[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"alveolar-bone-atrophy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:alveolar-bone-atrophy":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,52,88,112,146,172],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100625600","graftless-tsfe-via-self-tapping-implants-100625600",false,"NCT07424742","Graftless TSFE Via Self-tapping Implants","Transcrestal Graftless Schneiderian Membrane Elevation by Self-tapping Dental Implant","G-TSFE","Inclusion Criteria:\n\n1. Adults aged 18-80 years.\n2. Patients with edentulous posterior maxilla.\n3. Residual bone height approximately 4-6 mm.\n4. Indicated for transcrestal sinus membrane elevation.\n5. Good general health (ASA I or II).\n6. Ability to provide written informed consent.\n7. Willingness to attend follow-up visits.\n\nExclusion Criteria:\n\n1. Severe systemic diseases (ASA III or above).\n2. Uncontrolled diabetes mellitus.\n3. Active sinus pathology.\n4. History of radiotherapy in the head and neck region.\n5. Heavy smokers (\\>10 cigarettes\u002Fday).\n6. Pregnancy or lactation.\n7. Untreated periodontal disease.\n\n7\\. Poor oral hygiene.","ALL","18 Years","80 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","This prospective clinical trial aims to evaluate the efficiency, safety, and reliability of a minimally invasive graftless transcrestal sinus lifting approach with simultaneous dental implant placement in patients with edentulous posterior maxilla and limited residual bone height.\n\nThe study investigates bone formation beneath the Schneiderian membrane, implant stability, osseointegration, and long-term implant survival.",[28,29,30],"Edentulous Posterior Maxilla","Maxillary Sinus Pneumatization","Alveolar Bone Atrophy",[32,33,34,35,36,37,38],"Transcrestal Sinus Lift","Graftless Sinus Elevation","Schneiderian Membrane","Dental Implant","Posterior Maxilla","Osseointegration","CBCT","RECRUITING","2026-05-30",{"date":42,"type":43},"2026-06-02","ACTUAL",{"date":45,"type":43},"2024-09-09",{"date":47,"type":22},"2026-09-09",{"name":49,"class":50},"Sana'a University","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":71,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":86,"locationsCount":51},"100633411","digital-planning-and-clinical-assessment-of-the-treated-atrophic-posterior-maxilla-with-a-sinus-lift-procedure-a-cross-sectional-study-100633411","NCT07526337","Digital Planning and Clinical Assessment of the Treated Atrophic Posterior Maxilla With a Sinus Lift Procedure: a Cross-sectional Study.","Inclusion Criteria:\n\n* \\- Patient aged more than 18 years.\n* Partially edentulous patients having an implant rehabilitation treated with a sinus lift procedure in the atrophic posterior maxilla.\n* Patient with no systemic disease that contraindicate the surgical procedure as uncontrolled diabetes mellitus, bleeding disorders, recent myocardial infarction, head and neck radiation, and mental disorders.\n\nExclusion Criteria:\n\n* \\- Fully Edentulous patients.\n* Patients presenting sinus pathologies (sinusitis, thickening of the membrane).\n* Patient smoking more than 20 cigarettes.\n* Patient taking systemic drugs that could affect bone healing as immune suppressive drugs and bisphosphonates.\n* Patient with systemic disease that contraindicate the surgical procedure as uncontrolled diabetes mellitus, bleeding disorders, recent myocardial infarction, head and neck radiation, and mental disorders.",true,{"count":60,"type":22},100,"OBSERVATIONAL","Maxillary posterior area is the most challenging site for dental implant placement. Indeed, complex remodeling processes, resulting in changes of the maxillary sinus and shape of the alveolar ridge will cause difficulties in rehabilitating the posterior maxillae sites. Various techniques have been proposed in order to achieve the necessary bone volume for the placement of long term successful implants. However, unbalanced crown to implant ratio remains a risk factor after successful dental implants installation following sinus graft. No study on humans assessed the effect of apical positioning of the implants in posterior grafted sites (sinus graft or sinus graft + vertical GBR) on the following clinical parameters: The peri-implant bone remodeling (vertical bone loss (mm) and probing depth (mm) around the implants, crown bulkiness, emergence profile and crown height, and Patients satisfaction, food impaction (PROM)).\n\nThis study will elucidate these points and based on the parameter's results, suggest a treatment based classification facilitating the treatment decision-making of the clinicians in case of an atrophic posterior maxilla; aiming to ensure a long-term successful supra-implant rehabilitation which will maintain its bio-mechanically and biological success.",[30,64,65,66,67,68,69,70],"Alveolar Bone Grafting","Peri-Implant Health","Sinus Floor Augmentation","Vertical Ridge Deficiency","Guided Bone Regeneration","Digital Guided Bone Regeneration","Prosthetic Complication",[72,73,74,75,76,77,78,79],"alveolar bone atrophy","digital planning","guided bone regeneration","maxillary sinus","peri-implant disease","peri-implantits","sinus floor augmentation","vertical ridge deficiency","2026-04-06",{"date":82,"type":43},"2026-04-13",{"date":84,"type":43},"2025-01-01",{"date":40,"type":22},{"name":87,"class":50},"Saint-Joseph University",{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":58,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":95,"targetDuration":97,"studyType":61,"phases":4,"briefSummary":98,"conditions":99,"keywords":103,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":108,"startDateStruct":109,"completionDateStruct":110,"leadSponsor":111,"locationsCount":51},"100633395","impact-of-alveolar-ridge-preservation-on-the-potential-need-for-sinus-floor-elevation-a-10-year-retrospective-radiographical-study-100633395","NCT07526129","Impact of Alveolar Ridge Preservation on the Potential Need for Sinus Floor Elevation: A 10-year Retrospective Radiographical Study","Impact of Alveolar Ridge Preservation on the Potential Need for Sinus Floor Elevation in Posterior Maxillary Implant Sites: A 10-year Retrospective Radiographical Study","Inclusion Criteria:\n\n* • Patients aged ≥18 years.\n\n  * Patients who underwent alveolar ridge preservation after extraction of maxillary posterior teeth, as a test group.\n  * Patients who underwent extraction of maxillary posterior teeth with unassisted socket healing without alveolar ridge preservation as a control group.\n\nExclusion Criteria:\n\n* • The presence of a clinically symptomatic periapical radiolucency, acute abscesses, or chronic sinus tract, that may falsify the classification of posterior maxillary teeth on 2D radiographs.",{"count":96,"type":22},130,"12 Months","This research aims to investigate the influence of alveolar ridge preservation, after extraction of maxillary posterior teeth, on the potential need of sinus floor augmentation procedures (that include lateral or crestal sinus augmentations). From peri-apical radiographs, maxillary posterior teeth will be divided into 4 groups according to the relationship of their apexes with the sinus. Then, the patients will be divided into 2 sub-groups: unassisted socket healing (only extraction) and ARP group (extraction + ARP) and their CBCT scans before implant placement will be collected. The CBCT scans should be at least 4 months post-extraction and ARP. Depending on the residual bone height, patients will be divided into 3 categories, according to the ABC classification:\n\n1. In need of lateral sinus floor augmentation\n2. In need of crestal sinus floor augmentation\n3. No need for sinus floor augmentation, therefore, implant placement.\n\nThese divisions will be conducted, according to:\n\n\\- The residual bone height (RBH) which is the height in mm from the alveolar ridge crest to the lowest point of the maxillary sinus floor.\n\nThe results of the proposed hypothesis are verified and interpreted after statistical analysis.",[100,66,101,30,102],"Alveolar Bone Loss","Sinus Pneumatization","Alveolar Ridge Preservation",[104,105,106,107,78],"alveolar bone loss","alveolar process atrophy","extraction","tooth socket",{"date":82,"type":43},{"date":84,"type":43},{"date":40,"type":22},{"name":87,"class":50},{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":58,"sex":17,"minAge":118,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":23,"phases":120,"briefSummary":123,"conditions":124,"keywords":128,"overallStatus":136,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":51},"100439112","phase-1-autogenous-mesenchymal-stem-cell-culture-derived-signalling-molecules-as-enhancers-of-bone-formation-in-bone-grafting-100439112","NCT04998058","Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting","Inclusion Criteria:\n\n* patients \\>35 years-old.\n* presenting highly atrophic fully edentulous maxilla (residual bone height \\\u003C5 mm).\n* In need of bilateral sinus floor augmentation aiming full mouth implant-supported rehabilitation.\n* having teeth extraction at least 8 weeks prior to bone augmentation.\n\nExclusion Criteria:\n\n* smokers, illicit drug users and alcohol daily consumers.\n* patients with metabolic and\u002For systemic diseases leading to impaired healing (e.g. decompensated diabetes, leukocyte or coagulation disorders, immunosuppression).\n* history of radiotherapy in the head or neck region.\n* bisphosphonate-based therapy recipients.\n* intolerant to general\u002Flocal anesthesia.","35 Years",{"count":21,"type":22},[121,122],"PHASE1","PHASE2","This study aims to evaluate bone formation in grafts in terms of its quality (density), quantity (volume) and maturation obtained with the application of a tissue-engineered bone grafting compound containing concentrated autogenous cell-culture medium (CM) and a synthetic bone substitute. The present study was designed as an experimental prospective split-mouth randomized controlled clinical trial. After protocol approval by the Research Ethics Committee, a total of 20 consecutive participants in need of maxillary reconstruction aiming implant-supported oral rehabilitation will be invited to join the study. To collect autogenous adipose tissue-derived mesenchymal stem cells (hASCs), an outpatient lipoplasty procedure at the abdominal area of each patient will be performed. To isolate and expand hASCs from the lipoaspirate, specific cell culture protocols will be followed, resulting in cultured viable cells and their conditioned medium (CM). Cells and CM will be then separated by a sequence of filters and centrifugation, and isolated CM will be frozen. ELISA will analyze the presence of chemokines and their concentration in CM before grafting. Following pre-op surgical planning, both maxillary sinuses of each patient will be grafted internally applying a lateral window to each sinus. The bony floor of the test maxillary sinus will be augmented with synthetic bone substitute (BoneCeramic™ 1-2 mm) mixed with 10 to 15 ml of CM (test). The control site will receive bone substitute with saline. Lateral windows in both sinuses will be then closed with a collagen membrane (Bio-Gide™). After 6 months, first-stage implant surgery will be performed placing 6 implants in each patient. Registration of implant stability by manual torque wrench will be performed. Also, bone biopsies from each drilled implant site will be collected for histology, histomorphometry and immunohistochemistry (RT-PCR). Tomographic evaluation of the bone formation will include cone beam computed tomographies (CBCTs) at pre-operative \\[Baseline\\], 90 \\[T1\\] and 180 \\[T2 = implant placement\\] days for bone 3D image analysis.",[125,126,100,30,127],"Bone Loss, Osteoclastic","Bone Loss, Alveolar","Grafting Bone",[129,130,131,132,133,134,135],"bone","bone formation","bone graft","tissue engineering","stem cell","exosome","cell-free therapy","NOT_YET_RECRUITING","2025-06-02",{"date":139,"type":43},"2025-06-05",{"date":141,"type":22},"2025-12-15",{"date":143,"type":22},"2026-12-30",{"name":145,"class":50},"Pontificia Universidade Católica do Rio Grande do Sul",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":23,"phases":154,"briefSummary":155,"conditions":156,"keywords":158,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":51},"100590963","morphological-characteristics-of-anterior-maxillary-bone-and-dynamic-navigation-in-full-arch-implant-placement-100590963","NCT06974253","Morphological Characteristics of Anterior Maxillary Bone and Dynamic Navigation in Full-Arch Implant Placement","Morphological Characteristics of Anterior Maxillary Anchorage Sites and Application of Dynamic Navigation in Full-Arch Dental Implant Placement","Inclusion Criteria:\n\n* Aged 18 years or older\n* Good overall health (Class 1 and 2 according to the American Society of Anesthesiologists classification system)\n* Clinical diagnosis of complete edentulism of the upper arch classified as Class IV to VI according to Cawood and Howell\n\nExclusion Criteria:\n\n* Systemic or local conditions that may affect surgery, wound healing, or bone integration, such as cardiovascular diseases, diabetes, bone-related diseases, or medication affecting bone metabolism\n* Smoking more than 10 cigarettes per day\n* Presence of acute infections in the planned implant site\n* Limited mouth opening of less than 40mm",{"count":21,"type":22},[25],"The goal of this clinical trial is to evaluate the effectiveness of dynamic navigation in full-arch dental implant placement in patients with complete maxillary edentulism. The main questions it aims to answer are:\n\n* the accuracy of nasopalatine implants, trans-sinus implants, and trans-nasal implants placement in the anterior maxillary bone with dynamic navigation\n* the clinical effectiveness of nasopalatine implants, trans-sinus implants, and trans-nasal implants in full-arch rehabilitation\n* the correlation between the anatomical features of the nasal cavity and the anterior sinus wall on CBCT images and their influence on nasopalatine implants, trans-sinus implants, and trans-nasal implants position",[157,30],"Atrophy of Edentulous Maxillary Alveolar Ridge",[159,160,161,162],"Nasopalatine Implant","Trans-sinus Implant","Trans-nasal Implant","Piriform Rim Implant","2025-05-08",{"date":165,"type":43},"2025-05-15",{"date":167,"type":22},"2025-05-30",{"date":169,"type":22},"2028-02",{"name":171,"class":50},"University of Medicine and Pharmacy at Ho Chi Minh City",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":179,"enrollmentInfo":180,"targetDuration":4,"studyType":23,"phases":182,"briefSummary":183,"conditions":184,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":51},"100569284","efficacy-and-safety-of-additive-manufacturing-personalized-titanium-mesh-in-guided-bone-regeneration-100569284","NCT06692244","Efficacy and Safety of Additive Manufacturing Personalized Titanium Mesh in Guided Bone Regeneration","Efficacy and Safety of Additive Manufacturing Personalized Titanium Mesh in Guided Bone Regeneration: a Randomized, Single-blind, Positive-controlled Prospective Study","Inclusion Criteria:\n\n1. Patients missing single or multiple teeth with moderate to severe bone defects in the edentulous area requiring complex guided bone regeneration. （Moderate bone defects: bone loss with residual alveolar ridge width between 1 mm and 3 mm; severe bone defects: bone loss with residual alveolar ridge width ≤ 1 mm.）\n2. The edge of the edentulous area within 1 mm is alveolar bone, with no adjacent tooth roots or nerve canals, ensuring complete retention of the personalized titanium mesh edge. The apical edge of the edentulous area within 2 mm is alveolar bone, with no nerve canals, ensuring that retention screws for the personalized titanium mesh can be designed in this area.\n3. The patient and\u002For his\u002Fher guardian agrees to participate in this trial and signs the informed consent form.\n\nExclusion Criteria:\n\n1. Patients with edentulism.\n2. Patients with mild bone defects (residual alveolar ridge width greater than 3 mm).\n3. Presence of acute or chronic infection in the surgical area.\n4. Presence of acute or chronic infection in the teeth adjacent to the edentulous area.\n5. Participation in similar trials or other interventional clinical trials within 30 days prior to signing the informed consent form.\n6. History of metal allergies, severe allergy history, or severe immune deficiency.\n7. Uncontrolled metabolic diseases, such as Type 1 diabetes or Type 2 diabetes (HbA1c ≥ 7% or fasting blood glucose ≥ 7 mmol\u002FL despite medication control), severe liver or kidney dysfunction (ALT, AST \\> 2 times the upper limit of normal, serum creatinine above the upper limit of normal).\n8. Long-term use of steroid medications.\n9. History of drug abuse or alcoholism.\n10. Pregnant or breastfeeding women.\n11. Poor compliance.\n12. Other conditions deemed unsuitable for participation by the investigator.","60 Years",{"count":181,"type":22},142,[25],"This goal of this single-blind, simple randomized, positive-controlled prospective study is to evaluate the effects of additive-manufactured personalized titanium mesh and traditional titanium mesh in guided bone regeneration for large alveolar bone defects. The study will assess the short-term and long-term efficacy, safety, and incidence of complications of the additive-manufactured personalized titanium mesh, along with an analysis of risk factors. Participants will be followed up for two years after surgery with free-of-charge clinical and radiographic examinations.",[30,68],"2025-03-10",{"date":187,"type":43},"2025-03-11",{"date":189,"type":43},"2024-11-30",{"date":191,"type":22},"2028-12",{"name":193,"class":50},"Hospital of Stomatology, Sun Yat-Sen University"]