[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"alcohol-use-unspecified\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:alcohol-use-unspecified":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,42,75,109,136,159,182],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100457852","practice-facilitation-as-a-strategy-to-improve-alcohol-treatment-adoption-and-implementation-in-hiv-care-100457852",false,"NCT05241990","Practice Facilitation as a Strategy to Improve Alcohol Treatment Adoption and Implementation in HIV Care","A Hybrid Type III Implementation Trial Testing Practice Facilitation as a Strategy to Improve Alcohol Treatment Adoption and Implementation in HIV Care","Inclusion Criteria: Clinic Staff\n\n* Age \\> 18 years old\n* Confirmed to be clinic staff (clinical or administrative roles).\n* English speaking\n* Cognitively able to complete required survey or interview activities.\n\nExclusion Criteria Clinic Staff\n\n* Unable to speak English\n\nInclusion Criteria, Patients\n\n* Confirmed to be a person with HIV (PWH) receiving HIV care and participating in CNICS at one of the three clinic sites\n* Scoring AUDIT-C ≥3 for women or ≥4 for men, transgender women or men indicating unhealthy alcohol use.\n* Age ≥ 18 years old.\n* English speaking.\n* Cognitively able to participate in stepped care for unhealthy alcohol use.\n\nExclusion Criteria, Patients\n\n* Scoring AUDIT-C \\\u003C3 for women or \\\u003C4 for men or \\\u003C4 for transgender women or men\n* Age \\\u003C 18 years old\n* Participants cognitively unable to participate in the stepped care for unhealthy alcohol use.",true,"ALL","18 Years",{"count":20,"type":21},300,"ESTIMATED","INTERVENTIONAL",[24],"NA","Despite availability of evidence-based alcohol reduction interventions (EBI), unhealthy alcohol use remains a barrier to HIV medication adherence, viral suppression and retention in HIV care and consequently HIV treatment as prevention (TASP). Guided by complementary implementation and evaluation frameworks-the Consolidated Framework for Implementation Research (CFIR) and RE-AIM (Reach, Effectiveness, Adoption, Implementation and Maintenance), The investigators will conduct a Hybrid Type 3 effectiveness-implementation evaluating implementation trial testing whether practice facilitation, an evidence-based multifaceted implementation strategy increases reach, adoption, implementation, and maintenance of stepped care for unhealthy alcohol use in three Center for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) HIV clinics located in Boston, San Diego, and Chapel Hill. The investigators will secondarily test whether practice facilitation is associated with decreased unhealthy alcohol use, and improved Antiretroviral Therapy (ART) adherence and viral suppression at the patient level. In practice facilitation, a practice coach will offer tools, resources, hands-on guidance, and content expertise to assist sites in offering a stepped care model of alcohol treatment to patients with unhealthy alcohol use. Stepped care will include brief intervention, cognitive behavioral therapy, and alcohol pharmacotherapy. The practice facilitation intervention will be rolled out sequentially across sites. There will be three phases at each site: pre-implementation planning, implementation with formative evaluation, and post-implementation summative evaluation. Using mixed methods, The investigators specifically propose to meet the following specific aims: (Aim 1) Tailor the practice facilitation intervention to each site using mixed methods (pre-implementation); (Aim 2a) Determine the effects of practice facilitation on implementation of stepped care (primary) and alcohol use and HIV-related outcomes (secondary) using interrupted time series analysis with synthetic controls (summative evaluation); (Aim 2b) Determine the effect of practice facilitation on reach, adoption, and maintenance of evidence-based alcohol treatment using mixed methods (formative evaluation); and (Aim 3) Describe barriers and facilitators to implementation of alcohol-related interventions at each site to describe maintenance and inform widespread sustainable implementation.",[27,28],"Hiv","Alcohol Use, Unspecified","RECRUITING","2026-06-23",{"date":32,"type":33},"2026-06-26","ACTUAL",{"date":35,"type":33},"2023-02-15",{"date":37,"type":21},"2027-09-30",{"name":39,"class":40},"Johns Hopkins University","OTHER",3,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":58,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100560999","drinking-acetate-and-stress-100560999","NCT06584448","Drinking, Acetate, and Stress","Role of Acetate in Heavy Drinking","Inclusion Criteria:\n\n* Provision of signed and dated informed consent form\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* Medically stable male or female, aged 18-55.\n* Able to read, write and complete a multitude of self-assessments in English\n* Meets DSM-5 criteria for current Alcohol Use Disorder (AUD)\n* Participants who have Alcohol Use Disorder and are actively drinking must be willing to receive (at no cost) inpatient treatment for AUD for a period of up to 30 days. Participants who have been treated for an Alcohol Use Disorder and are now sober three months or longer will NOT be required to go inpatient.\n\nExclusion Criteria:\n\n* Subjects with any significant current medical conditions (neurological, cardiovascular, endocrine, thyroid, renal, liver), seizures (for LTS subjects only- seizures directly related to alcohol detoxification are not an exclusion) , delirium or hallucinations, or other unstable medical conditions, including HIV.\n* Current DSM-5 substance use disorder (other than AUD or tobacco use disorder)\n* Any metallic objects implanted in their body which would make imaging unsafe (pacemaker, etc)\n* Claustrophobia, or other inability to participate in an MRI\n* A positive test result at intake appointment and subsequent appointments on urine drug screens conducted for illicit drugs. (Note: participants will not be paid for study visits if they test positive for an illicit drug and will be immediately excluded from study).\n* Women who are pregnant or nursing. Women who have an IUD that would make imaging unsafe.\n* Recent taking of medications that may influence study outcomes (e.g., disulfiram, naltrexone, acamprosate, anticonvulsants).\n* Subjects likely to exhibit clinically significant alcohol withdrawal during the study.","55 Years",{"count":51,"type":21},50,[24],"The purpose of this study is to learn how drinking alcohol affects how people experience stress and how that is affected by the body's chemistry. Specifically, the investigators will be studying relationships of drinking and a stress hormone called cortisol. The investigators believe that results will lead us to find more effective ways to help people stop or reduce drinking when participants are drinking at harmful levels.",[55,28,56,57],"Alcohol Use Disorder","Heavy Drinker","Alcohol Use Disorder, Moderate, in Sustained Remission",[59,60,61,62,63,64],"Brain","Stress","Imaging","Detoxification","Recovery","Sobriety","2026-06-11",{"date":67,"type":33},"2026-06-15",{"date":69,"type":33},"2024-11-06",{"date":71,"type":21},"2030-01",{"name":73,"class":40},"Yale University",2,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":108},"100546254","online-intervention-for-transgendernonbinary-young-adults-experiences-with-alcohol-and-romantic-relationships-100546254","NCT06392542","Online Intervention for Transgender\u002FNonbinary Young Adults' Experiences With Alcohol and Romantic Relationships","Developing an Online Intervention Addressing Transgender\u002FNonbinary Young Adults' Experiences With Alcohol and Romantic Relationships","Inclusion Criteria:\n\n* Self-identify as transgender and\u002For nonbinary\n* Between 18 and 30 years of age, inclusive\n* Able to read and write in English\n* Residency in the United States\n* Currently in a romantic relationship that began at least six weeks prior to enrollment\n\nExclusion Criteria:\n\n* Prospective participants will be excluded as potentially inauthentic (i.e., not genuinely eligible for the study) based on scoring criteria developed through the investigators' prior online survey research with similar populations.","30 Years",{"count":84,"type":21},107,[24],"The objective of this study is to learn more about Whole Selves, an interactive online resource (\"intervention\") to help transgender and\u002For nonbinary young adults reflect on their experiences and goals related to both alcohol use and romantic relationships. Existing online interventions focused on alcohol use often aren't a good fit for trans\u002Fnonbinary people, and existing relationship education programs don't account for how being trans\u002Fnonbinary might influence someone's relationships. For these reasons, the investigator is working with trans\u002Fnonbinary young adults and other community stakeholders to create a new intervention specifically for trans\u002Fnonbinary young adults. The goals of this clinical trial are to:\n\n1. Find out what transgender\u002Fnonbinary young adults think of the Whole Selves intervention in order to improve it\n2. See whether the Whole Selves intervention seems to work as expected\n3. Help the investigator make plans for a bigger clinical trial of the Whole Selves intervention, which could tell us how well it works\n\nIn this study, participants will use the Whole Selves intervention; complete online surveys about themselves, their romantic relationship experiences, their mental health, their alcohol use; and provide feedback on the Whole Selves intervention.",[28,88,89,90],"Relationship, Social","Depression, Anxiety","Transgenderism",[92,93,94,95,96,97],"Transgender young adults","Nonbinary young adults","Interactive online alcohol education","Interactive online relationship education","Whole Selves intervention","Supportive romantic relationships","NOT_YET_RECRUITING","2026-04-27",{"date":101,"type":33},"2026-04-28",{"date":103,"type":21},"2026-07",{"date":105,"type":21},"2027-04",{"name":107,"class":40},"Boston University",1,{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":17,"minAge":117,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":22,"phases":121,"briefSummary":122,"conditions":123,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":108},"100476614","cars-cannabis-and-alcohol-reduction-study-100476614","NCT05486234","CARS: Cannabis and Alcohol Reduction Study","Brief Computerized Intervention for Reducing Adolescent Cannabis and Alcohol Use","CARS","Inclusion Criteria:\n\n* between the ages of 13 and 17\n* be seeking treatment for either cannabis or alcohol use;\n* report co-occurring alcohol and cannabis use during the past three months (i.e., participants who report using both alcohol and cannabis during the three months prior to participation in the study, regardless of if the use was simultaneous)\n* have a caregiver willing to participate and provide consent.","13 Years","17 Years",{"count":120,"type":21},52,[24],"The study will test a computerized treatment with subjects ages 13-17 years who are seeking treatment for alcohol and\u002For cannabis use. Follow-up assessments will be conducted at one- and three-months following treatment.",[124,28,125,126],"Cannabis Use","Substance Use","Substance Use Disorders","2026-03-05",{"date":129,"type":33},"2026-03-09",{"date":131,"type":33},"2023-01-25",{"date":133,"type":21},"2026-08-01",{"name":135,"class":40},"Medical University of South Carolina",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":22,"phases":147,"briefSummary":148,"conditions":149,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":108},"100524939","partnering-to-enhance-emerging-adults-response-to-programs-100524939","NCT06115252","Partnering to Enhance Emerging Adults' Response to Programs","Partnering to Enhance Emerging Adults' Response to Programs (PEER)","PEER","Inclusion Criteria:\n\n* within the specified age range\n* agree to be contacted for the 3, 6, and 12 month follow ups\n* provide fully informed consent\n\nExclusion Criteria:\n\n* left-handed\n* evidence of brain injury\u002Fillness and\u002For neurological, neurodevelopmental disorder including psychosis and related medications (e.g., antipsychotics; neuroleptics)\n* loss of consciousness ≥ 2 minutes\n* other fMRI contraindications (e.g., unremovable metal on\u002Fin body, pregnant)","19 Years",{"count":146,"type":21},248,[24],"The goal of this clinical trial (CT) is to learn more about emerging adults' and their peers. Here, we will see how co-participating with a peer in health program might impact brain and behavior change over time.\n\nEligible youth will be invited to come in for a \"Participation Day,\" during which they and a peer will independently complete questionnaires. With a peer, they will then complete a short health program, and undergo a brain scan (fMRI) while completing activities. Our study team will reach out to each participant individually again 3, 6, and 12 months later to learn about health behaviors over time.",[28],"2026-02-06",{"date":152,"type":33},"2026-02-10",{"date":154,"type":33},"2025-10-10",{"date":156,"type":21},"2028-03-31",{"name":158,"class":40},"UConn Health",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":16,"sex":17,"minAge":166,"maxAge":167,"enrollmentInfo":168,"targetDuration":4,"studyType":22,"phases":170,"briefSummary":171,"conditions":172,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":108},"100536060","distinguishing-alcohol-intoxication-cannabis-intoxication-and-co-intoxication-using-electroencephalography-eeg-100536060","NCT06259916","Distinguishing Alcohol Intoxication, Cannabis Intoxication and Co-intoxication Using Electroencephalography (EEG)","Developing Predictive Models to Distinguish Alcohol Use, Cannabis Use and Co-use: An Exploration of Electroencephalography (EEG) Metrics and Traditional Intoxication Measures","Inclusion Criteria:\n\n* 21-50 years old\n* Heavy drinkers (consuming more than 4 drinks\u002Fday or more than 14 drinks\u002Fweek for men, or more than 3 drinks\u002Fday or more than 7 drinks\u002Fweek for women)\n* Regular users of legal-market flower cannabis (at least 2x\u002Fweek in past 3 months)\n* report simultaneously using alcohol and legal-market flower cannabis at least once per month in the past 3 months\n* English speakers.\n\nExclusion Criteria:\n\n* Daily tobacco users\n* Diagnosed with or seeking treatment for alcohol use disorder (AUD) or other substance use disorder (SUD)\n* Females cannot be pregnant, breastfeeding or trying to become pregnant\n* Meet criteria for psychotic, bipolar or major depressive disorder with suicidal ideation, or history of these disorders, 5) Current use of psychotropic (except anti-depressants)\n* Report illicit drug use in past 60-days or fail drug screen on the day of the study appointment\n* Major medical condition contraindicating alcohol and\u002For cannabis consumption.","21 Years","50 Years",{"count":169,"type":21},99,[24],"This is a randomized, parallel-group study designed to explore the differences between cannabis intoxication, alcohol intoxication and co-intoxication involving both alcohol and cannabis, utilizing electroencephalography (EEG) as well as more traditional intoxication measures such as breath alcohol concentration and balance metrics. If eligible for the study, participants will be randomized to complete one study session in our mobile laboratory, during which they will use either alcohol, cannabis (which will be self-administered, ad libitum) or both alcohol and cannabis.",[124,28],"2025-11-12",{"date":175,"type":33},"2025-11-13",{"date":177,"type":33},"2024-01-05",{"date":179,"type":21},"2026-05-30",{"name":181,"class":40},"Colorado State University",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":16,"sex":189,"minAge":18,"maxAge":82,"enrollmentInfo":190,"targetDuration":4,"studyType":22,"phases":192,"briefSummary":194,"conditions":195,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":108},"100387973","phase-4-anchors-alcohol--sexual-health-study-uh3-project-100387973","NCT04331704","ANCHORS Alcohol & Sexual Health Study: UH3 Project","Advancing New Computer-based Health Outreach Regarding Sexual Behavior (ANCHORS) Study: UH3 Project","Inclusion Criteria:\n\n* Ability to read and write English\n* Consumption of 5 or more drinks per drinks in a day at least once in the past 30-days\n* Sexual intercourse with another man without condom use at least once in the past 30 days\n* HIV seronegative at medical screening\n* Report currently taking PrEP willingness to take PrEP\n\nExclusion Criteria:\n\n* History of clinically significant withdrawal from alcohol, defined as any one of the following: a) a lifetime history of seizures, delirium, or hallucinations during alcohol withdrawal; b) a Clinical Institute Withdrawal Assessment scale score \\> 8; c) a report of drinking to avoid withdrawal symptoms in the past 12 months; or d) a lifetime history of medical treatment for withdrawal.\n* Self report injection drug use\n* DSM-5 criteria for moderate or severe current substance use disorder besides alcohol and nicotine.\n* Serious psychiatric symptoms\n* Use of medications that interfere with PrEP including diuretics, nephrotoxic drugs, non-steroidal anti-inflammatory drugs, antiretroviral drugs or other drugs that may interfere with tenofovir excretion\n* Active hepatitis B infection\n* The following medical exclusions: serious or life-threatening conditions; inadequate biochemical, hepatic, hematologic, or pancreatic function according to laboratory testing\n* Participant reports currently taking injectable PrEP","MALE",{"count":191,"type":21},88,[193],"PHASE4","80 young adult men will complete an initial survey and receive 1 of 2 types of alcohol and sexual health education and information to encourage prevention of alcohol-related problems, HIV and other sexually transmitted infections (STIs). Participants will then take pre-exposure prophylaxis (PrEP) for HIV prevention and complete a daily 5-minute, telephone-based interactive voice response (IVR) assessment of alcohol\u002Fsubstance use, sexual behavior and PrEP taking for 30 days. Medication will all be active PrEP. There is no placebo control in this study. Follow-up will occur after 30-days and 6-months later.",[28,125,196],"Sex Behavior","2025-07-09",{"date":199,"type":33},"2025-07-10",{"date":201,"type":33},"2021-01-12",{"date":203,"type":21},"2026-06-30",{"name":205,"class":40},"University of Florida"]