Frailty","Elderly","Frail Scale","Tilburg Frailty Indicator","2020-08-14",{"date":180,"type":32},"2020-08-19",{"date":182,"type":32},"2017-09-02",{"date":149,"type":21},{"name":185,"class":39},"The Opole University of Technology",{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":190,"acronym":191,"eligibilityCriteria":192,"healthyVolunteers":16,"sex":17,"minAge":193,"maxAge":4,"enrollmentInfo":194,"targetDuration":4,"studyType":136,"phases":4,"briefSummary":196,"conditions":197,"keywords":201,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":40},"100339699","dc-longitudinal-study-on-aging-and-specimen-bank-100339699","NCT03702907","DC Longitudinal Study on Aging and Specimen Bank","(DC LSOA)","Inclusion Criteria:\n\n* Age 45 and older.\n* Subjects within the age range of 45-50 years old must have a first degree relative with a neurodegenerative disease.\n\nExclusion Criteria:\n\n* Individuals under 45 years of age","45 Years",{"count":195,"type":21},1000,"The Georgetown University Memory Disorders Program, part of the Department of Neurology, is conducting pilot studies of the feasibility of various diagnostic tests for Alzheimer's disease, mild cognitive impairment and other neurodegenerative diseases. Further, this study is assessing longitudinal changes in biological, lifestyle, and cognitive assessment collection.\n\nThe primary goal of this study is to examine the feasibility of biochemical assays, genetic testing, and cognitive and lifestyle assessments in the ante-mortem diagnosis of Alzheimer's disease, mild cognitive impairment and other neurodegenerative diseases. This research involves genetic and cognitive status testing but the findings will not be shared with research subjects. This will be accomplished ex vivo using blood, and\u002For cerebrospinal fluid (CSF) specimens from patients with a diagnosis of probable Alzheimer's disease, mild cognitive impairment, or other neurodegenerative diseases and from normal controls.",[198,199,200,54,27],"Alzheimer Disease","Dementia","Mild Cognitive Impairment",[202,203,54,204],"Frontotemporal Dementia","Lewy Body Dementia","Vascular Dementia","2019-10-23",{"date":207,"type":32},"2019-10-24",{"date":209,"type":32},"2007-01-01",{"date":211,"type":21},"2027-01",{"name":213,"class":39},"Georgetown University"]