[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"air-pollution\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:air-pollution":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,51,78,102,125,146,175,197,231],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100505899","using-indoor-air-filtration-to-slow-atherothrombosis-progression-in-adults-with-ischemic-heart-disease-history-100505899",false,"NCT05867381","Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History","Slowing Atherothrombosis Progression Through Indoor Air Filtration: A Crossover Trial in Hispanic and Non-Hispanic Adults With Ischemic Heart Disease History","SAPIA","Inclusion Criteria:\n\n* Age between 65 and 84 years old;\n* Weight ≥ 110 pounds;\n* Nonsmokers for at least 1 year;\n* Have ischemic heart disease history, clinically stable for 6 months, without any deterioration in symptoms or episodes of angina based on past electronic medical records;\n* Both English and Spanish speaking participants will be included in the recruitment;\n* Live in the Los Angeles County.\n\nExclusion Criteria:\n\n* Have history of degenerative disease of the nervous system such as dementia and Alzheimer's;\n* Currently have active cancer treatments;\n* The residential house has already had HEPA filters;\n* Participants will move out from the current residential address in the next 2 years;\n* Participants will spend more than 1 month living outside the primary home;\n* Have any health conditions that prohibit collecting health and covariate data and biospecimens;\n* Participants' residential houses are not feasible for setting up air purifiers and air pollutants monitors.","ALL","65 Years","84 Years",{"count":21,"type":22},112,"ESTIMATED","INTERVENTIONAL",[25],"NA","This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.",[28,29],"Air Pollution","Atherosclerosis",[31,32,33,34,29,35,36,37],"Air pollution","Particulate matter","Air purifier","HEPA filter","Ischemic Heart Disease","Thrombosis","Cardiovascular Disease","RECRUITING","2026-06-04",{"date":41,"type":42},"2026-06-08","ACTUAL",{"date":44,"type":42},"2023-07-11",{"date":46,"type":22},"2028-06-30",{"name":48,"class":49},"University of Southern California","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":17,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100633205","the-influence-of-climate-and-air-pollution-on-physical-activity-of-chinese-people-in-shenyang-and-shenzhen-100633205","NCT07523659","The Influence of Climate and Air Pollution on Physical Activity of Chinese People in Shenyang and Shenzhen","The Influence of Climate and Air Pollution on Physical Activity of Chinese People in Shenyang(41.481175ºN) and Shenzhen(22.324386ºN)","Inclusion Criteria:\n\n* Aged 18 to 55 years\n* Residing in Shenzhen or Shenyang for the entire year\n\nExclusion Criteria:\n\n* Disabilities that limit physical activity\n* Any condition preventing participation in physical activity\n* Pregnant or planning pregnancy during the study period\n* Lactating or planning to lactate during the study period",true,"18 Years","55 Years",{"count":62,"type":22},124,"OBSERVATIONAL","Physical activity (PA) refers to bodily movements that result in a significant increase in energy expenditure due to the contraction of skeletal muscles. Physical inactivity has become a major global public health concern and is currently the fourth leading cause of death worldwide. The World Health Organization (WHO) recommends that adults engage in at least 150 minutes of moderate-intensity physical activity (MPA) or 75 minutes of vigorous-intensity physical activity (VPA) per week.\n\nAlthough some studies suggest that individual differences in PA may have a genetic basis, PA is generally considered to be largely under voluntary control and influenced by climatic and environmental factors. For instance, extreme temperatures-either hot or cold-can increase health risks and reduce individuals' willingness to engage in physical activity. In addition, air pollution, particularly fine particulate matter (PM2.5), poses serious health risks. Exercising in polluted environments may trigger asthma, cardiovascular, or pulmonary conditions.\n\nSince the Industrial Revolution, fossil fuel emissions have contributed to a global surface temperature increase of approximately 1.1°C, with projections suggesting a further rise of 2.5-2.9°C by the end of the century. At the same time, PM2.5 pollution has become a pressing issue, contributing to an estimated 7 million deaths globally in 2012-over one-third of which occurred in rapidly developing Asian countries.\n\nGiven the seasonal and geographic variability in climate and air quality, physical activity levels are likely to be affected accordingly.This study aims to investigate the extent to which climatic and environmental factors influence physical activity levels and intensity.",[66,67,28],"Physical Activity","Climate","2026-04-08",{"date":70,"type":42},"2026-04-13",{"date":72,"type":42},"2024-08-01",{"date":74,"type":22},"2026-08-31",{"name":76,"class":49},"Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences",2,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":58,"sex":17,"minAge":59,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":91,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":50},"100500271","the-role-of-macrophage-activation-in-lung-injury-following-ozone-exposure-100500271","NCT05794087","The Role of Macrophage Activation in Lung Injury Following Ozone Exposure","Activated Macrophages and Ozone Toxicity II","Exclusion Criteria:\n\n* Cardiovascular disease\n* Respiratory disease\n* Recent (within 4 weeks) respiratory or COVID-19 symptoms\n* Diabetes\n* Pregnancy\n* HIV Infection\n* History of smoking within the past 5 years.\n* Orthopedic or rheumatologic conditions which would interfere with cycle use\n* Inability to produce a sputum plug at screening\n* Daily use of antioxidant supplements, excluding those in a multivitamin. These supplements include Vitamin C or E, selenium, beta-carotene, lycopene, lutein, zeaxanthin and ginkgo biloba. Supplements taken less frequently but at least once a week will be reviewed by the principal investigator for eligibility determination.","40 Years",{"count":87,"type":22},120,[25],"The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. The exposure visits will be at least 2 weeks apart. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.",[28],[92],"Macrophage","2025-12-12",{"date":95,"type":42},"2025-12-17",{"date":97,"type":42},"2023-02-07",{"date":99,"type":22},"2027-06-01",{"name":101,"class":49},"Rutgers, The State University of New Jersey",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":58,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":109,"targetDuration":4,"studyType":23,"phases":111,"briefSummary":112,"conditions":113,"keywords":115,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":50},"100494443","hepa-pm25-and-cardiometabolic-health-100494443","NCT05718245","HEPA, PM2.5, and Cardiometabolic Health","Using Indoor Air Filtration to Reduce PM2.5 Cardiometabolic Effects in At-risk Individuals","Inclusion Criteria:\n\n* Age between 65 and 84 years old;\n* Nonsmoker for at least 1 year;\n* History of BMI ≥ 25 kg\u002Fm2 in the past based on EMR information;\n* Either an English or Spanish speaker;\n* Live in the Los Angeles County.\n\nExclusion Criteria:\n\n* History of diabetes (both type 1 and type 2) or degenerative disease of the nervous system (Alzheimer's disease or dementia);\n* Currently have active cancer treatment;\n* The residential house has already had HEPA filters;\n* Participants will move out of the current house in the next 2 years;\n* Participants will spend more than one month living outside the primary home;\n* Have any health conditions that prohibit collecting health and covariate data and biospecimen;\n* The residential houses are not feasible for setting up air purifiers and air pollutants monitors;\n* Have high blood glucose from finger stick test (\\> 200 mg\u002FdL).",{"count":110,"type":22},52,[25],"The goal of this randomized, double-blind, crossover trial is to test the hypothesis that a longer-term indoor HEPA filtration intervention can improve cardiometabolic profiles by reducing indoor PM2.5 exposures in at-risk individuals.",[28,114],"Cardiometabolic Health",[31,32,33,34,116],"Cardiometabolic health","2025-07-29",{"date":119,"type":42},"2025-08-01",{"date":121,"type":42},"2023-03-15",{"date":123,"type":22},"2026-12-31",{"name":48,"class":49},{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":134,"conditions":135,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":144,"locationsCount":50},"100561597","awareness-of-individuals-with-chronic-lung-disease-about-climate-change-heat-waves-air-pollution-and-physical-activity-100561597","NCT06592235","Awareness of Individuals with Chronic Lung Disease About Climate Change, Heat Waves, Air Pollution and Physical Activity","Assessment of Awareness of Individuals with Chronic Lung Disease on Climate Change, Heat Waves, Air Pollution, and Their Interactions with Physical Activity","Inclusion criteria for the study:\n\n* Being 18 years of age or older,\n* Having a chronic lung disease (COPD, asthma, bronchiectasis, cystic fibrosis, interstitial lung disease) and being referred to the Cardiopulmonary Rehabilitation Unit of Hacettepe University, Faculty of Physical Therapy and Rehabilitation for cardiopulmonary physiotherapy and rehabilitation,\n* Being clinically stable,\n* Using a smartphone with a pedometer,\n* To cooperate with the tests to be conducted,\n* Being willing to participate in the study.\n\nExclusion criteria:\n\n* Having had an acute exacerbation or having changed medication in the last month,\n* Having a severe cardiovascular, orthopedic or neurological problem that may affect the tests.",{"count":133,"type":22},80,"Climate change is characterized by global temperature increase, melting of glaciers and increasing temperature of ocean waters. Increase in greenhouse gases such as nitrogen and carbon dioxide negatively affects air and water quality. Extreme events such as extreme heat waves, floods and hurricanes are events seen with climate change. It is known that climate change and air pollution have negative effects on public health. Its adverse effects are often seen in individuals with rhinosinusitis, asthma and chronic obstructive pulmonary disease. Air pollution is expected to increase due to the ongoing economic growth and population growth worldwide, resulting in more respiratory diseases and disease burden. This study aims to assess the awareness level of individuals with chronic lung disease on climate change, heat waves, air pollution and their interaction with physical activity and anxiety and depression levels, and to better understand the experiences of patients and learn their perspectives. Within the scope of the study, it is planned to provide patients brief information on this subject and receive feedback about this information.",[136,137,28],"Climate Change","Chronic Lung Disease","2024-09-09",{"date":140,"type":42},"2024-09-19",{"date":142,"type":42},"2024-09-01",{"date":119,"type":22},{"name":145,"class":49},"Hacettepe University",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":58,"sex":17,"minAge":154,"maxAge":4,"enrollmentInfo":155,"targetDuration":4,"studyType":23,"phases":157,"briefSummary":158,"conditions":159,"keywords":160,"overallStatus":164,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":50},"100555038","study-to-determine-the-difference-in-reduction-of-bioaerosols-in-a-long-term-care-facility-100555038","NCT06506890","Study to Determine the Difference in Reduction of Bioaerosols in a Long-term Care Facility","C-POLAR System Intervention in a Long-Term Care Facility HVAC Filter Study (C-Polar LTC)","C-PolarLTC","Inclusion Criteria:\n\n1\\. Any resident, staff, and any individual who enters the long term care facility will be in a broad sense, involved in this study, as the MERV 13 HVAC filters will be installed within the HVAC system and will not allow anyone to not participate in the study who enters the facility. It is impracticable to carry out this research of comparing two different HVAC filters in an active long term care setting by receiving prior consent from all individuals who may enter, such as vendors or visitors. This research involves no more than minimal risk and may or may not improve air quality or minimize bioaerosols in the facility.\n\nExclusion Criteria:\n\n1\\. Does not wish to enter the long-term care facility until completion of study.","19 Years",{"count":156,"type":22},100,[25],"This is a CONTROLLED PROSPECTIVE COHORT study of a long-term care facility. At the start of the study a dedicated section A of the facility ventilation system will have routine HVAC filters of the same dimensions installed, while section B of the same facility ventilation system will have C-POLAR (cationic polymeric coated) HVAC filters installed. There will be continuous Indoor Air Quality monitors (PM 2.5, CO2, VOC, Radon, Temp, and RH) installed at different vent locations throughout the long-term care facility for the duration of the study. Air samples with an Airport MD8 BAMS machine will be taken once a week at various vent locations at the long-term care facility.",[28],[161,162,163],"Long-term care","Air Quality","HVAC Filter","NOT_YET_RECRUITING","2024-07-18",{"date":167,"type":42},"2024-07-22",{"date":169,"type":22},"2024-09-05",{"date":171,"type":22},"2025-08-31",{"name":173,"class":174},"C-Polar Innovations","INDUSTRY",{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":11,"sex":17,"minAge":181,"maxAge":4,"enrollmentInfo":182,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":184,"conditions":185,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":50},"100553838","modelling-of-correlation-between-emergency-department-admissions-and-location-specific-air-quality-and-weather-in-the-florence-urban-area-100553838","NCT06491290","Modelling of Correlation Between Emergency Department Admissions and Location-specific Air Quality and Weather in the Florence Urban Area","Inclusion Criteria:\n\n* Consecutive emergency department visits within the study period\n\nExclusion Criteria:\n\n* Patients resident outside the metropolitan area investigated\n* Patients admitted to the emergency department for traumatic injuries","14 Years",{"count":183,"type":22},480000,"The goal of this observational study is to evaluate the impact of primary air pollutants and weather parameters on emergency department (ED) visits in the metropolitan area of Florence.",[186,28,187],"Emergency Service, Hospital","Weather","2024-07-08",{"date":190,"type":42},"2024-07-09",{"date":192,"type":42},"2024-01-01",{"date":194,"type":22},"2027-12-31",{"name":196,"class":49},"Azienda Ospedaliero-Universitaria Careggi",{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":203,"eligibilityCriteria":204,"healthyVolunteers":58,"sex":205,"minAge":206,"maxAge":207,"enrollmentInfo":208,"targetDuration":4,"studyType":23,"phases":210,"briefSummary":211,"conditions":212,"keywords":216,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":50},"100483093","12--bangladesh-center-for-global-environmental-and-occupational-health--bangladesh-100483093","NCT05570552","1\u002F2- Bangladesh Center for Global Environmental and Occupational Health- Bangladesh","Long Term Effects of Household Air Pollution (HAP) Reduction on Cardio-pulmonary and Immune Function Outcomes - a Household Level Randomized mHealth Intervention Trial","GEOHealth-II","Inclusion Criteria:\n\n* Participants in the previous GEOHEALTH round-I study\n* Aged between 25 and 70 years\n* Live in biomass-using home with traditional stoves\n* Non-smoker and live with non-smokers\n* Exposed to \\\u003C10 µg\u002FL of water arsenic\n\nExclusion Criteria:\n\n* Known to have immune related illness or taking any prescription medication (particularly those that suppress or enhance immune function)\n* Known to have any clinical events of CVD or lung disease, including stroke or coronary heart disease.","FEMALE","25 Years","70 Years",{"count":209,"type":22},1000,[25],"Almost 3 billion people worldwide, including 89% people in Bangladesh, are exposed to harmful household air pollutants (HAP) emitted from combustion of biomass (wood, agricultural residue, cow dung, etc.) fuel use for cooking. While health risks associated with air-pollution have been reasonably well-studied in developed countries, there is little evidence on health benefits achievable by HAP reduction through clean fuel use, especially in low- and middle-income countries (LMICs). Earlier the investigators showed that Liquid Petroleum Gas (LPG) for 24 months, reduced personal PM2.5 exposure by 58.17 percent which induced novel changes in immune and inflammatory responses in the participants; however cardiopulmonary markers remained relatively stable in post-intervention assessment.\n\nIn this study, the investigators aim to evaluate the effects of mobile phone based (mHealth) Behavioural Change Communication (BCC) intervention on adoption and exclusive use of LPG. The investigators also aimed to observe whether long-term effects of HAP reduction can impact the subclinical measures of cardio-vascular and pulmonary dysfunction and regulate innate and inflammatory immune function among women and children in semi-rural settings in Bangladesh. The investigators will also investigate the influence of exposure to HAP on antibody response to vaccines (adaptive immunity). The BCC intervention will be provided by conducting a large household level randomized controlled trial by educational intervention using mHealth based technology. In addition, the investigators will continue following the cohort and will conduct rigorous and repeated personalized (24 hours) and area (over 5 days) assessments of PM2.5 and black carbon (BC) exposure to examine the long-term effects of HAP reduction on subclinical measures of cardio-pulmonary and immune dysfunction including effect of HAP exposure on antibody response to vaccine.",[28,213,214,215],"mHealth Intervention","Cardiopulmonary Function","Immune Function",[217,218,219,220,221],"Mobile based Behavioral Change Communication intervention","Household air pollution reduction","Cardiopulmonary function","Immune function","Clean fuel LPG","2024-03-20",{"date":224,"type":42},"2024-03-22",{"date":226,"type":42},"2023-06-20",{"date":228,"type":22},"2027-06",{"name":230,"class":49},"International Centre for Diarrhoeal Disease Research, Bangladesh",{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":237,"eligibilityCriteria":238,"healthyVolunteers":11,"sex":205,"minAge":59,"maxAge":239,"enrollmentInfo":240,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":242,"conditions":243,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":256},"100471806","speckle-tracking-echocardiography-as-a-tool-for-early-diagnosis-of-impaired-fetal-growth-twin-pregnancies-100471806","NCT05423665","Speckle Tracking Echocardiography as a Tool for Early Diagnosis of Impaired Fetal Growth Twin Pregnancies","Speckle Tracking Echocardiography as a Tool for Early Diagnosis of Impaired Fetal Growth in Twin Pregnancies","HEART","Inclusion Criteria:\n\n* Singleton or dichorionic twin pregnancy\n* Pregnant women 21 weeks ( ± 2 weeks) of gestation at the first visit\n* Women ≥ 18 years\n\nExclusion Criteria:\n\n* Women pregnant of multiples of higher order (≥3 siblings) Monochorionic twin pregnancy\n* Fetal arrhythmia\n* Known fetal congenital or genetic abnormalities\n* Any suspicion of congenital fetal anomalies that might influence fetal cardiac function\n* Pre-existing maternal hypertensive disease\n* Autoimmune disease including systemic lupus erythematosus\n* History of stillbirth\n* Diabetes mellitus (mother)","45 Years",{"count":241,"type":22},360,"In this project there are 2 time points during the pregnancy included, namely at 21 weeks and 30 weeks of gestation, to measure the predictive values of FGR, strain and strain rate. The fetal growth parameters will be collected at the same time points, to define the growth (differences) throughout gestation of both fetuses. A maternal blood sample will be taken at 21 weeks of gestation to identify the level of exposure to air pollution (black carbon) and the level of biochemical markers of placental dysfunction. Doppler ultrasounds will be used for antenatal identification of placenta insufficiency. At birth, umbilical cord blood and the placenta will be collected. The placenta will be examined, to identify morphological findings which are associated with FGR. The umbilical cord blood and placental biopsy will be used for the level of exposure to air pollution and the level of oxidative stress. One to three days after birth, neonatal strain and strain rate will be measured to define postnatal cardiac remodeling as well as the neonatal blood pressure as cardiovascular risk factor.",[244,245,246,28],"Fetal Growth Restriction","Cardiac Remodeling, Ventricular","Placental Insufficiency","2023-09-25",{"date":249,"type":42},"2023-09-26",{"date":251,"type":42},"2023-06-22",{"date":253,"type":22},"2028-02-01",{"name":255,"class":49},"University Hospital, Ghent",3]