[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"airway-remodeling\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:airway-remodeling":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100587955","feasibility-of-tracheobronchial-defect-reconstruction-using-allogenic-aortic-patch-100587955",false,"NCT06935110","Feasibility of Tracheobronchial Defect Reconstruction Using Allogenic Aortic Patch","Inclusion Criteria:\n\n1. Congenital tracheal deformities: Includes congenital tracheomalacia, congenital tracheobronchial malformations, complete tracheal rings, etc., with severe clinical symptoms and cases where treatment is recommended after evaluation.\n2. Acquired tracheal stenosis: Includes tracheal narrowing caused by diseases, endotracheal intubation, or postoperative scar tissue, with severe clinical symptoms and cases where treatment is recommended after evaluation.\n3. Tracheal injury or tissue defect caused by trauma or burns: Cases requiring surgical repair.\n4. Tracheal tumors: Reconstruction of tracheal tissue following the removal of benign or malignant tumors.\n\nExclusion Criteria:\n\n1. Patients who are unable to provide informed consent.\n2. Pulmonary tumors that can be treated with standard lobectomy.\n3. Locally invasive tumors that are unresectable.\n4. Presence of contralateral lymph node metastasis.\n5. Presence of distant metastasis, except for solitary, resectable brain metastasis.\n6. Tracheal lesions amenable to standard resection with direct anastomosis.\n7. Preoperative evaluation indicates inability to undergo standard lobectomy.\n8. Patients infected with human immunodeficiency virus (HIV) or with other immunodeficiency disorders.\n9. Any condition or circumstance deemed by the principal investigator to potentially interfere with the conduct of the trial (e.g., severely impaired cardiopulmonary function, significant liver or kidney dysfunction, poorly controlled diabetes, high-risk groups, or pregnancy).\n10. Individuals with concerns about the potential risks of the trial.","ALL","18 Years",{"count":18,"type":19},10,"ESTIMATED","INTERVENTIONAL",[22],"NA","The investigators investigate the feasibility and safety of using cryopreserved aortic patches for tracheal or bronchial defect repair.",[25,26,27],"Trachea Diseases","Airway Remodeling","Reconstruction Surgery",[29,30,31,32],"cryopreserved aortic patch","airway repair","tracheal reconstruction","bronchial reconstruction","RECRUITING","2026-06-11",{"date":36,"type":37},"2026-06-12","ACTUAL",{"date":39,"type":37},"2025-09-15",{"date":41,"type":19},"2029-10",{"name":43,"class":44},"National Taiwan University Hospital","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":20,"phases":53,"briefSummary":54,"conditions":55,"keywords":59,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100551367","position-intervention-to-reduce-hypoxemia-in-sedation-patients-100551367","NCT06459167","Position Intervention to Reduce Hypoxemia in Sedation Patients","Inclusion Criteria:\n\n1. Patients with 18 years or older\n2. Without obvious cardiovascular or pulmonary dysfunction\n3. Scheduled to undergo procedure or surgery with sedation\n4. Signed the informed consent form\n\nExclusion Criteria:\n\n1. Preexisting bradycardia (heart rate \\\u003C50 beats\u002Fmin), hypotension (systolic blood pressure \\\u003C 80mmHg), or hypoxemia (SpO2 \\\u003C 90%);\n2. Requiring supplemental chronic or intermittent oxygen therapy because of preexisting diseases\n3. Preexisting diseases which unable to tolerate reduced SpO2 or Partial pressure of carbon dioxide in artery (PaCO2) diseases, such as severe cardiovascular and cerebrovascular diseases, intracranial hypertension or severe lung diseases;\n4. Coagulation disorders or a tendency of nose bleeding;\n5. Patients whose body position cannot be altered;\n6. Participated in other intervention clinical studies in the past 3 months;\n7. Other conditions deemed unsuitable for inclusion by the researcher;\n8. Patients and guardians refused to participate in this trial.",{"count":52,"type":19},1752,[22],"Hypoxemia was defined as an SpO2 of \\\u003C 90% for any duration. Failure to treat promptly can lead to hypoxemia, which may increase the risks of arrhythmia, nausea and vomiting, and cognitive dysfunction. Studies have shown that body position has a direct impact on respiratory function. In special environments, including outside the operating room where emergency airway management for critically ill and injured patients is needed, or in areas with limited medical resources like remote areas, adopting simple interventions by changing position to maintain patients' respiratory function can be more economical, convenient and safe.",[56,57,58,26],"Hypoxemia","Sedation Complication","Emergencies",[60,61,62,63,64],"position","hypoxemia","sedation","emergency","upper airway","NOT_YET_RECRUITING","2024-06-10",{"date":68,"type":37},"2024-06-14",{"date":70,"type":19},"2024-06-20",{"date":72,"type":19},"2026-06-30",{"name":74,"class":44},"First Affiliated Hospital of Zhejiang University",1]