[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aging-problems\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aging-problems":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,72,115],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100636287","vascular-aging-and-microcirculation-physiological-aspects-of-vascular-aging-in-the-elderly-population-vamp-aging-100636287",false,"NCT07563725","Vascular Aging and Microcirculation: Physiological Aspects of Vascular Aging in the Elderly Population (VAMP-Aging)","VAMP-Aging","Inclusion Criteria:\n\n* Absence of symptoms and history of cardiovascular and cerebrovascular diseases.\n* Baseline blood pressure levels within the normal range (\\\u003C 140\u002F90 mmHg, according to WHO criteria) and absence of use of antihypertensive medications.\n\nExclusion Criteria:\n\n* Diabetes Mellitus: Fasting blood glucose ≥ 126 mg\u002FdL or use of hypoglycemic agents.\n* Smoking: Active or quit less than 5 years ago.\n* Inflammatory Diseases: Autoimmune diseases, active neoplasms, or acute infectious processes.\n* Surgery or trauma in the last 60 days.\n* Renal Dysfunction: Chronic renal failure (estimated by eGFR \\\u003C 60 mL\u002Fmin\u002F1.73m²).\n* Medication Use: Chronic use of corticosteroids, immunosuppressants, or drugs with direct action on vascular reactivity (e.g., continuous use of nitrates).",true,"ALL","60 Years","100 Years",{"count":21,"type":22},62,"ESTIMATED","OBSERVATIONAL","Rising life expectancy worldwide challenges public health due to increased cardiovascular disease linked to vascular aging, where microvascular dysfunction serves as an early indicator of system-wide inflammation, or \"inflammaging\". The proposed study aims to validate non-invasive, high-resolution techniques, such as Laser Speckle Contrast Imaging, to identify early endothelial senescence biomarkers and map their correlation with metabolic, inflammatory, and anthropometric profiles to advance personalized, preventive translational medicine.",[26],"Aging Problems",[28,29,30],"microcirculation","Laser Speckle Contrast Imaging","vascular aging","NOT_YET_RECRUITING","2026-04-29",{"date":34,"type":35},"2026-05-04","ACTUAL",{"date":37,"type":22},"2026-06",{"date":39,"type":22},"2029-12",{"name":41,"class":42},"National Institute of Cardiology, Laranjeiras, Brazil","OTHER_GOV",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":16,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":71},"100555377","metabolic-control-of-aging-and-disease---the-metage-deep-phenotyping-cohort-100555377","NCT06511297","Metabolic Control of Aging and Disease - the MetAGE Deep Phenotyping Cohort","Metabolic Control of Aging and Disease - the MetAGE Deep Phenotyping Cohort (Pro-Metage)","Pro-Metage","Inclusion Criteria:\n\nGroup 1 - Lean, young adults (n = 150)\n\n* Age 18 - 35 years\n* Body mass index (BMI) ≥ 18.5 and ≤ 24.9 kg\u002Fm2 (≥ 12 months)\n\nGroup 2 - Overweight, young adults (n = 150)\n\n* Age 18 - 35 years\n* BMI ≥ 28kg\u002Fm2 (≥ 12 months)\n\nGroup 3 - Lean, older adults (n = 150)\n\n* Age ≥ 60 years\n* BMI ≥ 18.5 and ≤ 24.9 kg\u002Fm2 (≥ 3 years)\n\nGroup 4 - Overweight, older adults (n = 150)\n\n* Age ≥ 60 years\n* BMI ≥ 28 kg\u002Fm2 (≥ 3 years)\n* Subgroup A (n=75): with pre-existent cardiovascular disease defined as: history of myocardial infarction or evidence of coronary artery disease irrespective of revascularization status or history of ischemic or hemorrhagic stroke or presence of peripheral artery disease or heart failure with preserved ejection fraction (NYHA Class I-II).\n* Subgroup B (n=75): without pre-existent cardiovascular disease\n\nGroup 5 - Nonagenerians Age ≥ 90 (n = 50)\n\n* Age ≥ 90 years\n* BMI ≥ 18.5 kg\u002Fm2 (≥ 3 years)\n\nExclusion Criteria:\n\nGroup 1 - Lean, young adults (n = 150)\n\n* Highly physical active (i.e. \\> 5 times sporting activity \u002F week with moderate to high intensity \\[heart rate 140 - 200bpm\\])\n* Special diets (i.e. ketogenic diet and time-restricted eating)\n* Clinically significant metabolic or endocrine disorders\n* Claustrophobia\n* drug abuse, alcohol \\> 15 drinks\u002Fweek\n* Heart failure, cardiovascular disease, immunosuppressive therapies, chronic inflammatory diseases and active oncologic conditions\n* Metal implants that prohibit 3T MRI\n* Pregnancy or breastfeeding\n\nGroup 2 - Overweight, young adults (n = 150)\n\n* Highly physical active (i.e. \\> 5 times sporting activity \u002F week with moderate to high intensity \\[heart rate 140 - 200bpm\\])\n* Special diets (i.e. ketogenic diet and time-restricted eating)\n* Active anti-obesity treatment (e.g. glucagon-like peptide 1 (GLP-1) analogues, polyagonists, naltrexone and bupropion)\n* Clinically significant metabolic or endocrine disorders\n* Claustrophobia\n* drug abuse, alcohol \\> 15 drinks\u002Fweek\n* Heart failure, cardiovascular disease, immunosuppressive therapies, chronic inflammatory diseases and active oncologic conditions\n* Metal implants that prohibit 3T MRI\n* Pregnancy or breastfeeding\n\nGroup 3 - Lean, older adults (n = 150)\n\n* Highly physical active (i.e. \\> 5 times sporting activity \u002F week with moderate to high intensity \\[heart rate 140 - 200bpm\\])\n* Special diets (i.e. ketogenic diet and time-restricted eating)\n* Diabetes, overt hypo\u002Fhyperthyroidism\n* Claustrophobia\n* drug abuse, alcohol \\> 15 drinks\u002Fweek\n* Metal implants that prohibit 3T MRI\n* Known severe cardiovascular diseases (i.e. PAD IIa or higher, advanced heart failure = left ventricular ejection fraction (LVEF) \\\u003C 35% or NYHA Class III-IV)\n* No previous heart failure, cardiovascular disease, immunosuppressive therapies, chronic inflammatory diseases and active oncologic conditions up until the age of 35 years.\n* Life-threatening conditions with a life expectancy of less than 1 year or any other condition that would jeopardize proband safety\u002Fadherence while participating in this trial.\n\nGroup 4 - Overweight, older adults (n = 150)\n\n* Special diets (i.e. ketogenic diet and time-restricted eating)\n* Diabetes, overt hypo\u002Fhyperthyroidism\n* Active anti-obesity treatment (e.g. GLP-1 analogues, polyagonists, naltrexone and bupropion)\n* Claustrophobia\n* drug abuse, alcohol \\> 15 drinks\u002Fweek\n* Metal implants that prohibit 3T MRI\n* No previous heart failure, cardiovascular disease, immunosuppressive therapies, chronic inflammatory diseases and active oncologic conditions up until the age of 35 years.\n* Life-threatening conditions with a life expectancy of less than 1 year or any other condition that would jeopardize proband safety\u002Fadherence while participating in this trial.\n\nGroup 5 - \"healthy\" Nonagenerians Age ≥ 90 (n = 50)\n\n* Claustrophobia\n* Clinically significant cognitive impairment compromising study adherence\n* Metal implants that prohibit 3T MRI\n* Life-threatening conditions with a life expectancy of less than 1 year or any other condition that would jeopardize proband safety\u002Fadherence while participating in this trial.","18 Years",{"count":54,"type":22},650,"The goal of this prospective observational study is to identify and validate blood based aging biomarkers in relation to cardiometabolic phenotypes of young and old, female and male subjects with or without obesity.\n\nThe main question is to gain insights into the interaction of obesity related metabolic alteration and aging, and the relevance of loss of metabolic control in the development of age-related diseases in order to build a foundation for targeted drug- and lifestyle interventions in future studies.",[57,58,26,59],"Obesity","Aging","Metabolic Syndrome","RECRUITING","2026-02-13",{"date":63,"type":35},"2026-02-17",{"date":65,"type":35},"2025-05-05",{"date":67,"type":22},"2036-01-01",{"name":69,"class":70},"Thomas Scherer","OTHER",2,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":16,"sex":17,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":97,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":43},"100525638","brain-health-virtual-reality-study-100525638","NCT06124339","Brain Health Virtual Reality Study","Interventions to Promote Brain Health Virtual Reality Study","Inclusion Criteria:\n\n1. 50-85 years of age\n2. Fluent in English\n3. Can safely ride a stationary bike\n\nExclusion Criteria:\n\n1. Dementia\n2. History of a neurological disorder\n3. Severe sensory deficits\n4. Inability to perform intervention (e.g., inability to cycle safely)\n5. Contraindications to MRI scan (e.g., pacemaker)\n6. Fear of needles\u002F blood\n7. Prior history of fainting due to sight of needles of blood","50 Years","85 Years",{"count":82,"type":22},150,"INTERVENTIONAL",[85],"NA","The Interventions for Brain Health Virtual Reality Study is a NIH-funded clinical research trial at the University of California San Diego (UCSD) Health under the supervision of the study principal investigator Dr. Judy Pa. The overarching goal of this trial is to use a novel virtual reality (VR) based intervention that simultaneously engages physical and cognitive activity aimed at improving brain health and cognition in older adults. The investigators will compare 3 types of interventions: physical activity, VR cognitive activity, and combined VR physical and cognitive activity over 16 weeks to evaluate physical and brain health changes.",[58,26,88,89,90,91,92,93,94,95,96],"Memory Loss","Memory Impairment","Memory Disorders in Old Age","Memory Disorder, Spatial","Memory Disorders","Mild Cognitive Impairment","Cognitive Decline","Cognitive Change","Cognition Disorders in Old Age",[98,99,100,101,102,103,104,105],"Virtual Reality","technology","intervention","exercise","cycling","memory","brain health","aging","2024-07-08",{"date":108,"type":35},"2024-07-10",{"date":110,"type":35},"2023-08-08",{"date":112,"type":22},"2029-02-01",{"name":114,"class":70},"University of California, San Diego",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":16,"sex":17,"minAge":123,"maxAge":4,"enrollmentInfo":124,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":126,"conditions":127,"keywords":134,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":43},"100402297","prevalence-determinants-and-natural-history-of-frailty-and-pre-frailty-in-elderly-people-100402297","NCT04518423","Prevalence, Determinants and Natural History of Frailty and Pre-frailty in Elderly People","Prevalence, Determinants and Natural History of Frailty and Pre-frailty in People Over the Age of 65 Years in a Prospective 5-year Observation","FRAILPOL","Inclusion Criteria:\n\n* Community dwelling elderly individuals over the age of 65 years who get around by themselves.\n\nExclusion Criteria:\n\n* Institutionalization\n* Inability to move around\n* Terminal diseases with an anticipated survival of less than 1 year.","65 Years",{"count":125,"type":22},1093,"Frailty syndrome (i.e. frailty) is a geriatric syndrome which relies on the reduction of multisystem reserve capacity. Frail people have a lower potential to respond to external stressors and various life incidents as well as they present a weak prognosis particularly in cardiovascular diseases. Yet, frailty is not only a set of physical deficits, but it also concerns psychological and social dimensions of human functioning. Hence, an approach to frailty should be multidimensional because such a concept more adequately reflects a functional degradation in the elderly. Frailty is usually associated with the impaired condition of circulatory system, and therefore, an identification of subclinical cardiovascular abnormalities is paramount in the frailty prevention and treatment. Another potential mechanism which may predispose to frailty is a dysfunction of the autonomic nervous system. This system plays a crucial role in the response to internal or external stressors such as diseases and activities of daily living. An impairment of the autonomic nervous system function may maintain or accelerate the frailty process.\n\nIn this scientific project, a comprehensive echocardiography will investigate cardiac function with a particular attention to features which typically change with age, like flow parameters and chambers sizes. The activity of the autonomic nervous system will be explored with the analysis of heart rate, blood pressure and respiratory signals. The study participants will also undergo routine medical examination and a number of additional tests, including: assessment of cognitive function, psychological condition, nutrition status, activities of daily living, and risk of falls. The study group will comprise community dwelling elderly individuals over the age of 65 years who get around by themselves. After 2 years, the participants will be re-examined for their frailty and independence status, as well as their survival will be checked with the National Health Found electronic system. The aim of this project is to seek for factors determining frailty and to explore the frailty impact on the elderly people survival. Particular attention will be paid to the multidimensional frailty which is a new concept of the functional decline in the elderly. In addition, the prevalence of different modes of frailty in Polish community will be investigated. The results of this research should help to establish preventative and therapeutic strategies against frailty.",[128,129,130,131,58,26,132,133],"Frailty","Frailty Syndrome","Frail Elderly Syndrome","Fragility","Aging Disorder","Aging Well",[128,135,136,137,138,139,58,140,141],"Physical Frailty","Cognitive Frailty","Social Frailty","Multidimensional Frailty","Elderly","Frail Scale","Tilburg Frailty Indicator","2020-08-14",{"date":144,"type":35},"2020-08-19",{"date":146,"type":35},"2017-09-02",{"date":148,"type":22},"2026-12",{"name":150,"class":70},"The Opole University of Technology"]