[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"alcohol-related-carcinoma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:alcohol-related-carcinoma":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100600257","studying-the-effects-of-nicotine-concentration-and-flavor-on-alcohol-use-in-young-adults-100600257",false,"NCT07095140","Studying the Effects of Nicotine Concentration and Flavor on Alcohol Use in Young Adults","Assessing Co-Use of Oral Nicotine Pouches and Alcohol Among Young Adults","Inclusion Criteria:\n\n* 21-30 years old\n* Use ONPs daily\n* Drink alcohol at least three days\u002Fweek\n* Read and speak English\n* Own an iPhone (required for BACtrack Skyn wristband)\n* Used 6 mg nicotine concentration ONPs on at least 20 days of past month\n\nExclusion Criteria:\n\n* Use of other tobacco products \\> 10 days\u002Fmonth\n* Unstable or significant medical condition\n* Unstable or significant psychiatric conditions (past and stable conditions will be allowed)\n* History of cardiac event or distress within the past three months\n* Currently pregnant, planning to become pregnant within six months, or breastfeeding (all participants assigned female at birth will take a pregnancy test at each clinic visit before provision of study products; a negative test will be needed to proceed with product sampling)",true,"ALL","21 Years","30 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","This clinical trial studies the use of both (co-use) oral nicotine pouches (ONPs) and alcohol among young adults and whether ONP nicotine concentration and flavor affect alcohol use. The co-use of nicotine and alcohol has grown among young adults and the increase in ONP use among young adults may be a contributing factor. ONPs do not contain tobacco leaf and may reduce cancer risk for those who switch from traditional tobacco products (e.g., cigarettes, moist snuff) to ONPs. However, given that alcohol is a cancer-causing agent, using ONPs might increase alcohol use among young adults, which may cause an increase in their risk of cancer. ONPs come in different nicotine concentrations and flavors, with young adults expressing a preference in nicotine concentration or flavor for use while drinking. The different nicotine concentrations and flavors could lead users to drink more or longer. Studying the co-use of ONPs and alcohol among young adults may help researchers understand whether ONP nicotine concentrations and flavors affect alcohol use. This information may be used to help guide future ONP regulations and cancer prevention interventions targeted to young adults.",[28],"Alcohol-Related Carcinoma","RECRUITING","2025-11-21",{"date":32,"type":33},"2025-11-26","ACTUAL",{"date":35,"type":33},"2025-09-03",{"date":37,"type":22},"2027-12-31",{"name":39,"class":40},"Ohio State University Comprehensive Cancer Center","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":16,"sex":17,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":41},"100514067","role-of-acetaldehyde-in-the-development-of-oral-cancer-100514067","NCT05973656","Role of Acetaldehyde in the Development of Oral Cancer","Dissecting the Role of Acetaldehyde in Oral Carcinogenesis","Inclusion Criteria:\n\n* 21-45 years of age for alcohol drinkers\n* Occasionally consume alcohol\n* At least 1 drink per month for healthy volunteers\n* At least 1 drink in the last 3 months for Fanconi anemia patients\n* Meets one of the three criteria\n* Healthy volunteer - ALDH2\\*1\u002F1\\* homozygotes-not of Eastern Asian decent;\n* Healthy volunteer - ALDH2\\*1\u002F2\\* heterozygotes-of Eastern Asian decent and experience flushing when drinking\n* Individual's with Fanconi anemia (FA).\n* 18-45 years of age for non-drinkers\n* Never consume alcohol\u002Fnot had alcohol in the last 6 months\n* Healthy volunteers.\n* Non-smoker (smoked \\\u003C 100 cigarettes in a lifetime)\n\nExclusion Criteria:\n\n* Pregnant or nursing\n* Taking any medication or drug that might affect alcohol use and absorption or that might be affected by alcohol consumption\n* Healthy volunteers who have taken any antibiotics in the last 3 months\n* Currently consuming more than 21 drinks per week\n* Have any history of alcohol or drug related problems\n* Current or former tobacco\u002Fnicotine product(s) user\n* Any regular use of tobacco\u002Fnicotine products or marijuana in the last year (cigarettes, e-cigarettes, cigars, pipes, smokeless tobacco)\n* \"Trying\" or limited use of any nicotine products or marijuana in the last 1 month\n* Active infection (influenza, cold, COVID, respiratory \u002F sinus infection) - admission in the study will be delayed pending improved health\n* Non-FA volunteers who have an unstable medical condition or condition that could be affected by alcohol consumption (insulin-dependent diabetes, ulcers, heart issues)\n* Experience severe adverse events (nausea, blacking out) when consuming even low doses of alcohol","18 Years","45 Years",{"count":52,"type":22},170,[25],"This is a minimal risk intervention study where healthy volunteers and individuals with Fanconi anemia will consume a single dose of alcohol and provide primarily non-invasive biological samples at various time points. Biospecimens to be collected include saliva, oral cells collected via mouthwash and cheek brush, and urine. The collection of two blood samples (5 mL each) will be optional and banked for future use.",[28,56,57],"Fanconi Anemia","Oral Cavity Carcinoma","2025-08-21",{"date":60,"type":33},"2025-08-22",{"date":62,"type":33},"2022-07-08",{"date":64,"type":22},"2027-09-30",{"name":66,"class":40},"Masonic Cancer Center, University of Minnesota"]