[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aki\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aki":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,45,68,88,121,145,170],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100643136","phase-4-mgfr-vs-tgfr-in-aki-100643136",false,"NCT07632469","mGFR vs tGFR in AKI","Comparison of Agreement Between mGFR and tGFR in ICU Patients With Acute Kidney Injury","Inclusion Criteria:\n\n* CU stay ≤ 72 hours;\n* meets KDIGO AKI criteria;\n* age 18-85 years;\n* able to complete blood\u002Furine collection and monitoring\n\nExclusion Criteria:\n\n* prior history of CKD stage 4 or higher;\n* anuria;\n* recent contrast agent exposure or kidney transplant history;\n* pregnancy or breastfeeding; expected survival \\\u003C 24 hours.","ALL","18 Years","85 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","The goal of this study is to learn if the TGFR device (which uses telmapirazin to continuously measure real-time GFR) works to provide accurate and dynamic kidney function assessment in critically ill adults with acute kidney injury (AKI). It will also learn how tGFR compares with the gold standard measured GFR (mGFR) and other commonly used estimate methods. The main questions it aims to answer are:\n\n* Does tGFR show good agreement with mGFR over the 0-12 hour period in AKI patients?\n* How do tGFR, mGFR, 4-hour creatinine clearance, kinetic GFR (keGFR), and CKD-EPI eGFR compare across different AKI stages?\n* What are the bias and variability of each method over time?\n\nResearchers will compare tGFR to mGFR (iohexol clearance) to see if tGFR is a reliable alternative for bedside, continuous GFR monitoring. They will also compare tGFR against 4-hour creatinine clearance, keGFR, and eGFR to assess consistency across AKI stages.\n\nParticipants will:\n\n* Wear a single-use tGFR sensor patch on the chest for continuous GFR monitoring\n* Receive iohexol injection for mGFR measurement (gold standard)\n* Provide blood and urine samples for 4-hour creatinine clearance and other tests\n* Undergo repeated GFR assessments over the 12-hour study period",[27,28],"AKI","GFR",[30,31,32],"acute kidney injury","intensive care","glomerular filtration rate","NOT_YET_RECRUITING","2026-06-06",{"date":36,"type":37},"2026-06-10","ACTUAL",{"date":39,"type":21},"2026-06-08",{"date":41,"type":21},"2027-05-05",{"name":43,"class":44},"Bin Du","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":17,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":4},"100632765","what-are-the-predictors-of-acute-kidney-injury-in-children-admitted-to-pediatrics-intensive-care-unit-at-assiut-university-children-hospital-100632765","NCT07517939","What Are the Predictors of Acute Kidney Injury in Children Admitted to Pediatrics Intensive Care Unit at Assiut University Children Hospital?","Predictors of Acute Kidneyinjury in Children Admitted to Pediatrics Intensive Care Unit at Assiut University ChildrenHospital","Inclusion Criteria:\n\n* All cases of acute kidney injury in pediatrics from 1 month to 18years who admitted to PICU Assiut University Children Hospital according to (KDIGO) AKI Staging criteria during the duration of the study.\n\nExclusion Criteria:\n\n* Neonates\n* patients above 18 years of age\n* patients with chronic kidney disease\n* patients with renal malformations","1 Month",{"count":54,"type":21},100,"OBSERVATIONAL","Identify the Predictors of Acute Kidney Injury in critically ill children admitted to PICU during one year",[27,58],"ICU","2026-04-02",{"date":61,"type":37},"2026-04-08",{"date":63,"type":21},"2026-05-01",{"date":65,"type":21},"2027-08-01",{"name":67,"class":44},"Assiut University",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":77,"conditions":78,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":4},"100629667","what-is-the-effect-of-acute-kidney-injury-on-weaning-from-mechanical-ventilation-in-critically-ill-adult-patients-100629667","NCT07477652","What is the Effect of Acute Kidney Injury on Weaning From Mechanical Ventilation in Critically Ill Adult Patients?","Effect of Acute Kidney Injury on Weaning From Mechanical Ventilation in Critically Ill Adult Patients","Inclusion Criteria:\n\n* • Age ≥ 18 years of either sex.\n\n  * Admission to the ICU and receiving invasive mechanical ventilation via endotracheal tube.\n  * Expected duration of mechanical ventilation ≥ 24 hours.\n  * Hemodynamically stable or stabilized at the time of first spontaneous breathing trial (SBT) according to unit protocol (e.g., mean arterial pressure ≥ 65 mmHg with or without low dose vasopressors).\n  * Availability of baseline and daily serum creatinine, urine output, and relevant clinical data to diagnose and stage acute kidney injury according to KDIGO criteria.\n\nExclusion Criteria:\n\n* Pre existing end stage renal disease on chronic dialysis (hemodialysis or peritoneal dialysis).\n\n  * Known advanced chronic kidney disease (e.g., baseline estimated GFR \\\u003C 30 mL\u002Fmin\u002F1.73 m²) if baseline creatinine is available.\n  * Previous tracheostomy before current ICU admission.\n  * Neuromuscular diseases or spinal cord injury causing chronic ventilatory dependence.\n  * Severe pre existing cognitive impairment or brain death at ICU admission.\n  * Do not intubate or comfort care only orders at time of eligibility assessment.\n  * Re intubation after ICU discharge (only the first ICU admission episode will be considered).\n  * Patients or legal representatives refusing or withdrawing consent",{"count":76,"type":21},85,"The aim of this study is to evaluate the impact of acute kidney injury (AKI) on the success rate, duration, and complications of weaning from mechanical ventilation in critically ill adult patients admitted to the intensive care unit (ICU), and to identify whether AKI is an independent predictor of difficult, failed or complicated or weaning.",[27,79],"Critical Illness","2026-03-13",{"date":82,"type":37},"2026-03-17",{"date":84,"type":21},"2026-04-01",{"date":86,"type":21},"2027-07-01",{"name":67,"class":44},{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":97,"conditions":98,"keywords":104,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":120},"100613110","epidemiology-and-processes-of-care-for-renal-replacement-therapy-in-acute-kidney-injury-in-latin-america-100613110","NCT07262320","Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America","LATAM-AKID","Inclusion Criteria:\n\n* Adult patient (≥18) admitted to the ICU\n* First ICU admission during current hospitalization\n* Diagnosis of acute kidney injury stage 3 according to KDIGO guidelines\n* RRT initiated no earlier than 3 days before or no later than 7 days after ICU admission\n\nExclusion Criteria:\n\n* Transfer from outside hospital with ongoing RRT\n* RRT exposure of less than 2 days (if CRRT or PD was provided) or less than 2 HD\u002FSLED sessions\n* Kidney failure (ESRD) patients on maintenance dialysis\n* Kidney transplant recipients\n* Previous or new diagnosis of glomerulonephritis",{"count":96,"type":21},1000,"This is an international, multicenter, observational study aimed at investigating acute kidney injury requiring renal replacement therapy (AKI-RRT) in Latin American countries. The main questions this study aims to answer are:\n\n* What is the epidemiology, outcomes, and processes of care for patients with AKI-RRT in Latin America?\n* How do outcomes differ across different countries in Latin America?\n* What factors (demographics, clinical, socioeconomic) influence outcomes in patients with AKI-RRT in Latin America?\n\nThe main aims of this study are to:\n\n* Establish a comprehensive database containing clinical, laboratory, treatment, process, and outcome data of patients with AKI-RRT in Latin America\n* Describe current epidemiology of AKI-RRT in Latin America\n* Compare processes of care and outcomes across different countries in Latin America\n* Provide data resources to facilitate and promote clinical research in AKI-RRT",[99,100,101,102,103,27],"Dialysis","Critically Ill Acute Kidney Injury","Renal Replacement Therapy for Acute Kidney Injury in ICU","Acute Kidney Injury","Renal Replacement Therapy",[27,58,105,106,30,107,108,109],"RRT","Latin America","renal replacement therapy","intensive care unit","dialysis","RECRUITING","2026-03-11",{"date":113,"type":37},"2026-03-12",{"date":115,"type":37},"2026-03-01",{"date":117,"type":21},"2027-06-30",{"name":119,"class":44},"University of Alabama at Birmingham",15,{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":22,"phases":130,"briefSummary":132,"conditions":133,"keywords":4,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":140,"leadSponsor":142,"locationsCount":144},"100601104","outpatient-recovery-from-acute-kidney-injury-requiring-dialysis---2-100601104","NCT07106151","Outpatient Recovery From Acute Kidney Injury Requiring Dialysis - 2","ORKID-2","Inclusion Criteria:\n\n* AKI-D (not ESKD, as determined by the clinical inpatient nephrology team)\n* Age ≥ 18 years\n* Planned for continued dialysis outside the acute hospital setting (at outpatient dialysis unit\u002FSNF\u002FLTACH, not planned transfer to another short-stay acute care hospital).\n\nExclusion Criteria:\n\n* Pregnant\n* Prisoner\n* Unable to consent and no surrogate decision maker available\n* Clinical team declines to allow approach for study",{"count":129,"type":21},40,[131],"NA","Providing additional information to patients with acute kidney injury who continue dialysis after hospital discharge and to the accepting kidney doctor (nephrologist) who manages their dialysis may be feasible and beneficial. This study will pilot measuring the patient's residual kidney function at the time of discharge and communicating that result to the accepting nephrologist and the patient, along with information on recommended recovery monitoring frequency and criteria for consideration of a twice-weekly hemodialysis schedule.",[27,134,135],"AKI - Acute Kidney Injury","Dialysis Patients","2026-02-23",{"date":138,"type":37},"2026-02-27",{"date":136,"type":37},{"date":141,"type":21},"2028-01",{"name":143,"class":44},"University of California, San Francisco",1,{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":16,"minAge":152,"maxAge":153,"enrollmentInfo":154,"targetDuration":4,"studyType":22,"phases":155,"briefSummary":157,"conditions":158,"keywords":4,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":144},"100379157","phase-3-no-during-cpb-in-neonates-to-reduce-risk-of-aki-100379157","NCT04216927","NO During CPB in Neonates to Reduce Risk of AKI","Efficacy of Nitric Oxide Administration During Cardiopulmonary Bypass in Neonates at Reducing the Risk of Acute Kidney Injury","Inclusion Criteria:\n\n* All neonates (≤31 days) undergoing cardiac surgery with CPB for CHD will be deemed eligible for enrollment.\n\nExclusion Criteria:\n\n1. Failure to obtain informed consent from parent\u002Fguardian\n2. Clinical signs of preoperative persistent elevated pulmonary vascular resistance,\n3. Emergency surgery,\n4. Episode of cardiac arrest within 1 week before surgery,\n5. Recent treatment with steroids and\u002For a condition that may require treatment with steroids (excluding steroid administration specifically for CPB),\n6. Use of inhaled NO (iNO) immediately prior to surgery,\n7. Structural renal abnormalities by ultrasound,\n8. Preoperative AKI,\n9. Use of other investigational drugs,\n10. Weight less than \\\u003C2 kg,\n11. Gestational age \\\u003C36 weeks,\n12. Major extracardiac congenital anomalies,\n13. Non-English speakers.","1 Day","31 Days",{"count":129,"type":21},[156],"PHASE3","Acute kidney injury (AKI) following cardiac surgery for congenital heart defects (CHD) in children affects up to 60% of high risk-patients and is a major cause of both short- and long-term morbidity and mortality. Despite effort, to date, no successful therapeutic agent has gained widespread success in preventing this postoperative decline in renal function. Nitric oxide is an intricate regulator of acute inflammation and coagulation and is a potent vasodilator. The investigators hypothesize that nitric oxide, administered during cardiopulmonary bypass (CPB), may reduce the incidence of AKI.",[27,159,160],"CHD - Congenital Heart Disease","Surgery","2025-07-21",{"date":163,"type":37},"2025-07-24",{"date":165,"type":37},"2023-01-10",{"date":167,"type":21},"2026-06-30",{"name":169,"class":44},"Children's Hospital Medical Center, Cincinnati",{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":177,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":179,"conditions":180,"keywords":188,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":144},"100548112","genetics-in-the-progression-of-nephropathies-100548112","NCT06416761","Genetics in the Progression of Nephropathies","The Genetic Contribution to Progression of Kidney Disease","Inclusion Criteria:\n\n. presence of specific renal disease\n\nExclusion Criteria:\n\n* to be evaluated in the different sub-protocols",{"count":178,"type":21},10000,"This study evaluates the role of genetic in the development and progression of different nephropaties with particular attention to:\n\n* AKI\n* CKD\n* Hypertension\n* ADPKD\n* CKD-MBD\n* Patients with decompensated heart failure undergoing either medical or surgery therapy\n* Patients with hematologic cancer exposed to chemotherapeutic agents or undergoing allogeneic bone marrow transplantation\n* glomerular diseases",[27,181,182,183,184,185,186,187],"CKD","Ckd-Mbd","CKD (Chronic Kidney Disease) Stage 5D","ADPKD","Hypertension","Hematologic Malignancy","Bone Marrow Transplant Complications",[189,190,191,192,193,194],"genetic in hypertensive kidney disease","salt intake in BP control and CKD progression","genetic in CKD","endogenous Ouabain as marker of AKI","protein intake restriction in CKD progression","hypertension in allogenic bone marrow transplantation","2024-05-11",{"date":197,"type":37},"2024-05-16",{"date":199,"type":37},"2006-05-19",{"date":201,"type":21},"2041-05-19",{"name":203,"class":44},"Ospedale San Raffaele"]