[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"airway-extubation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:airway-extubation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,71,98,114],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100592983","phase-4-inhaled-sedation-in-critically-ill-patients-100592983",false,"NCT07000526","Inhaled Sedation in Critically Ill Patients","Inhaled Sedation in Critically Ill Patients: a Multicentre Randomized Clinical Trial","IS-CRITIC","Inclusion Criteria:\n\n\\- Adult patients receiving mechanical ventilation, with an anticipated duration \\>48 hours after randomization, and requiring deep sedation (target RASS between -3 and -5).\n\nExclusion Criteria:\n\n* Contraindication to isoflurane or propofol\n* Patients with maternal ancestry from Venezuela, due to the potential presence of an mt-ND4 gene mutation associated with neurological injury after exposure to certain volatile anaesthetic agents\n* Significant air leak, defined as a leak exceeding 30% of the delivered minute ventilation\n* Allergy to isoflurane or propofol\n* Cardiopulmonary arrest\n* History of ventricular tachycardia or long QT syndrome\n* Tidal volume \\\u003C 300 mL or PaCO₂ \\> 50 mmHg at the time of randomization.\n* Invasive mechanical ventilation for more than 48 hours at the time of randomization.\n* Pregnancy\n* Breast feeding\n* Acute neurological condition\n* Patients expected to require repeated surgical interventions during their ICU stay.\n* ECMO\n* ECCO2R\n* Active humidification strictly required\n* Neuromuscular disease or high spinal cord injury likely to prevent discontinuation of mechanical ventilation due to baseline condition\n* Requirement for benzodiazepine use for a specific indication\n* Burns\n* Life expectancy less than 48 hours, or patients with such a level of severity that death during the ICU stay is considered highly likely.\n* Any condition (e.g., blindness, deafness, dementia) or language barrier that prevents the administration of delirium or cognitive assessment scales.\n* Lack of informed consent","ALL","18 Years","80 Years",{"count":21,"type":22},620,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","The proposal of this study is to compare inhaled sedation with isoflurane administered via the Sedaconda ACD-S system with intravenous sedation with propofol. Patients will be randomized 1:1 to receive either inhaled sedation with isoflurane administered via the Sedaconda ACD device (Sedana Medical, Uppsala, Sweden) or intravenous propofol. The primary endpoint is the number of ventilator-free days at 28 days after randomization.",[28,29],"Sedation","Airway Extubation",[31,32,33],"Inhaled sedation","Mechanical ventilation","Delirium","RECRUITING","2026-06-26",{"date":37,"type":38},"2026-06-29","ACTUAL",{"date":40,"type":38},"2025-12-15",{"date":42,"type":22},"2027-12",{"name":44,"class":45},"Instituto de Investigación Hospital Universitario La Paz","OTHER",22,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":70},"100478202","liberation-from-mechanical-ventilation-using-extubation-advisor-decision-support-100478202","NCT05506904","Liberation From Mechanical Ventilation Using Extubation Advisor Decision Support","Liberation From Mechanical Ventilation Using Extubation Advisor Decision Support: The Multicentre (LEADS) Pilot Trial","LEADS","Inclusion Criteria:\n\n* Critically ill adults (age≥18)\n* Invasive ventilation for \\>48 hours\n* Who are expected to undergo an initial SBT within the next 48 hours with a view to extubation as per treating MDs. As per the FAST trial, an SBT will be defined as a focused assessment on low ventilator settings \\[T-piece, continuous positive airway pressure (CPAP), or PS \\\u003C 8 cm H2O regardless of positive end-expiratory pressure (PEEP)\n\nExclusion Criteria:\n\n* Suffer from known or suspected peripheral severe myopathy or neuropathy, or limb weakness or paralysis or central (e.g., post arrest, large intracranial stroke or bleed) injury or Glasgow Coma Scale (GCS) \\\u003C 6\n* Do not wish to be re-intubated as part of their treatment goals\n* Were previously extubated during the same ICU admission\n* Have undergone 1 or more SBTs where the SBT was clearly documented in the chart and\u002For the PS was reduced to the SBT level of 8 or less during the 24 hour period prior to randomization\n* Already have a tracheostomy\n* Are moribund or expected to die.",{"count":56,"type":22},200,[58],"NA","Timely and safe extubation in critically ill patients is vitally important as prolonged mechanical ventilation and failed attempts at extubation are associated with increased morbidity, mortality, costs, intensive care unit (ICU) stays, and a risk for aerosolization of COVID-19 to health care providers. A Spontaneous Breathing Trial (SBT) is the current standard of care to assess a patient's readiness for extubation. However, SBTs are performed in various ways and have poor ability to predict successful extubation on their own. There is an urgent need to improve and standardize extubation decision-making. In a prior multicenter study, the investigators showed that decreased respiratory rate variability during SBTs predicted extubation failure better than other predictive indices.\n\nThe Extubation Advisor (EA) tool combines clinician's assessments of extubation readiness with predictive analytics and risk mitigation strategies for individual patients. In a single centre observational study, the investigators demonstrated the ability to deliver EA reports to the bedside and acceptability of this decision-support tool to respiratory therapists (RTs) and physicians (MDs).\n\nThe investigators will conduct the Liberation from mechanical ventilation using EA Decision Support (LEADS) Pilot Trial to assess feasibility outcomes. They will include critically ill adults who are invasively ventilated for \\>48 hours and are ready to undergo an SBT.\n\nPatients in the intervention arm undergo an EA assessment and treating clinicians (RTs, MDs) will receive an EA report for each SBT conducted. The EA report will help to guide extubation decision-making. Patients in the control arm receive standard care. SBTs will be directed by clinicians.\n\nThe primary feasibility outcome will reflect the ability to recruit the desired population. The investigators will also assess the usefulness of the tool to MDs and complete an analysis of resource utilization to inform future economic analyses of cost-effectiveness. The investigators aim to recruit 1 to 2 patients\u002Fmonth\u002Fcenter.\n\nThe LEADS trial is novel and low-risk. It is the first trial to evaluate use of a bedside decision support tool to assist ICU clinicians with extubation decision-making. The LEADS pilot trial will inform the design of a future, large-scale randomized controlled trial that is expected to enhance the care delivered to critically ill patients, improve extubation outcomes, and inform extubation practice in ICUs.",[29],"2026-04-17",{"date":63,"type":38},"2026-04-22",{"date":65,"type":38},"2024-04-22",{"date":67,"type":22},"2026-12-31",{"name":69,"class":45},"Ottawa Hospital Research Institute",12,{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":23,"phases":80,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100617887","one-hour-positive-pressure-ventilation-after-a-pressure-support-spontaneous-breathing-trial-100617887","NCT07324460","One-Hour Positive Pressure Ventilation After a Pressure Support Spontaneous Breathing Trial","One-Hour Positive Pressure Ventilation After a Pressure Support Spontaneous Breathing Trial: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients aged \\> 18 years.\n* Admitted to the intensive care unit (surgical or medical).\n* With endotracheal intubation.\n* Mechanical ventilation for more than 72 hours.\n* Who underwent successful spontaneous breathing trial (according to the study protocol) and is considered able to be extubated.\n\nExclusion Criteria:\n\n* Patients unable to obey commands.\n* With non-planned extubation.\n* Neuromuscular disease and cervical spinal cord injury.\n* Tracheostomy.\n* Contraindication for cardiopulmonary resuscitation or reintubation.\n* Terminal extubation.\n* Lack of informed consent.\n* Previously included in the trial.",{"count":79,"type":22},4000,[58],"This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to intensive care units, with more than 72 hours of mechanical ventilation and with a successful spontaneous breathing trial on pressure support. Immediately after a successful spontaneous breathing trial, eligible patients will be randomized into 2 groups that will be treated according to one of the following interventions:1) One-hour positive pressure ventilation: as soon as the success of the spontaneous breathing trial is confirmed, the patient is submitted to mechanical ventilation for 1 hour using the previous ventilatory parameters and, afterwards, extubated.2) Immediate extubation: the patient is extubated immediately after the success of the spontaneous breathing trial.",[29,83,84],"Weaning Mechanical Ventilation","Extubation Failure",[86,83,87],"Airway extubation","Extubation failure","NOT_YET_RECRUITING","2026-02-11",{"date":91,"type":38},"2026-02-12",{"date":93,"type":22},"2026-02",{"date":95,"type":22},"2030-02",{"name":97,"class":45},"Hospital do Coracao",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":23,"phases":106,"briefSummary":107,"conditions":108,"keywords":109,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":110,"startDateStruct":111,"completionDateStruct":112,"leadSponsor":113,"locationsCount":4},"100617881","one-hour-positive-pressure-ventilation-after-a-t-piece-spontaneous-breathing-trial-100617881","NCT07324382","One-Hour Positive Pressure Ventilation After a T-Piece Spontaneous Breathing Trial","One-Hour Positive Pressure Ventilation After a T-Piece Spontaneous Breathing Trial: A Randomized Clinical Trial","GS-Wean Tpiece",{"count":79,"type":22},[58],"This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to intensive care units, with more than 72 hours of mechanical ventilation and with a successful spontaneous breathing trial on T-piece. Immediately after a successful spontaneous breathing trial, eligible patients will be randomized into 2 groups that will be treated according to one of the following interventions:\n\n1. One-hour positive pressure ventilation: as soon as the success of the spontaneous breathing trial is confirmed, the patient is submitted to mechanical ventilation for 1 hour using the previous ventilatory parameters and, afterwards, extubated.\n2. Immediate extubation: the patient is extubated immediately after the success of the spontaneous breathing trial.",[29,84,83],[86,87,83],{"date":91,"type":38},{"date":93,"type":22},{"date":95,"type":22},{"name":97,"class":45},{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":23,"phases":123,"briefSummary":124,"conditions":125,"keywords":130,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":140},"100618529","site-of-tracheal-extubation-and-operating-room-efficiency-during-robot-assisted-surgery-100618529","NCT07332806","Site of Tracheal Extubation and Operating Room Efficiency During Robot-assisted Surgery","Impact of Site of Tracheal Extubation on Operating Room Efficiency During Robot-assisted Surgery: a Randomized Trial","Inclusion Criteria:\n\n1. Aged ≥18 years;\n2. Scheduled to undergo elective robot-assisted laparoscopic surgery under general anesthesia;\n3. Expected tracheal extubation during daytime working hours (before 4:00 PM).\n\nExclusion Criteria:\n\n1. Refuse to participate in the study;\n2. Morbid obesity (body mass index ≥35 kg\u002Fm²);\n3. Preoperatively diagnosed obstructive sleep apnea, or patients with a STOP-Bang score ≥3 in combination with serum bicarbonate (HCO₃-) ≥28 mmol\u002FL;\n4. Patients at high risk of difficult airway (anticipated difficult intubation and\u002For extubation during preoperative assessment);\n5. Preexisting sick sinus syndrome, severe sinus bradycardia (heart rate \\\u003C 50 beats\u002Fmin), or second-degree or higher atrioventricular block without pacemaker implantation; congenital heart disease with any type of arrhythmia; or other severe cardiovascular diseases with New York Heart Association (NYHA) functional class ≥III;\n6. Significant pulmonary function impairment (FEV₁\u002FFVC ratio \\\u003C 70%, and total lung capacity \\[TLC\\] and vital capacity \\[VC\\] \\\u003C 80% of predicted values);\n7. Severe hepatic dysfunction (Child-Pugh class C); severe renal dysfunction (estimated glomerular filtration rate \\\u003C 30 mL\u002Fmin\u002F1.73 m²); or American Society of Anesthesiologists (ASA) physical status classification ≥IV;\n8. Preoperative diagnoses of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis;\n9. Inability to communicate due to coma, severe dementia, or language impairment;\n10. Planned postoperative admission to the intensive care unit;\n11. Any other conditions that are deemed for study participation.",{"count":122,"type":22},218,[58],"This study aims to evaluate the impact of different extubation strategy on the occupancy time of operating room (OR) and the incidence of adverse events and quality of recovery after robotic-assisted surgery. The investigators hypothesize that extubation in the post-anesthesia care unit (PACU) may reduce OR occupancy time without increasing adverse events or worsening quality of recovery early after robotic-assisted surgery. This strategy may enhance perioperative efficiency while maintaining clinical safety.",[126,29,127,128,129],"Robotic Surgical Procedures","Operating Rooms","Anesthesia Recovery Period","Postoperative Complications",[126,29,127,128,129],"2026-01-13",{"date":133,"type":38},"2026-01-15",{"date":135,"type":38},"2026-01-12",{"date":137,"type":22},"2026-04",{"name":139,"class":45},"Peking University First Hospital",1]