[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"allergic-reaction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:allergic-reaction":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100623075","human-seminal-plasma-allergy-quality-of-life-100623075",false,"NCT07391917","Human Seminal Plasma Allergy: Quality of Life","ALExSEM - Hypersensibilité au Liquide séminal : Qualité de Vie ALExSEM - Human Seminal Plasma Allergy: Quality of Life","ALExSEM","Inclusion Criteria:\n\n* Adult patient\n* Treated at Angers University Hospital for Human Seminal Plasma Allergy during the period of interest (2010-2026)\n\nExclusion Criteria:\n\n* Objecting to participating in the research","FEMALE","18 Years",{"count":20,"type":21},20,"ESTIMATED","1 Day","OBSERVATIONAL","Human Seminal Plasma Allergy (HSPA) is a rare allergy with localized and\u002For generalized manifestations following exposure during unprotected sex. Its cause remains undetermined and is certainly underdiagnosed. It is an under-recognized cause of acute or chronic pain related to penetration and vaginal inflammation affecting sexually active women.\n\nTo date, no quality-of-life questionnaire specific to this condition exists to demonstrate its impact on the physical, mental, and sexual health of patients.\n\nTo try to highlight the suffering of these patients, non-specific sexual quality-of-life questionnaires exist and could be used, such as the \"Female Sexual Function Index\" (including questions on desire, arousal, and the ability to reach orgasm), but these do not address the sexual impact of psychological distress related to any pathology and do not assess the impact of HSPA-specific symptoms on sexuality. The symptoms of endometriosis can be compared to those of patients with HSPA due to chronic abdominopelvic pain that worsens during sexual intercourse, the psychological impact, and the potential effect on fertility.\n\nA specific questionnaire exists for patients with endometriosis that documents these commonalities: the EHP-30. It is recognized as a specific and sensitive tool for measuring the quality of life of women with endometriosis in routine clinical practice. However, the EHP-30 questionnaire focuses on symptoms that are often chronic and persistent, even outside of sexual intercourse, whereas HSPA is characterized by acute episodes, sometimes spaced out and dependent on exposure to seminal fluid, making the tool less relevant for assessing the quality of life of patients with HSPA.\n\nThis study aims to evaluate and compare the measurement of quality of life in patients with HSPA using these different tools and a specific general question in order to describe quality of life in this population. This will also provide evidence to question the value of creating a questionnaire specific to the pathology.",[26],"Allergic Reaction",[28,29,30,31,32],"seminal fluid","allergy","sexuality","quality of life","Human Seminal Plasma Allergy (HSPA)","NOT_YET_RECRUITING","2026-02-13",{"date":36,"type":37},"2026-02-18","ACTUAL",{"date":39,"type":21},"2026-02-23",{"date":41,"type":21},"2026-08-22",{"name":43,"class":44},"University Hospital, Angers","OTHER_GOV",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":45},"100480175","quercus-ilex-and-quercus-robur-allergen-extracts-standardisation-100480175","NCT05532566","Quercus Ilex and Quercus Robur Allergen Extracts Standardisation","Quercus Ilex and Quercus Robur Allergen Extracts. Determination of the in Vivo Allergenic Potency in Histamine Equivalent Units (HEP).","Inclusion Criteria:\n\n* Subjects must live in a geographical area where allergic problems caused by Quercus ilex and Quercus robur are relevant.\n* Positive clinical history of inhalant allergy (rhinitis and\u002For rhinoconjunctivitis and\u002For asthma) to asthma) to Quercus ilex and Quercus robur.\n* A positive prick-test (mean papule diameter ≥ 3 mm) with an extract of the same allergen and\u002For presence of specific IgE against that allergen.\n* The mean papule area obtained with Histamine dichlorhydrate at 10 mg\u002FmL should be ≥ 7 mm2.\n* Age: Between 18 and 64 years old.\n* Subjects must be able to give informed consent.\n\nExclusion Criteria:\n\n* Subjects should not be excluded in terms of low or high sensitivity to Quercus ilex and Quercus robur.\n* Subjects outside the age range.\n* Subjects who have previously received immunotherapy in the last 5 years for the treatment of asthma or rhinoconjunctivitis for the treatment of asthma or allergic rhinoconjunctivitis induced by allergens that may interfere with Quercus ilex and Quercus robur extracts.\n* Subjects with significant symptoms of rhinoconjunctivitis and\u002For bronchial asthma in which the suspension of the systemic antihistamine treatment is contraindicated.\n* Subjects who have previously presented a severe secondary reaction during the performance of diagnostic skin tests by prick test.\n* Subjects under treatment with ß-blockers.\n* Subjects clinically unstable (acute asthma, febrile, etc.).\n* Subjects with active urticaria lesions, severe active dermographism, severe atopic dermatitis, sunburn, eczema, psoriasis lesions in the area where the prick test is performed (risk of false positives).\n* Subjects with active viral infection by herpes simplex or herpes varicella zoster in the area where the prick test is performed.\n* Subjects with any pathology in which the administration of adrenaline is contraindicated (hyperthyroidism, HTA, cardiopathy, etc.).\n* States of the subject in which he\u002Fshe cannot offer cooperation and severe psychiatric disorders.\n* Pregnant women or women at risk of pregnancy and lactating women.","ALL","64 Years",{"count":56,"type":21},30,"INTERVENTIONAL",[59],"NA","The objective of this study is to determine the biological activity of Quercus illex and Quercus robur allergen extracts in histamine equivalent prick (HEP) units, in order to be used as in-house reference preparation (IHRP).",[26,62,63],"Allergic Skin Reaction","Allergy Pollen",[65],"Allergy","RECRUITING","2025-04-30",{"date":69,"type":37},"2025-05-01",{"date":71,"type":37},"2023-01-24",{"date":73,"type":21},"2025-11-30",{"name":75,"class":76},"Inmunotek S.L.","INDUSTRY"]