[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aging-healthy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aging-healthy":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,49,78,100,128,157,186],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100641643","aging-well-together---getting-to-know-you-better-characterization-of-health-factors-in-people-advancing-in-age-100641643",false,"NCT07651527","Aging Well Together - 'Getting to Know You Better': Characterization of Health FACTors in People Advancing in AGE","BVE-FACTAGE: Aging Well Together - 'Getting to Know You Better': Characterization of Health FACTors in People Advancing in AGE","BVE-FACTAGE","Inclusion Criteria:\n\n* Age 55 or older\n* Affiliation with, or beneficiary of, a social security system\n* No objection to the study\n\nExclusion Criteria:\n\n* Individuals protected by law\n* unable to participate in a clinical trial\n* deprived of liberty",true,"ALL","55 Years",{"count":21,"type":22},4500,"ESTIMATED","INTERVENTIONAL",[25],"NA","In order to implement effective actions to prevent the loss of autonomy in older adults, which has become a major issue, a crucial first step is to identify the conditions that influence it. Current approaches to health increasingly rely on a comprehensive and multidisciplinary vision, in line with so-called \"socio-ecological\" approaches, which argue that health is influenced by a wide range of interacting factors. However, these interdependencies and interactions are still poorly understood. It therefore seems necessary to move beyond the isolated analyses of risk factors carried out to date and adopt a holistic\u002Fsystemic vision by examining both individual and environmental factors, as well as their interactions, which together can contribute to functional decline or the development of pathologies in older adults and those aging.\n\nThe aim of this study is to identify the relationships between intrapersonal and environmental factors, and their cumulative, moderating, and mediating effects on the health of older adults and those experiencing aging.\n\nTo this end, participants will be asked to complete a series of questionnaires and perform tests on various health-related dimensions. The evaluation criteria are: health, autonomy and quality of life, individual factors (health practices (e.g., physical activity), psychological characteristics (e.g., personal beliefs), socioeconomic status, etc.) and environmental factors (accessibility, living environment).",[28,29,30],"Aging","Aging Disorder","Aging, Healthy",[32,33,34,35],"aging","physical activity","diet","environmental factors","NOT_YET_RECRUITING","2026-06-11",{"date":39,"type":40},"2026-06-16","ACTUAL",{"date":42,"type":22},"2026-09",{"date":44,"type":22},"2031-09",{"name":46,"class":47},"Centre Hospitalier Universitaire de Nice","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":57,"enrollmentInfo":58,"targetDuration":60,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":48},"100571927","physical-and-cognitive-aging-study-in-older-adults-100571927","NCT06726616","Physical and Cognitive Aging Study in Older Adults","PASOS: Physical and Cognitive Aging Study in Older Adults","PASOS","Inclusion Criteria:\n\n• Hispanic and non-Hispanic adults age 55-85 years, at least 8th grade education, community dwelling.\n\nAdditional Inclusion for Hispanic Americans\n\n* Self-identify as Hispanic American\n* Report Spanish as primary language • No evidence of dementia or mild cognitive impairment based on cognitive screening \\[i.e., Montreal Cognitive Assessment (MoCA) administered during Visit 1; ≥26 among non-Hispanic White, ≥25 among Hispanics, ≥24 among non-Hispanic Blacks (Milani et al., 2018)\\]\n\nExclusion Criteria:\n\n* Inability to provide informed consent\n* Artificial joint or severe disability that would make it impossible or contraindicated performing the isokinetic test\n* Sensory loss (vision, hearing) or motor deficits that would preclude participation in the experimental tasks or neuropsychological assessment\n* Previous major strokes or other known significant brain abnormalities or diseases affecting the brain and\u002For cognition (e.g., Parkinson disease, multiple sclerosis, seizure disorder, brain surgery, moderate TBI, REM Behavior Sleep Disorder, untreated sleep apnea, etc.)\n* Unstable and uncontrolled medical conditions (metastatic cancer, HIV, moderate-severe kidney disease, uncontrolled diabetes, uncontrolled hypertension, severe cardiac disease, etc.). No current cancer diagnosis.\n* Current or past history of major psychiatric disturbance including schizophrenia, or active psychosis, bipolar disorder, current major depressive episode, current alcohol or substance abuse or history thereof within the past six months\n* Use of antipsychotics, sedatives, or other medications with significant anticholinergic properties (due to potential influence on memory)\n* Use of prescribed 'memory enhancing' medications, such as Aricept or Namenda\n* Previous participation in a cognitive or physical activity training study within the last 6 months or current involvement in another study involving cognitive, physical or other intervention at the time of enrollment","85 Years",{"count":59,"type":22},100,"12 Months","OBSERVATIONAL","Hispanic Americans are the fastest growing older adult group in the United States, disproportionally increasing the risk of an Alzheimer's disease and related dementias diagnosis. Efforts to reduce this risk and mitigate the related cognitive\u002Fphysical declines are critical. The aim of this study is to assess the feasibility of enrolling older adults into an aging trajectory cohort, while generating preliminary data on associations of physical and cognitive aging trajectories. Our secondary objective is to generate preliminary data on the association of standard measures of physical activity and physical function with cognitive status. This study fits within our longitudinal research goal to reduce dementia incidence by understanding the mechanisms that drive the cognitive-physical aging trajectory.",[64,65,66,30,67],"Older Adults (65 Years and Older)","Hispanic Americans","Cognitive Aging","Exercise","RECRUITING","2026-06-03",{"date":71,"type":40},"2026-06-04",{"date":73,"type":40},"2025-03-19",{"date":75,"type":22},"2027-09-20",{"name":77,"class":47},"University of Florida",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":17,"sex":18,"minAge":86,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":90,"conditions":91,"keywords":92,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":98,"leadSponsor":99,"locationsCount":48},"100640727","long-term-engagement-and-motivation-through-innovative-strategies-in-adapted-physical-activity-100640727","NCT07596056","Long-Term Engagement and Motivation Through Innovative Strategies in Adapted Physical Activity","IMPULSION: Long-Term Engagement and Motivation Through Innovative Strategies in Adapted Physical Activity","IMPULSION","Inclusion Criteria:\n\n* Age 60 or older\n* Affiliation with, or beneficiary of, a social security system\n* No objection to the study\n\nExclusion Criteria:\n\n* Neurocognitive disorder preventing the provision of informed consent (MOCA \\\u003C18)\n* Individuals under legal protection\n* Individuals deprived of liberty\n* Presence of a physical or cognitive condition preventing participation in the adapted physical activity protocol over 3 months:\n* Neurocognitive disorder (MOCA \\\u003C18)\n* Neurodegenerative disease with severe symptoms preventing participation in the protocol\n* Neuromuscular disease with severe symptoms preventing participation in the protocol\n* Severe sensory impairments (blindness or profound deafness)\n* Amputation of one or more limbs\n* Non-independent mobility","60 Years",{"count":88,"type":22},600,[25],"Aging is associated with progressive declines in physical, functional, and psychosocial capacities, leading to reduced autonomy, increased risk of falls, chronic diseases, and decreased quality of life. Physical inactivity is a major aggravating factor, despite strong evidence that regular physical activity helps prevent age-related decline.\n\nAdapted Physical Activity (APA) has demonstrated beneficial effects on physical function, mental health, pain, and healthcare utilization. However, long-term adherence to APA programs among older adults remains low, with fewer than 20% meeting World Health Organization recommendations. Therefore, innovative strategies are needed to improve sustained engagement in physical activity.\n\nThis multicenter, randomized, single-blind interventional study aims to compare the effectiveness of different APA strategies on long-term engagement in physical activity among adults aged 60 years and older.\n\nA total of 600 participants will be randomized into four groups combining two key factors: (1) autonomy-based vs. non-autonomy-based approaches, and (2) classical APA vs. TEMPA-based APA programs. Each intervention consists of a 12-week program including 24 supervised sessions, with some groups incorporating a progressive transition toward autonomous practice.\n\nThe primary outcome is long-term physical activity engagement assessed using the QAPPA questionnaire at baseline, 6 months, and 12 months.\n\nSecondary outcomes include:\n\nObjective and self-reported physical activity levels (questionnaires and wearable devices) Functional capacities (muscle strength, endurance, gait speed, balance, cardiorespiratory fitness) Motivational and perceptual factors (e.g., enjoyment, fatigue, perceived effort, motivation) Quality of life (EQ-5D-5L) Biological markers (inflammatory, metabolic, metabolomic, and epigenetic profiles) to identify predictors of adherence and physiological response Cost-effectiveness and cost-utility analyses (incremental cost-effectiveness ratio)\n\nStatistical analyses will be conducted using mixed linear models for repeated measures to evaluate time, group, and interaction effects. Additional analyses will include descriptive statistics, group comparisons, longitudinal trends, and economic evaluations.\n\nThis study aims to identify effective and sustainable APA strategies to improve long-term physical activity engagement and inform public health policies for older adults.",[30,28],[93,32],"Adapted Physical Activity","2026-05-12",{"date":96,"type":40},"2026-05-19",{"date":42,"type":22},{"date":44,"type":22},{"name":46,"class":47},{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":17,"sex":18,"minAge":86,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":23,"phases":111,"briefSummary":112,"conditions":113,"keywords":114,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":48},"100626935","safe-age-study-a-safety-and-tolerability-study-of-a-nutritional-supplement-in-healthy-older-adults-100626935","NCT07442097","Safe-Age Study: A Safety and Tolerability Study of a Nutritional Supplement in Healthy Older Adults","An Open-Label, Single-Arm Study to Assess the Safety of Youniqor Consumption in Healthy Adults","SAFE-AGE","Inclusion Criteria:\n\n* Body mass index (BMI) between 22.5 and 29.9 kg\u002Fm², inclusive.\n* High-sensitivity C-reactive protein (hsCRP) levels between 0.7 and 5.0 mg\u002FL, inclusive.\n* Willingness to provide written informed consent.\n* Willingness to comply with all study procedures and follow-up visits.\n* Willingness to avoid major lifestyle changes, including new structured physical training or cognitive training targeting study endpoints, during the study period.\n\nExclusion Criteria:\n\n* Presence of chronic, inflammatory, or cardiometabolic disease requiring daily medication.\n* Uncontrolled diabetes mellitus (fasting blood glucose ≥126 mg\u002FdL).\n* Hypertension.\n* Estimated glomerular filtration rate (eGFR) \\\u003C60 mL\u002Fmin\u002F1.73 m².\n* Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \\>2× the upper limit of normal.\n* White blood cell count \\\u003C3500\u002Fmm³.\n* Ongoing or recent acute infection within 2 weeks prior to screening.\n* Vaccination within 4 weeks prior to screening.\n* Known allergy or intolerance to N-acetyl-L-cysteine (NAC) or glycine.\n* Participation in another clinical trial within 90 days prior to screening.\n* Current or recent use of systemic corticosteroids, immunosuppressants, or chronic pain medications.\n* neurodegenerative, neurological, or major psychiatric disorders.\n* History of alcohol or drug abuse based on medical history, physical examination, or investigator judgment.\n* Current smokers.\n* Any other condition which, in the opinion of the investigator, may interfere with study participation or safety.","80 Years",{"count":110,"type":22},16,[25],"The goal of this clinical trial is to evaluate the safety and tolerability of the nutritional supplement Youniqor in healthy older adults. The main questions it aims to answer are:\n\nIs Youniqor safe and well tolerated when taken daily by healthy adults aged 60 to 80 years? Are there any adverse events or clinically relevant changes in vital signs or laboratory parameters during the study period?\n\nParticipants will:\n\nTake Youniqor daily for 8 weeks Attend scheduled study visits for safety assessments, including vital signs, blood and urine tests, and electrocardiograms Report any adverse events during the study period",[30],[28,115,116,117],"Healthy Volunteers","nutritional supplement","safety study","2026-02-23",{"date":120,"type":40},"2026-03-02",{"date":122,"type":22},"2026-02-12",{"date":124,"type":22},"2026-07-31",{"name":126,"class":127},"YOXLO B.V.","INDUSTRY",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":17,"sex":18,"minAge":135,"maxAge":136,"enrollmentInfo":137,"targetDuration":4,"studyType":23,"phases":139,"briefSummary":140,"conditions":141,"keywords":144,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":48},"100618629","emotional-well-being-and-measures-of-healthy-aging-100618629","NCT07334106","Emotional Well-being and Measures of Healthy Aging","Emotional Well-being and Biomarkers of Healthy Aging","Inclusion Criteria:\n\n* Age 40-70\n* Speaks and reads English\n* Able to access the online platform through their phone, a public device (i.e., at the library) or at home.\n* Lives in the Chicagoland area\n* Willing\u002Fable to travel to the Human Longevity Lab for in-person visits\n\nExclusion Criteria:\n\n* Adults unable to consent\n* Individuals who are not yet adults (infants, children, teenagers)\n* Pregnant women\n* Prisoners\n* Vulnerable Populations\n* Pre-existing heart disease (prevalent coronary heart and cerebrovascular disease or heart failure)\n* Type 2 diabetes\n* Severe psychiatric illness","40 Years","70 Years",{"count":138,"type":22},80,[25],"This randomized control study is designed to understand the role of a positive psychology intervention (PARK: Positive Affect Regulation sKills) in biological aging and well-being. PARK provides a series of positive emotion skills in a self-guided online format, making the program accessible and convenient.\n\nOur main aims are:\n\nAim 1: To explore the effects of PARK on psychological well-being (e.g., depression, anxiety, positive affect).\n\nAim 2: To explore the effects of PARK on biological age as defined by DNA methylation (DNAm) GrimAge and electrocardiogram-age (ECG-age), as well as physiological well-being in adults (e.g., cardiovascular, endocrine, musculoskeletal functioning, etc.).",[28,30,142,143],"Aging Well","Aging, Biological",[28,145,146,142,147],"Resilience, Psychological","Psychological Well-Being","Internet-Based Intervention","2026-01-02",{"date":150,"type":40},"2026-01-12",{"date":152,"type":40},"2025-09-01",{"date":154,"type":22},"2028-08",{"name":156,"class":47},"Northwestern University",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":163,"eligibilityCriteria":164,"healthyVolunteers":17,"sex":18,"minAge":165,"maxAge":108,"enrollmentInfo":166,"targetDuration":4,"studyType":23,"phases":168,"briefSummary":170,"conditions":171,"keywords":172,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":48},"100614117","phase-2-study-of-healthy-aging-and-physical-function-with-elamipretide-100614117","NCT07275424","Study of Healthy Aging and Physical Function With Elamipretide","Open-Label, Single-Arm Phase 2a Pilot Study to Evaluate the Safety and Tolerability of a Daily Subcutaneous Dose of Elamipretide in Older Adults","SHAPE","Inclusion Criteria:\n\n1. Male or female aged ≥65 and ≤80 years\n2. VO2peak ≤ 37.3ml\u002Fkg\u002Fmin for men and ≤ 25.7ml\u002Fkg\u002Fmin for women as evidence of lower mitochondrial function\n3. Are ambulatory and able to perform activities of daily living without assistance\n4. Have sufficient venous access for clinical blood draw\n5. Willing and able to self-administer injections or have a willing caregiver who is able to administer injections.\n6. Speak and read English\n7. Have no established daily exercise routine and are not participating in any exercise training program or physical hobby (i.e. dance, martial arts, yoga) and agree to not start any such activities during the course of study participation\n8. Willing to avoid the following medications during the course of the study:\n\nAnti-seizure medications\n\n* Coenzyme Q10, creatine, L-carnitine, and other supplements intended to increase muscle mass, energy or function\n* Muscle relaxants\n* Systemic steroid or immunosuppressive use\n* Opioids (regular use of \\> 10 mg\u002Fday morphine equivalents) 9. No known allergies\u002Fadverse effects from Fexofenadine 10. Provide documentation of informed consent\n\nExclusion Criteria:\n\n1. Have significant disease(s) or condition(s) which, in the opinion of the investigator, may put the subject at risk because of their participation in the study or may influence either the results of the study or the subject's ability to participate in the study\n2. Presence of severe renal disease (eGFR \\\u003C30 mL\u002Fmin) or hepatic disease (aspartate aminotransferase \\[AST\\] or alanine aminotransferase \\[ALT\\] \\>2x the upper limit of normal) as evidenced by laboratory results at Screening.\n3. Have a history of rhabdomyolysis\n4. Have been hospitalized within 3 months prior to screening for major atherosclerotic events (e.g., myocardial infarction, target-vessel revascularization, coronary bypass surgery or stroke) or other major medical condition (as deemed by the primary investigator)\n5. Are currently enrolled in a clinical study involving an investigational product or non- approved use of a drug or device or concurrently enrolled in any other type of medical research judged to be scientifically or medically incompatible with this study\n6. Have participated within the last 30 days of screening visit in a clinical study involving an investigational product.\n\n   \\-","65 Years",{"count":167,"type":22},30,[169],"PHASE2","This study will utilize a daily dose of elamipetide for 4 weeks and will screen a sufficient number of subjects for 30 subjects to enroll in the study. The planned duration of the study includes baseline measurement, followed by 4 weeks intervention period, a midpoint (2week ±3days) check-in phone interview, and post intervention visits that mirror the baseline visits. After the last injection, subjects will enter the 2-week follow-up period, concluded by the end-of-study contact.",[30],[173,174,175,176],"healthspan","healthy aging","mobility","cognitive function","2025-12-09",{"date":179,"type":40},"2025-12-10",{"date":181,"type":40},"2025-11-26",{"date":183,"type":22},"2026-04-15",{"name":185,"class":47},"David Marcinek",{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":190,"acronym":191,"eligibilityCriteria":192,"healthyVolunteers":17,"sex":18,"minAge":135,"maxAge":4,"enrollmentInfo":193,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":195,"conditions":196,"keywords":199,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":48},"100611611","evaluation-of-the-effect-of-seasonality-on-biological-age-in-adults-100611611","NCT07242833","Evaluation of the Effect of Seasonality on Biological Age in Adults","SeasonAGE","Inclusion Criteria:\n\n1. Males and females aged over 40 years, inclusive, at enrolment.\n2. Assessed by the investigator to be in general good health or have stable, well-controlled chronic medical conditions (e.g. hypertension, type 2 diabetes, etc.) that are not expected to interfere with study participation or outcomes. (Note: stable medical condition is defined as controlled medical condition, with no change in medication, worsening of the condition, or hospitalization in the past 3 months prior to enrolment).\n3. Body mass index (BMI) ≥18.5 kg\u002Fm².\n4. Able to understand and to sign a written informed consent prior to study enrolment.\n5. Willing and able to comply with the requirements for participation in this study.\n\nExclusion Criteria:\n\n1. Any past or on-going significant medical\u002Fsurgical condition and\u002For psychiatric condition, which in the opinion of the investigator may risk participant's wellbeing\u002Fsafety, impede participant compliance with study procedures or ability to complete the study and\u002For could confound the primary objectives of the study (such as seasonal allergy).\n2. Any acute illness or any recent medical\u002Fsurgical intervention, including vaccination, within 21 days prior to enrolment.\n3. Female participants who are pregnant or intending to become pregnant, lactating and\u002For breastfeeding\n4. Currently participating in another interventional research study.\n5. Family or direct hierarchical relationship with the research team members.",{"count":194,"type":22},60,"This research aims to provide insights on how seasonal variations influence biological age and enhance the design and analysis of long-term lifestyle interventions targeting biological clocks.\n\nAging is a gradual decline in cellular and organ functions, significantly increasing the risk of non-communicable and infectious diseases. Recent research has focused on identifying aging biomarkers that can better predict functional capability in healthy individuals. Biological age clocks, which can be measured from samples like blood or saliva, are emerging as valuable tools for assessing the pace of aging and calculating age acceleration-the difference between chronological and biological age.\n\nThese clocks utilize molecular and clinical data, including DNA methylation and plasma proteomics, to predict future health outcomes, such as disease risk and mortality. Various DNA methylation-based clocks have been developed, with the Dunedin Pace of Aging (PoAm) offering a more precise modeling of physiological changes over time. Lifestyle factors, including diet and physical activity, can influence age acceleration, suggesting that lifestyle interventions may impact biological aging.\n\nCurrent evidence indicates that three specific epigenetic clocks-PhenoAge, GrimAge, and Dunedin PACE-are particularly effective in detecting beneficial effects on aging trajectories. However, the stability of these clocks during long-term lifestyle interventions remains unclear, as they can exhibit variability over short periods and may be affected by factors influenced by seasonal changes, such as Vitamin D levels, climate, and white blood cells composition.\n\nTo investigate these seasonal effects on biological age, a proposed observational study will track changes over a 12-month period in middle-aged and older adults.",[28,143,30,197,198],"BIOLOGICAL CLOCKS","Biological Clock Disturbance",[32,200,201,202],"biological age","biological clock","lifestyle","2025-12-03",{"date":179,"type":40},{"date":206,"type":40},"2025-11-24",{"date":208,"type":22},"2027-08",{"name":210,"class":127},"Société des Produits Nestlé (SPN)"]