[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"allostatic-load\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:allostatic-load":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,55,81,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100609572","our-voices-matter-intervention-for-depression-in-youth-100609572",false,"NCT07216326","Our Voices Matter: Intervention for Depression in Youth","Our Voices Matter: Racial Justice Activism Intervention to Address Structural Racism and Prevent Depression in Black and Latinx Youth","OVM","Inclusion Criteria:\n\n1. 15-20 years old\n2. Identify as Black and\u002F or Latinx\n3. Speak English\n\nExclusion Criteria:\n\n1. Younger than 15 years old, or older than 20 years old\n2. Unable to attend the in-person sessions\n3. Non-fluent English speaker\n4. Do not identify as Black or Latinx",true,"ALL","15 Years","20 Years",{"count":22,"type":23},300,"ESTIMATED","INTERVENTIONAL",[26],"NA","Over 15 million people participated in racial justice protests nationwide during 2020-2021 spotlighting activism as a collective tool against structural racism and discrimination (SRD). SRD manifests as policies and practices (e.g., redlining, voter suppression, mass incarceration) that produce hostile environments that contribute to psychological distress, elevated allostatic load, and an elevated risk for chronic diseases and premature death, concentrated within Black and Latinx populations. While the connection between SRD and health is well documented, few studies provide evidence on strategies to reduce SRD and mitigate consequences on psychological and physiological outcomes. Thus, there is a critical need to rigorously test interventions that improve the mental and physical health of Black and Latinx populations, beginning in adolescence. The study's specific aims are to 1) Determine whether a racial justice activism behavioral intervention prevents and reduces depressive symptoms in Black and Latinx adolescents and young adults and 2) Determine whether a racial justice activism behavioral intervention lowers allostatic load scores in Black and Latinx adolescents and young adults. To accomplish these aims, the team will conduct a stage II group-based, multi-component, and multilevel randomized behavioral clinical trial. The investigators will collect psychological and physiological measures at baseline, then at defined intervals for 2 years post the racial justice activism intervention.",[29,30,31],"Depressive Symptoms","Allostatic Load","Metabolic Syndrome",[33,34,35,36,37,38,39,40,41],"mental health","youth intervention","allostatic load","stress","depressive symptoms","depression","metabolic syndrome","prevention","inflammation","RECRUITING","2026-06-12",{"date":45,"type":46},"2026-06-15","ACTUAL",{"date":48,"type":46},"2025-06-06",{"date":50,"type":23},"2028-12-29",{"name":52,"class":53},"Ann & Robert H Lurie Children's Hospital of Chicago","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":18,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":24,"phases":66,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":54},"100591306","impact-of-periodontal-inflammation-on-allostatic-load-100591306","NCT06978712","Impact of Periodontal Inflammation on Allostatic Load","Impact of Subgingival Instrumentation on Allostatic Load in Periodontitis","Inclusion Criteria:\n\n* Patients with age group 30-50 years diagnosed with generalized periodontitis.\n* Presence of minimum 20 teeth excluding third molars.\n\nExclusion Criteria:\n\n* Periodontal treatment within last 6 months\n* History of antibiotic use within the previous 3 months\n* History of use of steroid, immunosuppressive and psychiatric drugs\n* Pregnant and lactating women\n* History of substance abuse","30 Years","50 Years",{"count":65,"type":23},112,[26],"Periodontitis is a prevalent global health issue that contributes to systemic inflammation and is closely linked to stress as a risk factor. Both conditions have been investigated for bidirectional relationship. However, the results are inconsistent, and the mechanistic links remain unclear. Allostatic load, which measures the cumulative biological effects of stress, may be relevant in elucidating this connection. Inconsistent results have been reported in previous studies exploring the association between periodontitis and individual biomarkers of allostatic load. Furthermore, none of these studies has taken into consideration staging and grading of periodontitis. Additionally, while periodontal treatment has been shown to reduce both local and systemic inflammation, its effect on allostatic load remains unexplored till date. This study aims to fill these gaps by evaluating the relationship between these parameters of periodontitis and allostatic load. Evaluation of impact of subgingival instrumentation on allostatic load may further provide insights into the broader systemic benefits of periodontal interventions.",[30,69],"Periodontitis, Chronic",[71,41,35],"periodontitis","2026-05-21",{"date":74,"type":46},"2026-05-26",{"date":76,"type":46},"2025-06-10",{"date":78,"type":23},"2026-12-01",{"name":80,"class":53},"Postgraduate Institute of Dental Sciences Rohtak",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":89,"targetDuration":4,"studyType":24,"phases":90,"briefSummary":91,"conditions":92,"keywords":93,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":101,"locationsCount":4},"100635564","rise--thrive-community-engagement-intervention-for-stress-and-depression-in-youth-100635564","NCT07554326","Rise & Thrive: Community-Engagement Intervention for Stress and Depression in Youth.","Rise & Thrive: Community-Engagement Intervention to Address Chronic Stress and Prevent Depression in Adolescents and Young Adults","R&T","Inclusion Criteria:\n\n1. 15-20 years old\n2. Identify as Black and\u002F or Hispanic\u002FLatine\n3. Speak English\n\nExclusion Criteria:\n\n1. Younger than 15 years old, or older than 20 years old\n2. Unable to attend the in-person sessions\n3. Non-fluent English speaker\n4. Do not identify as Black or Hispanic\u002FLatine",{"count":22,"type":23},[26],"American youth and young adults face persistent and chronic stressors, which have contributed to a mental health crisis in the United States. Four in 10 American high school students experience chronic feelings of sadness and hopelessness, 2 in 10 report suicidal ideation, and 1 in 10 attempt suicide. For adolescents and young adults, chronic stress translates to weathering, or wear and tear on the mind and body. Chronic stress in youth contributes to psychological distress, elevated allostatic load, and an elevated risk for chronic diseases and premature death. While the connection between chronic stress and health is well documented, few studies provide evidence on innovative, non-medication strategies to reduce stress and mitigate the consequences of chronic stress on psychological and physiological outcomes. Thus, there is a critical need to rigorously test interventions that prevent the negative influence of chronic stress on mental and physical health, beginning in adolescence. The specific aims of the study are to 1) Determine whether a community-engagement, peer-based behavioral intervention reduces depressive symptoms in adolescents and young adults, 2) Determine whether a community-engagement behavioral intervention lowers allostatic load scores in adolescents and young adults, and 3) Identify factors that help sustain or inhibit community-engagement and intervention effects for adolescents and young adults. To accomplish these aims, the team will conduct a phase II community-engaged, peer group-based, multi-component randomized behavioral clinical trial. We will collect psychological and physiological measures at baseline, then at 6-month intervals for 2 years post-community-engaged, skills training.",[29,30,31],[33,34,35,36,37,38,39,40],"NOT_YET_RECRUITING","2026-04-21",{"date":97,"type":46},"2026-04-28",{"date":99,"type":23},"2026-06-09",{"date":50,"type":23},{"name":52,"class":53},{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":17,"sex":18,"minAge":110,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":24,"phases":113,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":54},"100504282","students-rising-above-offsetting-the-health-and-mental-health-costs-of-resilience-100504282","NCT05846282","Students Rising Above: Offsetting the Health and Mental Health Costs of Resilience","Project STRIVE (STudents RIsing Above) - Offsetting the Health and Mental Health Costs of Resilience","STRIVE","Inclusion Criteria:\n\n* Enrolled in 10th or 11th grade at a participating high school\n* Black, Latinx, Asian American\u002FPacific Islander, or American Indian\u002FAlaskan Native\n* High achieving (e.g., GPA above 3.5 and\u002For in the top 20% of their grade, enrolled in advanced classes such as AP\u002FIB\u002Fhonors classes)\n\nExclusion Criteria:\n\n* Intellectual Disability","13 Years",{"count":112,"type":23},504,[26],"Students who 'strive' to rise above significant stressors to achieve academic success are considered 'resilient'. However, youths' resilience in one domain (i.e. academic) can come at a cost in other domains including physical and mental health morbidities that are under-identified and under-treated. Previous research suggests that individuals from populations experiencing documented health disparities who exhibit a \"striving persistent behavioral style\" in the face of stress evince later health morbidities. Ironically, the same self-regulatory skills that promote academic achievement amid chronic stress can also result in physiological dysregulation that harms health and mental health. Self-regulatory processes that involve emotion suppression, experiential avoidance, and unmodulated perseverance can culminate in allostatic load which fuels health disparities and internalizing symptoms of depression and anxiety.\n\nThe proposed mechanistic trial will utilize mindfulness training to permit examination of questions about the causal role of emotion regulation strategies linked to the striving persistent behavioral style in driving mental health and health morbidities among individuals from populations experiencing documented health disparities. The proposed Project STRIVE (STudents RIsing aboVE) will identify students who are academically resilient in the face of stress and will offer a tailored mindfulness intervention targeting self-regulation processes as a putative mechanism to interrupt the links between the striving persistent behavioral style and negative health outcomes. Investigators propose a multisite randomized trial randomizing 504 high achieving Black, Latinx, or Asian America\u002FPacific Islander students in 18 schools to receive a mindfulness intervention or an attention control condition focused on study skills. The study will: (1) test the effects of the STRIVE intervention on putative self-regulation mechanisms (emotion suppression, experiential avoidance, and unmodulated perseverance) among identified students, (2) test the effects of the STRIVE intervention on health and mental health outcomes at 12-month post-treatment, including biomarkers of allostatic load (cortisol, blood pressure, body-mass-index, waist\u002Fhip\u002Fneck circumference), health complaints, and internalizing symptoms, and (3) examine the mechanistic model linking striving persistent behavioral style and health outcomes within the STRIVE trial.",[116,30,117],"Internalizing Mental Health Symptoms","Health Complaints","2026-03-04",{"date":120,"type":46},"2026-03-06",{"date":122,"type":46},"2023-01-09",{"date":124,"type":23},"2027-06",{"name":126,"class":53},"University of California, Los Angeles"]