[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"countryName\":\"Guinea-Bissau\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":133},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,78,103],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100640887","regular-growth-monitoring-rgm-of-young-children-in-guinea-bissau-100640887",false,"NCT07584395","Regular Growth Monitoring (RGM) of Young Children in Guinea-Bissau","Pilot Study to Assess the Benefits and Sustainability of Regular Growth Monitoring (RGM) of Young Children in Villages in Guinea-Bissau","Inclusion Criteria:\n\n* Children aged 6 months to 5 years residing in one of the two selected villages in Guinea-Bissau\n* Caregiver willing to enroll the child in the study (verbal consent provided)\n* Caregiver can provide birth certificate or documentation of child's age\n* Child does not have severe acute malnutrition (SAM) at the baseline assessment\n\nExclusion Criteria:\n\n* Children diagnosed with severe acute malnutrition (SAM) at baseline (these children will be referred to the local malnutrition clinic)\n* Children whose caregivers do not wish to participate",true,"ALL","6 Months","5 Years",{"count":21,"type":22},400,"ESTIMATED","INTERVENTIONAL",[25],"NA","Wasting (severe thinness) is a common and serious problem among young children in rural Guinea-Bissau. Community Health Agents (CHAs) can help prevent malnutrition by regularly measuring children's growth and advising families on nutritious local foods. However, this practice is not consistently implemented.\n\nThis pilot study will test whether implementing Regular Growth Monitoring (RGM) by CHAs every month is feasible and effective in reducing malnutrition among children aged 6 months to 5 years in two rural villages. Investigators will also compare three methods for measuring mid-upper arm circumference (MUAC), which is used to detect malnutrition: the standard WHO tape measure, a photograph of the arm, and a simple bracelet. The goal is to identify which method is easiest for CHAs to use reliably.\n\nBaseline and final measurements will be taken in both villages. One village will receive the monthly RGM intervention first, followed by the second village. Families will also be asked about their experiences with the program through brief questionnaires.",[28,29],"Severe Acute Malnutrition","Moderate Acute Malnutrition (MAM)",[31,32,33,34,35],"Childhood malnutrition","Growth monitoring","Guinea-Bissau","Wasting","Mid-upper arm circumference","NOT_YET_RECRUITING","2026-05-07",{"date":39,"type":40},"2026-05-13","ACTUAL",{"date":42,"type":22},"2026-05-02",{"date":44,"type":22},"2026-12",{"name":46,"class":47},"Trustees of Dartmouth College","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":16,"sex":57,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":48},"100625202","burden-of-tuberculosis-among-pregnant-and-postpartum-women-in-guinea-bissau-100625202","NCT07419568","Burden of Tuberculosis Among Pregnant and Postpartum Women in Guinea-Bissau","Assessing the Burden of Tuberculosis Among Pregnant and Postpartum Women: Implications for Integrating Tuberculosis Screening Into Routine Antenatal Care in Guinea-Bissau","TIPP","Inclusion Criteria:\n\n* Pregnant women ≥ 15 years of age\n* Residing in the study\n* Attending ANC consultations at health centre in Bandim, Belem or Cuntum\n* Must provide informed consent\n\nExclusion Criteria:\n\n* Pregnant women ≤ 15 years of age\n* Inability to provide informed consent\n* Residing outside of the study area\n* Receives TB treatment at the time of, or a year prior to, enrolment","FEMALE","15 Years",{"count":60,"type":22},720,[25],"This study aims to address critical diagnostic and data gaps in tuberculosis (TB) care among pregnant and postpartum women in Guinea-Bissau, a high-burden, resource-limited setting. Recognising that current TB screening during antenatal care (ANC) relies largely on unstructured symptom questions, the study will integrate more systematic and innovative approaches into routine maternal health services.\n\nThe project will implement the Bandim TBscore II as a structured triage tool to classify symptom severity and guide referrals. To strengthen diagnostic capacity, two novel tools will be evaluated: stool-based GeneXpert testing (a method recommended in children and explored here as a feasible alternative for pregnant women) and artificial intelligence-powered chest X-ray interpretation software designed to enhance TB detection where radiological expertise is lacking.\n\nThe study will also generate comprehensive, population-based data on TB and TB infection (TBI) among pregnant, postpartum women and women of reproductive age in Guinea-Bissau. The results are intended to inform health policy, both locally and in high-income countries, by providing evidence to improve TB screening protocols and care for this vulnerable group. Ultimately, the study seeks to develop scalable strategies that can be replicated across low- and middle-income countries to advance maternal and child health and support global TB eradication efforts.",[64,65,66,67,68],"Tuberculosis (TB)","Tuberculosis Infection, Latent","Pregnancy","Tuberculosis Diagnosis","Maternal Health","2026-02-14",{"date":71,"type":40},"2026-02-19",{"date":73,"type":22},"2026-02",{"date":75,"type":22},"2027-11",{"name":77,"class":47},"Aarhus University Hospital",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},"100549680","increased-tuberculosis-case-detection---dioptb-100549680","NCT06437184","Increased Tuberculosis Case Detection - DiOpTB","Increased Tuberculosis Case Detection - a Cluster-randomized Trial Combining Available Resources and Novel Strategies for High Endemic Areas","DiOpTB","Inclusion Criteria:\n\n* ≥15 years old\n* presumed TB with cough, sputum production, and\u002For weight loss of any duration\n\nExclusion Criteria:\n\n* TB treatment within the past year.\n* Cerebral disturbances impairing the ability to give informed consent or follow the treatment regime.","120 Years",{"count":88,"type":22},1584,[25],"As estimated by the WHO 10.6 million new Tuberculosis (TB) cases were identified in 2022- while more than three million went undetected and untreated. The low detection rate illustrates the failure to recognise and diagnose TB in the current cascade of healthcare and is a major obstacle to effective TB control programs. This multi-centre cluster-randomised clinical trial will evaluate the effect (i.e., diagnostic yield) of improving the point-of-care diagnostics already in place in most primary health-care centres in low-resource settings. The present study will be conducted in two different geographical settings in the Western and Eastern African countries of Guinea Bissau and Ethiopia. This improved clinical diagnostic pathway may improve case detection rates at primary healthcare level, ensuring prompt commencement of treatment, thereby diminishing transmission risk in the community and improving treatment outcomes. The Optimized Diagnostic Procedure (ODP) will utilize instructed sputum sampling and pooling as well as computer-aided detection (CAD) chest X-ray (CXR) and additional pooled sputum sample as well as non-sputum sampling (faecal and a buccal\u002Ftongue swab and saliva) for GeneXpert Ultra PCR (Xpert) as state-of-the-art add-ons to the routine diagnostic pathway for TB. This adds to the key components of the WHO \"End TB\" strategy - early diagnosis - and if successful, may be rapidly approved by the WHO and implemented by governments globally with potentially major public health benefits.\n\nThe study will be conducted in close liaison with the national Ministries of Health and TB programs in Guinea-Bissau and Ethiopia. This will facilitate any relevant findings to be taken forward for implementation into policy and practice. Capacity development, training and educational activities will be closely aligned to this study.",[92],"Tuberculosis","RECRUITING","2025-09-30",{"date":96,"type":40},"2025-10-03",{"date":98,"type":40},"2024-06-03",{"date":100,"type":22},"2026-03-31",{"name":77,"class":47},2,{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":16,"sex":57,"minAge":58,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":116,"conditions":117,"keywords":122,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":48},"100431567","phase-4-measles-and-bcg-vaccines-for-mother-and-child-100431567","NCT04899765","Measles and BCG Vaccines for Mother and Child","Specific and Non-specific Effects of Measles and BCG Vaccines for Mother and Child","MATVAC","Inclusion Criteria:\n\n* Female women in the fertile age\n* Non-pregnant\n* HIV-negative\n* Living in the BHP HDSS study area\n* Delivered a child that has reached 12 months of age\n* Currently not using contraceptives.\n\nExclusion Criteria:\n\n* Positive pregnancy test\n* Positive HIV test\n* Tuberculosis (previous or current)\n* Immunodeficiency\n* Cancer within the last 2 years\n* Mid-upper-arm-circumference\\\u003C200\n* Acute ongoing infection","35 Years",{"count":113,"type":22},2400,[115],"PHASE4","In Africa, the mortality from infectious diseases remains high. The investigators have discovered that live vaccines such as the BCG vaccine against tuberculosis and the measles vaccine can strengthen resistance to other infections: they have beneficial \"non-specific effects\". The investigators have now seen signs that these non-specific effects for children are stronger if their mother has been given the same vaccines.\n\nIn Africa, BCG vaccine is recommended at birth and measles vaccine at 9 months of age. They are not used beyond childhood.\n\nThe investigators will randomize 2400 women to BCG vaccine, measles vaccine, or placebo. The investigators will further randomize their children to an extra early measles vaccine or placebo. The investigators will assess which of the resulting six vaccination schedules are best for women's and children's protection against measles, for the child's immune system, and for general health.\n\nThe project will be the first in the world to investigate the importance of vaccinating women with live vaccines.",[118,119,120,121],"Vaccine Preventable Disease","Measles","Mother-Infant Interaction","BCG Vaccination Reaction",[123],"Non-specific effects of vaccines","2024-01-18",{"date":126,"type":40},"2024-01-19",{"date":128,"type":40},"2021-05-20",{"date":130,"type":22},"2027-12-31",{"name":132,"class":47},"Bandim Health Project",""]