[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"airway-clearance-impairment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:airway-clearance-impairment":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,51,84,105,127,155],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":34,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100524838","phase-4-prevention-of-infection-of-the-respiratory-tract-through-application-of-non-invasive-methods-of-secretion-suctioning-100524838",false,"NCT06113939","Prevention of Infection of the Respiratory Tract Through Application of Non-Invasive Methods of Secretion Suctioning","Prevention of Infection of the Respiratory Tract by Applying Methods That Are Non-Invasive for Extraction of Secretions. An Open Label, Randomized, Assessor-blinded, Pilot Trial.","PIRAMIDES","Inclusion criteria\n\n1. Endotracheal intubation with an anticipated duration \\> 48 hours.\n2. High risk of early respiratory infection associated with a diagnosis of:\n\n   1. Severe trauma.\n   2. Severe traumatic brain injury.\n   3. Ischaemic or haemorrhagic stroke.\n   4. Other causes of impaired consciousness: post-resuscitated cardiac arrest status, intoxications, acute infections or diseases of the central nervous system, seizures.\n3. Informed consent signed by the patient or, when impossible due to clinical status, by their legal representative, with re-consent by the patients themselves upon regaining capacity (section 15).\n\nExclusion criteria\n\n1. Intubation with an anticipated duration \\\u003C 48 hours.\n2. Foreseeable ominous prognosis within \\\u003C 7 days.\n3. Already established indication for systemic antibiotic therapy, either for suspected aspiration pneumonia with radiological pulmonary infiltrate or for suspected non-respiratory source infection.\n4. Active haemoptysis or pulmonary haemorrhage.\n5. Unstable chest.\n6. Undrained pneumothorax (inclusion may be considered once drained).\n7. Known allergy or intolerance to beta-lactam antibiotics.","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Adults who are unconscious or severely ill and need a breathing tube connected to a ventilator are at high risk of developing a lung infection (pneumonia) within the first few days in the intensive care unit. This early pneumonia affects up to 30 to 50 % of certain high-risk patients, prolongs the time on the ventilator and in hospital, and increases the use of antibiotics.\n\nTwo strategies are commonly used today to try to prevent this infection: a short, three-day course of an intravenous antibiotic, and removal of secretions from the airway with a sterile suction catheter. Both have limitations - antibiotics can favour the growth of resistant bacteria, and catheter suctioning is uncomfortable and may injure the airway.\n\nPIRÁMIDES is a small (60-patient) pilot study that compares the current practice with two non-invasive, mechanical alternatives for keeping the airway clear: a continuous low-pressure suction system built into a special breathing tube, and a device that produces a gentle, programmed \"artificial cough\" through the ventilator. Adult patients who are intubated for severe trauma, severe brain injury, stroke, resuscitated cardiac arrest or other causes of decreased consciousness are randomly assigned, in equal numbers, to one of the three approaches and followed for 14 days, with a final visit at day 90.\n\nThe main goal is to find out which of the three strategies best prevents early pneumonia, and which provides the best overall result for patients when survival, severity of infection, need for additional antibiotics and side effects are considered together. To make these comparisons as fair as possible in an open-label study, an independent committee of doctors not involved in patient care reviews each suspected pneumonia case without knowing which strategy the patient received. The results will help design a larger trial to confirm which approach is safest and most effective for preventing early pneumonia in critically ill patients on a ventilator.",[27,28,29,30,31,32,33],"Intubation Complication","Stroke, Ischemic","Stroke Hemorrhagic","Head Trauma","Cardiac Arrest","Ventilator Associated Pneumonia","Airway Clearance Impairment",[35,36,37],"ventilator-associated pneumonia","prevention","airway clearance","NOT_YET_RECRUITING","2026-06-25",{"date":41,"type":42},"2026-06-29","ACTUAL",{"date":44,"type":21},"2026-09-15",{"date":46,"type":21},"2029-06-30",{"name":48,"class":49},"Hospital San Carlos, Madrid","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":17,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":50},"100530718","does-the-coaching-function-improve-the-learning-of-mechanical-in-exsufflation-mi-e-in-paediatric-subjects-100530718","NCT06190431","Does the Coaching Function Improve the Learning of Mechanical In-exsufflation (MI-E) in Paediatric Subjects?","MI-Ecoaching","Part 1:\n\n* Inclusion criteria\n\n  * Age 6-12 (F\u002FM)\n  * Acceptance of consent (child + 2 parents)\n  * Non-smoker\n  * Speak and understand French\n  * Schooling in mainstream education\n* Exclusion criteria\n\n  * Comorbidities: congenital heart disease, chronic lung disease, immune deficiency, neuromuscular disease, neurological disease or multiple disabilities\n  * History or clinical signs of disease affecting lung function, recent lung infection, spinal or thoracic deformity.\n\nPart 2:\n\n* Inclusion criteria\n\n  * Age 6-12 (F\u002FM)\n  * Acceptance of consent (child + 2 parents)\n  * Non-smoker\n  * Speak and understand French\n  * Patient with a neuromuscular disease\n  * Able to perform the MI-E maneuver\n* Exclusion criteria\n\n  * Hemodynamic instability\n  * Current or recent pneumothorax\n  * Hemoptysis",true,"6 Years","12 Years",{"count":62,"type":21},40,[64],"NA","The use of mechanical insufflation-exsufflation (MI-E) in children with neuromuscular diseases (NMD) is recommended by international guidelines and societies and well documented. Many authors have shown that MI-E is safe and effective for airway clearance and has a significant benefit in reducing the duration of the airway clearance session in children with respiratory infections and atelectasis or in the postoperative period. However, its use in paediatrics is still poorly supervised and learning the technique is too often therapist- and\u002For patient-dependent. The use of a protocol or means of help to guide the initiation and learning of MI-E would allow better use, better adaptation of the settings and potentially better compliance with the treatment. The aim of this study is to test whether the use of a coaching module (playful visual stimulation) in addition to guidance by a physiotherapist improves the learning and effectiveness of the technique compared to guidance alone.This randomized controlled study will first include healthy children, aged 6 to 12 years, with no history or recent respiratory infection affecting lung function or other chronic diseases. In a second phase, the investigators will test the use of the learning process in children with neuromuscular diseases. The investigators hope that the results of this study will provide a better framework for the learning and effectiveness of MI-E. Furthermore, if the results are positive, this will allow better support for the use of MI-E in chronic treatments and help to ensure that this costly treatment for hospitals and public health is used efficiently.",[67,33,68],"Cough","Neuromuscular Diseases",[70,71,72,73],"Mechanical In-Exsufflation","Coaching","Cough Assistance","Pediatric","RECRUITING","2026-05-29",{"date":77,"type":42},"2026-06-01",{"date":79,"type":42},"2023-11-20",{"date":81,"type":21},"2026-05-31",{"name":83,"class":49},"Cliniques universitaires Saint-Luc- Université Catholique de Louvain",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":22,"phases":93,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":50},"100506370","outcome-comparisons-of-vibratory-airway-clearance-devices-100506370","NCT05873504","Outcome Comparisons of Vibratory Airway Clearance Devices","Outcome Comparisons of Two Vibratory Positive Expiratory Pressure Devices in Patients Unable to Clear Airway Secretions","Inclusion Criteria:\n\n* Adults 18 years or older\n* Respiratory assess and treat (RAAT) score of at least 10 and a secretion score of at least 5\n\nExclusion Criteria:\n\n* Younger than 18 years of age\n* Pregnant\n* Slow vital capacity (SVC) of \\\u003C10 mL\u002Fkg\n* Unable to follow instructions\n* Currently receiving cough assist, vest therapy or intrapulmonary percussive ventilation\n* Received more than 1 therapy session using oscillatory index device\n* Multiple ICU admission with previous study enrollment",{"count":92,"type":21},64,[64],"This pilot study aims to compare the ability of a higher oscillatory index device versus a lower oscillatory index device on airway secretion clearance and other clinically significant outcomes.",[33],"2026-02-17",{"date":98,"type":42},"2026-02-19",{"date":100,"type":42},"2023-05-01",{"date":102,"type":21},"2026-12-01",{"name":104,"class":49},"Rush University Medical Center",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":114,"phases":4,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":4},"100617196","characteristics-of-patients-intubated-for-airway-protection-in-the-intensive-care-unit-and-timing-of-tracheostomy-100617196","NCT07315477","Characteristics of Patients Intubated for Airway Protection in the Intensive Care Unit and Timing of Tracheostomy","Characteristics of Patients Intubated for Airway Protection in the Intensive Care Unit and Timing of Tracheostomy: a Retrospective Study","Inclusion Criteria: All patients aged 18-99 who were admitted to the intensive care unit from January 2012 to November 2025 and ventilated for airway protection for any reason.\n\n\\-\n\nExclusion Criteria:Patients who did not meet the above criteria or patients for whom data was missing.\n\n\\-",{"count":113,"type":21},200,"OBSERVATIONAL","Every year, approximately 10-15 patients are admitted to the general intensive care unit at our institution who have been intubated for airway protection for various reasons, the main ones being soft tissue infection of the head\u002Fneck, anaphylaxis with airway edema, oral and maxillofacial\u002FENT surgery with airway threat, and head\u002Fneck injury with airway threat. Some patients are successfully extubated after the acute condition that caused the need for ventilation in the first place has passed, and some require tracheostomy for reasons related to the primary disease (unresolved edema, continued infectious process, need for additional invasive interventions, etc.) or for reasons related to difficulty in respiratory weaning (poor awakening, muscle weakness, development of respiratory infection, etc.).\n\nWe would like to examine whether it is possible to characterize certain parameters in the above patient population that are associated with a higher likelihood of requiring tracheostomy during hospitalization (such as age Adult). In these cases, we may consider performing the tracheostomy earlier.",[33,117],"Intubating Conditions","2025-12-23",{"date":120,"type":42},"2026-01-02",{"date":122,"type":21},"2026-02-01",{"date":124,"type":21},"2029-02-01",{"name":126,"class":49},"Meir Medical Center",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":17,"minAge":134,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":22,"phases":137,"briefSummary":138,"conditions":139,"keywords":141,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":154},"100572203","bronchial-clearance-carried-out-with-a-mechanical-in-exsufflator-vs-a-manual-respiratory-physiotherapy-technique-in-hospitalized-elderly-people-100572203","NCT06730217","Bronchial Clearance Carried Out With a Mechanical In-exsufflator vs. a Manual Respiratory Physiotherapy Technique in Hospitalized Elderly People","INEXPA2","Inclusion Criteria:\n\n* Patients aged 60 or over, hospitalised in intensive care units or general medical wards, with bronchial congestion and a peak expiratory flow \\\u003C 180 L\u002Fmin, requiring respiratory physiotherapy\n* Montreal Cognitive Assessment (MoCA) score ≥ 26\n* Able to provide informed consent\n* Affiliated with social health insurance\n\nExclusion Criteria:\n\n* Neuromuscular disorders\n* Spinal cord injury\n* Contraindications to the use of mechanical insufflation-exsufflation:\n\n  * History of bullous emphysema, surgical emphysema, or undrained pneumothorax\n  * Recent barotrauma\n  * Tracheoesophageal fistula\n  * Bronchospasm\n  * Hemodynamic instability\n  * Refusal to participate.\n* Inability to cough on command\n* Pregnant or breastfeeding women\n* People under protective legal measures","60 Years",{"count":136,"type":21},120,[64],"Everywhere in the world, life expectancy is increasing. Currently, most individuals can expect to live up to 60 years and beyond. In all countries, the number and proportion of older adult in the population are rising. By 2030, one in six people in the world will be 60 years old or older.\n\nFrance is also seeing its population age, with the number of older people increasing from 14% in 2014 to 21% in 2022. In 2018, elderly people accounted for 30% of short-stay hospitalizations. One of the most common causes of hospitalization for older adult is respiratory system pathologies, second only to cardiovascular system pathologies. Admission for a respiratory pathology is often associated with bronchial congestion. Infectious or viral pneumonia is often the terminal illness for the older adult. In the United States, 1 million old patients are hospitalized for this pathology, and 30% of them will die within the year.\n\nOld people are more susceptible to pneumonia due to several factors, including impaired gag reflex, reduced muco-ciliary function, weakened immunity, impaired fever response, and various degrees of cardiopulmonary dysfunction. Additionally, central nervous system disorders and\u002For impaired gag reflex increase the risk of aspiration pneumonia in old patients. The majority of these patients develop a productive cough, but unfortunately, their ability to cough effectively is often reduced.\n\nAging leads to various changes in the respiratory system. The thoracic cage and spine deform due to calcification and osteoporosis, resulting in stiffness. The thoracic wall stiffens, making mobilization more difficult and increasing the muscular work required for expansion during inspiration. The diaphragm is in a less favorable position to contract effectively. Expiration becomes less efficient, leading to an increase in residual volume (RV) and promoting what is called \"senile emphysema,\" where air spaces dilate and dead spaces increase. This leads to an increase in functional residual capacity and RV, reducing vital capacity. Additionally, respiratory muscles lose strength due to muscle atrophy and decreased fast-twitch fibers. These mechanisms can compromise ventilation, mucus clearance, and cough effectiveness, all essential for preventing bronchial congestion.\n\nThe effectiveness of Mechanical Insufflation-Exsufflation (MI-E) in airway clearance has been demonstrated in children and adults with neuromuscular pathologies.\n\nSince the respiratory function of old people may be similar to that of patients with neuromuscular pathologies due to age-related loss of respiratory capacity and cough strength, it would be interesting to specifically study the use of MI-E in this population. Our previous study (ClinicalTrials.gov Identifier: NCT05090696) showed that old people tolerated MI-E well (low discomfort and no changes in vital signs). After the first session of bronchial clearance with MI-E, dyspnea decreased significantly (median Borg scale before session = 2.8 versus after = 1.8, p = 0.004). Additionally, cough strength increased across all sessions (mean pre = 130 vs. post = 145, p = 0.005).\n\nFollowing this initial study, the investigators wondered if the use of MI-E would be more effective than a session of manual physiotherapy.",[140,33],"Bronchial Congestion",[142,143,144],"respiratory muscle","mechanical ventilators","bronchial congestion","2025-11-24",{"date":147,"type":42},"2025-11-25",{"date":149,"type":21},"2025-12-15",{"date":151,"type":21},"2028-09-18",{"name":153,"class":49},"University Hospital, Clermont-Ferrand",4,{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":17,"minAge":162,"maxAge":163,"enrollmentInfo":164,"targetDuration":4,"studyType":22,"phases":166,"briefSummary":167,"conditions":168,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":50},"100576938","effects-of-ventilator-hyperinflation-versus-vibrocompression-in-mechanically-ventilated-patients-100576938","NCT06791798","Effects of Ventilator Hyperinflation Versus Vibrocompression in Mechanically Ventilated Patients","Effects of Ventilator Hyperinflation Versus Vibrocompression on Lung Compliance in Mechanically Ventilated Patients","Inclusion Criteria:\n\n* Eighty-one mechanically ventilated patients more than 48 hours up to 7 days\n* Their ages range from 35 to 55 years old.\n* Medical stability (mean arterial pressure \\> 60 \\\u003C 110, systolic blood pressure \\> 80, diastolic blood pressure \\> 60, fraction of inspired oxygen \\\u003C 60, positive end expiratory pressure (PEEP) \\\u003C10)\n\nExclusion Criteria:\n\nPatients will be excluded if they have the following conditions or diseases:\n\n* Unstable hemodynamics\n* Fraction of inspired oxygen (FiO2) ≥ 0.6\n* PEEP ≥ 10 cmH2O\n* undrained pneumothorax and hemothorax or subcutaneous emphysema\n* Pulmonary pathology (e.g., acute respiratory distress syndrome, exacerbation of chronic obstructive pulmonary disease, and acute pulmonary edema)\n* Unstable neurological problems (raised intracranial pressure).\n* Lung Cancer\n* Recent\u002Funhealed rib fracture\n* Any disease obstructs our study.","35 Years","55 Years",{"count":165,"type":21},81,[64],"The aim of the current study is to compare the effects of ventilator hyperinflation and vibrocompression on lung compliance in mechanically ventilated patients.",[169,170,33],"Mechanically Ventilated Patients","Lung Compliance","2025-02-05",{"date":173,"type":42},"2025-02-07",{"date":175,"type":42},"2025-02-01",{"date":177,"type":21},"2025-05",{"name":179,"class":49},"Cairo University"]