[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"alcohol-misuse\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:alcohol-misuse":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,49,73,106,131,156,182,207,238,259,285,313,338,365,390,418],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100642089","advancing-scalable-alcohol-brief-interventions-in-the-ed-a-trial-of-conversational-ai-with-digital-reinforcements-100642089",false,"NCT07661563","Advancing Scalable Alcohol Brief Interventions in the ED: A Trial of Conversational AI With Digital Reinforcements","A Randomized Trial of an AI Intervention to Help Individuals With Risky Alcohol Use Among Emergency Department Patients","MICA-ED","Inclusion Criteria:\n\n1. For men: 1+ days with 5 or more drinks OR any week with 14+ drinks\u002Fweek in the past 3 months\n2. For women: 1+ days with 4 or more drinks OR any week with 7+ drinks\u002Fweek in the past 3 months\n3. Owns a mobile phone\n4. Reads English language\n\nExclusion Criteria:\n\n1. For women: current or planned pregnancy in next 12 months\n2. Prisoner or active military status","ALL","18 Years","65 Years",{"count":21,"type":22},750,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn if a novel digital strategy combining a generative AI counseling agent (MICA) and weekly SMS boosters works to reduce risky drinking among Emergency Department patients.",[28],"Alcohol Misuse",[30,31,32,33,34,35],"alcohol","emergency department","adults","AI","motivational interviewing","text messaging","NOT_YET_RECRUITING","2026-06-16",{"date":39,"type":40},"2026-06-22","ACTUAL",{"date":42,"type":22},"2026-08",{"date":44,"type":22},"2031-02",{"name":46,"class":47},"Stanford University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":4},"100633488","phase-2-mechanisms-of-cannabidiol-and-sleep-in-the-context-of-alcohol-use-100633488","NCT07527338","Mechanisms of Cannabidiol and Sleep in the Context of Alcohol Use","CALM","Inclusion Criteria:\n\n* Able to provide informed consent\n* Self reported poor sleep quality (PSQI score \\>5)\n* Hazardous or harmful levels of alcohol consumption (MINI AUD score ≧2)\n* No current moderate or severe alcohol withdrawal symptoms (CIWA-Ar)\n* For female participants of childbearing potential: Not pregnant or lactating at the time of study enrollment or trying to become pregnant as confirmed by urine preg. Lack of childbearing potential confirmed by a history of amenorrhea for at least 12 consecutive months and serum FSH level within the laboratory's reference range for postmenopausal females OR documented bilateral oophorectomy and\u002For hysterectomy\n* For female participants of childbearing potential: Agree to use a highly effective contraception method (i.e., a method with a failure rate of less than 1 percent per year when used consistently and correctly) starting at least five days before you begin the study and continuing for full participation.\n* No current use of sleep medications including CBD in the last 90 days\n* No history of complicated alcohol withdrawal (i.e., seizure, delirium tremens, or alcohol hallucinosis).\n* No current or past 6 months active suicidal ideation or suicidal behavior\n* No current diagnosis, or family history of diagnosis, of psychosis; current major psychiatric illness, such as bipolar disorder, major depression, or schizophrenia\n* No current cannabis use disorder (MINI SUD for cannabis score ≧2)\n* History of previous exposure to guaiol through CBD or other cannabis product\n\nExclusion Criteria:\n\n* Current use of anti-epileptic medications (e.g., clobazam, sodium valproate, lamotrigine)\n* Greater than low risk for obstructive sleep apnea (STOP-BANG \\\u003C=4 or Moderate or greater risk as calculated by Nox Noxturnal Software from baseline PSG data)\n* Current use of medications known to have major interactions with Epidiolex (e.g., brexanolone, buprenorphine, colchicine, esketamine, fezolinetant, ketamine, leflunomide, levoketoconazole, levomethadyl acetate, lomitapide, mipomersen, morphine, pexidartinib, pralsetinib, propoxyphene, relugolix, sodium oxybate, teriflunomide, and venetoclax)\n* Current use of anti-psychotic medications\n* Current use of potent CYP2C19 or CYP3A4 inducers (e.g., Rifampin, apalutamide, carbamazepine, enzalutamide, ivosidenib9, lumacaftor, ivacaftor, phenytoin, St. John's wort, Fosphenytoin, Mitotane, Phenobarbital, Primidone)\n* History of hypersensitivity reactions to cannabidiol\n* Liver function test (Alanine transaminase \\[ALT\\] and Aspartate transaminase \\[AST\\]) levels ≥2x the upper normal limits at baseline\n* Moderate or severe liver disease\n* Allergy or aversion to gelatin (softgels contain porcine gelatin)\n* Report of illegal drug use (e.g., cocaine, methamphetamine) in the past 90 days or positive screening on urine toxicology test at Baseline visit.\n* Uncontrolled hypertension\n* Blood pressure findings concerning for moderate or severe alcohol withdrawal at baseline\n* Abnormal resting heart rate, defined as \\\u003C60 bpm or \\>100 bpm at baseline","21 Years",{"count":58,"type":22},58,[60],"PHASE2","The goal of this clinical trial is to learn if cannabidiol helps to improve sleep and decrease alcohol use. It will also learn about the safety of cannabidiol. The main questions it aims to answer are:\n\nDoes 4 weeks of nightly cannabdiol use:\n\n1. improve sleep quality and time spent in REM sleep?\n2. decrease alcohol use and alcohol craving?\n3. pose any safety risks?\n\nResearchers will compare cannabidiol to a placebo (a look-alike substance that contains no drug).\n\nParticipants will:\n\nTake cannabidiol every night for 4 weeks Visit the clinic once at the beginning and once at the end of the study Wear an activity monitoring watch while in the study Complete an at-home sleep test both at the beginning and the end of the study Check in once a week with researchers via video conference",[63,28],"Sleep","2026-06-09",{"date":66,"type":40},"2026-06-11",{"date":68,"type":22},"2026-07-01",{"date":70,"type":22},"2031-04-01",{"name":72,"class":47},"University of Colorado, Boulder",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":23,"phases":82,"briefSummary":83,"conditions":84,"keywords":89,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":48},"100575899","transition-health-and-resilience-through-valued-experiences-thrive-pilot-for-newly-separated-veterans-100575899","NCT06778278","Transition Health and Resilience Through Valued Experiences (THRiVE) Pilot for Newly Separated Veterans","Adapting Behavioral Activation to Improve Mental Health Outcomes and Reduce Suicide Risk During the Military Transition","Inclusion Criteria:\n\n* Be either (a) a United States military veteran who separated no more than 12 months prior to study enrollment or (b) a United States transitioning service member on terminal leave\n* Be at least 18 years old\n* Have access to the internet; a desktop computer, laptop, tablet, or other \"smart\" device with video camera, speakers, and microphone; and a private place from which to attend THRiVE sessions\n* Reside and complete all study activities within the United States\n\nExclusion Criteria:\n\n* Endorse lifetime manic, hypomanic, or psychotic episodes\n* Meet Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for current severe alcohol use disorder or substance use disorder (except for tobacco use disorder, which will not be exclusionary)\n* Screen positive for moderate or high acute risk for suicide\n* Screen positive for more than minimal risk for other-directed violence\n* Are receiving or plan to receive BA therapy for any mental health condition between enrollment and the 3-month follow-up assessment",{"count":81,"type":22},40,[25],"The objective of this study is to develop and pilot a program designed to improve mental health outcomes and reduce suicide risk during the transition from military to civilian life. It is hypothesized that the Transition Health and Resilience through Valued Experiences (THRiVE) program, to be developed as part of this study, will meet participant recruitment, retention, and satisfaction benchmarks (primary outcomes) and show positive preliminary effects on mental health symptoms, risk factors for suicidal ideation, and psychosocial functioning outcomes (secondary outcomes).\n\nThe specific aims of this study are to:\n\n1. Develop a small-group, peer-led, cross-cutting prevention program for newly separated veterans (NSVs) called THRiVE and\n2. Evaluate the feasibility, acceptability, and preliminary effects of the THRiVE program on mental health symptoms, risk factors for suicidal ideation, and psychosocial functioning outcomes.\n\nUp to 40 NSVs participating in this Stage 1 pilot study will complete validated self-report measures at baseline, immediately after completing the THRiVE program (post-THRiVE), and 3 months after completing the THRiVE program (follow-up). The duration of a participant's time in the study is anticipated to be 5 months.",[85,86,87,88,28],"Military Transition","Community Reintegration","Mental Health","Suicidal Ideation",[90,91,92,93,94,95],"Military transition","Community reintegration","Mental health","Suicidal ideation","Transitioning Service Members","Newly separated Veterans","RECRUITING","2026-06-08",{"date":99,"type":40},"2026-06-10",{"date":101,"type":40},"2025-07-30",{"date":103,"type":22},"2026-10-31",{"name":105,"class":47},"RTI International",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":23,"phases":115,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":48},"100643593","healthy-choices-to-reduce-stigma-and-improve-self-management-of-alcohol-and-hiv-among-young-adults-100643593","NCT07638618","Healthy Choices to Reduce Stigma and Improve Self-Management of Alcohol and HIV Among Young Adults","Inclusion Criteria:\n\n* Aged 18-29 years\n* Have HIV\n* Live in the Dominican Republic\n* Speak Spanish\n* Are unsuppressed\n* Report being stigmatized in the past 6 months\n* Report problem alcohol use in the past 6 months\n* Can provide informed consent\n\nExclusion Criteria:\n\n* Doe not meet the inclusion criteria.","29 Years",{"count":114,"type":22},45,[25],"The Spanish language Healthy Choices intervention pilot study (N=45) holds direct relevance to the United States and federal priorities related to improving HIV outcomes to reduce transmission using implementation science models. If Healthy Choices is found to have a clinical signal of impact, our team is committed to testing the intervention in the United States and training Spanish speaking HIV care navigators on the intervention, specifically in the southern United States where Spanish speaking populations are concentrated, namely in Alabama, Texas, New Mexico, Arizona, Nevada, and Florida.",[118,28,119],"HIV","Stigma",[121,122],"Behavioral Intervention","Young Adults with HIV","2026-06-04",{"date":99,"type":40},{"date":126,"type":22},"2027-10-01",{"date":128,"type":22},"2029-02-28",{"name":130,"class":47},"Florida State University",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":23,"phases":141,"briefSummary":142,"conditions":143,"keywords":145,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":48},"100598355","substance-use-in-assault-injured-young-adults-100598355","NCT07070414","Substance Use in Assault-Injured Young Adults","Alcohol and Cannabis Use Among Assault-Injured Emerging Adults","Inclusion Criteria:\n\nAim 1:\n\n* Be clients of the Yale Hospital Violence Intervention Program (YHVIP)\n* Be between the ages of 18-25 y\u002Fo upon study enrollment\n* Have sustained an intentional injury inflicted by another person not considered to be a boy\u002Fgirlfriend, fiancée, or spouse in the past year\n* Report current alcohol and\u002For cannabis misuse\n* Be English-speaking and able to provide informed consent.\n\nAim 2 and 3:\n\n* Present to Yale New Haven Hospital ED for an intentional injury inflicted by another person not considered to be a boy\u002Fgirlfriend, fiancée, or spouse\n* Be between the ages of 18-25 y\u002Fo upon study enrollment\n* Report current alcohol and\u002For cannabis misuse\n* Be English-speaking and able to provide informed consent.\n\nExclusion Criteria:\n\nAim 1:\n\n* Be actively suicidal or severely cognitively impaired precluding informed consent\n* Sustain an intentional injury from a boy\u002Fgirlfriend, fiancée, or spouse or sexual assault\n* Be incarcerated or in police custody\n* Currently engaged in addiction treatment\n\nAim 2 and 3:\n\n* Be actively suicidal or severely cognitively impaired precluding informed consent\n* Sustain intentional injury from a boy\u002Fgirlfriend, fiancée, spouse or by sexual assault\n* Be incarcerated or in police custody\n* Currently engaged in addiction treatment","25 Years",{"count":140,"type":22},50,[25],"This study aims to improve a short motivational conversation to better help young adults who were injured in assaults and also use alcohol or cannabis. Researchers will gather both interview and survey data from young adults who came to the emergency department after an assault and currently use alcohol or cannabis. Guided by a theory about risky behaviors, the study will focus on how confident young people feel about making changes to their alcohol and cannabis use, and how their friends and family influence their alcohol and cannabis use and involvement in injuries from assault. The team will follow a step-by-step process used by the NIH to adapt and test the improved motivational conversation in the emergency department.",[28,144],"Cannabis Misuse",[146,147],"alcohol misuse","cannabis misuse","2026-06-03",{"date":123,"type":40},{"date":151,"type":22},"2027-03",{"date":153,"type":22},"2028-02",{"name":155,"class":47},"Yale University",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":162,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":164,"targetDuration":4,"studyType":166,"phases":4,"briefSummary":167,"conditions":168,"keywords":171,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":4},"100643650","intensive-care-outcome-prediction-using-admission-carbohydrate-deficient-transferrin-100643650","NCT07632716","Intensive Care Outcome Prediction Using Admission Carbohydrate-deficient Transferrin","IMPACT - Intensive Care Outcome Prediction Using Admission Carbohydrate-deficient Transferrin A Prospective Single-center Cohort Study","IMPACT","Inclusion Criteria:\n\n* all patients ≥ 18 admitted to the Department of Emergency Medicine and subsequently transferred to an in-house intensive care unit (ICU)\n\nExclusion Criteria:\n\n* Patients transferred to other hospital departments prior to completion of intensive care\n* Patients admitted directly to the ICU without passing the ED\n* Patients admitted to intermediate care units\n* Patients with pre-existing or newly diagnosed hepatic cirrhosis\n* Patients with known or obvious pregnancy will be excluded.\n* Patients with no vascular access",{"count":165,"type":22},800,"OBSERVATIONAL","The goal of this observational study is to learn whether hazardous alcohol consumption, measured objectively by carbohydrate-deficient transferrin (CDT) levels at intensive care unit (ICU) admission, is associated with worse outcomes in critically ill patients. The main question it aims to answer is:\n\nDo elevated CDT levels at ICU admission predict increased short-term mortality and adverse clinical outcomes in adult non-traumatic ICU patients? Participants admitted to the intensive care unit via the emergency department will have CDT levels measured as part of the study. Researchers will then collect and analyze clinical data, including mortality, duration of mechanical ventilation, delirium, ICU length of stay, renal replacement therapy, and ICU readmission rates, during hospitalization and follow-up.",[169,170,28],"Intensive Care (ICU)","Critical Illness",[172,170,173],"Alcohol-Related Disorders","Intensive Care Units","2026-06-02",{"date":97,"type":40},{"date":177,"type":22},"2026-06",{"date":179,"type":22},"2028-07",{"name":181,"class":47},"Medical University of Vienna",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":188,"eligibilityCriteria":189,"healthyVolunteers":190,"sex":17,"minAge":18,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":23,"phases":194,"briefSummary":195,"conditions":196,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":48},"100497164","gathering-online-for-dialogue-and-discussion-to-enhance-social-support-100497164","NCT05753683","Gathering Online for Dialogue and Discussion to Enhance Social Support","GODDESS (Gathering Online for Dialogue and Discussion to Enhance Social Support): Engaging Young African American Women in a Virtual Group App to Address Alcohol Misuse, Sexual Risk, and Pre-exposure Prophylaxis (PrEP) in North Carolina (NC)","GODDESS","Selected Inclusion Criteria:\n\n* identify as Black\u002FAfrican American\n* identify as female\n* be between 18 and 30 years old\n* recent substance use\n* HIV negative and not currently on PrEP\n* have an Android or iOS-based smartphone\n\nSelected Exclusion Criteria:\n\n* test positive for HIV\n* participated in the previous study activities of the current study or previous related studies",true,"30 Years",{"count":193,"type":22},500,[25],"The goal of this trial is to test a modified mobile health intervention (with a group component) relative to a mobile health intervention in a two-arm randomized trial with up to 500 young women who are human immunodeficiency virus (HIV)-negative and who misuse alcohol.\n\nThe expected outcomes are to: (1) determine the efficacy of the virtual group component in reducing alcohol use and sexual risk and increasing pre-exposure prophylaxis (PrEP) utilization; and (2) understand selected outcomes for implementation.\n\nParticipants will be randomized to receive either the mHealth app or the mHealth app plus the group component, and followed up at 3- and 6-months post-enrollment.",[28,118,197,198],"Sexually Transmitted Infections","Pre-exposure Prophylaxis","2026-05-15",{"date":201,"type":40},"2026-05-19",{"date":203,"type":40},"2025-04-07",{"date":205,"type":22},"2027-11",{"name":105,"class":47},{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":4,"eligibilityCriteria":213,"healthyVolunteers":190,"sex":17,"minAge":18,"maxAge":214,"enrollmentInfo":215,"targetDuration":4,"studyType":166,"phases":4,"briefSummary":217,"conditions":218,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":236,"locationsCount":48},"100640122","exploration-of-acceptability-of-alcohol-interventions-100640122","NCT07580378","Exploration of Acceptability of Alcohol Interventions","A Mixed-methods Study Exploring the Acceptability of Psychosocial Interventions and Social Determinants of Engagement With an NHS-led Alcohol Care Service.","Inclusion Criteria:\n\n* Clinical staff who worked in the ELHT alcohol care service, and received training in the delivery of psychosocial interventions using the ITEP Manual, and who are still employed by ELHT in other roles (following de-commissioning of the alcohol care service).\n* Patient data under part 2 of the study, who have not opted to have their data removed, in accordance with the NHS MESH, opt out scheme.\n\nExclusion Criteria:\n\n* Clinical staff who worked in the ELHT alcohol care service, but who no longer work for the trust, or are retired.\n* Clinical staff who did not receive training in the delivery of psychosocial interventions.\n* Any patient data under part 2 of the study, who have opted to have their data removed for use, under the NHS MESH protocols.","67 Years",{"count":216,"type":22},2000,"This is a mixed-methods study consisting of a qualitative assessment the acceptability of psychosocial interventions, delivered by clinical staff. The study will also investigate the correlation between demographic variables and engagement with a North West England, NHS-led, alcohol care service, amongst the patient population.",[28,219,220,221,222,223,224,225,226,227,228,229],"Alcohol Use Disorder","Behaviour Change","Health Behaviour","Brief Intervention","Outcome Assessment","Social Determinants of Health","Psychosocial Intervention","Socioeconomic Factors","Primary Healthcare","Primary Heath Care","Problem Behavior","2026-05-05",{"date":232,"type":40},"2026-05-12",{"date":234,"type":22},"2026-05-01",{"date":99,"type":22},{"name":237,"class":47},"East Lancashire Hospitals NHS Trust",{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":242,"acronym":4,"eligibilityCriteria":243,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":244,"targetDuration":4,"studyType":23,"phases":246,"briefSummary":247,"conditions":248,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":255,"locationsCount":258},"100617949","phase-2-human-laboratory-study-of-apremilast-for-alcohol-use-disorder-100617949","NCT07325266","Human Laboratory Study of Apremilast for Alcohol Use Disorder","Inclusion Criteria (not exhaustive list):\n\n1. Be at least 21 years of age.\n2. Have a current (past 12 months) DSM-5 diagnosis of AUD (4 or more symptoms) assessed using the MINI neuropsychiatric interview version 7.0.2 (at least moderate severity).\n3. Have a BAC by breathalyzer equal to 0.000 when s\u002Fhe signed the informed consent document (either just prior to or immediately after signing consent).\n4. Be seeking treatment for problems with alcohol and express a goal of abstinence or a reduction in drinking.\n5. Be able to verbalize an understanding of the consent form, able to provide written informed consent, verbalize willingness to complete study procedures, able to understand written and oral instructions in English and able to complete the questionnaires required by the protocol.\n6. Agree (if the participant is female and of childbearing potential) to use at least one of the following methods of birth control, unless she is surgically sterile, partner is surgically sterile or she is postmenopausal:\n\n   * oral contraceptives,\n   * contraceptive sponge,\n   * patch,\n   * double barrier (diaphragm\u002Fspermicidal or condom\u002Fspermicidal),\n   * intrauterine contraceptive system,\n   * etonogestrel implant,\n   * medroxyprogesterone acetate contraceptive injection,\n   * complete abstinence from sexual intercourse, and\u002For\n   * hormonal vaginal contraceptive ring.\n7. Be willing to adhere to the investigational product dosing schedule.\n8. Complete all assessments required at screening and baseline.\n9. Have a place to live in the 2 weeks prior to randomization and not be at risk that s\u002Fhe will lose his\u002Fher housing by Study Week 6.\n10. Not anticipate any significant problems with transportation arrangements or available time to travel to the study site by Study Week 6.\n11. Not have any plans to move within Study Week 6 to a location which would make continued participation in the study impractical.\n12. Provide contact information of someone, such as a family member, spouse, or significant other, who may be able to contact the participant in case of a missed clinic appointment.\n13. Be someone who in the opinion of the investigator would be expected to complete the study protocol.\n14. Agree to the schedule of visits, verbally acknowledge that s\u002Fhe will be able to attend each scheduled visit, participate in phone visits and that s\u002Fhe does not have any already scheduled events or a job that may substantially interfere with study participation.\n15. If taking a medication for depression, must have been taking a stable dose in the 2-months prior to randomization and plan to continue during the study. This includes drugs such as the following:\n\n    * SSRIs\n    * Dual uptake inhibitors\n    * SNRIs\n    * Tricyclic antidepressants\n    * MAOIs\n    * Bupropion\n16. Not currently taking apremilast and agree not to take non-study supplied apremilast for the duration of the study.\n17. Have normal renal function defined as creatinine clearance ≥ 60 mL per minute by the Cockcroft-Gault equation.\n\nExclusion Criteria:\n\nContact study site for exclusion criteria",{"count":245,"type":22},100,[60],"Primary: The primary objective of this study is to compare the efficacy of two different maintenance doses of apremilast (tablets) in reducing alcohol craving among subjects with moderate to severe alcohol use disorder (AUD) after two weeks of daily dosing.\n\nSecondary: Secondary objectives include evaluation of two different maintenance doses of apremilast compared with matched placebo on other measures of self-reported alcohol consumption, alcohol craving, alcohol-related negative consequences, AUD symptoms, pain, sleep disturbances, depression, anxiety, quality of life, cigarette smoking, other nicotine use, cannabis use, retention in the study, and safety.",[219,28],"2026-04-30",{"date":234,"type":40},{"date":252,"type":40},"2026-04-03",{"date":254,"type":22},"2027-07-31",{"name":256,"class":257},"National Institute on Alcohol Abuse and Alcoholism (NIAAA)","NIH",3,{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":265,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":267,"targetDuration":4,"studyType":23,"phases":269,"briefSummary":270,"conditions":271,"keywords":273,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":283,"locationsCount":48},"100627109","the-peth-results-communication-study-100627109","NCT07444359","The PEth Results Communication Study","The Phosphatidylethanol (PEth) Results Communication (PERC) Study","PERC","Inclusion Criteria:\n\n* 18 years and older;\n* Resident in the study catchment area (\\\u003C60 km or \\\u003C2 hours travel);\n* Fluent in Runyankole or English;\n* Ability to give informed consent;\n* Unhealthy alcohol use (AUDIT-C ≥3 for women, ≥4 for men, OR PEth≥20); ng\u002FmL at a previous study visit or PERC screening);\n* Having participated in a previous study, except for TRAC and PERC studies.\n\nExclusion Criteria:\n\n* Having already participated in Aim 1 of this study;\n* Having participated in the TRAC Study;\n* Not fluent in English or Runyankole;\n* Gross inebriation, cognitive impairment, or inability to provide informed consent.",{"count":268,"type":22},80,[25],"This is a randomized controlled trial (RCT) to test whether adding PEth (a blood test that shows recent alcohol use) to a standard alcohol counseling session in clinic helps people with HIV reduce their drinking. A total of 80 participants will be enrolled with unhealthy alcohol use: 40 will receive the standard MOH brief alcohol counseling plus discussion of their PEth results and 40 will receive the standard Uganda Ministry of Health (MOH) brief alcohol counseling alone. After 3 months, the study will look at whether participants found the intervention acceptable, appropriate, and feasible. The study also explore changes in alcohol use, motivation to reduce drinking, and experiences of stigma.",[28,272],"Alcohol Biomarkers",[274,275,276],"Brief intervention (BI)","Alcohol misuse","Alcohol counseling","2026-04-29",{"date":230,"type":40},{"date":280,"type":22},"2026-06-01",{"date":282,"type":22},"2026-12-31",{"name":284,"class":47},"University of California, San Francisco",{"id":286,"slug":287,"hasResults":11,"nctId":288,"briefTitle":289,"officialTitle":290,"acronym":291,"eligibilityCriteria":292,"healthyVolunteers":190,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":293,"targetDuration":4,"studyType":23,"phases":295,"briefSummary":297,"conditions":298,"keywords":300,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":307,"completionDateStruct":309,"leadSponsor":311,"locationsCount":48},"100579207","phase-2-efficacy-of-a-smartphone-based-jitai-to-reduce-drinking-among-adults-experiencing-homelessness-100579207","NCT06821295","Efficacy of a Smartphone-Based JITAI to Reduce Drinking Among Adults Experiencing Homelessness","Efficacy of a Smartphone-Based Just-In-Time Adaptive Intervention to Reduce Drinking Among Adults Experiencing Homelessness","SmartT_A","Inclusion Criteria:\n\n* At least 18 years old\n* 8 or above on the AUDIT\n* Receiving shelter-based services\n* Consuming 1 or more standard drink of alcohol in the past week\n* Score of 4 or higher on the REALM-SF\n* Score under 8 on the 6CIT\n\nExclusion Criteria:\n\n* Under 18 years old\n* Not meeting other inclusion criteria",{"count":294,"type":22},600,[60,296],"PHASE3","Approximately 1 out of every 3 adults experiencing homelessness has a current alcohol use disorder (AUD). Alcohol use plays a central role in increased morbidity and mortality in this population, with some studies suggesting it plays a direct role in as many as 17% of deaths. Alcohol is also a leading cause of homelessness and contributes to its chronicity by inhibiting progress toward obtaining employment and a stable living environment. Shelter-based treatments are common, but compliance is often poor. There are many documented challenges to effectively implementing traditional evidence-based interventions in shelter settings. In the current project, we will conduct a randomized controlled trial. Adults currently experiencing homelessness who report hazardous alcohol use (N = 600) will be recruited from five shelters across the Dallas, TX and Oklahoma City, OK metropolitan areas. Individuals will attend screening and training visits, then complete one week of self-monitoring (via smartphone app) before being randomized to receive either standard shelter-based treatment (Usual Care; UC), or the Smart-T Alcohol intervention + UC. The Smart-T Alcohol intervention offers on-demand content and automated contextually tailored messages to reduce alcohol consumption. The intervention period will span eight-weeks (i.e., weeks 2-9), with follow-up assessments occurring at weeks 9, 13, and 26. All participants will complete brief daily smartphone-based surveys for 13 weeks. Aims of the project will be to assess the effects of the Smart-T Alcohol intervention on alcohol use and alcohol-related problems (Aim 1), intervention effects on key drinking risk indicators and their mediation of use outcomes (Aim 2), and identify specific subpopulations (e.g., women, racial\u002Fethnic minorities, younger adults; Exploratory Aim 3) for which the intervention is most effective. Findings will provide a rigorous evaluation of the efficacy of the Smart-T Alcohol intervention and guide future smartphone-based interventions for this population.",[28,299],"Homeless",[301,302,303,304],"Just In Time Adaptive Intervention","Mobile Health","homeless","ecological momentary assessment","2026-04-27",{"date":234,"type":40},{"date":308,"type":40},"2025-03-05",{"date":310,"type":22},"2029-04-30",{"name":312,"class":47},"University of Oklahoma",{"id":314,"slug":315,"hasResults":11,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":4,"eligibilityCriteria":319,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":320,"enrollmentInfo":321,"targetDuration":4,"studyType":23,"phases":323,"briefSummary":324,"conditions":325,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":48},"100632584","a-mindfulness-based-intervention-for-sexual-assault-survivors-100632584","NCT07515586","A Mindfulness-based Intervention for Sexual Assault Survivors","Leveraging Implementation Science to Develop a Mindfulness-Based Intervention to Reduce Alcohol Misuse and Tobacco Use Among Sexual Violence Survivors","Inclusion Criteria:\n\n* 18-24 years of age\n* currently enrolled as a full-time undergraduate at GSU\n* self-reported lifetime SV victimization\n* self-reported SV victimization in the past 6 months\n* drank alcohol within the last 30 days\n* must own a smartphone\n\nExclusion Criteria:\n\n* not applicable","24 Years",{"count":322,"type":22},120,[25],"The goal is this pilot randomized trial is to learn if intervention 1 is feasible and acceptable. As a secondary goal, we aim to learn if intervention 1 reduces alcohol misuse and tobacco use in sexual assault survivors. The main questions it aims to answer are:\n\n* Is intervention 1 feasible to implement?\n* Is intervention 1 an acceptable intervention among the primary population, sexual assault survivors?\n* Does intervention 1 reduce alcohol misuse and tobacco use?\n\nResearchers will compare intervention 1 to an attention-placebo control group (e.g., online resources on healthy eating and nutrition).\n\nParticipants will:\n\n* take online surveys at baseline, 1 month follow-up, and 3-month follow-up\n* answer text-message questions at baseline and post-test\n* view and engage in an educational program",[28,326,327,328],"Tobacco Use","Mindfulness","Stress","2026-03-31",{"date":331,"type":40},"2026-04-07",{"date":333,"type":22},"2027-10",{"date":335,"type":22},"2030-08",{"name":337,"class":47},"Georgia State University",{"id":339,"slug":340,"hasResults":11,"nctId":341,"briefTitle":342,"officialTitle":343,"acronym":344,"eligibilityCriteria":345,"healthyVolunteers":11,"sex":17,"minAge":346,"maxAge":18,"enrollmentInfo":347,"targetDuration":4,"studyType":23,"phases":348,"briefSummary":349,"conditions":350,"keywords":351,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":357,"startDateStruct":359,"completionDateStruct":361,"leadSponsor":363,"locationsCount":4},"100627241","bridging-opportunities-for-substance-use-screening-and-treatment-for-teens-with-chronic-illness-100627241","NCT07446075","Bridging Opportunities for Substance Use Screening and Treatment for Teens With Chronic Illness","Adaptation and Implementation of SBIRT for Adolescents With Chronic Medical Conditions Hospitalized in Pediatric Inpatient Units","BOSSTT","Inclusion Criteria:\n\n* A-CMCs who screen positive for alcohol misuse on the S2BI during their hospital admission.\n\nExclusion Criteria:\n\n* There are no exclusion criteria to enhance generalizability and capture a diverse range of partner perspectives and preferences.","12 Years",{"count":140,"type":22},[25],"Adolescents with a chronic medical condition (A-CMC) are more likely to misuse and initiate alcohol and other drugs (AOD) at younger ages compared to adolescents without CMCs. A-CMCs account for the majority of pediatric inpatient hospitalizations as A-CMCs are often admitted for an acute inpatient stay following an emergency department visit for an exacerbation of their disease. However, A-CMCs are not routinely screened for alcohol use in pediatric inpatient settings. Thus, the pediatric inpatient setting provides clinicians a critical, but missed, opportunity to universally screen for alcohol use among A-CMCs once medical concerns are stabilized. The current study addresses this gap in the care cascade by examining the workflow processes in an urban pediatric hospital's inpatient units, adapting Screening, Brief Intervention, and Referral to Treatment (SBIRT) to the population and setting, and identifying SBIRT implementation strategies to pilot in a single arm hybrid type III effectiveness-implementation trial. This research is attained via three Specific Aims. In Aim 1, the candidate will observe inpatient workflows and collaborate with a Partner Steering Committee (PSC) composed of hospital staff (e.g., clinicians, administrators, information technology), A-CMCs, and parents to adapt SBIRT delivery and intervention components for the inpatient setting and population. Aim 2 will involve continued partnership with the PSC, to select, specify, and prioritize a set of SBIRT implementation strategies ideally suited for the inpatient setting and population. Aim 3 will consist of a single arm pilot hybrid type III effectiveness-implementation trial that simultaneously tests the set of implementation strategies selected in Aim 2 (primary outcome) and the SBIRT intervention adapted in Aim 1 (secondary outcome). To conduct this research, the candidate, Dr. Summersett Williams, requires training in three key areas: 1) expert knowledge and application of intermediate and advanced IS methods, including implementation strategy selection and evaluation of implementation outcomes; 2) application of human- and equity-centered design methods, including intervention adaptation and usability testing; and 3) expert application of the learning health system model to improve the health of A-CMCs who engage in risky drinking through enhanced healthcare system performance. These training aims will be supported by Ann \\& Robert H. Lurie Children's Hospital of Chicago and by the candidate's mentorship team. The mentorship team will be led by Primary Mentor Dr. Sara Becker, an expert in implementing SBIRT targeting risky drinking in pediatric health settings. The proposal will also be supported by Drs. Robert Garofalo, Lisa Kuhns, and Patricia Franklin, experts in intervention adaptation, human- and equity-centered design methods, and the learning health system model, respectively. Taken together, this research and career development plan will advance a significant public health issue by advancing access to evidence-based alcohol health services for a vulnerable pediatric population while launching Dr. Summersett William's career as an independent implementation scientist.",[28],[30,352,353,354,355],"adolescents with chronic medical conditions","SBIRT","pediatric inpatient screening","implementation science","2026-02-25",{"date":358,"type":40},"2026-03-03",{"date":360,"type":22},"2028-09-01",{"date":362,"type":22},"2029-08-31",{"name":364,"class":47},"Faith Summersett Williams",{"id":366,"slug":367,"hasResults":11,"nctId":368,"briefTitle":369,"officialTitle":370,"acronym":4,"eligibilityCriteria":371,"healthyVolunteers":11,"sex":372,"minAge":18,"maxAge":4,"enrollmentInfo":373,"targetDuration":4,"studyType":23,"phases":375,"briefSummary":376,"conditions":377,"keywords":378,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":381,"lastUpdatePostDateStruct":382,"startDateStruct":384,"completionDateStruct":386,"leadSponsor":387,"locationsCount":48},"100624819","brief-alcohol-treatment-for-women-veterans-in-primary-care-100624819","NCT07414589","Brief Alcohol Treatment for Women Veterans in Primary Care","A Brief, Integrated Intervention for Women Veterans With Unhealthy Alcohol Use in Primary Care","Inclusion Criteria:\n\n* Veteran status\n* past-year Syracuse VAMC or community-based outpatient clinic (CBOC) primary care appointment\n* identify as woman OR use women's PC services\n* unhealthy alcohol use (AUDIT ≥ 7)\n\nExclusion Criteria:\n\n* current substance use treatment outside PC\n* current psychosis, mania, or dementia (\\>10 on the BOMC)\n* need for a higher level of alcohol or substance use care (detoxification, residential treatment) as indicated by a) patient preference b) withdrawal symptoms that indicate a need to monitor (≥23 on the AWSC) or high risk substance use (≥27 on the ASSIST)\n* imminent risk of suicide.","FEMALE",{"count":374,"type":22},70,[25],"The goal of this study is to develop and test a brief behavioral treatment for women Veterans with alcohol use in primary care. The study involves a development phase, an open trial phase, and a pilot randomized controlled trial. The main questions it aims to answer are:\n\n* Is the treatment feasible and acceptable to women Veteran primary care patients?\n* Can the treatment help reduce alcohol use, alcohol-related problems, and improve quality of life? Researchers will compare the new treatment to usual treatment that primary care patients would normally receive. Participants will be asked to participate in either the new behavioral treatment or usual primary care treatment and attend 3 appointments to answer questions about their alcohol use, quality of life, other mental health symptoms, and what they thought of their behavioral treatment.",[28],[30,379,380],"integrated primary care","women Veterans","2026-02-10",{"date":383,"type":40},"2026-02-17",{"date":385,"type":22},"2026-10",{"date":335,"type":22},{"name":388,"class":389},"Syracuse VA Medical Center","FED",{"id":391,"slug":392,"hasResults":11,"nctId":393,"briefTitle":394,"officialTitle":395,"acronym":4,"eligibilityCriteria":396,"healthyVolunteers":190,"sex":17,"minAge":18,"maxAge":397,"enrollmentInfo":398,"targetDuration":4,"studyType":23,"phases":400,"briefSummary":401,"conditions":402,"keywords":403,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":408,"lastUpdatePostDateStruct":409,"startDateStruct":411,"completionDateStruct":413,"leadSponsor":414,"locationsCount":417},"100619017","mirea-ac-for-reducing-problematic-alcohol-and-marijuana-use-in-college-students-100619017","NCT07339150","MiREA-AC for Reducing Problematic Alcohol and Marijuana Use in College Students","MiREA, a mHealth Intervention to Reduce Health Disparities by Improving Access to Mandated College Students With Problematic Alcohol and Marijuana Use","Inclusion Criteria:\n\n* College student, alcohol consumption in past 90 days\n\nExclusion Criteria:\n\n* non-college student, no alcohol use in the past 90 days","26 Years",{"count":399,"type":22},150,[25],"The goal of this STTR Phase I funded study is to address the urgent need for an effective primary prevention approach to the problem of heavy episodic drinking and cannabis misuse among mandated college students. Smartphone app interventions are expanding and can offer accessible, scalable, and cost-effective tools. The study will be used to attune a successful evidence-based mHealth smartphone (SP) application (MiREA-AC) focused on alcohol and Cannabis misuse by college students with enhanced content to promote health-seeking behaviors. To test and disseminate the adapted prototype (MiREA-AC), a multisite pilot trial will be conducted to obtain data on the intervention's usability and feasibility in modifying alcohol and cannabis use.",[28,144],[404,405,146,406,407],"mHealth","smart phone application","Cannabis misuse","health-seeking behaviors","2026-01-12",{"date":410,"type":40},"2026-01-14",{"date":412,"type":40},"2025-08-15",{"date":249,"type":22},{"name":415,"class":416},"mHealth Systems Inc.","INDUSTRY",2,{"id":419,"slug":420,"hasResults":11,"nctId":421,"briefTitle":422,"officialTitle":423,"acronym":4,"eligibilityCriteria":424,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":425,"targetDuration":4,"studyType":23,"phases":427,"briefSummary":428,"conditions":429,"keywords":430,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":412,"lastUpdatePostDateStruct":432,"startDateStruct":434,"completionDateStruct":436,"leadSponsor":438,"locationsCount":48},"100594561","adaptive-actions-and-alcohol-use-outcomes-during-internet-delivered-cognitive-behaviour-therapy-100594561","NCT07021053","Adaptive Actions and Alcohol Use Outcomes During Internet-delivered Cognitive Behaviour Therapy","Adaptive Actions and Alcohol Use Outcomes During Internet-delivered Cognitive Behaviour Therapy: An Observational Study During Routine Care","Inclusion Criteria:\n\n* Be a resident of Canada\n* Be 18 years or older\n* Have access to a computer or appropriate device and the internet\n* Endorse alcohol misuse\n\nExclusion Criteria:\n\n* Current severe medical or psychiatric problem that requires immediate or alternate treatment (e.g. current and recent mania or psychosis requiring hospitalization, actively suicidal and unable to keep themselves safe, medical condition requiring immediate surgery or other invasive treatment, severe substance use, severe cognitive impairment);\n* Currently receiving or expecting to receive individual alcohol treatment more than twice per month\n* Other treatment in our clinic\n* Unable to read and understand English. (All content is provided in English and staff is English speaking; it is cost prohibitive at this time to provide the complete service in languages other than English)",{"count":426,"type":22},165,[25],"This observational study investigates an Internet-delivered Cognitive Behaviour Therapy (ICBT) intervention for alcohol misuse, called the Alcohol Change Course Enhanced (ACCE). The intervention will be offered through the Online Therapy Unit, which is a routine care ICBT clinic. The primary objective of the study is to examine whether engagement in adaptive actions measured by the Things You Do Questionnaire (TYDQ), including healthy thinking, meaningful activities, social connections, healthy habits and goal setting - increase during ICBT for alcohol misuse. Using data collected during routine care, the relationship between adaptive actions and alcohol use will be investigated, and specifically explore if the frequency of adaptive actions increases as alcohol use reduces during the intervention.",[28],[431,275],"Internet-delivered cognitive behaviour therapy",{"date":433,"type":40},"2025-08-21",{"date":435,"type":40},"2025-05-14",{"date":437,"type":22},"2026-05-14",{"name":439,"class":47},"University of Regina"]