[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"alcohol-consumption\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:alcohol-consumption":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,18,0,[8,50,82,107,130,157,182,210,237,272,301,339,362,387,414,438,469,502],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100590067","mentor-moms-study-100590067",false,"NCT06962592","Mentor Moms+ Study","A Community-based Adaptation of a Peer-led Intervention to Address Alcohol Use and HIV Risk in Pregnant Women in South Africa (Mentor Moms+)","(MM+)","Inclusion Criteria:\n\n* • ≥ 16 years;\n\n  * Pregnancy confirmed;\n  * reported alcohol use during pregnancy (in last 2 months);\n  * lives within 20 kilometers of the study facility;\n  * able and willing to consent to study participation.\n\nExclusion Criteria:\n\n* Individuals not meeting the above criteria will be excluded.",true,"FEMALE","16 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this study is to adapt an existing evidence based intervention for use in pregnant and lactating people (PLP) who use alcohol. Through the pilot RCT, we aim to understand if tailored intervention, Mentor Mothers+, is effective in reducing alcohol use (primary outcome) and improving antiretroviral (PrEP or ART) adherence (secondary outcomes) among pregnant and breastfeeding women living with and without HIV in a community heavily burdened by this syndemic.\n\nThe investigators will conduct an pilot randomized control trial in 100 pregnant women, recruited during antenatal care (ANC) visits within the Saldanha Bay Municipality clinic in Cape Town, South Africa. The RCT will involve the delivery of brief, individual motivational interviewing sessions provided by trained mentor mothers from the community who are on either PrEP (living without HIV) or ART (living with HIV) and who stopped or reduced alcohol use during pregnancy. The enrolled participants will be followed for a 6-month period spanning both pregnancy and postpartum stages.",[28,29],"HIV","Alcohol Consumption",[31,32,33,34,35,36],"pregnant","postpartum","HIV prevention","HIV treatment","Alcohol use","breastfeeding","RECRUITING","2026-07-01",{"date":40,"type":41},"2026-07-02","ACTUAL",{"date":43,"type":41},"2025-09-01",{"date":45,"type":22},"2027-08-31",{"name":47,"class":48},"University of California, Los Angeles","OTHER",2,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":58,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100585305","pilot-of-an-intervention-to-reduce-alcohol-use-and-improve-art-adherence-among-men-living-with-hiv-with-pregnant-partners-in-uganda-100585305","NCT06900634","Pilot of an Intervention to Reduce Alcohol Use and Improve ART Adherence Among Men Living With HIV With Pregnant Partners in Uganda.","Utilizing Implementation Research Methodologies to Adapt an Intervention to Reduce Alcohol Use and Improve HIV Care Outcomes Among Men Living With HIV Who Have Serodiscordant Pregnant Partners","Kisoboka Amaka","Inclusion Criteria:\n\nFOR MEN\n\n1. living with HIV;\n2. AUDIT-C positive (≥4) indicating potential hazardous drinking;\n3. \\>6 months since initial antiretroviral treatment (ART) initiation;\n4. an indicator of potential suboptimal treatment as prevention (TasP) either: (i) last HIV viral load test (within 6 months) was detectable (\\>20) or (ii) last viral load test between 6 and 13 months ago was detectable (\\>20) and reports missing ≥2 ART doses in the past 2 weeks or (iii) a lack of viral load test results for the prior 13 months in clinic records and reports missing ≥2 ART doses in the past 2 weeks\n5. not planning to move from the area within the next 6 months;\n6. have their own mobile phone and can be reached via phone.\n\nFOR WOMEN\n\n1. 18+ years of age (or emancipated minor)\n2. Pregnant\n3. HIV negative\n\nFOR COUPLES (IF INDIVIDUAL ELIGIBILITY CRITERIA ABOVE ARE MET)\n\n1. married\u002Fliving together \\>6 months;\n2. planning to stay together \\>6 months\n3. lived in the area for \\>3 months and\n4. not planning to move within \\\u003C6 months.\n5. similar responses on Couple Verification Screening (CVS) form, an instrument to determine if couples are legitimate (e.g., asking each person what they ate the last time they shared a meal with their partner).\n\nExclusion Criteria:\n\nFOR MEN\n\n1. visibly intoxicated at enrollment (eligible to enroll when not intoxicated);\n2. does not speak Luganda or English;\n3. currently receiving a majority of work payments via mobile money\u002Fdigital payments;\n4. participated in the Kisoboka pilot RCT;\n5. unable to read basic Luganda or English\n\nFOR WOMEN For safety purposes, we will not enroll women who do not feel they can safely participate in the study.","ALL","18 Years",{"count":61,"type":22},60,[25],"Hazardous alcohol use, which is common among men in Uganda, is a primary driver of both HIV risk and intimate partner violence (IPV) in this setting. Among men living with HIV, alcohol use is associated with non-adherence to antiretroviral therapy (ART) and a detectable viral load, increasing the risk of onward HIV transmission to partners. This risk is further heightened when the partner is pregnant, due to the potential for vertical transmission. Therefore, addressing factors that interfere with optimal HIV care outcomes among men living with HIV is critical to HIV prevention in pregnant women.\n\nThe goal of this randomized controlled trial (RCT) is to pilot test an intervention that combines alcohol reduction and economic strengthening to improve ART adherence. The study will assess implementation outcomes and preliminary efficacy among men living with HIV who engage in hazardous alcohol use and their pregnant partners (n=30 couples). The main questions it aims to answer are:\n\n1. What are the implementation outcomes (acceptability, appropriateness, feasibility, fidelity, and safety) at the individual, implementer, and organizational levels, and what bridging factors may impede success (e.g., community-academic partnership)?\n2. Does the intervention reduce hazardous alcohol use and improve ART adherence among men living with HIV?\n\nResearchers will compare the intervention group (n=15 couples) to the standard of care group (n=15 couples) to determine if the intervention leads to behavior change in alcohol use and ART adherence among men living with HIV.\n\nParticipants will:\n\n1. Men in the intervention group will receive the Amaka intervention, designed to reduce alcohol use and improve ART adherence.\n2. Complete assessments on hazardous alcohol use, ART adherence, and implementation outcomes at multiple time points (baseline, 3 and 6 months).\n3. Engage with implementers to provide post-implementation feedback on feasibility and acceptability.",[65,29],"HIV Antiretroviral Therapy (ART) Adherence",[67,68,69,70],"hiv","motivational interviewing","behavioral economics","alcohol use disorder","NOT_YET_RECRUITING","2026-06-17",{"date":74,"type":41},"2026-06-22",{"date":76,"type":22},"2027-02-01",{"date":78,"type":22},"2028-02-01",{"name":80,"class":48},"San Diego State University",1,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":17,"sex":58,"minAge":59,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":93,"conditions":94,"keywords":95,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":102,"completionDateStruct":103,"leadSponsor":105,"locationsCount":81},"100575593","evaluating-telehealth-delivery-of-brief-alcohol-screening-and-intervention-for-college-students-100575593","NCT06774300","Evaluating Telehealth Delivery of Brief Alcohol Screening and Intervention for College Students","Tele-BASICS","Inclusion Criteria:\n\n* between 18 and 26 years of age\n* fluent in understanding English\n* a registered student at one of the two intervention sites\n* adequate internet capabilities to support video-conferencing\n* access to a webcam, which is a standard features of most laptops, mobile devices, and desktops\n* engage in binge drinking (i.e., 4 or more standard drinks in a sitting for women or 5 or more standard drinks in a sitting for men) at least once in the past month (for the volunteer sample only)\n* experienced at least one negative alcohol-related consequence in the previous month (mandated students would meet this due to receiving an alcohol sanction)\n* reports a score of 2 or higher on questions about a) interest in reducing their drinking, or b) interest in not increasing their drinking.\n\nExclusion Criteria:\n\n* not meeting inclusion criteria or unwillingness to participate","26 Years",{"count":91,"type":22},600,[25],"This research study will test the efficacy of a telehealth version of the Brief Alcohol Screening and Intervention for College Students (BASICS), which is the gold standard prevention and intervention approach to target heavy alcohol use on college campuses across the United States.",[29],[96,97,98,99],"alcohol","drinking","brief intervention","teleheath","2026-06-15",{"date":72,"type":41},{"date":43,"type":41},{"date":104,"type":22},"2030-07-31",{"name":106,"class":48},"University of Southern California",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":17,"sex":58,"minAge":114,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":23,"phases":118,"briefSummary":119,"conditions":120,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":81},"100641145","impact-of-risk-feedback-on-behavioral-trajectories-100641145","NCT07657221","Impact of Risk Feedback on Behavioral Trajectories","Alcohol Metabolism and Disease Risk in Asians: Examining the Impact of Personalized Phenotypic\u002FGenotypic Feedback on Early Drinking Trajectories","Inclusion Criteria:\n\n* USC student of Chinese, Japanese, Korean, or Vietnamese heritage\n\nExclusion Criteria:\n\n* not a USC student, not 17-25 years old, not of Chinese, Japanese, Korean, or Vietnamese heritage","17 Years","25 Years",{"count":117,"type":22},450,[25],"The goal of this study is to examine the effects of providing personalized information about behavioral, physical, and genetic factors that are associated with elevations in risk for some health problems. The main research question is: can we affect young adult behaviors through communication about these health-related risks? Participants will be asked to complete an in-person baseline session where they provide a DNA sample, complete online surveys, and do a brief interview. They will then receive one of several brief online information sessions and be followed in online surveys approximately every 3 months over the next 2 years.",[121,29],"Healthy","2026-06-12",{"date":124,"type":41},"2026-06-18",{"date":126,"type":22},"2026-08-18",{"date":128,"type":22},"2030-08-31",{"name":106,"class":48},{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":17,"sex":58,"minAge":59,"maxAge":115,"enrollmentInfo":137,"targetDuration":4,"studyType":23,"phases":139,"briefSummary":140,"conditions":141,"keywords":143,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":49},"100635827","usafeus-app-pilot-testing-100635827","NCT07557745","uSafeUS+ App Pilot Testing","Expanding the uSafeUS Mobile App to Reduce Alcohol-Involved Sexual Assault on College Campuses","Inclusion Criteria:\n\n* Participants must be between the ages of 18 and 25 years old;\n* Currently enrolled as a residential undergraduate student at a participating university;\n* Intend to reside on or near (in the same town) campus over the two-month study period\n* Own a smartphone\u002Fmobile device;\n* Have consumed at least one alcoholic beverage per week or engaged in dating or social behaviors where alcohol is present at least once a week over the past 30 days;\n* Intend to drink or go out at the same frequency (at least weekly) over the two-month study period\n\nExclusion Criteria:\n\n* Unable or unwilling to provide informed consent",{"count":138,"type":22},90,[25],"The purpose of this study is to test the feasibility and acceptability of an innovative mobile application (uSafeUS+) to reduce college student drinking and sexual assault (SA) risk in real time. Following an initial period of app development, this study will use a pilot 3-arm randomized controlled trial (N = 90; 30\u002Farm) to examine the acceptability, feasibility, and initial evidence of efficacy of the novel, expanded uSafeUS+ app, relative to the existing SA-only focused uSafeUS app (already in use on 24 college campuses), and an assessment-only control condition.\n\nSpecifically, the investigators aim to answer the following research questions:\n\n1. Do students like the app (overall and specific features)?\n2. How frequently do students use the app within the 1-month exposure period?\n3. What barriers and facilitators impact app use?\n4. Is there evidence of increased use of protective behaviors on drinking days and over time?\n5. Is there evidence of decreased drinking (amount, frequency) or SA risk on drinking days and over time?\n\nParticipants will complete:\n\n* A baseline assessment\n* A 1-month app exposure period with daily surveys about app use on the weekends\n* Follow-up surveys at 1- and 2-months post-intervention.",[29,142],"Sexual Assault",[144,145,146,147,148],"Alcohol harm reduction","Sexual Assault Risk Reduction","Protective Behavioral Strategy Use","College students","MHealth","2026-06-11",{"date":100,"type":41},{"date":152,"type":41},"2026-05-11",{"date":154,"type":22},"2026-08-31",{"name":156,"class":48},"University of Florida",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":58,"minAge":163,"maxAge":164,"enrollmentInfo":165,"targetDuration":4,"studyType":23,"phases":167,"briefSummary":169,"conditions":170,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":49},"100526550","phase-1-influence-of-mavoglurant-on-alcohol-craving-and-drinking-in-heavy-drinkers-100526550","NCT06136195","Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers","Inclusion Criteria:\n\n1. Ages 21-50 (The lower limit is to avoid offering alcohol to individuals below the drinking age of 21. The upper age is determined by experience recruiting for our prior studies).\n2. Ability to read English at 6th grade level or higher.\n3. Meet DSM-V criteria for moderate or severe Alcohol Use Disorder (AUD).\n4. Average weekly alcohol consumption of 30-70 standard drinks for men and 20-65 drinks for women. The lower limits are consistent with the lower sex-specific cut-offs defining high-risk drinking based on World Health Organization Risk Levels (WHO, 2000); the upper limits are designed to avoid recruiting participants whose drinking is likely to exceed the number of drinks available in the Alcohol Drinking Paradigm (ADP).\n\nExclusion Criteria:\n\n1. Individuals who are seeking alcohol treatment or have been in alcohol treatment within the past 6 months.\n2. Meet current Diagnostic and Statistical Manual v.5 (DSM-V) criteria for substance use disorder, except for tobacco use disorder or mild cannabis use disorder.\n3. Positive urine drug screens at more than 1 baseline appointment for opiates, cocaine, benzodiazepines and barbiturates.\n4. Psychotic or other severe psychiatric disorders as determined by clinical evaluation (Structured Clinical Interview for DSM-V; SCID). Note that if a subject endorses any harm\u002Frisk behaviors (e.g. suicidal\u002Fhomicidal risk) a licensed clinician will be consulted immediately.\n5. Regular use of psychoactive drugs, except for individuals on a stable dose of an antidepressant for at least 2 months.\n6. Medical conditions that would contraindicate the consumption of alcohol or use of mavoglurant.\n7. Clinically significant abnormalities in screening laboratories, including aspartate aminotransferase (AST) \\>3 times upper limit of normal (ULN); alanine aminotransferase (ALT) \\> 3 times ULN; total bilirubin \\>1.5 times ULN; serum creatinine \\>2.0 times ULN.\n8. Neurological trauma or disease, delirium or hallucinations, or clinically significant or unstable medical conditions, including uncontrolled hypertension or diabetes, or significant cardiac, pulmonary, renal, hepatic, endocrine, or other systemic diseases, which in the opinion of the study physician and Principal Investigator, may put the patient at risk because of participation in the study.\n9. Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar) scores of 8 or greater or a history of significant repeated alcohol withdrawals to reduce the likelihood of withdrawal symptomatology if subjects reduce their drinking.\n10. Women who are pregnant or nursing.\n11. Participants who refuse to use a reliable method of birth control.\n12. Subjects who report disliking spirits will be excluded because hard liquor will be provided during the ADP.\n13. Subjects who have taken any investigational drug within 4 weeks of the anticipated date of the first study dose.\n14. Individuals who report heavy drinking days in the 2 days prior to their intake appointment but have a negative ethyl glucuronide (EtG) test to rule out subjects who are misrepresenting their drinking history.\n15. Subjects who have donated blood within the past 6 weeks.","21 Years","50 Years",{"count":166,"type":22},63,[168],"PHASE1","The purpose of this research study is to find out about the effects of a drug called mavoglurant on alcohol consumption.",[29,171,172],"Heavy Drinker","Alcohol Use Disorder (AUD)","2026-06-04",{"date":175,"type":41},"2026-06-08",{"date":177,"type":41},"2024-07-01",{"date":179,"type":22},"2027-05-31",{"name":181,"class":48},"Yale University",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":188,"eligibilityCriteria":189,"healthyVolunteers":17,"sex":58,"minAge":163,"maxAge":190,"enrollmentInfo":191,"targetDuration":4,"studyType":23,"phases":193,"briefSummary":194,"conditions":195,"keywords":198,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":81},"100575305","transcranial-magnetic-stimulation-tms-effects-using-magnetoencephalography-meg-study-100575305","NCT06770556","Transcranial Magnetic Stimulation (TMS) Effects Using Magnetoencephalography (MEG) Study","An Investigation of TMS Effects Using Magnetoencephalography (MEG) Among Individuals With and Without Heavy Alcohol Use","TMS","Inclusion Criteria non-AUD Participants:\n\n* Diagnostic and Statistical Manual of Mental Disorders (DSM-5) score for AUD = 0\n* Alcohol Use Disorders Identification Test (AUDIT) score ≤ 7\n* Is not a heavy alcohol consumer\n\nInclusion Criteria AUD Participants:\n\n* DSM-5 score for AUD ≥ 3\n* AUDIT score ≥ 8\n* Is a heavy alcohol consumer\n\nExclusion Criteria:\n\n* Current substance use disorder other than alcohol use disorder and\u002For frequent use of non-prescribed psychoactive substances.\n* Current serious psychiatric disorder, and\u002For any history of a psychotic disorder\n* Any health problem that would interfere with the study or could be aggravated by study procedures (e.g., history of migraines, claustrophobia).\n* Is currently taking or initiates a medication known to affect alcohol intake and\u002For craving.\n* History of traumatic brain injury resulting in hospitalization, loss of consciousness, and\u002For having ever been informed he\u002Fshe has an epidural, subdural, or subarachnoid hemorrhage.\n* Does not meet safety criteria for TMS or MRI.\n* Females of childbearing potential who are pregnant (by urine HCG), planning to become pregnant, nursing, or who are not using a reliable form of birth control.\n* Is at an elevated risk of seizure (i.e. has a history of seizures, is currently prescribed medications known to lower seizure threshold and has had a change in their medication).\n* Clinical Intake Withdrawal Assessment (CIWA\\>5) (to prevent delivering TMS to individuals in withdrawal).\n* Not able to read and understand questionnaires, assessments, and\u002For the informed consent.","65 Years",{"count":192,"type":22},10,[25],"Alcohol use disorder (AUD) is a complex chronic brain disease characterized by compulsive alcohol use, loss of control over drinking, and negative emotional states. Extensive research has identified the general neural circuitry underlying AUD. There is an exciting opportunity to intervene in AUD using neuromodulation. Transcranial magnetic stimulation (TMS) offers a non-invasive method to modulate brain activity, making it a promising tool for investigating, modulating, and potentially treating AUD. However, the precise effects of TMS on neural circuits involved in AUD and the mechanisms underlying these effects must first be understood. Magnetoencephalography (MEG) is a neuroimaging method that provides direct measurement of brain activity within neural circuits with high temporal resolution. Critically, MEG can measure brain activity in a wide range of frequencies that are consistent with those targeted by TMS. The goal of this proposal is therefore to collect preliminary and feasibility data to support a future NIH grant application that would use MEG to investigate TMS effects in individuals with AUD (iAUD).",[196,197,29],"Alcohol Use Disorder","Alcohol Dependence",[199,200,196],"Transcranial Magnetic Stimulation (TMS)","Magnetoencephalography (MEG)","2026-04-15",{"date":203,"type":41},"2026-04-17",{"date":205,"type":41},"2025-03-21",{"date":207,"type":22},"2026-12-31",{"name":209,"class":48},"Wake Forest University Health Sciences",{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":216,"eligibilityCriteria":217,"healthyVolunteers":11,"sex":58,"minAge":59,"maxAge":4,"enrollmentInfo":218,"targetDuration":4,"studyType":23,"phases":220,"briefSummary":222,"conditions":223,"keywords":225,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":233,"leadSponsor":235,"locationsCount":81},"100602062","phase-2-probenecid-administration-for-alcohol-craving-and-consumption-100602062","NCT07118618","Probenecid Administration for Alcohol Craving and Consumption","Probenecid, Pannexin 1 Channels for Alcohol Use Disorder","PROB2","Inclusion Criteria:\n\n* • Male or female, ≥18 years.\n\n  * women \\>7 drinks\u002Fweek; men \\>14 drinks\u002Fweek.\n  * meet moderate to severe AUD score for DSM-5 criteria.\n  * Breath Alcohol Content (BrAC)=0.00 at each visit.\n  * in good health as confirmed by medical history, physical examination and lab tests.\n  * willing to adhere to the study procedures.\n  * understand informed consent and questionnaires in English at an 8th grade level.\n\nExclusion Criteria:\n\n* • Women who are breastfeeding or positive urine test for pregnancy.\n\n  * clinically significant medical abnormalities: unstable hypertension, clinically significant abnormal EKG, bilirubin \\>150% of the upper normal limit, ALT\u002FAST \\>300% the UNL, creatinine clearance ≤60 dl\u002Fmin\n  * meet DSM-5 criteria for a diagnosis of schizophrenia, bipolar disorder, or other psychoses\n  * medications that reduce alcohol consumption (naltrexone, disulfiram).\n  * use aspirin (salicylates may reduce effect of probenecid), penicillin, methotrexate (may increase concentration).\n  * history of suicide attempts in the last three years.\n  * current diagnosis of a moderate or severe cannabis use disorder as assessed by self-report, SCID-E for SUD, and urine toxicology screen at baseline.\n  * current diagnosis of another substance disorder at any severity, other than nicotine, as assessed by self-report, SCID-E for SUD, and urine toxicology screen at baseline.\n  * current use of medications that may interact with probenecid.\n  * history of hypersensitivity to sulfa drugs.",{"count":219,"type":22},120,[221],"PHASE2","This study proposes a 16-week, between-subject, double-blind, randomized controlled trial (RCT) with probenecid (2g \u002Fday) compared to placebo in individuals with AUD to test if reduces craving and alcohol consumption.",[172,29,224],"Craving",[226,227,224,228],"AUD","Probenecid","Alcohol","2026-03-14",{"date":231,"type":41},"2026-03-17",{"date":229,"type":41},{"date":234,"type":22},"2030-12-31",{"name":236,"class":48},"Brown University",{"id":238,"slug":239,"hasResults":11,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":243,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":58,"minAge":245,"maxAge":4,"enrollmentInfo":246,"targetDuration":4,"studyType":248,"phases":4,"briefSummary":249,"conditions":250,"keywords":257,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":270,"locationsCount":81},"100581888","a-novel-blood-test-as-a-biomarker-in-mental-health-100581888","NCT06856161","A Novel Blood Test as a Biomarker in Mental Health","A Novel Blood Test as a Differential Diagnosis and Drug Efficacy Biomarker in Mental Health","LEADING-MH","Inclusion Criteria:\n\nI. Age 19+. II. Informed consent by participant\n\nIII. Any of the following situations:\n\n1. Suspected, new onset or established depression.\n2. First episode of psychosis or suspected\u002Festablished schizophrenia. IV. In the opinion of the Investigator, the participant will likely be able to complete the standardized mental health questionnaires administered in each study visit.\n\nExclusion Criteria:\n\nI. Inability to provide informed consent. II. Currently enrolled in any other research study involving drugs or devices that may confound mental health treatment outcomes.\n\nIII. Currently declared on extended leave Under British Columbia's Mental Health Act.","19 Years",{"count":247,"type":22},500,"OBSERVATIONAL","This longitudinal, observational study aims to assess whether the characteristics of a novel blood peripheral biomarker can serve as indicators for depression and schizophrenia in patients at the Royal Columbian Hospital Psychiatric Clinics. The study will evaluate whether changes in these biomarker characteristics can help distinguish between depressed patients who do or do not respond to treatment and between individuals experiencing a single psychotic episode and those at risk of progressing to schizophrenia. To achieve this, blood samples and standardized mental health assessments will be collected across three study visits from up to 500 participants, grouped into two study arms based on their diagnosis: Depression (DEP) or Psychosis\u002FSchizophrenia (PSY).",[251,252,253,254,29,255,256,196],"Depression - Major Depressive Disorder","Schizophenia Disorder","Psychosis","Mania (Neurotic)","Anxiety Disorder (Panic Disorder or GAD)","Substance Use Disorders",[258,259,260,261,262,263],"mental health","biomarker","depression","schizophrenia","psychosis","SERT","2026-03-03",{"date":266,"type":41},"2026-03-05",{"date":268,"type":41},"2025-03-25",{"date":45,"type":22},{"name":271,"class":48},"Fraser Health",{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":278,"eligibilityCriteria":279,"healthyVolunteers":11,"sex":58,"minAge":59,"maxAge":4,"enrollmentInfo":280,"targetDuration":4,"studyType":23,"phases":282,"briefSummary":283,"conditions":284,"keywords":289,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":81},"100567451","enhancing-hiv-prevention-and-reducing-alcohol-use-among-people-receiving-sti-care-in-lilongwe-malawi-100567451","NCT06668363","Enhancing HIV Prevention and Reducing Alcohol Use Among People Receiving STI Care in Lilongwe, Malawi","Enhancing HIV Prevention and Reducing Alcohol Use Among People Receiving STI Care in Lilongwe, Malawi: A Pilot Implementation Study","Treat4All","Inclusion Criteria:\n\n* Men and women age 18 years or older.\n* Receiving care at Bwaila STI clinic.\n* Report recent heavy drinking (greater than or equal to 4 drinks a day in the past 30 days for men and greater than or equal to 3 drinks a day in the past 30 days for women\n* Willing to receive an HIV test at study enrollment, if not previously diagnosed Report not taking ART, recent suboptimal adherence to ART, or recent history of unsuppressed HIV viral load \\[for PWH\\] or no recent oral PrEP use (self-reported taking no PrEP pills in past 7 days) \\[for those at risk of HIV\\]\n* Plan to reside in the Lilongwe area for at least 6 months.\n* Not participating in other HIV or alcohol programs\n* Ability and willingness of participant to provide informed consent.\n* Willingness to provide contact\u002Flocator information to be contacted for follow up study activities.\n\nExclusion Criteria:\n\n* Unable to participate in study activities due to psychological disturbance, cognitive impairment, or threatening behavior\n* Pregnant or breastfeeding\n* At risk of experiencing alcohol-related withdrawal symptoms\n* Acute physical or mental illness, including suicidal thoughts or behaviors\n* Participating in in other HIV or alcohol programs\n* Active drug dependence that would interfere with adherence to study requirements.\n* History of using injectible PrEP\n* Any other condition that in the opinion of the study investigator would compromise the safety of the study participant or study staff or would prevent proper conduct of the study.",{"count":281,"type":22},160,[25],"Purpose: To evaluate short-term efficacy and implementation of Treat4All, an alcohol reduction evidence-based intervention, for decreasing heavy drinking and optimizing HIV outcomes (viral suppression among People with HIV (PWH); Pre-exposure prophylaxis (PrEP) use among those at high risk of HIV)\n\nParticipants: Approximately 160 participants aged 18 years or older will be enrolled into this study.\n\nEligible participants will be recruited from two groups of individuals:\n\nPersons at risk of HIV: Individuals receiving (STI) care who report recent heavy drinking (n=80) and no recent use of PrEP. Persons with HIV: Individuals with HIV who report recent heavy drinking and either a history of unsuppressed viral load or recent suboptimal adherence to ART (n=80).\n\nProcedures (methods): Pilot two-arm randomized controlled trial (1:1; Treat4All Intervention vs Usual Care)",[29,285,286,287,288],"PrEP Uptake","Recent Heavy Drinking","HIV Prevention","HIV Treatment",[290,28,287,291,228],"PrEP","Alcohol reduction","2026-01-28",{"date":294,"type":41},"2026-01-30",{"date":296,"type":41},"2024-12-12",{"date":298,"type":22},"2026-06",{"name":300,"class":48},"University of North Carolina, Chapel Hill",{"id":302,"slug":303,"hasResults":11,"nctId":304,"briefTitle":305,"officialTitle":305,"acronym":306,"eligibilityCriteria":307,"healthyVolunteers":11,"sex":58,"minAge":308,"maxAge":309,"enrollmentInfo":310,"targetDuration":4,"studyType":23,"phases":312,"briefSummary":313,"conditions":314,"keywords":320,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":81},"100603330","targeting-lifestyle-to-improve-colorectal-cancer-screening-100603330","NCT07135115","Targeting Lifestyle to Improve Colorectal Cancer Screening","KoloPrev","Inclusion Criteria:\n\n* Invited to the first round of immunochemical faecal blood testing in the national colorectal cancer screening program via a digital platform.\n\nExclusion Criteria:\n\n* Not invited to the national colorectal cancer screening program.","55 Years","56 Years",{"count":311,"type":22},16000,[25],"The goal of this study is to learn whether receiving personalized, digital lifestyle advice during colorectal cancer screening leeds to changes in lifestyle over a two-year follow-up period. Changes will be measured using a composite score including diet, alcohol consumption, physical activity, body mass index and smoking habits. The main questions it aims to answer are:\n\n* Do participants who receive short, personalized digital feedback on their lifestyle - either once or through repeated rounds -change their lifestyle during the two-year study period, compared to those who do not receive any feedback?\n* Does the inclusion of additional contact, such as telephone consultation with healthcare providers, result in further lifestyle changes?\n\nResearchers will compare three groups which receive digital feedback at different intensities and a control group which does not get any feedback to see if lifestyle changes differ between the groups.\n\nParticipants in four different groups will fill in a digital diet and lifestyle questionnaire at the start of the study and 2-4 times after this during the following 2 years.\n\n* Participants in three of the groups will receive a short digital feedback report on their lifestyle related to health recommendations after each completion of the questionnaire.\n* One of these groups will also be offered to go through the feedback report together with a healthcare provider in a telephone call.\n* This group will also receive invitations to motivational webinars every half year during the 2-year study period. The topics in the webinars address cancer preventive lifestyle.\n\nA secondary goal of the study is to understand whether the invitation to fill in the diet and lifestyle questionnaire affects participation in colorectal cancer screening. Therefore, a fifth group of individuals invited to colorectal cancer screening but not to be invited to fill in the questionnaire will be included for extra comparison. Participation in colorectal cancer screening will be compared between this group and the four groups that are additionally invited to complete the questionnaire.\n\nAnother secondary goal is to learn which groups in the society consent to the current study. Therefore, sociodemographic characteristics will be compared between the invited individuals who consent and those who do not consent to the study.",[315,316,317,318,29,319],"Lifestyle Alteration","Tobacco","Diet Modification","Physical Activity","Body Weight Control",[321,322,323,324,325,326,327,328],"Lifestyle intervention","Colorectal cancer screening","Diet","Alcohol consumption","Smoking","Body mass index","Physical activity","Digital questionnaire","2025-08-26",{"date":331,"type":41},"2025-09-03",{"date":333,"type":22},"2025-10-15",{"date":335,"type":22},"2041-12-31",{"name":337,"class":338},"Norwegian Institute of Public Health","OTHER_GOV",{"id":340,"slug":341,"hasResults":11,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":345,"eligibilityCriteria":346,"healthyVolunteers":17,"sex":58,"minAge":163,"maxAge":347,"enrollmentInfo":348,"targetDuration":4,"studyType":23,"phases":350,"briefSummary":351,"conditions":352,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":354,"lastUpdatePostDateStruct":355,"startDateStruct":357,"completionDateStruct":359,"leadSponsor":361,"locationsCount":81},"100564332","social-facilitation-of-alcohol-effects-and-alcohol-misuse-in-young-adults-100564332","NCT06627803","Social Facilitation of Alcohol Effects and Alcohol Misuse in Young Adults","Multi-Method Investigation of Social Facilitation of Alcohol Effects and Alcohol Misuse in Young Adults","PALS","Inclusion Criteria:\n\n* 21-28 years of age\n* Drink regularly (1+ times\u002Fweek) with a same-sex platonic friend that also meets eligibility and is willing to participate\n* Regular alcohol use (3+ times\u002Fweek) with at least one binge drinking episode (5+ drinks \\[male\\] or 4+ drinks \\[female\\] in about 2 hours) in the past month\n* BMI of 18-30\n* Own a smart device operating on the iOS or Android operating system\n* Fluent in English\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding or intent to get pregnant in the next 60 days (females)\n* medical conditions counter-indicated for alcohol administration\n* seeking treatment for alcohol use","28 Years",{"count":349,"type":22},200,[25],"The purpose of this study is to understand social contexts and alcohol use. We hope to learn how being around peers affects alcohol consumption in young adults. About 200 young adults who drink alcohol frequently will take part in the study. This research is being funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA).\n\nParticipation involves one in-person screening session with a same-sex platonic friend. Then participants will complete four in-person laboratory sessions where they will drink beverages containing alcohol or no alcohol. After completion of the laboratory sessions, participants will complete smartphone surveys for 28 days. Lastly, they will complete follow-up surveys 6 months and 12 months post-study enrollment.",[29,353],"Alcohol Abuse\u002FDependence","2025-08-07",{"date":356,"type":41},"2025-08-12",{"date":358,"type":41},"2025-02-20",{"date":360,"type":22},"2029-08-31",{"name":106,"class":48},{"id":363,"slug":364,"hasResults":11,"nctId":365,"briefTitle":366,"officialTitle":367,"acronym":4,"eligibilityCriteria":368,"healthyVolunteers":17,"sex":58,"minAge":59,"maxAge":4,"enrollmentInfo":369,"targetDuration":4,"studyType":248,"phases":4,"briefSummary":371,"conditions":372,"keywords":374,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":378,"lastUpdatePostDateStruct":379,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":385,"locationsCount":81},"100436007","alcotail---implementation-of-tailored-interventions-100436007","NCT04957628","AlcoTail - Implementation of Tailored Interventions","Implementation of Tailored Interventions to Treat Harmful Alcohol and Drug Use for Medical Patients in Norwegian Hospitals and the Municipality Service - AlcoTail","Inclusion Criteria:\n\n* Patients admitted to Medical wards\n\nExclusion Criteria:\n\n* Inability to understand written and verbal Norwegian\n* Cognitive or mental inability to consent to participation\n* Injury or planned surgery as primary reason for admission",{"count":370,"type":22},4200,"This study aims to investigate the implementation and real-world effects of an intervention for harmful use of alcohol and psychoactive medicinal drugs among hospital inpatients. Due to the negative impact of alcohol consumption on health outcomes, a call for action has been made by the Norwegian Ministry of Health, with focus on screening patients for alcohol consumption and evidence-based tailored interventions for those with medium or high consumption. In addition, non-prescribed use of psychoactive medicinal drugs, or concomitant use with alcohol, can also have negative health effects, therefore improved monitoring of the use of these are warranted. Interventions will be introduced as routine procedures at Norwegian hospitals in the upcoming year, and 2500 patients receiving acute medical care will be included in the control group before the intervention is implemented, and 2500 patients in the case group after the implementation is effectuated. This study will evaluate the implementation process using baseline data on self-reported alcohol- and psychoactive medicine use, motivation to reduce consumption and mental distress. In addition, left-over blood samples used for diagnostic purposes will be collected and analyzed for alcohol, psychoactive medicinal and illicit drugs. After 12 months baseline data will be coupled to patient journal data and relevant registry data in order to evaluate the effects of the intervention.",[29,373],"Psychoactive Substance Use",[228,375,376,377],"Psychoactive drugs","Intervention","Somatic patients","2025-07-29",{"date":380,"type":41},"2025-07-31",{"date":382,"type":41},"2021-09-13",{"date":384,"type":22},"2027-12",{"name":386,"class":48},"Oslo University Hospital",{"id":388,"slug":389,"hasResults":11,"nctId":390,"briefTitle":391,"officialTitle":392,"acronym":4,"eligibilityCriteria":393,"healthyVolunteers":17,"sex":58,"minAge":163,"maxAge":394,"enrollmentInfo":395,"targetDuration":4,"studyType":23,"phases":397,"briefSummary":398,"conditions":399,"keywords":402,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":405,"lastUpdatePostDateStruct":406,"startDateStruct":408,"completionDateStruct":410,"leadSponsor":412,"locationsCount":81},"100579281","drinking-in-young-adult-duos-dyad-study-100579281","NCT06822257","Drinking in Young Adult Duos (DYAD) Study","Understanding Alcohol Use in Young Adult Couples","Inclusion Criteria:\n\nBoth members of the couple must:\n\n* be between the ages of 21 and 30\n* regularly consume alcohol\n* own a smartphone\n\nExclusion Criteria:\n\nNeither member of the couple:\n\n* has a history of adverse reaction to the amount of beverage used in the study\n* has a history of major problems related to alcohol\n* is taking medications that could adversely interact with alcohol\n* is pregnant","30 Years",{"count":396,"type":22},504,[25],"This study examines the role of alcohol use in understanding the dynamics of romantic relationships. Couples will participate in a research session where they consume either an alcoholic or non-alcoholic beverage and complete study tasks. After the session, participants will provide information about their drinking habits, alcohol- and non-alcohol-related experiences, and relationship factors through brief surveys on their smart phones and again at 6-month and 12-month follow-up sessions. The findings from this study aim to improve understanding of alcohol use in close relationships and may inform future strategies for promoting healthier relationships and behaviors.",[29,400,401],"Alcohol Drinking","Alcohol Intoxication",[403,404],"alcohol administration","couples","2025-05-22",{"date":407,"type":41},"2025-05-28",{"date":409,"type":41},"2025-02-01",{"date":411,"type":22},"2029-09",{"name":413,"class":48},"Carnegie Mellon University",{"id":415,"slug":416,"hasResults":11,"nctId":417,"briefTitle":418,"officialTitle":418,"acronym":4,"eligibilityCriteria":419,"healthyVolunteers":17,"sex":58,"minAge":163,"maxAge":4,"enrollmentInfo":420,"targetDuration":4,"studyType":23,"phases":422,"briefSummary":423,"conditions":424,"keywords":426,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":429,"lastUpdatePostDateStruct":430,"startDateStruct":432,"completionDateStruct":434,"leadSponsor":436,"locationsCount":49},"100573521","phosphatidylethanol-and-other-ethanol-consumption-markers-100573521","NCT06747364","Phosphatidylethanol and Other Ethanol Consumption Markers","Inclusion Criteria:\n\n1. are ≥ 21 years old;\n2. are height and weight proportionate (body mass index 18-30); and\n3. report drinking on \\> 1 days in the last month, with at least one day equal to at least achieving \\~0.06% BAC.\n\nExclusion Criteria:\n\n1. have significant current or predicted alcohol withdrawal symptoms (CIWA-AR scores ≥ 10);\n2. are currently in alcohol treatment;\n3. have substance use disorder (except nicotine, and\u002For caffeine);\n4. have a medical condition that would contraindicate participation (a positive urine pregnancy test, self-reported scheduled surgery or liver disease);\n5. are currently breast feeding;\n6. have a presence of a DSM-5 psychiatric disorder with symptoms of psychosis and\u002For delirium; or\n7. are unable to comprehend the informed consent process or study instructions.",{"count":421,"type":22},80,[25],"This study is intended to help the investigators understand how a biomarker found in the blood may be used to better identify the quantity and different patterns of alcohol use.\n\nThe investigators hope that the results of this study will help identify the uses of alcohol-use markers in the blood in future alcohol prevention and treatment programs. It is hoped that the information learned from this study will benefit other people in the future.\n\nThe study participants will come into the lab and will (1) consume alcohol in the lab designed to produce a peak blood alcohol concentration of 0.06% and have blood collected over 6 hours followed by abstinence for 10 days to give a small blood sample 4 times and (2) to give a small amount of blood 5 times within 28 days (naturalistic drinking) and provide answers about alcohol use.",[425,29],"Healthy Volunteer",[427,428],"Healthy adult","Light, moderate and heavy drinkers","2025-05-07",{"date":431,"type":41},"2025-05-13",{"date":433,"type":41},"2025-01-07",{"date":435,"type":22},"2029-06",{"name":437,"class":48},"The University of Texas Health Science Center at San Antonio",{"id":439,"slug":440,"hasResults":11,"nctId":441,"briefTitle":442,"officialTitle":443,"acronym":4,"eligibilityCriteria":444,"healthyVolunteers":17,"sex":58,"minAge":245,"maxAge":4,"enrollmentInfo":445,"targetDuration":4,"studyType":23,"phases":447,"briefSummary":448,"conditions":449,"keywords":452,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":460,"lastUpdatePostDateStruct":461,"startDateStruct":463,"completionDateStruct":465,"leadSponsor":467,"locationsCount":81},"100587950","ethanol-consumption-in-the-heat-100587950","NCT06935045","Ethanol Consumption in the Heat","Evaluating How Alcohol Impacts Physiological Responses and Perception During Heat Exposure","Inclusion Criteria:\n\n* Male or Female above the age of 19\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* History of cardiovascular disease, cancer, type 1 or 2 diabetes, chronic obstructive pulmonary disorder, cystic fibrosis, or alcohol addiction or dependence\n* Been hospitalized due to COVID-19\n* Pregnant\u002FBreastfeeding\n* Scoring an eight or above on the Alcohol Use Disorders Identification Test (AUDIT)",{"count":446,"type":22},34,[25],"Climate change has significantly increased the earth's average surface temperature and heat waves have been predicted to increase in frequency, intensity and duration. Extreme heat events have increased the susceptibility to heat-related illnesses, such as heat exhaustion, heat stroke or death. Heat health action plans have been designed to advertise cooling behaviours to mitigate physiological strain. Heat health action plans suggest avoiding alcohol consumption during extreme heat as it may increase dehydration and impair behavioural or physiological temperature regulation and thermal perception. Regardless of these messages, alcohol sales continue to remain high during the summer months year after year, and 1\u002F5 of adults identify alcohol as a hydration strategy during extreme heat events. A recent scoping review investigating the effects of alcohol and heat has demonstrated that acute alcohol consumption does not negatively influence thermoregulation, hydration, or hormone markers of fluid balance in the heat compared to a control fluid (https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12940-024-01113-y). Further, alcohol consumption may elicit sex- and age-specific alterations in physiological and perceptual responses, neither of which have been explored.\n\nTherefore, this study aims to comprehensively evaluate how alcohol consumption systematically alters physiological responses and perceptions during conditions similar to those experienced indoors during extreme heat events in younger and older adults.",[29,450,451],"Heat Stress","Age",[96,453,454,455,456,457,458,459],"heat stress","heat wave","sweating","core temperature","micturition","perception","behaviour","2025-04-11",{"date":462,"type":41},"2025-04-18",{"date":464,"type":41},"2023-12-04",{"date":466,"type":22},"2025-08",{"name":468,"class":48},"Lakehead University",{"id":470,"slug":471,"hasResults":11,"nctId":472,"briefTitle":473,"officialTitle":474,"acronym":4,"eligibilityCriteria":475,"healthyVolunteers":17,"sex":58,"minAge":163,"maxAge":4,"enrollmentInfo":476,"targetDuration":4,"studyType":23,"phases":478,"briefSummary":479,"conditions":480,"keywords":483,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":493,"lastUpdatePostDateStruct":494,"startDateStruct":496,"completionDateStruct":498,"leadSponsor":500,"locationsCount":81},"100571641","phase-2-rapid-bac-reduction-with-nutraceutical-blend-study-100571641","NCT06722898","Rapid BAC Reduction with Nutraceutical Blend Study","Rapid Blood Alcohol Concentration Reduction with Nutraceutical Blend Study","Inclusion Criteria:\n\n* Over age 21\n* Provide signed Informed Consent form electronically in advance of the first study date.\n* Provided signed Acknowledgement Form of what is required as part of the study, including use of Uber for transportation to and from each session.\n* Not taking certain prescription medications to be listed.\n* No history of alcohol or substance abuse issues or alcohol-related medical conditions.\n* No history of liver disease.\n* No history of significant violent behavior.\n* Uses alcohol socially on a regular basis.\n* Not naïve to consuming more than 4 drinks at one time.\n* Not pregnant or at risk for being pregnant.\n* Able to attend all three session dates.\n* Own smartphone with text messaging abilities.\n\nExclusion Criteria:\n\n* Score consistent with Alcohol Use Disorder on the Alcohol Use Disorder Identification Test (AUDIT) a 10 question self-report tool developed by the World Health Organization (WHO).\n* Ongoing or regular use of any of the following medications for medical conditions: Antabuse (disulfiram): (Slows alcohol metabolism by inhibiting the elimination of acetaldehyde), Beta-lactam antibiotics: (Some, such as cefmandole, cefoperazone, and moxalactam, can cause a disulfiram-like reaction when alcohol is consumed), Nitrates (Can cause a disulfiram-like reaction when alcohol is consumed), Sulfonylureas (Longer acting ones, such as chlorpropamide and tolbutamide, can cause a disulfiram-like reaction when alcohol is consumed, as well as Pyrazoles and isobutyramide, Inhibit ADH, which decreases the rate at which alcohol is eliminated.)\n* Current use of medications likely to be synergistic with one-time excessive use of alcohol: opioids, benzodiazepines, anti-histamines.\n* Current use of psychoactive products such as delta 8 or delta 9 tetrahydrocannabinol (THC), Kava, Kratom or psychedelic mushroom (psilocybin).\n* Current use of any illegal drug or substance, that includes, but is not limited to -cocaine, methamphetamine, MDMA (ecstasy, molly).\n* Active medical conditions that would preclude one-time excessive use of alcohol: Liver disease, diabetes mellitus, seizure disorder\u002Fepilepsy, uncontrolled hypertension, cardiac arrhythmia, Multiple Sclerosis, Schizophrenia, Traumatic Brain Injury (TBI), active peptic ulcer disease (PUD), and opioid use disorder",{"count":477,"type":22},35,[221],"Study Title: Nutritional Supplement to Rapidly Decrease Blood Alcohol Concentration (BAC): Safety and Efficacy Study Design: Double-blind, randomized, placebo-controlled clinical trial Objective: Evaluate safety and efficacy of a nutritional supplement to rapidly decrease blood alcohol concentration (BAC), alcohol-induced impairment, and hangover symptoms after excessive alcohol consumption.\n\nPrimary Outcomes:\n\nBAC reduction rate\u002Fextent (BACtrack S80™ breathalyzer) Cognitive\u002Fphysical impairment change (DRUID app™)\n\nSecondary Outcome:\n\nHangover symptom reduction (Acute Hangover Scale) Participants: 35 participants, recruited via social media Duration: 2 weeks, 2 testing sessions (4 hours each) Location: Closed facility in St. Petersburg, FL\n\nProcedure:\n\nSubjects consume standardized alcohol (1g ethanol\u002Fkg body weight) 40-minute drinking period BAC and impairment measurements Administration of test formulation or placebo\n\nMeasurements:\n\nBAC: Baseline, 40min, 15min, 30min, 60min, 90min post-drinking Impairment: Baseline, 15min, 30min, 60min post-drinking Hangover: Next morning via text message\n\nSafety Measures:\n\nGRAS ingredients Lab testing of formulations Medical screening Adverse effect questionnaires Pregnancy tests BAC \\<0.08% before leaving\n\nKey Features:\n\nPaired measurements: active vs. placebo for mini-drink and capsule formulations Uber transportation provided Strict inclusion\u002Fexclusion criteria\n\nData Analysis:\n\nElectronic data entry Blinded submission for statistical analysis Paired comparisons and multiple statistical tests\n\nThis study aims to provide robust data on the efficacy in mitigating alcohol's effects, potentially offering a new tool for reducing alcohol-related impairment and hangover symptoms. The design prioritizes safety, consistency, and scientific rigor to ensure reliable results.",[29,228,481,482],"Hangover Symptoms, NAC","Veisalgia",[96,484,485,486,487,488,489,490,491,492],"blood alcohol","alcohol intoxication","alcohol impairment","BAC","BAC reduction","alcohol half-life","blood alcohol concentration","veisalgia","hangover","2024-12-03",{"date":495,"type":41},"2024-12-09",{"date":497,"type":22},"2024-12-01",{"date":499,"type":22},"2025-02-07",{"name":501,"class":48},"Medical Life Care Planners, LLC",{"id":503,"slug":504,"hasResults":11,"nctId":505,"briefTitle":506,"officialTitle":507,"acronym":4,"eligibilityCriteria":508,"healthyVolunteers":11,"sex":58,"minAge":163,"maxAge":4,"enrollmentInfo":509,"targetDuration":510,"studyType":248,"phases":4,"briefSummary":511,"conditions":512,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":515,"lastUpdatePostDateStruct":516,"startDateStruct":518,"completionDateStruct":520,"leadSponsor":522,"locationsCount":81},"100375166","patient-trajectories-for-older-adults-admitted-to-hospital-for-alcohol-related-problems-100375166","NCT04164940","Patient Trajectories for Older Adults Admitted to Hospital for Alcohol-related Problems","A Multi-centre Registry Study on Patient Trajectories After Interventions for Alcohol-related Health Problems in Somatic Hospital Wards, for People in Late Adulthood (60+)","Inclusion Criteria:\n\n* Age 21 or older, no previous alcohol use disorder or substance use disorder, admitted to hospital which has implemented screening and brief alcohol intervention strategies, written consent to participate\n\nExclusion Criteria:\n\n* specialized treatment for alcohol use disorder og drug use disorder during the three years prior to recruitment",{"count":247,"type":22},"3 Years","Alcohol is contributing to many health problems and disorders, as well as accidents and social problems. Alcohol consumption has been on the rise the past 25 years, especially in Norway. The highest increase is found in older adults, in line with the development in most other countries in the western world. Older adults have a higher risk for alcohol related health problems, due to age related physiological changes, medical conditions and medications. Still, alcohol use is seldom addressed for older people. This means that older people rarely receive help to change alcohol habits.\n\nNorwegian health authorities have issued mandates ordering the regional health trusts to implement strategies in somatic hospital wards, mental health services and drug treatment services to identify and treat alcohol and drug problems affecting the patients' health.\n\nIn this observational study we will explore patient trajectories three years prior to and three years after an admittance to hospital where risky or harmful alcohol consumption is identified and brief interventions are delivered. Hospitals that have implemented such strategies are invited to the study. Patient trajectories are studied in national health registries. This will provide important knowledge on what characterizes the patients identified, and what happens after they have received a brief intervention related to a hospital admittance.",[29,513,514,197],"Alcohol; Harmful Use","Health Risk Behaviors","2023-11-21",{"date":517,"type":41},"2023-11-24",{"date":519,"type":41},"2019-10-23",{"date":521,"type":22},"2030-12",{"name":523,"class":338},"Helse Stavanger HF"]