[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"alcohol-use\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:alcohol-use":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,18,0,[8,48,71,102,127,152,179,204,227,253,280,301,331,357,394,416,438,464],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100626897","efficacy-of-the-proactive-automatized-lifestyle-intervention-100626897",false,"NCT07441603","Efficacy of the Proactive Automatized Lifestyle Intervention","Investigating the Efficacy of the Proactive Automatized Lifestyle Intervention Among General Hospital Patients","ePAL","Inclusion Criteria:\n\n* Admitted to participating wards of the University Medicine Hospital Greifswald on Mondays through Thursdays\n\nExclusion Criteria:\n\n* cognitively or physically incapable\n* presence of a highly infectious disease\n* discharged or transferred within the first 24 hours\n* already recruited for study during previous stay\n* insufficient German language skills\n* employed the conducting research department\n* accompanying persons\n* no email address (and no phone number)","ALL","18 Years","64 Years",{"count":21,"type":22},788,"ESTIMATED","INTERVENTIONAL",[25],"NA","Background: Individual brief behavior change interventions often do not sufficiently address the common co-occurrence of multiple health risk behaviors among people. In addition, many interventions often fail to reach the majority of the target population and particularly those people who need them the most. To address these core challenges of individual prevention research, the \"Proactive Automatised Lifestyle intervention (PAL)\" was developed, a proactive screening and brief intervention driven by psychological health behavior change theory to motivate participants for behavior change. The trial ePAL aims to investigate the efficacy of the multi-behavior change intervention adressing tobacco smoking, alcohol use, diet and physical activity among general hospital patients over 2 years; and to investigate differential efficacy in different subgroups of patients.\n\nMethods: All patients admitted to non-intensive care wards on five medical departments within the University Medicine Hospital Greifswald (internal medicine A \\& B, surgery, trauma surgery, ear-nose-throat) and aged 18 to 64 years are systematically approached by study assistants and asked to first participate in a survey and then in the randomizd controlled trial, irrespective of their reason of admission. A total of 788 participants is allocated to two study groups. The intervention group receives individualized feedback on all four health risk behaviors to enhance motivation to change identified health risk behaviors. The feedback is driven by psychological behavior change theory, tailored to the participants' current stages of change and delivered after baseline and at months 1 and 3. The control group receives routine care and minimal assessment only. Follow-ups are conducted at months 6, 12 and 24 after baseline; and more are planned for. Efficacy will be measured concerning self-reported change in health risk behaviors, health and motivation to change measures using latent growth curve modelling.\n\nDiscussion: The trial will provide information on the efficacy of a population-based and individually tailored brief intervention to systematically provide individualized feedback to each patient for a healthy living. When found to be effective and implemented widely, such interventions may contribute to the prevention of widespread non-communicable diseases.",[28,29,30,31,32,33,34],"Health Risk Behaviors","Tobacco Smoking","Alcohol Use","Unhealthy Diet, Exercise, Smoking, and Alcohol Use","Unhealthy Diet","Insufficient Physical Activity","Vegetable Intake","RECRUITING","2026-06-30",{"date":38,"type":39},"2026-07-02","ACTUAL",{"date":41,"type":39},"2026-06-25",{"date":43,"type":22},"2029-06",{"name":45,"class":46},"University Medicine Greifswald","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":47},"100641452","smartphone-based-intervention-for-young-adults-with-adhd-100641452","NCT07654205","Smartphone-based Intervention for Young Adults With ADHD","Training Inhibitory Control Using Personalized Strategies (TIPS): A Randomized Controlled Feasibility Trial of a Smartphone-Based Intervention for Alcohol Use in Young Adults With ADHD","Inclusion Criteria:\n\n* Age 18-25\n* Current diagnosis of Attention Deficit\u002FHyperactivity Disorder-Combined Type according to the Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM 5)\n* Drinks at least 4 (for females) \u002F 5 (for males) alcoholic drinks in a single drinking session at least once per week\n* Owns a smartphone\n* Reads and understands English\n\nExclusion Criteria:\n\n* Currently in high school\n* Actively in treatment for Alcohol Use Disorder\n* Alcohol use disorder-severe","25 Years",{"count":57,"type":22},70,[25],"The primary goal of this clinical trial is to test if a smartphone-based intervention is feasible \\& acceptable among young adults with ADHD who also engage in risky drinking behaviors. A secondary aim is to test preliminary intervention efficacy. The main questions it aims to answer are:\n\nIs the smartphone intervention feasible \\& acceptable for participants (e.g., are they responding regularly, is there a low level of burden reported)?\n\nDoes the smartphone intervention improve symptom awareness, inhibitory control, and problematic alcohol use?\n\nParticipants will:\n\nAttend a virtual baseline visit to assess ADHD, alcohol use, and other life experiences.\n\nComplete either the TIPS smartphone intervention or a control smartphone protocol over the course of 31-days, starting the first Friday after the baseline visit.\n\nAttend a virtual follow-up visit, where many of the same questions from the baseline visit will be asked again.",[61,30],"Attention Deficit\u002FHyperactivity Disorder(ADHD)","2026-06-12",{"date":64,"type":39},"2026-06-17",{"date":66,"type":22},"2026-06",{"date":68,"type":22},"2027-05-01",{"name":70,"class":46},"Traci Kennedy",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":23,"phases":81,"briefSummary":82,"conditions":83,"keywords":87,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":47},"100619275","better-experiences-in-substance-treatment-a-brief-alcohol-focused-intervention-tailored-for-patients-in-opioid-agonist-treatment-100619275","NCT07342504","Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment","Better Experiences in Substance Treatment: A Brief Alcohol-Focused Intervention Tailored for Patients in Opioid Agonist Treatment","Project BEST","Inclusion Criteria for the RCT:\n\n* Participants must be taking prescribed buprenorphine for at least 2 weeks\n* Participants must be 18 years or older.\n* Meet DSM-5 criteria for alcohol use disorder (AUD)\n* Participants must report alcohol use ≥ 1 day\u002Fweek on average in the past 28 days\n* Participants must be able to read simple English\n\nExclusion Criteria:\n\n* Currently receiving formal alcohol use treatment.\n* Currently experiencing psychosis",{"count":80,"type":22},60,[25],"This study will help determine the feasibility and acceptability of a brief opioid-informed alcohol intervention in patients receiving prescribed buprenorphine for opioid use who are currently drinking alcohol. It will also provide initial information on whether the intervention improves outcomes related to alcohol use. The results of this proof-of-concept study will inform whether a future larger clinical trial is warranted.",[84,85,30,86],"Alcohol Use Disorder","Opioid Use Disorder","Opioid Use",[84,88,89,85,90,91,92],"Alcohol Use Disorder (AUD)","Cognitive Behavioral Therapy","Opioid Use Disorder (OUD)","Motivational Enhancement Therapy","Cognitive Behavior Therapy (CBT)","2026-06-05",{"date":95,"type":39},"2026-06-09",{"date":97,"type":39},"2026-03-24",{"date":99,"type":22},"2027-03-01",{"name":101,"class":46},"University of Notre Dame",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":110,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":111,"targetDuration":4,"studyType":23,"phases":113,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":47},"100592556","multi-component-breath-alcohol-intervention-phase-3-100592556","NCT06994962","Multi-Component Breath Alcohol Intervention Phase 3","Development and Initial Testing of a Multi-Component Breath Alcohol-Focused Intervention for Young Adults, Stage 3","BAMTECH","1. Be between the ages of 18-25\n2. Be able to read English and complete study evaluations\n3. Report at least four days with heavy episodic drinking (i.e., 4 or more drinks for women and 5 or more drinks for men) out of the prior 30 days\n4. Report having consumed at least one alcoholic drink during a minimum of 12 days out of the prior 30 so that subjects will have multiple opportunities to use the moderate drinking technologies during the intervention period.\n5. Meet, at minimum, DSM-5 criteria for a mild alcohol use disorder (i.e., meet at least 2 diagnostic criteria)\n6. Self-report interest in using a smartphone app to help reduce drinking with a score of at least 3 on a 0-10 scale indicating at least a degree of openness to using technology to moderate drinking.\n\nExclusion Criteria\n\nNo subject may:\n\n1. Have been in inpatient or intensive outpatient treatment within the past 12 months\n2. Have used a smartphone application to facilitate moderate drinking more than 1 time within the past 12 months\n3. Meet DSM-5 criteria for current substance use disorder with the exception of tobacco use disorder, mild or moderate alcohol use disorder or mild cannabis use disorder.\n4. History of alcohol withdrawal or medically-assisted detoxification as individuals with this history will likely be in need of more intensive treatment than is offered in this study.\n5. Be psychotic or otherwise severely psychiatrically disabled\n6. Report a history of a medical condition that would contraindicate the consumption of alcohol (e.g., liver disease, cardiac abnormality, pancreatitis, diabetes, neurological problems, and gastrointestinal disorders).",true,{"count":112,"type":22},90,[25],"This is the third stage of a three-stage, NIH-funded study to develop and test a multi-modal intervention concerning blood\u002Fbreath alcohol concentration for young adults who drink heavily. The multimodal intervention will be made up of brief telehealth counseling and psychoeducation and use of three existing mobile technologies. The brief counseling\u002Fpsychoeducation and mobile technologies provide personalized feedback regarding blood or breath alcohol content. The long-term goal of use of these mobile technologies will be to facilitate moderate drinking. However, the main goals of the proposed research are to learn more about feasibility of our procedures, perceived value of the technologies and ease of use from the research participants' points of view. In this third stage of the study, the investigators will conduct a randomized controlled trial building on the formative research conducted in Stages 1 and 2.",[30,116,117],"Alcohol Drinking","Drinking Behavior","2026-05-18",{"date":120,"type":39},"2026-05-20",{"date":122,"type":39},"2025-05-01",{"date":124,"type":22},"2027-01-31",{"name":126,"class":46},"Northeastern University",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":110,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":23,"phases":136,"briefSummary":137,"conditions":138,"keywords":140,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":147,"completionDateStruct":148,"leadSponsor":150,"locationsCount":47},"100627361","testing-an-mbi-for-smoking-cessation-and-alcohol-use-among-cancer-survivors-100627361","NCT07447635","Testing an MBI for Smoking Cessation and Alcohol Use Among Cancer Survivors","Smoking Cessation and Alcohol Use Among Cancer Survivors: Investigating the Efficacy of a Mindfulness-Based Intervention","Inclusion Criteria:\n\n* ≥18 years old\n* History of a cancer diagnosis at any point in lifetime\n* Smoked ≥1 cigarette\u002Fday in past month\n* At least one binge drinking episode in past month or exceeds weekly drinking limits\n* Motivated to quit smoking and modify alcohol use in next 30 days\n* Valid home address in Florida\n* English-speaking, reading, and writing ability\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Active psychotic disorder\n* History of severe alcohol withdrawal\n* Current use of tobacco cessation medication or other treatments to quit smoking\n* End-of-life or hospice care\n* Household member already enrolled",{"count":135,"type":22},600,[25],"This study will examine the efficacy of Mindfulness-Based Relapse Prevention for Smoking and Alcohol (MBRP-SA) compared to standard care among cancer survivors who smoke cigarettes and engage in at-risk alcohol use. Investigators will evaluate implementation outcomes through structured stakeholder interviews across medical centers, cancer-focused organizations, and community-based programs in Florida, and will conduct a cost-assessment and an incremental cost-effectiveness analysis of the two conditions.",[139,30],"Smoking Cessation",[141,142,143,144],"Mindfulness-based intervention","Cancer survivors","Smoking cessation","Alcohol use","2026-05-15",{"date":118,"type":39},{"date":145,"type":39},{"date":149,"type":22},"2029-12",{"name":151,"class":46},"H. Lee Moffitt Cancer Center and Research Institute",{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":160,"minAge":18,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":23,"phases":163,"briefSummary":164,"conditions":165,"keywords":4,"overallStatus":169,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":47},"100630235","maternal-outcomes-mood-alcohol-use-and-depressive-symptoms-100630235","NCT07485036","Maternal Outcomes: Mood, Alcohol Use, and Depressive Symptoms","Maternal Outcomes: Mood, Alcohol Use, and Depressive Symptoms (MOMS-AD Pilot Study)","MOMS-AD","Inclusion Criteria:\n\n* Biologically female\n* Age ≥18 years\n* Within 12 months postpartum\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Serious medical or psychiatric conditions requiring hospitalization\n* Lifetime DSM-5 diagnosis of schizophrenia, bipolar disorder, or any psychiatric disorder\n* Current use of psychoactive drugs, medication to treat problematic alcohol use, or depression\n* Participation in past 6 months in problematic alcohol use or substance use treatment\n* Unable to provide consent","FEMALE",{"count":162,"type":22},30,[25],"This study aims to learn about depression and alcohol use in postpartum mothers and whether an intervention based on contingency management and problem-solving therapy (CM-PST) can help reduce these symptoms. The main questions it seeks to answer are:\n\n1. How do new mothers fare with depressive symptoms and alcohol use in the first 12 months after giving birth?\n2. Will a CM-PST intervention reduce depressive symptoms and alcohol use frequency among new mothers?\n3. Is a CM-PST intervention practical for new mothers?\n\nThe researchers will recruit approximately 30 new mothers and randomly select half to attend a 6-week CM-PST intervention. They will compare those who received the intervention versus those who did not to see if there are any differences in their depressive symptoms and alcohol usage.\n\nParticipants will:\n\n* Complete 4 remote intervention sessions over 6 weeks\n* Conduct at-home urine drug tests 2x per week during the 6-week intervention\n* Answer online surveys about their mental health and alcohol use",[166,30,167,168],"Postpartum Depression (PPD)","Contingency Management","Problem Solving Therapy","NOT_YET_RECRUITING","2026-05-05",{"date":172,"type":39},"2026-05-11",{"date":174,"type":22},"2026-06-01",{"date":176,"type":22},"2027-11-30",{"name":178,"class":46},"University of Illinois at Chicago",{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":185,"targetDuration":4,"studyType":23,"phases":187,"briefSummary":188,"conditions":189,"keywords":190,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":47},"100604960","college-student-alcohol-behaviors-and-strategies-100604960","NCT07156305","College Student Alcohol Behaviors and Strategies","Inclusion Criteria:\n\n* Must report being between the ages of 18-25\n* Must report engaging in alcohol use at least one time per week over the past two weeks, on average\n\nExclusion Criteria:\n\n* Reports currently receiving or having received treatment for their alcohol or other substance use during the past two months\n* Age below 18 or above 25 years\n* Does not report having engaged in alcohol use at least one time per week over the past two weeks, on average",{"count":186,"type":22},300,[25],"The primary goal of this clinical trial is to examine whether the use of personalized goal setting related to protective behavioral strategies (PBS)-behavioral techniques enacted before, during, or after alcohol consumption to reduce risk and minimize harm-increases the use of personally selected PBS implementation. A secondary goal of this trial is to examine whether increasing the frequency of PBS use will lead to decreases in alcohol consumption, fewer alcohol-related negative consequences, and increased alcohol-related positive consequences. Researchers will compare a control condition, a PBS-only condition, and a PBS+Goals condition to address the aims of the study. Participants in all conditions will complete measures about current PBS use, alcohol use and consequences, and likelihood and confidence to change current alcohol and strategy use. All participants will receive brief psychoeducation on PBS. Participants in the PBS-only and PBS+Goals condition will select three PBS to use over the following two weeks, and select a strategy for remembering the PBS they chose. Participants in the PBS+Goals condition will receive psychoeducation about goal setting and identify two goals related to each PBS strategy they selected. Participants in all conditions will complete a follow-up after two weeks containing measures about PBS use, alcohol use and consequences, and likelihood and confidence to change alcohol and strategy use. Participants in the PBS-only and PBS+Goals condition will complete a measure to indicate whether they used the reminder strategy they selected at the two-week follow-up. Participants in the PBS+Goals condition will complete a measure indicating whether they believe they achieved their goals at the two-week follow-up.",[30],[191,192,193,144,194],"Protective behavioral strategy","PBS","Protective behavioral strategies","Alcohol consequences","2026-04-27",{"date":197,"type":39},"2026-04-28",{"date":199,"type":39},"2025-09-01",{"date":201,"type":22},"2027-05",{"name":203,"class":46},"University of Wyoming",{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":208,"acronym":4,"eligibilityCriteria":209,"healthyVolunteers":11,"sex":17,"minAge":210,"maxAge":211,"enrollmentInfo":212,"targetDuration":4,"studyType":23,"phases":214,"briefSummary":216,"conditions":217,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":47},"100521519","phase-1-the-potential-therapeutic-effects-of-psychedelic-n-n-dimethyltryptamine-dmt-on-alcohol-use-disorder-aud-100521519","NCT06070649","The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)","Inclusion Criteria:\n\n* Diagnostic and Statistical Manual of Mental Disorders-5th edition (DSM-5) diagnosis of Alcohol Use Disorder\n* Medically healthy\n* Ability to provide consent\n\nExclusion Criteria:\n\n* Unstable medical conditions","21 Years","65 Years",{"count":213,"type":22},63,[215],"PHASE1","This proposed study is a double-blind, randomized, placebo-controlled, parallel-group, laboratory study to determine the effects of DMT, plus psychotherapy, on Alcohol Use Disorder.",[88,218,30],"Alcohol-Related Disorders","2026-04-26",{"date":197,"type":39},{"date":222,"type":39},"2025-08-04",{"date":224,"type":22},"2026-08-01",{"name":226,"class":46},"Yale University",{"id":228,"slug":229,"hasResults":11,"nctId":230,"briefTitle":231,"officialTitle":232,"acronym":4,"eligibilityCriteria":233,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":234,"enrollmentInfo":235,"targetDuration":4,"studyType":23,"phases":237,"briefSummary":238,"conditions":239,"keywords":242,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":47},"100572682","brief-interventions-to-reduce-comorbid-alcohol-and-cannabis-misuse-and-sleep-impairment-in-young-adults-rest-up-rct-100572682","NCT06736444","Brief Interventions to Reduce Comorbid Alcohol and Cannabis Misuse and Sleep Impairment in Young Adults (Rest-Up RCT)","Efficacy of Brief Interventions to Reduce Comorbid Alcohol and Cannabis Misuse and Sleep Impairment in Young Adults (Rest-Up RCT)","Inclusion Criteria:\n\n* Participants must: 1) be 18-29 years old; 2) reside in Washington State; 3) have valid email address; 4) score on the Insomnia Severity Index (ISI) of 10 or higher, indicating at least a moderate score (score of 2 or more) on one or more of the first three items of the ISI measuring difficulty falling asleep, staying asleep, or waking up too early; 5a) report at least two heavy drinking episodes (4+ drinks for women \u002Fgender diverse, 5+ for men in a 2-hour period) in the past month; or 5b) 1 heavy drinking occasion and at least 4 total drinking occasions in the past month; 6) have used cannabis 4+ times in the past month; and 7) did not participate in the R34 pilot feasibility trial on which the current RCT is based.\n\nExclusion Criteria:\n\n* Participants that don't meet inclusion criteria and\u002For failure to consent to further participation.","29 Years",{"count":236,"type":22},800,[25],"This study is designed to evaluate an integrated intervention to reduce alcohol and marijuana use and consequences and improve sleep among young adults with comorbid heavy episodic drinking, marijuana use, and sleep impairment.",[240,30,241],"Insomnia","Marijuana Use",[240,30,241,243],"Young Adults","2026-04-09",{"date":246,"type":39},"2026-04-14",{"date":248,"type":39},"2025-07-02",{"date":250,"type":22},"2029-04-01",{"name":252,"class":46},"University of Washington",{"id":254,"slug":255,"hasResults":11,"nctId":256,"briefTitle":257,"officialTitle":258,"acronym":259,"eligibilityCriteria":260,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":261,"enrollmentInfo":262,"targetDuration":4,"studyType":23,"phases":264,"briefSummary":265,"conditions":266,"keywords":267,"overallStatus":169,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":47},"100595726","cpnf-intervention-development-and-testing-100595726","NCT07036198","CPNF Intervention Development and Testing","A User-Customizable Personalized Normative Feedback Intervention for Alcohol Harm Reduction in Young Adults: Feasibility, Acceptability, and Preliminary Efficacy","Project SHIFT","Inclusion Criteria:\n\n* Enrolled at the University of Washington either part- or full-time\n* Report 3 or more past-month drinking occasions\n* Report 3 or more drinks per occasion in the past month, on average\n* Report 4 or more drinks during the peak drinking occasion in the past month\n* Pass attention-check items\n\nExclusion Criteria:\n\nN\u002FA","24 Years",{"count":263,"type":22},250,[25],"The project will develop brief interventions that allow participants to customize which groups they receive feedback for in relation to things such as drinking norms for younger or older students, student athletes, etc. The goal is to provide content that is meaningful and engaging to all users.",[30],[268,269,270,271],"young adults","alcohol-related harm","RCT","normative feedback","2026-03-10",{"date":274,"type":39},"2026-03-13",{"date":276,"type":22},"2026-04",{"date":278,"type":22},"2027-09-01",{"name":252,"class":46},{"id":281,"slug":282,"hasResults":11,"nctId":283,"briefTitle":284,"officialTitle":284,"acronym":4,"eligibilityCriteria":285,"healthyVolunteers":110,"sex":17,"minAge":210,"maxAge":286,"enrollmentInfo":287,"targetDuration":4,"studyType":23,"phases":289,"briefSummary":291,"conditions":292,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":294,"startDateStruct":296,"completionDateStruct":298,"leadSponsor":300,"locationsCount":47},"100344394","phase-2-mechanistic-evaluation-of-guanfacine-on-drinking-behavior-in-women-and-men-with-alcohol-use-disorders-100344394","NCT03764098","Mechanistic Evaluation of Guanfacine on Drinking Behavior in Women and Men With Alcohol Use Disorders","Inclusion Criteria:\n\n1. Age 21 70;\n2. Able to read and write English;\n3. Meets DSM V criteria for current (past 6 months) alcohol use disorder or Drinking criteria: Males Drinks more than 14 drinks per week and exceeds 4 drinks per day at least twice per week; Females Drinks \\> more than 7 drinks per week and exceeds 3 drinks per day at least twice per week. Must meet drinking criteria during a consecutive 30 day period prior to baseline;\n4. Laboratory sessions will be scheduled such that subjects will not have major responsibilities on the following day which might limit drinking during the self administration session (e.g., job interview, exam);\n5. Able to take oral medications and willing to adhere to medication regimen;\n6. indicate willingness to cut down on drinking during the treatment period.\n\nExclusion Criteria:\n\n1. Subjects with any significant current medical conditions (neurological, cardiovascular \\[including hypertension or hypotension: sitting BP more than 160\u002F100 or less than 90\u002F60mmHg at baseline screening\\], endocrine, thyroid, renal, liver), seizures, delirium or hallucinations, or other unstable medical conditions including HIV;\n2. Current DSM V substance use disorder, other than alcohol abuse disorder or nicotine dependence;\n3. A positive test result at intake appointment on urine drug screens conducted for illicit drugs;\n4. Past 30 day use of psychoactive drugs including anxiolytics and antidepressants;\n5. Women who are pregnant or nursing, or fail to use one of the following methods of birth control unless she or partner is surgically sterile or she is postmenopausal (hormone contraceptives \\[oral, implant, injection, patch, or ring\\], contraceptive sponge, double barrier \\[diaphragm or condom plus spermicide\\], or IUD);\n6. Suicidal, homicidal or evidence of current (past 6 month) mental illness such as schizophrenia, bipolar disorder or major depression, or anxiety disorders;\n7. Meet DSM V criteria for current (past 6 month) ADHD;\n8. Only one member per household can participate in the study\n9. Specific exclusions for administration of guanfacine not already specified include: EKG evidence at baseline screening of any clinically significant conduction abnormalities or arrhythmias; known intolerance for guanfacine or any alpha blocker; history of fainting, syncopal attacks, heart failure or myocardial infarction, or impaired liver (AST, ALT \\> 3x normal) or renal function (estimated creatinine clearance \\\u003C60 cc\u002Fmin); treatment with any antihypertensive drug or any alpha adrenergic blocker; use of any CNS depressant (e.g., phenothiazines, barbiturates, benzodiazepines);\n10. Subjects likely to exhibit clinically significant alcohol withdrawal during the study. Specifically, we will exclude subjects who a) have a history of perceptual distortions, seizures, delirium, or hallucinations upon withdrawal, or b) have a score of more than 8 on the Clinical Institute Withdrawal Assessment scale at intake appointments;\n11. Subjects who have taken any investigational drug within 4 weeks immediately preceding admission to the treatment period;\n12. Participation within the past 8 weeks in other studies that involve additive blood sampling and\u002For interventional measures that would be considered excessive in combination with the current application;\n13. at intake express desire to completely abstain from alcohol;\n14. currently in treatment for alcohol use","70 Years",{"count":288,"type":22},160,[290],"PHASE2","For this protocol, the investigators plan to collect pilot data to examine sex differences in guanfacine's effect on 1) counteracting stress and stimulation based drinking behavior in the laboratory and 2) improving clinical outcomes during a subsequent treatment phase.",[30],"2026-02-23",{"date":295,"type":39},"2026-02-27",{"date":297,"type":39},"2020-08-10",{"date":299,"type":22},"2026-08-31",{"name":226,"class":46},{"id":302,"slug":303,"hasResults":11,"nctId":304,"briefTitle":305,"officialTitle":305,"acronym":4,"eligibilityCriteria":306,"healthyVolunteers":11,"sex":17,"minAge":307,"maxAge":308,"enrollmentInfo":309,"targetDuration":4,"studyType":23,"phases":311,"briefSummary":312,"conditions":313,"keywords":317,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":325,"completionDateStruct":327,"leadSponsor":329,"locationsCount":47},"100561706","evaluating-caregiver-involvement-in-primary-care-based-brief-interventions-for-adolescent-alcohol-use-problems-100561706","NCT06593652","Evaluating Caregiver Involvement in Primary Care-Based Brief Interventions for Adolescent Alcohol Use Problems","Inclusion Criteria:\n\n* 12-17 years old;\n* Mild to moderate severity for alcohol use (based on standardized surveys from their primary care provider or clinical indication) or other substance use\n* English language fluency\n\nExclusion Criteria:\n\n* N\u002FA","12 Years","17 Years",{"count":310,"type":22},615,[25],"Intervention for mild severity alcohol use among U.S. teens is crucial, as alcohol is the most commonly used substance in this age group, yet few receive the necessary interventions. Primary care, where over 90% of youth regularly visit, is an ideal setting for identifying and addressing mild alcohol use disorder (AUD) through brief interventions like motivational interviewing (MI) and cognitive-behavioral therapy (CBT). However, for teens with mild AUD, a single brief session may not be sufficient, raising questions about the role of caregiver involvement. This study seeks to determine the most effective level of caregiver involvement-no involvement, a single live session, or an online self-paced program-in reducing alcohol use among adolescents with mild AUD in primary care settings. The study also explores the impact of these interventions on other outcomes such as substance use and psychosocial functioning, as well as the factors influencing treatment response. The results will guide the selection and implementation of effective, scalable interventions in primary care to address youth alcohol use disorders.",[30,314,315,316],"Adolescent","Mild Alcohol Use Disorder","Mild Substance Use Disorder",[318,319,320,30,321],"Brief Intervention","Teen Intervene","Caregiver Involvement","Substance Use","2025-12-29",{"date":324,"type":39},"2026-01-02",{"date":326,"type":39},"2025-08-19",{"date":328,"type":22},"2028-09",{"name":330,"class":46},"Indiana University",{"id":332,"slug":333,"hasResults":11,"nctId":334,"briefTitle":335,"officialTitle":336,"acronym":337,"eligibilityCriteria":338,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":339,"targetDuration":4,"studyType":23,"phases":341,"briefSummary":342,"conditions":343,"keywords":344,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":348,"lastUpdatePostDateStruct":349,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":47},"100591593","wellness-alcohol-vitals-and-emotions-100591593","NCT06982443","Wellness, Alcohol, Vitals, and Emotions","Mindfulness-Based Relapse Prevention and Psychophysiological Self-Regulation","WAVE","Inclusion Criteria:\n\n1. 18 years of age or older\n2. Meet criteria for a moderate to severe alcohol use disorder within the previous 3-months.\n3. Able to attend group meetings at the time listed on the recruitment materials.\n4. Willing to wear a sensor for the 8-week intervention period and return the sensor after the immediate follow-up.\n5. Have a phone\u002Ftablet\u002Fcomputer with internet access.\n6. Be able to comprehend and consent to study requirements in English.\n7. Have access to a valid U.S. mailing address for receiving the HRV sensors and reside in the United States.\n\nExclusion Criteria:\n\n1. Current symptoms of psychosis or mania.\n2. Have a substance use disorder requiring a higher level of care than outpatient treatment (e.g., severe alcohol use disorder requiring inpatient detoxification).\n3. Have a history of pulmonary or cardiovascular disease that interferes with sensor data collection and HRV metrics (i.e., ectopic beats, arrythmia, congenital heart disease).",{"count":340,"type":22},120,[25],"The goal of this clinical trial is to examine the effects of mindfulness based relapse prevention on self-regulation overtime and drinking in daily life through the use of wearable heart rate sensors during mindfulness groups and answering assessment questions 3 times per day during the course of treatment. The main questions that it aims to answer are:\n\n1. What changes in self-regulation as measured through heart rate variability are observed during a mindfulness intervention and how do those self-regulatory changes affect drinking after treatment?\n2. How do changes in heart rate variability affect drinking, craving, and negative affectivity in daily life?\n\nParticipants will:\n\n1. Answer questions related to their mood and drinking behaviors.\n2. Wear their sensors during an 8-week treatment period with 1 group per week.\n3. Answer questions 3 times a day during the treatment period. 4.) Return their sensors via a pre-stamped package and answer questions about their mood and drinking behaviors 3- and 6-months after the mindfulness groups end.",[30],[345,346,347],"alcohol","mindfulness","harm reduction","2025-11-05",{"date":350,"type":39},"2025-11-10",{"date":352,"type":39},"2025-10-01",{"date":354,"type":22},"2029-09-01",{"name":356,"class":46},"University of New Mexico",{"id":358,"slug":359,"hasResults":11,"nctId":360,"briefTitle":361,"officialTitle":362,"acronym":363,"eligibilityCriteria":364,"healthyVolunteers":110,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":365,"targetDuration":4,"studyType":23,"phases":367,"briefSummary":368,"conditions":369,"keywords":376,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":47},"100600344","get-better-together-relationship-education-for-military-couples-100600344","NCT07096271","Get Better Together: Relationship Education For Military Couples","Better Together: A Relationship Enrichment Program Targeting Transdiagnostic Interpersonal Emotion Regulation Among Military Couples","GBT RCT","Inclusion Criteria:\n\n* Couple is in a committed romantic relationship of at least six months\n* At least one partner is a military Service member on active duty\n* Both partners are age 18 or older\n* Couple has not previously attended a relationship enrichment retreat or workshop together (e.g., CREDO, Strong Bonds, BSRT). This does not include couples therapy or pre-marital counseling.\n\nExclusion Criteria:\n\n* One or both partners decline to provide informed consent\n* Required command endorsement for retreat attendance is not received (for Service members E-6 and below)\n* Couple is unable or unwilling to attend any of the scheduled retreats during the study period",{"count":366,"type":22},1000,[25],"This study is testing a program called Get Better Together, a relationship education program designed to help military couples effectively navigate life stressors as a team. The goal is to find out if attending Get Better Together improves mental health and relationship skills, and reduces problems like alcohol misuse, aggression, and suicide risk. Couples who join the study will be randomly placed into one of two groups. One group will attend Get Better Together at a weekend retreat. The other group will continue their usual activities and later receive access to an online relationship education program. All participants will complete surveys before the retreat and again 2, 4, and 6 months later.",[370,371,372,30,373,374,375],"Emotion Regulation","Relationship Conflict","Suicide Risk","Intimate Partner Violence (IPV)","Relationship Distress","Interpersonal Emotion Regulation",[377,378,379,380,381,382,383,384],"Behavioral: Get Better Together (GBT)","military","intimate relationships","suicide prevention","primary prevention","emotion regulation","relationship education","interpersonal emotion regulation","2025-10-15",{"date":387,"type":39},"2025-10-20",{"date":389,"type":39},"2025-09-22",{"date":391,"type":22},"2028-07",{"name":393,"class":46},"Henry M. Jackson Foundation for the Advancement of Military Medicine",{"id":395,"slug":396,"hasResults":11,"nctId":397,"briefTitle":398,"officialTitle":399,"acronym":4,"eligibilityCriteria":400,"healthyVolunteers":11,"sex":17,"minAge":401,"maxAge":286,"enrollmentInfo":402,"targetDuration":4,"studyType":23,"phases":403,"briefSummary":404,"conditions":405,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":406,"lastUpdatePostDateStruct":407,"startDateStruct":409,"completionDateStruct":411,"leadSponsor":413,"locationsCount":415},"100451077","the-less-is-more-study-100451077","NCT05153811","The Less is More Study","Novel Extensions of Alcohol Contingency Management in People Living With HIV","Inclusion Criteria:\n\n* Frequent alcohol use in the past 30 days based on responses on the Timeline Followback (TLFB; Sobell and Sobell, 2003)\n* HIV positive\n* Fluency in English\n* Willingness to attempt alcohol abstinence for at least 30 days and then to attempt alcohol use on fewer days than at baseline after that\n* Willingness to use smartphone applications and biosensor devices (i.e., breathalyzer device and wrist sensor) for alcohol use reduction purposes in the study. If participants do not have a compatible smartphone to use, they will be loaned one by the study\n\nExclusion Criteria:\n\n* Psychiatric conditions that would interfere with participation in the study\n* Current alcohol withdrawal as indicated by a score of 8 or higher on the Clinical Institute Withdrawal Scale (CIWA; Sullivan et al., 1989) or lifetime history of medically assisted detoxification\n* Two positive breath alcohol concentration (BrAC) readings (i.e., \\> 0.00%) at an in-person screening appointment. After participants blow their first positive BrAC, they will be allowed to reschedule and participate at another time, however if they blow a second positive BrAC, they will be excluded from this study and offered referrals for alcohol treatment.\n* Currently seeking or past-12-month history of inpatient or intensive treatment for addictive behaviors\n* Psychosis or other severe psychiatric disability\n* Pregnancy, nursing or lack of reliable birth control use for women who have not yet reached menopause","35 Years",{"count":340,"type":22},[25],"In this project, the investigators will implement innovations to extend use of Contingency Management (CM) to facilitate alcohol use reduction among people living with HIV (PLWH). The investigators' approach to extending CM will use mobile health (mHealth) tools including a smartphone breathalyzer device with accompanying app and a wrist worn alcohol biosensor. Participants will be engaged in mobile facilitated CM for 30-60 days with follow-up out to 6 months.",[30],"2025-07-29",{"date":408,"type":39},"2025-07-31",{"date":410,"type":39},"2022-06-10",{"date":412,"type":22},"2026-09-01",{"name":414,"class":46},"University of Florida",2,{"id":417,"slug":418,"hasResults":11,"nctId":419,"briefTitle":420,"officialTitle":421,"acronym":4,"eligibilityCriteria":422,"healthyVolunteers":110,"sex":17,"minAge":18,"maxAge":423,"enrollmentInfo":424,"targetDuration":4,"studyType":23,"phases":426,"briefSummary":427,"conditions":428,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":431,"startDateStruct":433,"completionDateStruct":435,"leadSponsor":437,"locationsCount":415},"100551265","stress-and-resilience-100551265","NCT06457841","Stress and Resilience","Black Adult Resilience Study","Inclusion Criteria:\n\n* Of Afro-descent\n* Proficient in English\n* Alcohol and\u002For cannabis use at least 2-3 times in the past month\n* Endorse having used alcohol and\u002For cannabis to cope\n\nExclusion Criteria:\n\n* Having participated in similar studies by the research team\n* Obtain cut-off scores on scale items indicating possible loss of control and needing to cut down or quit alcohol and\u002For cannabis use\n* In or seeking treatment for alcohol and\u002For cannabis use disorder","30 Years",{"count":425,"type":22},456,[25],"Alcohol and cannabis are the most misused psychoactive substances in the United States. The proposed research examines how personally relevant stressful experiences may lead to alcohol and cannabis use. The proposed research is also designed to identify possible targets for prevention and treatment efforts to help reduce drug use.",[30,429],"Cannabis Use","2025-07-10",{"date":432,"type":39},"2025-07-15",{"date":434,"type":39},"2024-05-09",{"date":436,"type":22},"2027-07",{"name":252,"class":46},{"id":439,"slug":440,"hasResults":11,"nctId":441,"briefTitle":442,"officialTitle":443,"acronym":4,"eligibilityCriteria":444,"healthyVolunteers":110,"sex":17,"minAge":18,"maxAge":445,"enrollmentInfo":446,"targetDuration":4,"studyType":23,"phases":448,"briefSummary":449,"conditions":450,"keywords":451,"overallStatus":169,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":457,"completionDateStruct":459,"leadSponsor":461,"locationsCount":4},"100575161","alcohol-related-risk-reduction-in-veterans-100575161","NCT06768684","Alcohol Related Risk Reduction in Veterans","Alcohol Related Risk Reduction in Rural Veterans","Inclusion Criteria:\n\n* Veteran status, English-speaking, report current alcohol use, receiving treatment through the Iowa City VA Health Care System\n\nExclusion Criteria:\n\n* History of significant alcohol withdrawal, evidence of significant alcohol dependence, lack of regular access to a telephone, inability to participate in phone counseling","99 Years",{"count":447,"type":22},50,[25],"This project is designed to refine and evaluate the feasibility and preliminary effectiveness of a brief, telephone-administered alcohol risk reduction intervention for Veterans.",[30],[345,347,452,453],"behavioral intervention","Veterans","2025-01-09",{"date":456,"type":39},"2025-01-10",{"date":458,"type":22},"2025-01",{"date":460,"type":22},"2026-12-30",{"name":462,"class":463},"Iowa City Veterans Affairs Medical Center","FED",{"id":465,"slug":466,"hasResults":11,"nctId":467,"briefTitle":468,"officialTitle":468,"acronym":469,"eligibilityCriteria":470,"healthyVolunteers":110,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":471,"targetDuration":4,"studyType":23,"phases":472,"briefSummary":473,"conditions":474,"keywords":4,"overallStatus":169,"whyStopped":4,"lastUpdateSubmitDate":478,"lastUpdatePostDateStruct":479,"startDateStruct":481,"completionDateStruct":483,"leadSponsor":485,"locationsCount":4},"100558598","mataspire-mental-health-awareness-tailored-app-for-substance-prevention-and-integrated-resilience-education-100558598","NCT06553196","MATAspire: Mental Health Awareness Tailored App for Substance Prevention and Integrated Resilience Education","MATAspire","Inclusion Criteria:\n\n* Current Cal State Northridge (CSUN) matriculated students with active CSUN email\n* Age 18 and older\n\nExclusion Criteria:\n\n* Not currently a CSUN student\n* CSUN students under the age of 18 years\n* Have previously participated in this study\n* Identified as having an alcohol or substance use disorder (AUD or SUD) as determined by the brief Diagnostic and Statistical Manual of Mental Disorders (DSM) 5 screener",{"count":366,"type":22},[25],"The MATAspire intervention is a web-app designed to promote substance misuse prevention education and bolster protective coping skills whereby students complete six weekly interactive modules using a smart device or computer. Each module is approximately 15-20 minutes long and focuses on select substances and coping strategies: (i) adaptive coping strategies, (ii) alcohol, (iii) cannabis, (iv) nicotine, (v) prescription drugs and opioids, (vi) final module. The modules are based on key theoretical constructs, behavior change strategies, and practical module components: attitudes (knowledge), perceived susceptibility (risk perceptions), and subjective norms (normative re-education). The intervention will be evaluated via a time series design using a sample of (\\~1000 students) randomly assigned to either the intervention or the control conditions at a public institution in Southern California.",[30,429,475,476,477],"Nicotine Use","Illicit Drug Use","Prescription Opioid Misuse","2024-08-12",{"date":480,"type":39},"2024-08-14",{"date":482,"type":22},"2024-08-24",{"date":484,"type":22},"2028-12-31",{"name":486,"class":46},"California State University, Northridge"]