[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"alveolar-bone-grafting\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:alveolar-bone-grafting":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,54,90,117,140,158],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100643193","early-phase-1-assessment-of-the-impact-of-neocement-inject-p-beta-tricalcium-phosphate-on-bone-volume-in-alveolar-ridge-preservation-after-tooth-extraction-100643193",false,"NCT07638319","Assessment of the Impact of Neocement Inject P® (Beta-Tricalcium Phosphate) on Bone Volume in Alveolar Ridge Preservation After Tooth Extraction","Assessment of Safety and Performance of Neobone®: A Prospective Observational Study in the Field of Dentistry","BTCPARPBV","Inclusion Criteria:\n\n* 18 years or older\n* Acceptance of informed consent\n* Type 1 or 2 extraction sockets (Elian et al. 2007)\n\nExclusion Criteria:\n\n* Presence of active infection or severe inflammation in the intervention zone\n* Relevant medical history that contraindicates implant surgery\n* Patients with poor oral hygiene (full-mouth plaque score and full-mouth bleeding score \\>15%) and lack of motivation\n* Uncontrolled diabetes (reported levels of glycated haemoglobin exceeding 7%)\n* Uncontrolled and \u002For untreated periodontal disease\n* Heavy smokers (more than 10 cigarettes per day)\n* Immunosuppression",true,"ALL","18 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"EARLY_PHASE1","The goal of this randomized clinical trial is to assess whether β-TCP (Beta-Tricalcium Phosphate) improves alveolar ridge preservation (ARP) in patients who need tooth extraction. The main question it aims to answer is whether using β-TCP for alveolar ridge preservation has a positive effect on bone volume compared with natural healing.\n\nThe main questions it aims to answer are:\n\nDoes β-TCP improve ridge preservation compared with natural healing?\n\nResearchers will compare β-TCP grafted sockets to natural healing sockets to see if β-TCP better preserves ridge volume.\n\nParticipants will:\n\nHave a tooth indicated for extraction.\n\nBe assigned to either β-TCP or natural healing.\n\nUndergo CBCT (Cone Beam Computed Tomography) and intra-oral scanning after extraction and after six months of healing to measure horizontal and vertical resorption and bone density.",[28,29,30,31],"Tooth Extraction","Tooth Extraction Site Healing","Alveolar Bone Grafting","Alveolar Bone Loss",[33,34,35,36,37,38,39,40],"Beta-tricalcium phosphate","Alveolar ridge preservation","Bone volume","Implant site development","Socket preservation","Ridge augmentation","Tooth extraction","Volumetric Changes","RECRUITING","2026-06-09",{"date":44,"type":45},"2026-06-11","ACTUAL",{"date":47,"type":45},"2025-12-01",{"date":49,"type":22},"2028-12",{"name":51,"class":52},"Egas Moniz - Cooperativa de Ensino Superior, CRL","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":72,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":53},"100633411","digital-planning-and-clinical-assessment-of-the-treated-atrophic-posterior-maxilla-with-a-sinus-lift-procedure-a-cross-sectional-study-100633411","NCT07526337","Digital Planning and Clinical Assessment of the Treated Atrophic Posterior Maxilla With a Sinus Lift Procedure: a Cross-sectional Study.","Inclusion Criteria:\n\n* \\- Patient aged more than 18 years.\n* Partially edentulous patients having an implant rehabilitation treated with a sinus lift procedure in the atrophic posterior maxilla.\n* Patient with no systemic disease that contraindicate the surgical procedure as uncontrolled diabetes mellitus, bleeding disorders, recent myocardial infarction, head and neck radiation, and mental disorders.\n\nExclusion Criteria:\n\n* \\- Fully Edentulous patients.\n* Patients presenting sinus pathologies (sinusitis, thickening of the membrane).\n* Patient smoking more than 20 cigarettes.\n* Patient taking systemic drugs that could affect bone healing as immune suppressive drugs and bisphosphonates.\n* Patient with systemic disease that contraindicate the surgical procedure as uncontrolled diabetes mellitus, bleeding disorders, recent myocardial infarction, head and neck radiation, and mental disorders.",{"count":61,"type":22},100,"OBSERVATIONAL","Maxillary posterior area is the most challenging site for dental implant placement. Indeed, complex remodeling processes, resulting in changes of the maxillary sinus and shape of the alveolar ridge will cause difficulties in rehabilitating the posterior maxillae sites. Various techniques have been proposed in order to achieve the necessary bone volume for the placement of long term successful implants. However, unbalanced crown to implant ratio remains a risk factor after successful dental implants installation following sinus graft. No study on humans assessed the effect of apical positioning of the implants in posterior grafted sites (sinus graft or sinus graft + vertical GBR) on the following clinical parameters: The peri-implant bone remodeling (vertical bone loss (mm) and probing depth (mm) around the implants, crown bulkiness, emergence profile and crown height, and Patients satisfaction, food impaction (PROM)).\n\nThis study will elucidate these points and based on the parameter's results, suggest a treatment based classification facilitating the treatment decision-making of the clinicians in case of an atrophic posterior maxilla; aiming to ensure a long-term successful supra-implant rehabilitation which will maintain its bio-mechanically and biological success.",[65,30,66,67,68,69,70,71],"Alveolar Bone Atrophy","Peri-Implant Health","Sinus Floor Augmentation","Vertical Ridge Deficiency","Guided Bone Regeneration","Digital Guided Bone Regeneration","Prosthetic Complication",[73,74,75,76,77,78,79,80],"alveolar bone atrophy","digital planning","guided bone regeneration","maxillary sinus","peri-implant disease","peri-implantits","sinus floor augmentation","vertical ridge deficiency","2026-04-06",{"date":83,"type":45},"2026-04-13",{"date":85,"type":45},"2025-01-01",{"date":87,"type":22},"2026-05-30",{"name":89,"class":52},"Saint-Joseph University",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":23,"phases":100,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":53},"100566920","bone-augmentation-techniques-in-the-mandible-posterior-region-100566920","NCT06661447","Bone Augmentation Techniques in the Mandible Posterior Region","Comparison of Bone Augmentation Techniques in the Mandibular Posterior Region: A Randomized Clinical Trial","Inclusion Criteria:\n\nPosterior mandibular edentulism requiring horizontal ridge augmentation (Cawood \\& Howell Classes IV-VI).\n\nOne or two eligible posterior mandibular sites suitable for cortical shell augmentation.\n\nAdequate residual bone height to allow safe fixation above the mandibular canal.\n\nGood general health (ASA I or II). Plaque index \\\u003C 20% and absence of active periodontal infection. Ability and willingness to attend scheduled follow-up visits (up to 12 months). Written informed consent provided prior to any study-related procedure.\n\nExclusion Criteria:\n\nUncontrolled systemic diseases affecting bone healing (e.g., uncontrolled diabetes mellitus, immunosuppressive disorders).\n\nCurrent heavy smoking (\\>5 cigarettes\u002Fday). Pregnancy or lactation. Current use of medications known to affect bone metabolism or healing (e.g., bisphosphonates, long-term corticosteroids, anticoagulants).\n\nActive periodontal disease or untreated oral infection. History of chemotherapy or radiotherapy to the head and neck region.","64 Years",{"count":99,"type":22},78,[101],"NA","This study will compare three methods to rebuild lost bone in the back part of the lower jaw (posterior mandible) before dental implant placement. Seventy-eight adults will be randomly assigned to receive one of three \"cortical shell\" techniques using either the patient's own bone (autogenous) or prefabricated bone plates from animal (xenogeneic) or human donors (allogeneic). In all groups, the space inside the shell will be filled with a mixture of small bone chips and bone substitute material. The main outcome is the increase in jawbone width measured on 3D cone-beam CT scans at 6 months after surgery. Additional scans and clinical assessments up to 12 months will evaluate healing, bone stability, and postoperative recovery.",[104,30],"Bone Substitutes",[65,104,106],"Bone Resorption","NOT_YET_RECRUITING","2026-02-18",{"date":110,"type":45},"2026-02-20",{"date":112,"type":22},"2026-04-01",{"date":114,"type":22},"2027-04-01",{"name":116,"class":52},"Universidad de Especialidades Espiritu Santo",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":126,"conditions":127,"keywords":4,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":53},"100621558","wound-healing-following-extraction-and-ridge-preservation-in-smokers-and-non-smokers-100621558","NCT07372183","Wound Healing Following Extraction and Ridge Preservation in Smokers and Non-smokers","Inclusion Criteria:\n\n* Adult patients (18-75 years)\n* Good general health (controlled conditions)\n* Smokers (≥10 cigarettes\u002Fday for ≥5 years) and never smokers. Confirmation of smoking status will be done via use of a smokerlyzer. The cut-off point for distinguishing smokers from non-smokers is 8 carbon monoxide parts per million (ppm).\n* Periodontal status: periodontal health, gingivitis on intact or reduced periodontium, treated periodontitis\n* Intact post-extraction bony walls or less than 50% bone dehiscence\n* Distance at least 8 mm of vertical bone height between bone crest and anatomical structures (i.e. sinus floor, inferior alveolar nerve (IAN) canal, mental foramen)\n* Extracted tooth root in the same three-dimensional position as the future implant placement so that the bone core biopsy can be taken from a site totally within the confines of the former tooth socket without inclusion of surrounding native alveolar bone\n* Scheduled for single tooth extraction with bone graft placement and membrane\n\nExclusion Criteria:\n\n* Uncontrolled periodontal disease\n* Uncontrolled systemic disease\n* Pregnancy\n* Use of therapy and\u002For medication that impairs wound healing (e.g., bisphosphonates, steroids, chemotherapy, radiotherapy etc.)","75 Years",{"count":125,"type":22},12,"The goal of this study is to evaluate bone wound healing following extraction and alveolar ridge preservation (bone graft and membrane) clinically, histologically and in relation to gene expression in smokers and non-smokers. Data from a small group of participants will be analyzed after age-matched subjects undergo extraction and alveolar ridge preservation prior to implant placement. The data obtained in this pilot study will be used to plan a full-fledged study involving a larger number of smoking and non-smoking participants to compare the two groups.",[128,30,129,130,29],"Smoking, Cigarette","Wound Healing","Bone Healing","2026-01-20",{"date":133,"type":45},"2026-01-28",{"date":135,"type":22},"2026-01-25",{"date":137,"type":22},"2028-10-01",{"name":139,"class":52},"Marquette University",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":123,"enrollmentInfo":146,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":148,"conditions":149,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":53},"100564116","determinants-of-bone-dimensional-changes-after-extraction-and-alveolar-ridge-preservation-100564116","NCT06624982","Determinants of Bone Dimensional Changes After Extraction and Alveolar Ridge Preservation","Inclusion Criteria:\n\n* Adult patients (18-75 years)\n* Good general health (controlled conditions)\n* Controlled periodontal disease\n* Scheduled for single tooth extraction with bone graft placement and resorbable membrane\n* Tooth to be extracted must have adjacent teeth\n* Socket wall integrity\n\nExclusion Criteria:\n\n* Smoking\n* Pregnancy\n* Active periodontal disease\n* Systemic conditions that affect healing\n* Lack of socket wall integrity (bone loss ≥50 %) prior to extraction, teeth with severe infection requiring pre-extraction antibiotic treatment to control infection), and contraindications for tooth extraction.",{"count":147,"type":22},160,"The main purpose of the study is to measure and localize immediate post extraction changes i.e. socket expansion versus no width change along the socket wall and identify whether the immediate post-extraction ridge width condition (expansion or no change) is a determinant of buccolingual ridge width and height changes 4 months following extraction and ridge preservation.",[30,130,29,129],"2025-11-13",{"date":152,"type":45},"2025-11-17",{"date":154,"type":45},"2025-10-08",{"date":156,"type":22},"2027-10-01",{"name":139,"class":52},{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":164,"eligibilityCriteria":165,"healthyVolunteers":17,"sex":18,"minAge":166,"maxAge":167,"enrollmentInfo":168,"targetDuration":4,"studyType":23,"phases":170,"briefSummary":171,"conditions":172,"keywords":173,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":53},"100577255","use-of-particulate-cortico--cancellous-anterior-iliac-graft-with-periosteum-membrane-in-unilateral-alveolar-cleft-grafting-versus-particulate-cortico-cancellous-anterior-iliac-grafting-alone-100577255","NCT06795919","Use of Particulate Cortico- Cancellous Anterior Iliac Graft with Periosteum Membrane in Unilateral Alveolar Cleft Grafting Versus Particulate Cortico-cancellous Anterior Iliac Grafting Alone.","Use of Particulate Cortico- Cancellous Anterior Iliac Graft with Periosteal Membrane in Treatment of Unilateral Alveolar Cleft Grafting Versus Particulate Cortico-cancellous Anterior Iliac Grafting Alone a Randomized Clinical Trial","periosteum","Inclusion Criteria:\n\n* 9 -12 years, depending on dental age not chronological.\n* systemically healthy patients (American Society of Anesthesiologists -ASA I and II)\n* Patients secondary alveolar cleft patient.\n\nExclusion Criteria:\n\n* Patients with recurrent palatal fistula.\n* Existence of syndromic cleft palate.\n* Patient with uncontrolled systematic disease.\n* Patients undergoing radiotherapy or chemotherapy for malignancy.","9 Years","12 Years",{"count":169,"type":22},20,[101],"In the past few years, periosteal membrane has been used in orthopedic surgery as well as periodontal surgery as a mechanism to promote bone healing without the ingrowth of fibrous tissues. It has shown its efficiency in maintaining the bone volume and density in postoperative follow up. This can in turn solve the problem of potential bone loss in patients of alveolar cleft.\n\nThe study aims to see if fixing the periosteum of the anterior ilium with tacks after bone graft application in the donor site will help maintain the graft and promote healing for the alveolar cleft patients",[30],[174,175,176,177],"alveolar cleft","alveolar cleft bone graft","periosteum membrane","anterior ilium bone graft","2025-01-21",{"date":180,"type":45},"2025-01-28",{"date":182,"type":22},"2025-03",{"date":184,"type":22},"2026-12",{"name":186,"class":52},"Nesma Mattar"]