[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"alveolar-bone-loss\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:alveolar-bone-loss":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,26,0,25,[9,45,81,109,135,166,194,220,241,272,305,330,358,384,404,428,457,480,509,538,558,580,605,627,648],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100626260","alveolar-ridge-preservation-arp-in-the-posterior-maxilla-after-the-extraction-of-maxillary-molars-100626260",false,"NCT07433322","Alveolar Ridge Preservation (ARP) in the Posterior Maxilla After the Extraction of Maxillary Molars","Alveolar Ridge Preservation (ARP) in the Posterior Maxilla: A Clinical and Economic Evaluation of ARP After the Extraction of Maxillary Molars","Inclusion Criteria:\n\n* Intact or \\\u003C5mm dehiscence buccally and palatally\n* Initial residual bone height (RBH) of at least 6 mm. 3-A minimum distance of 1 mm between root apices and sinus membrane.\n\nExclusion Criteria\n\n* Medically compromised\n* heavy smokers\n* young (\\\u003C18 yrs.) or those refusing treatment are excluded.","ALL","18 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","Dental implants are a fixed replacement solution with reported long-term survival rates between 94-98% over 20-40 years. In order to ensure successful implant therapy, adequate bone and soft tissue as well as correct 3D positioning of the implant are required. Upon extraction of a tooth, socket width can decrease by up to 60% within six months post-extraction, with a 11-22% vertical reduction. Additionally, sinus pneumatization occurs post-extraction as the maxillary sinus expands into the empty socket due to disuse atrophy and intra-sinus air pressure, as explained by Wolff's law. This further reduces residual bone height (RBH), often resulting in posterior maxillary sites requiring supplemental procedures to prevent bone loss or to augment the bone height at the time of implant placement. However, if the bone height and width dimensions are sufficient before and after extraction - in that, even with the aforementioned loss in width and height percentages in the latter, a standard implant may still be placed in the surrounding bone, one can argue that grafting may not be necessarily done at the time of extraction. Rather, it can be tailored to the patients' needs; thus potentially reducing overall post-operative discomfort and pain.",[27],"Alveolar Bone Loss",[29,30,31],"Dental Implant","Alveolar Ridge Preservation (ARP)","Maxilla","RECRUITING","2026-06-25",{"date":35,"type":36},"2026-06-26","ACTUAL",{"date":38,"type":21},"2026-06",{"date":40,"type":21},"2028-04",{"name":42,"class":43},"Virginia Commonwealth University","OTHER",1,{"id":46,"slug":47,"hasResults":12,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":44},"100643193","early-phase-1-assessment-of-the-impact-of-neocement-inject-p-beta-tricalcium-phosphate-on-bone-volume-in-alveolar-ridge-preservation-after-tooth-extraction-100643193","NCT07638319","Assessment of the Impact of Neocement Inject P® (Beta-Tricalcium Phosphate) on Bone Volume in Alveolar Ridge Preservation After Tooth Extraction","Assessment of Safety and Performance of Neobone®: A Prospective Observational Study in the Field of Dentistry","BTCPARPBV","Inclusion Criteria:\n\n* 18 years or older\n* Acceptance of informed consent\n* Type 1 or 2 extraction sockets (Elian et al. 2007)\n\nExclusion Criteria:\n\n* Presence of active infection or severe inflammation in the intervention zone\n* Relevant medical history that contraindicates implant surgery\n* Patients with poor oral hygiene (full-mouth plaque score and full-mouth bleeding score \\>15%) and lack of motivation\n* Uncontrolled diabetes (reported levels of glycated haemoglobin exceeding 7%)\n* Uncontrolled and \u002For untreated periodontal disease\n* Heavy smokers (more than 10 cigarettes per day)\n* Immunosuppression",true,{"count":55,"type":21},30,[57],"EARLY_PHASE1","The goal of this randomized clinical trial is to assess whether β-TCP (Beta-Tricalcium Phosphate) improves alveolar ridge preservation (ARP) in patients who need tooth extraction. The main question it aims to answer is whether using β-TCP for alveolar ridge preservation has a positive effect on bone volume compared with natural healing.\n\nThe main questions it aims to answer are:\n\nDoes β-TCP improve ridge preservation compared with natural healing?\n\nResearchers will compare β-TCP grafted sockets to natural healing sockets to see if β-TCP better preserves ridge volume.\n\nParticipants will:\n\nHave a tooth indicated for extraction.\n\nBe assigned to either β-TCP or natural healing.\n\nUndergo CBCT (Cone Beam Computed Tomography) and intra-oral scanning after extraction and after six months of healing to measure horizontal and vertical resorption and bone density.",[60,61,62,27],"Tooth Extraction","Tooth Extraction Site Healing","Alveolar Bone Grafting",[64,65,66,67,68,69,70,71],"Beta-tricalcium phosphate","Alveolar ridge preservation","Bone volume","Implant site development","Socket preservation","Ridge augmentation","Tooth extraction","Volumetric Changes","2026-06-09",{"date":74,"type":36},"2026-06-11",{"date":76,"type":36},"2025-12-01",{"date":78,"type":21},"2028-12",{"name":80,"class":43},"Egas Moniz - Cooperativa de Ensino Superior, CRL",{"id":82,"slug":83,"hasResults":12,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":44},"100640921","effect-of-collagen-membrane-on-ridge-preservation-100640921","NCT07580495","Effect of Collagen Membrane on Ridge Preservation","Effect of Collagen Membrane on Ridge Preservation for Delayed Implant Placement in Sites With Absent Buccal Bone Wall: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18-80\n* Indicated for extraction of a single-rooted maxillary tooth\n* ≥ 50% buccal bone dehiscence confirmed by CBCT reconstructions\n* Presence of both adjacent teeth\n* No interproximal bone loss\n* ASA I-II health status\n* Ability to comply with required procedures, including attending required number of clinic visits\n\nExclusion Criteria:\n\n* Patients diagnosed with periodontitis adjacent to the area to be treated\n* History of allergic reactions to local anesthetics or bone graft material (self-reported);\n* Current heavy smokers (≥ 10 cigarettes\u002Fday) or those who quit smoking recently (self-reported; last 6 months);\n* Diagnosis of diabetes mellitus, liver or kidney failure (self-reported);\n* Presence of active infectious diseases of any kind;\n* History of chemotherapy or radiation therapy to the head or neck within the past 5 years (self-reported);\n* Severe hematologic disorders (risk for hemorrhage)(self-reported);\n* Assumption of corticosteroids, IV bisphosphonates or immunosuppressive drugs;\n* Any history of alcohol or drug abuse (self-reported);\n* Pregnancy or plans to become pregnant within 4 months of study enrollment (self-reported);","80 Years",{"count":55,"type":21},[24],"This study will evaluate whether adding a resorbable collagen membrane to an anorganic bone-collagen composite (ABCC) graft improves ridge preservation after tooth extraction. Ridge preservation is a procedure used to maintain the shape and volume of the jawbone following tooth removal, which is important for future dental implant placement.\n\nParticipants will be randomly assigned to receive either ABCC alone or ABCC combined with a collagen membrane. Healing outcomes will be assessed after approximately 4 months using three-dimensional cone beam computed tomography (CBCT) scans.\n\nThe primary outcome is the change in horizontal ridge dimension (width). Secondary outcomes include vertical and contour changes in ridge dimensions, changes in soft tissue contour assessed with digital scans, postoperative healing and complications (such as wound dehiscence, swelling, or infection), and patient-reported outcomes, including pain and satisfaction. In a subset of participants, bone healing will also be evaluated using laboratory and imaging analyses of bone samples obtained at the time of implant placement. The study will additionally assess whether the treatment allows implant placement in the ideal position without the need for further bone grafting.",[93,60,27],"Dehiscence",[95,96,97,98,99],"Ridge preservation","Collagen membrane","Socket grafting","Buccal bone loss","Delayed implant placement","2026-06-02",{"date":102,"type":36},"2026-06-04",{"date":104,"type":36},"2026-05-26",{"date":106,"type":21},"2027-10-31",{"name":108,"class":43},"Debora Dias",{"id":110,"slug":111,"hasResults":12,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":22,"phases":118,"briefSummary":119,"conditions":120,"keywords":121,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":44},"100630208","reduced-time-interval-for-implant-placement-after-extraction-socket-preservation-using-the-vega-plus-implants-100630208","NCT07484685","Reduced Time Interval for Implant Placement After Extraction Socket Preservation Using the Vega Plus Implants","Effect of Reducing the Time Interval for Implant Placement After Extraction Socket Preservation Using the Vega Plus Implant System (Klockner): A Randomized Controlled Clinical Trial","RIP-VEGA","Inclusion Criteria:\n\n* Age: ≥ 18 years.\n* Good general health.\n* Need of extraction of incisors, canines or premolars due to carious lesion, endodontic complication, root fracture or prosthetic reason.\n* Presence of three intact socket walls after tooth extraction with a defect of 50% or more of the buccal wall.\n* Need of single-tooth implant treatment, with presence of adjacent teeth and opposing occluding teeth (for measurement stent indexing).\n* Enough available bone assessed on CBCT to place implants with 3.6 mm diameter and 10 mm in length.\n* Periodontal health in intact or reduced periodontium.\n* Full-mouth plaque and bleeding scores \\\u003C 20%.\n* Able and willing to follow study procedures and instructions.\n\nExclusion Criteria:\n\n* \\\u003C 18 years.\n* Compromised health. Existence of any systemic condition such as uncontrolled diabetes mellitus, cancer, HIV, disorders that compromise wound healing, chronic high dose steroid therapy, intravenous and oral bisphosphonate therapy, bone metabolic diseases, history of irradiation of the head and neck area, or any other immunosuppressive therapy that would contraindicate oral surgical treatment.\n* Absence of any adjacent teeth or the opposing occluding teeth.\n* The hopeless tooth is a molar.",{"count":20,"type":21},[24],"This randomized controlled clinical trial aims to evaluate whether reducing the healing interval for implant placement after extraction socket preservation improves clinical and radiographic outcomes compared with the conventional waiting period. Participants requiring single-tooth extraction and implant therapy will be randomly assigned to implant placement either 4 months or 6 months after ridge preservation using the Vega Plus implant system (Klockner).\n\nClinical and radiographic assessments will be performed at baseline and during follow-up visits. The primary outcome will be the mean change in horizontal alveolar ridge width measured using cone-beam computed tomography (CBCT). Secondary outcomes will include vertical bone height changes measured on CBCT, implant stability measured using resonance frequency analysis (ISQ values), marginal bone level changes assessed on standardized periapical radiographs, and postoperative pain assessed using the Visual Analog Scale (VAS).\n\nThe results of this study may contribute to optimizing treatment timing and improving efficiency in implant dentistry while maintaining favorable clinical outcomes.",[27,60],[122,70,65,123,124,125],"Dental implant","Guided Bone Regeneration","Bone regeneration","Dental Implant Placement","2026-04-27",{"date":128,"type":36},"2026-05-01",{"date":130,"type":36},"2026-02-28",{"date":132,"type":21},"2027-02-27",{"name":134,"class":43},"Universidad Catolica Santiago de Guayaquil",{"id":136,"slug":137,"hasResults":12,"nctId":138,"briefTitle":139,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":22,"phases":142,"briefSummary":143,"conditions":144,"keywords":146,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":44},"100557075","the-application-of-a-biphasic-calcium-sulfate-graft-material-in-sinus-floor-elevation-100557075","NCT06533397","The Application of a Biphasic Calcium Sulfate Graft Material in Sinus Floor Elevation","Inclusion Criteria:\n\n* Patients over the age of 18 years,\n* Patients who need dental implant-borne prostheses,\n* Patients with insufficient bone height in the posterior maxilla due to sinus pneumatization.\n\nExclusion criteria:\n\n.• Patients who had major systemic diseases as classified by the American Society of Anesthesiologists (ASA grades III-IV),\n\n* psychiatric contraindications,\n* patients on medication interfering with bone metabolism, including steroid therapy and antiresorptive medication,\n* radiation to the head or neck region within the previous five years,\n* localized periapical disease, odontogenic and nonodontogenic cysts, and maxillary sinusitis,\n* evidence of uncontrolled periodontal disease,\n* Alcohol Use Disorder defined by the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5),\n* recreational drug abuse,\n* heavy smoking (\\>10 cigarettes\u002Fday),\n* diseases of the oral mucosa, including blisters and ulcers, i.e.: red and white lesions, pigmented lesions, benign tumors of the oral cavity, and oral cancer. Leukoplakia, Erythroplakia, Precancerous lesions, Oral squamous cell carcinoma and malign tumors of the soft and hard tissues, Oral candidiasis, Oral lichen planus, Psoriasis, Pemphigus, and Pemphigoid.\n* pregnancy or nursing,\n* poor oral hygiene",{"count":20,"type":21},[24],"Pneumatization of the maxillary sinus may lead to insufficient bone volume for dental implant placement in the edentulous posterior maxilla. Sinus floor elevation (SFE) surgery with the lateral window technique is a safe and predictable surgical intervention to restore bone height in the maxillary premolar and molar areas. According to the literature, several bone graft materials may be successfully applied for SFE surgery. There is a lack of evidence regarding the application of biphasic calcium sulfate (BCS) for SFE. The healing period following staged SFE is 2-9 months.\n\nThe aim of this study is:\n\n* to evaluate the success of SFE surgery using BCS as graft material,\n* to compare the microarchitecture of the augmented bone depending on the healing period,\n* to evaluate the success of dental implants placed in the augmented bone and that of the prostheses delivered on the dental implants.",[27,145],"Edentulism Nos",[147,148,149,150,151,152,153,154,155,156],"bone graft material","biphasic calcium sulfate","sinus floor elevation","sinus lift","maxillary sinus augmentation","microcomputed tomography","cone beam computed tomography","histology","histomorphometry","dental implant","2026-04-21",{"date":159,"type":36},"2026-04-24",{"date":161,"type":36},"2024-08-24",{"date":163,"type":21},"2031-09",{"name":165,"class":43},"Semmelweis University",{"id":167,"slug":168,"hasResults":12,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":172,"eligibilityCriteria":173,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":174,"targetDuration":4,"studyType":22,"phases":176,"briefSummary":177,"conditions":178,"keywords":180,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":44},"100633040","evaluation-of-guided-tissue-regeneration-with-autogenous-bone-chips-and-cgf-during-implant-placement-100633040","NCT07521514","Evaluation of Guided Tissue Regeneration With Autogenous Bone Chips and CGF During Implant Placement","Clinical and Radiographic Evaluation of Guided Tissue Regeneration Using Autogenous Bone Chips and Concentrated Growth Factors Membranes With Simultaneous Implant Placement. (Case Series)","CGF","inclusion criteria:\n\n* A medical history that contraindicates oral surgical treatment such as (uncontrolled\u002Funtreated diabetes mellitus, immuno-compromised status, radio or chemotherapy of the oral and maxillofacial region, treatment with oral and\u002For intravenous bisphosphonates).\n* Presence of active or untreated periodontal disease.\n* Vertical root fractures involving the buccal aspect.\n* Tooth \u002Fteeth with horizontal fractures below bone level.\n* Tooth \u002Fteeth with external or internal resorption.\n* Patients with destructive oral habits such as smoking, chewing tobacco, bruxism,etcetera(Chrcanovic et al., 2014).\n\nexclusion criteria: A medical history that contraindicates oral surgical treatment such as (uncontrolled\u002Funtreated diabetes mellitus, immuno-compromised status, radio or chemotherapy of the oral and maxillofacial region, treatment with oral and\u002For intravenous bisphosphonates).\n\n* Presence of active or untreated periodontal disease.\n* Vertical root fractures involving the buccal aspect.\n* Tooth \u002Fteeth with horizontal fractures below bone level.\n* Tooth \u002Fteeth with external or internal resorption.\n* Patients with destructive oral habits such as smoking, chewing tobacco, bruxism, etcetera(Chrcanovic et al., 2014).",{"count":175,"type":21},8,[24],"CGF membranes will be prepared using a swing-lock centrifuge. A full-thickness mucoperiosteal flap will be elevated in a narrow alveolar ridge. Implants will be inserted. Autologous bone chips will be harvested via bone scraping and used for augmentation, CGF membranes will be placed over the grafted area. Suturing of the mucoperiosteal flap. Radiographic evaluation of the bone density and tissue thickness will be performed by CBCT preoperatively, immediate postoperative and after the procedure by 4 months. Clinical evaluation of the tissue thickness using periodontal probe preoperatively, immediate postoperatively and after the procedure by 4 months",[27,179,29],"Alveolar Ridge Augmentation",[172,181,182,156,183],"autogenous bone graft","gingival biotype","guided tissue regeneration","NOT_YET_RECRUITING","2026-04-08",{"date":187,"type":36},"2026-04-13",{"date":189,"type":21},"2026-04-16",{"date":191,"type":21},"2026-10",{"name":193,"class":43},"Cairo University",{"id":195,"slug":196,"hasResults":12,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":172,"eligibilityCriteria":200,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":201,"targetDuration":4,"studyType":22,"phases":203,"briefSummary":204,"conditions":205,"keywords":210,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":214,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":44},"100632964","immediate-implant-placement-using-socket-shield-with-cgf-100632964","NCT07520526","Immediate Implant Placement Using Socket Shield With CGF","Clinical and Radiographic Evaluation of Concentrated Growth Factors With Simultaneous Immediate Implant Placement in Socket Shield Technique","Inclusion Criteria:\n\n* Age ≥18 years old. (Younis, W., \\& El-Rashidy, A. 2020).\n* Both male and female patients.\n* Maxillary, anterior and premolar segment.\n\nExclusion Criteria:\n\n* A medical history that contraindicates oral surgical treatment such as (uncontrolled\u002Funtreated diabetes mellitus, immuno-compromised status, radio or chemotherapy of the oral and maxillofacial region, treatment with oral and\u002For intravenous bisphosphonates).\n* Presence of active or untreated periodontal disease.\n* Vertical root fractures involving the buccal aspect.\n* Tooth \u002Fteeth with horizontal fractures below bone level.\n* Tooth \u002Fteeth with external or internal resorption.\n* Patients with destructive oral habits such as smoking, chewing tobacco, bruxism, etcetera.",{"count":202,"type":21},7,[24],"This prospective case series study aims to clinically and radiographically evaluate the effectiveness of the socket shield technique combined with concentrated growth factors (CGF) in immediate implant placement in the esthetic zone. Outcomes will include crestal bone level changes assessed by CBCT and implant stability measured using Osstell.",[206,207,208,209,27],"Socket Shield Technique","Concentrated Growth Factors","Immediate Dental Implant Placement","Alveolar Bone Preservation",[211,212,213],"Socket shield technique","immediate implants","concentrated growth factor",{"date":187,"type":36},{"date":216,"type":21},"2026-04-01",{"date":218,"type":21},"2026-12-30",{"name":193,"class":43},{"id":221,"slug":222,"hasResults":12,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":172,"eligibilityCriteria":226,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":22,"phases":228,"briefSummary":229,"conditions":230,"keywords":233,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":236,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":240,"locationsCount":44},"100632963","socket-shield-technique-with-cgf-and-xenograft-for-immediate-implants-100632963","NCT07520513","Socket Shield Technique With CGF and Xenograft for Immediate Implants","Clinical and Radiographic Evaluation of Bone Grafting Using Concentrated Growth Factors and Xenograft With Simultaneous Immediate Implant Placement in Socket Shield Technique","Inclusion criteria:\n\n* Age ≥18 years old. (Younis, W., \\& El-Rashidy, A. 2020).\n* Both male and female patients.\n* Maxillary, anterior and premolar segments.\n\nExclusion Criteria:\n\n* A medical history that contraindicates oral surgical treatment such as (uncontrolled\u002Funtreated diabetes mellitus, immuno-compromised status, radio or chemotherapy of the oral and maxillofacial region, treatment with oral and\u002For intravenous bisphosphonates).\n* Presence of active or untreated periodontal disease.\n* Vertical root fractures involving the buccal aspect.\n* Tooth \u002Fteeth with horizontal fractures below bone level.\n* Tooth \u002Fteeth with external or internal resorption.\n* Patients with destructive oral habits such as smoking, chewing tobacco, bruxism, etcetera.",{"count":202,"type":21},[24],"This prospective case series aims to evaluate the clinical and radiographic outcomes of immediate implant placement using the socket shield technique combined with concentrated growth factors (CGF) and xenograft in the esthetic zone. The study will assess crestal bone level changes and implant stability over a 6-month follow-up period.",[27,206,231,208,207,232,209],"Bone Resorption","Xenograft",[212,234,235,232],"socket shield technique","Concentrated growth factor",{"date":187,"type":36},{"date":238,"type":21},"2026-04-05",{"date":218,"type":21},{"name":193,"class":43},{"id":242,"slug":243,"hasResults":12,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":4,"eligibilityCriteria":247,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":248,"targetDuration":250,"studyType":251,"phases":4,"briefSummary":252,"conditions":253,"keywords":258,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":44},"100633395","impact-of-alveolar-ridge-preservation-on-the-potential-need-for-sinus-floor-elevation-a-10-year-retrospective-radiographical-study-100633395","NCT07526129","Impact of Alveolar Ridge Preservation on the Potential Need for Sinus Floor Elevation: A 10-year Retrospective Radiographical Study","Impact of Alveolar Ridge Preservation on the Potential Need for Sinus Floor Elevation in Posterior Maxillary Implant Sites: A 10-year Retrospective Radiographical Study","Inclusion Criteria:\n\n* • Patients aged ≥18 years.\n\n  * Patients who underwent alveolar ridge preservation after extraction of maxillary posterior teeth, as a test group.\n  * Patients who underwent extraction of maxillary posterior teeth with unassisted socket healing without alveolar ridge preservation as a control group.\n\nExclusion Criteria:\n\n* • The presence of a clinically symptomatic periapical radiolucency, acute abscesses, or chronic sinus tract, that may falsify the classification of posterior maxillary teeth on 2D radiographs.",{"count":249,"type":21},130,"12 Months","OBSERVATIONAL","This research aims to investigate the influence of alveolar ridge preservation, after extraction of maxillary posterior teeth, on the potential need of sinus floor augmentation procedures (that include lateral or crestal sinus augmentations). From peri-apical radiographs, maxillary posterior teeth will be divided into 4 groups according to the relationship of their apexes with the sinus. Then, the patients will be divided into 2 sub-groups: unassisted socket healing (only extraction) and ARP group (extraction + ARP) and their CBCT scans before implant placement will be collected. The CBCT scans should be at least 4 months post-extraction and ARP. Depending on the residual bone height, patients will be divided into 3 categories, according to the ABC classification:\n\n1. In need of lateral sinus floor augmentation\n2. In need of crestal sinus floor augmentation\n3. No need for sinus floor augmentation, therefore, implant placement.\n\nThese divisions will be conducted, according to:\n\n\\- The residual bone height (RBH) which is the height in mm from the alveolar ridge crest to the lowest point of the maxillary sinus floor.\n\nThe results of the proposed hypothesis are verified and interpreted after statistical analysis.",[27,254,255,256,257],"Sinus Floor Augmentation","Sinus Pneumatization","Alveolar Bone Atrophy","Alveolar Ridge Preservation",[259,260,261,262,263],"alveolar bone loss","alveolar process atrophy","extraction","tooth socket","sinus floor augmentation","2026-04-06",{"date":187,"type":36},{"date":267,"type":36},"2025-01-01",{"date":269,"type":21},"2026-05-30",{"name":271,"class":43},"Saint-Joseph University",{"id":273,"slug":274,"hasResults":12,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":278,"eligibilityCriteria":279,"healthyVolunteers":53,"sex":17,"minAge":280,"maxAge":281,"enrollmentInfo":282,"targetDuration":4,"studyType":22,"phases":283,"briefSummary":286,"conditions":287,"keywords":289,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":44},"100632003","phase-1-evaluation-of-stem-cell-exosomes-versus-platelet-rich-fibrin-in-tooth-extraction-socket-healing-100632003","NCT07508033","Evaluation of Stem Cell Exosomes Versus Platelet-Rich Fibrin in Tooth Extraction Socket Healing","Evaluation of Mesenchymal Stem Cell-Derived Exosomes Versus Platelet-Rich Fibrin (PRF) in Post-Extraction Socket Healing: A Randomized Controlled Clinical Trial.","MSC-EXO vs PRF","Inclusion Criteria:\n\n* Patients aged between 20 and 45 years.\n* Patients requiring a single tooth extraction of a non-infected tooth in the aesthetic zone (incisors, canines) or premolar area.\n* Presence of adjacent teeth to the extraction site.\n* Adequate oral hygiene (Plaque Index \\\u003C 20%).\n* Patients willing and able to comply with the follow-up schedule and 3-month CBCT scan.\n* Signed informed consent provided by the participant.\n\nExclusion Criteria:\n\n* Patients with systemic diseases that contraindicate oral surgery or interfere with bone healing (e.g., uncontrolled diabetes, osteoporosis, hyperparathyroidism).\n* History of head and neck radiation therapy or bisphosphonate medication use.\n* Active infection or acute abscess at the extraction site.\n* Heavy smokers (more than 10 cigarettes per day).\n* Pregnant or lactating women.\n* Patients with poor oral hygiene or active periodontal disease in the rest of the mouth.\n* Use of any medications known to affect bone metabolism (e.g., long-term corticosteroids).","20 Years","45 Years",{"count":20,"type":21},[284,285],"PHASE1","PHASE2","This study evaluates two different treatments used to help the jawbone heal after a tooth is removed. When a tooth is extracted, the surrounding bone often shrinks, which can make it difficult to place dental implants later. Currently, doctors often use Platelet-Rich Fibrin (PRF), which is made from the patient's own blood, to help the area heal.\n\nThis research compares PRF to a newer treatment using \"exosomes\" derived from stem cells. Exosomes are tiny particles that carry signals to tell the body to repair tissue and grow new bone. The goal of this study is to see if these exosomes work better than PRF at keeping the bone strong and thick after an extraction. Researchers will use specialized X-rays (CBCT) to measure the bone three months after the procedure to see which treatment provided better results.",[27,60,288],"Bone Regeneration",[290,291,257,292,293,294,295],"MSC-derived Exosomes","Platelet-Rich Fibrin (PRF)","Socket Grafting","Cone-Beam Computed Tomography (CBCT)","Stem Cell Secretome","Bone Density","2026-03-27",{"date":298,"type":36},"2026-04-02",{"date":300,"type":36},"2026-01-15",{"date":302,"type":21},"2026-08-01",{"name":304,"class":43},"Al Salam University",{"id":306,"slug":307,"hasResults":12,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":4,"eligibilityCriteria":311,"healthyVolunteers":53,"sex":17,"minAge":312,"maxAge":313,"enrollmentInfo":314,"targetDuration":4,"studyType":22,"phases":315,"briefSummary":316,"conditions":317,"keywords":318,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":44},"100551229","demineralized-dentin-allograft-versus-demineralized-dentin-autograft-for-socket-preservation-100551229","NCT06457373","Demineralized Dentin Allograft Versus Demineralized Dentin Autograft for Socket Preservation","The Demineralized Dentin Allograft Versus Demineralized Dentin Autograft for Socket Preservation After Surgical Extraction of Impacted Mandibular Third Molar","Inclusion Criteria:\n\n1. Patients aged between 25 to 35 years old.\n2. Patients scored as (ASA I).\n3. No adverse habits such as smoking, tobacco chewing, alcohol.\n4. Patients having bilaterally impacted mandibular third molar with similar degree of difficulty according to (Kim JY, et al).\n5. The recipient alveolar sockets are free of any pre-existing periapical pathology, based on x-ray.\n6. Alveolar sockets with a depth of 5 mm or more, using periodontal probe for assessment.\n7. Patients sign a consent for all procedures.\n\nExclusion Criteria:\n\n* 1\\) Pregnant or lactating patients. 2) Relevant systemic diseases. 3) Patients with history of chemotherapy or radiotherapy.","25 Years","35 Years",{"count":20,"type":21},[24],"This study is designed to evaluate and compare clinically and radiographically the effectiveness of Demineralized Dentin Allograft (DDA) versus Demineralized Dentin Autograft (Auto-DD) for preservation of alveolar ridge dimensions after surgical extraction of the impacted mandibular third molar.",[27],[68,319,320],"Impacted mandibular third molar","Alveolar ridge Augmentation","2026-03-08",{"date":323,"type":36},"2026-03-11",{"date":325,"type":21},"2026-07-01",{"date":327,"type":21},"2027-07-30",{"name":329,"class":43},"Horus University",{"id":331,"slug":332,"hasResults":12,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":336,"eligibilityCriteria":337,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":338,"targetDuration":4,"studyType":22,"phases":340,"briefSummary":341,"conditions":342,"keywords":344,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":350,"startDateStruct":352,"completionDateStruct":354,"leadSponsor":356,"locationsCount":44},"100628318","immediate-implant-placement-with-autogenous-maxillary-tuberosity-graft-in-the-esthetic-zone-100628318","NCT07460076","Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone","Clinical and Esthetic Outcomes of Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone: A Prospective Case Series","TUBERO-IMPLANT","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Patients requiring single implant placement in the maxillary esthetic zone\n* Indication for immediate implant placement following tooth extraction\n* Presence of a buccal bone defect requiring augmentation with an autogenous maxillary tuberosity bone graft\n* Adequate oral hygiene and ability to maintain postoperative care\n* Willingness to participate in the study and provide informed consent\n\nExclusion Criteria:\n\n* Uncontrolled sHistory of radiotherapy in the head and neck region ystemic diseases\n* History of radiotherapy in the head and neck region\n* Active periodontal disease or untreated oral infection\n* Heavy smoking (more than 10 cigarettes per day)\n* Pregnancy or lactation\n* Severe parafunctional habits\n* Insufficient bone volume preventing implant placement with the planned protocol\n* Patients unable to attend follow-up visits",{"count":339,"type":21},15,[24],"Immediate implant placement in the esthetic zone is often associated with buccal bone deficiency, which may compromise esthetic outcomes and long-term implant stability. Autogenous bone graft harvested from the maxillary tuberosity provides corticocancellous bone with favorable biological properties and may help reconstruct the buccal bone plate during immediate implant placement.\n\nThis prospective case series aims to evaluate the clinical and esthetic outcomes of immediate implant placement combined with autogenous maxillary tuberosity graft in the esthetic zone. The primary outcomes include buccal bone thickness measured on cone-beam computed tomography (CBCT), facial soft tissue thickness measured clinically, and the pink esthetic score (PES) after implant restoration.",[27,343],"Esthetic Zone Implant Rehabilitation",[345,346,347,29,348],"Immediate Implant Placement","Maxillary Tuberosity Graft","Autogenous Bone Graft","Pink Esthetic Score","2026-03-04",{"date":351,"type":36},"2026-03-10",{"date":353,"type":36},"2026-01-01",{"date":355,"type":21},"2026-11",{"name":357,"class":43},"University of Medicine and Pharmacy at Ho Chi Minh City",{"id":359,"slug":360,"hasResults":12,"nctId":361,"briefTitle":362,"officialTitle":363,"acronym":4,"eligibilityCriteria":364,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":365,"targetDuration":4,"studyType":22,"phases":366,"briefSummary":367,"conditions":368,"keywords":370,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":44},"100627528","assessment-of-labial-plate-thickness-after-immediate-implant-placement-using-two-different-xenografts-in-the-esthetic-zone-100627528","NCT07449806","Assessment of Labial Plate Thickness After Immediate Implant Placement Using Two Different Xenografts in the Esthetic Zone","Assessment of Labial Plate Thickness After Immediate Implant Placement in Type II Extraction Sockets Using Two Different Xenografts in the Esthetic Zone: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients with one or more non-restorable teeth or remaining roots without signs of acute infection in the maxillary anterior region.\n* Type II extraction sockets.\n* Sufficient bone (\\>3 mm) apically and palatally to allow for proper implant positioning with sufficient primary stability (≥ 30 N cm).\n* Good compliance.\n\nExclusion Criteria:\n\n* Teeth with current acute periapical infection.\n* Medically compromised patients.\n* Heavy smokers (smoking of more than 10 cigarettes per day ).\n* Alcohol or drug abuse.\n* Patients undergoing chemotherapy and radiotherapy.\n* Poor oral hygiene.\n* Vulnerable groups (pregnant females and decision- impaired individual).",{"count":5,"type":21},[24],"This randomized clinical trial aims to evaluate labial bone plate changes following immediate implant placement in Type II extraction sockets using two different xenograft materials and de-epithelialized free gingival graft in the esthetic zone . Patients requiring extraction and immediate implant placement will be randomly allocated into two groups according to the xenograft material used for defect grafting. Clinical and radiographic outcomes will be assessed to determine dimensional bone changes and implant success",[27,369,345],"Tooth Extraction Status Nos",[371,372,373,374,375],"immediate implant placement","type II extraction socket","esthetic zone.","xenograft","randomized controlled clinical trial",{"date":377,"type":36},"2026-03-06",{"date":379,"type":36},"2025-09-05",{"date":381,"type":21},"2026-09-25",{"name":383,"class":43},"Basma Gamal Mohamed Ahmed",{"id":385,"slug":386,"hasResults":12,"nctId":387,"briefTitle":388,"officialTitle":388,"acronym":389,"eligibilityCriteria":390,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":391,"targetDuration":4,"studyType":22,"phases":392,"briefSummary":393,"conditions":394,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":395,"lastUpdatePostDateStruct":396,"startDateStruct":398,"completionDateStruct":400,"leadSponsor":402,"locationsCount":44},"100625179","comparison-of-customized-allogenic-versus-autogenous-bone-block-graft-for-alveolar-ridge-augmentation-100625179","NCT07419269","Comparison of Customized Allogenic Versus Autogenous Bone Block Graft for Alveolar Ridge Augmentation","IndiALLO","INCLUSION CRITERIA\n\n* 1-4 missing teeth that need to be replaced with dental implants\n* Bone ridge width insufficient for dental implant placement; \\\u003C5 mm of width as measured in a cone beam computed tomography at the ideal prosthetic position\n* Medically healthy with no known allergies to antibiotics\n* Non-smoker or light smoker (\\\u003C 10) or previous smoker who had quit for 5 years or more\n* Periodontal health, as confirmed by clinical examination (Full mouth bleeding score and full mouth plaque score \\\u003C 25%) and at least one neighboring natural tooth to the defect site(s)\n* Age of 18 or above\n\nEXCLUSION CRITERIA\n\n* All contraindications against implant treatment or augmentative procedures (e.g., advanced systemic diseases, corticosteroid medication, immunodeficiency, pregnancy, intention to become pregnant, breastfeeding, lack of safe contraception)\n* Treatments or diseases that may have an effect on bone turnover or the bone itself or non-mineralized tissue metabolism (e.g., bisphosphonates or local radiotherapy, skeletal immaturity)\n* Pathological fractures such as those observed in (but not limited to) Paget's disease or in metastatic bone diseases\n* Any active malignancy or patient undergoing treatment for a malignancy Study protocol: IndiALLO Version 4\u002F19.03.2025 Page 9 von 32\n* Contraindications to the class of drugs under study, e.g., known hypersensitivity or allergy to class of drugs or the investigational product\n* Persistent compartment syndrome or neurovascular residua of compartment syndrome",{"count":5,"type":21},[24],"The aim of this study is to determine whether jawbone augmentations using allogeneic and autogenous bone blocks lead to comparable three-dimensional clinical and radiological outcomes.\n\nIn addition, the study seeks to investigate whether there are differences regarding safety, biocompatibility, complications, and PROMs.\n\nFurthermore, it aims to clarify whether differences exist between the two groups with respect to implant condition (one year after implantation and during annual follow-ups for up to five years).",[27],"2026-02-16",{"date":397,"type":36},"2026-02-18",{"date":399,"type":36},"2025-04-01",{"date":401,"type":21},"2032-08-01",{"name":403,"class":43},"Medical University of Graz",{"id":405,"slug":406,"hasResults":12,"nctId":407,"briefTitle":408,"officialTitle":409,"acronym":4,"eligibilityCriteria":410,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":411,"targetDuration":4,"studyType":251,"phases":4,"briefSummary":413,"conditions":414,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":419,"lastUpdatePostDateStruct":420,"startDateStruct":422,"completionDateStruct":424,"leadSponsor":426,"locationsCount":44},"100517411","ultrasound-for-socket-healing-evaluation-100517411","NCT06017193","Ultrasound for Socket Healing Evaluation","Ultrasonic Imaging of Bone Graft Healing in Extraction Sockets for Precise and Personalized Implant Therapy (HUM00226516)","Inclusion Criteria:\n\n* Patients at least 18 years of age and have at least a tooth that is considered hopeless, planned for an extraction and a bone grafting procedure for subsequent dental implant surgery.\n\nExclusion Criteria:\n\n* Patients not willing or not able to have an extraction, bone graft and subsequent implant surgery due to health, finance, or any other reasons.",{"count":412,"type":21},140,"The design is a single blinded, dual comparative study of ultrasound versus micro-CT\u002FLASCA in one study group. Up to a total of 140 subjects registered will be recruited. Subjects who are treatment planned for extraction of a hopeless tooth and socket augmentation with bone graft and are planned for a dental implant surgery. The socket will be evaluated before the extraction and multi-time points during healing until an implant is placed with various evaluation tools, including ultrasound.",[415,416,27,417,418],"Healing Wound","Alveolar; Wound","Image","Dent Disease","2025-10-30",{"date":421,"type":36},"2025-10-31",{"date":423,"type":36},"2024-07-25",{"date":425,"type":21},"2027-07-01",{"name":427,"class":43},"University of Michigan",{"id":429,"slug":430,"hasResults":12,"nctId":431,"briefTitle":432,"officialTitle":433,"acronym":434,"eligibilityCriteria":435,"healthyVolunteers":12,"sex":17,"minAge":280,"maxAge":436,"enrollmentInfo":437,"targetDuration":4,"studyType":22,"phases":439,"briefSummary":440,"conditions":441,"keywords":444,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":450,"startDateStruct":452,"completionDateStruct":454,"leadSponsor":455,"locationsCount":4},"100602617","efficacy-of-bioactive-glass-vs-xenograft-in-maxillary-sinus-augmentation-100602617","NCT07125846","Efficacy of Bioactive Glass vs. Xenograft in Maxillary Sinus Augmentation","Clinical, Radiographic and Histologic Assessment of the Efficacy of Bioactive Glass as a Novel Grafting Material in Maxillary Sinus Floor Augmentation: A Randomized Controlled Study","BIOXENO","Inclusion Criteria:\n\n* Patients requiring maxillary sinus floor augmentation for dental implant placement.\n* Residual alveolar bone height ≤ 4 mm in posterior maxilla (SA4 classification).\n* Age between 20 to 65 years.\n* Good general health and able to attend scheduled follow-up visits.\n* Signed written informed consent.\n\nExclusion Criteria:\n\n* Presence of systemic conditions that could affect bone healing (e.g., uncontrolled diabetes, osteoporosis).\n\nHistory of radiotherapy in the head and neck region.\n\n* Heavy smoking (more than 10 cigarettes\u002Fday).\n* Active sinus pathology or previous sinus surgery.\n* Pregnant or breastfeeding women.\n* Use of medications affecting bone metabolism (e.g., bisphosphonates or corticosteroids).\n* Poor oral hygiene or untreated periodontal disease.","65 Years",{"count":438,"type":21},20,[24],"This randomized controlled study aims to evaluate the clinical, radiographic, and histologic efficacy of using bioactive glass bone graft (UNIGRAFT by Biomed Inc., USA) compared to a conventional xenograft in maxillary sinus augmentation procedures. A total of 20 patients classified as SA4 according to the Misch classification will be enrolled and randomly allocated into two groups. Outcomes will be assessed using Cone Beam Computed Tomography (CBCT) for vertical bone gain and, where applicable, histologic analysis. The study is conducted at the Faculty of Dentistry, Suez Canal University.",[27,442,443],"Maxillary Sinus Disease","Tooth Loss",[445,446,232,447,448,29],"Maxillary Sinus Augmentation","Bioactive Glass","Sinus Lift","Bone Grafting","2025-08-14",{"date":451,"type":36},"2025-08-15",{"date":453,"type":21},"2025-10-15",{"date":216,"type":21},{"name":456,"class":43},"Suez Canal University",{"id":458,"slug":459,"hasResults":12,"nctId":460,"briefTitle":461,"officialTitle":462,"acronym":463,"eligibilityCriteria":464,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":465,"enrollmentInfo":466,"targetDuration":4,"studyType":22,"phases":468,"briefSummary":469,"conditions":470,"keywords":4,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":472,"startDateStruct":474,"completionDateStruct":476,"leadSponsor":478,"locationsCount":44},"100599086","alveolar-ridge-augmentation-using-minimally-invasive-subperiosteal-tunneling-with-xenogenic-bone-graft-and-prf-100599086","NCT07079917","Alveolar Ridge Augmentation Using Minimally Invasive Subperiosteal Tunneling With Xenogenic Bone Graft and PRF","Alveolar Ridge Augmentation Using Minimally Invasive Subperiosteal Tunneling With Xenogenic Bone Graft and Platelet-Rich Fibrin: Randomized Controlled Trial","MISTT","Inclusion Criteria:\n\n* Adults over 18 years old seeking an implant-supported restoration with deficient horizontal posterior maxillary alveolar ridge, at area of one or two missed teeth of less than 5 mm buccolingual width.\n* Minimum vertical height of 8 mm.\n* Gingival tissue of healthy adequate keratinization, more than 2mm.\n\nExclusion Criteria:\n\n* The presence of uncontrolled diabetes or any other systemic condition which may complicate the surgical procedure or interfere with bone healing\n* Radiotherapy to the head and neck region\n* Chemotherapy within the last 12 months\n* Uncontrolled periodontitis\n* Smoking\n* Bisphosphonate therapy\n* Pregnancy\n* Presence of periapical infection or lesion","60 Years",{"count":467,"type":21},16,[24],"surgical horizontal augmentation for maxillary alveolar ridge using minimally invasive subperiosteal tunneling in comparison to conventional surgical technique",[27],"2025-07-14",{"date":473,"type":36},"2025-07-23",{"date":475,"type":21},"2025-08-01",{"date":477,"type":21},"2026-06-21",{"name":479,"class":43},"Fayoum University",{"id":481,"slug":482,"hasResults":12,"nctId":483,"briefTitle":484,"officialTitle":484,"acronym":4,"eligibilityCriteria":485,"healthyVolunteers":53,"sex":17,"minAge":313,"maxAge":4,"enrollmentInfo":486,"targetDuration":4,"studyType":22,"phases":487,"briefSummary":488,"conditions":489,"keywords":493,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":501,"lastUpdatePostDateStruct":502,"startDateStruct":504,"completionDateStruct":506,"leadSponsor":507,"locationsCount":44},"100439112","phase-1-autogenous-mesenchymal-stem-cell-culture-derived-signalling-molecules-as-enhancers-of-bone-formation-in-bone-grafting-100439112","NCT04998058","Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting","Inclusion Criteria:\n\n* patients \\>35 years-old.\n* presenting highly atrophic fully edentulous maxilla (residual bone height \\\u003C5 mm).\n* In need of bilateral sinus floor augmentation aiming full mouth implant-supported rehabilitation.\n* having teeth extraction at least 8 weeks prior to bone augmentation.\n\nExclusion Criteria:\n\n* smokers, illicit drug users and alcohol daily consumers.\n* patients with metabolic and\u002For systemic diseases leading to impaired healing (e.g. decompensated diabetes, leukocyte or coagulation disorders, immunosuppression).\n* history of radiotherapy in the head or neck region.\n* bisphosphonate-based therapy recipients.\n* intolerant to general\u002Flocal anesthesia.",{"count":438,"type":21},[284,285],"This study aims to evaluate bone formation in grafts in terms of its quality (density), quantity (volume) and maturation obtained with the application of a tissue-engineered bone grafting compound containing concentrated autogenous cell-culture medium (CM) and a synthetic bone substitute. The present study was designed as an experimental prospective split-mouth randomized controlled clinical trial. After protocol approval by the Research Ethics Committee, a total of 20 consecutive participants in need of maxillary reconstruction aiming implant-supported oral rehabilitation will be invited to join the study. To collect autogenous adipose tissue-derived mesenchymal stem cells (hASCs), an outpatient lipoplasty procedure at the abdominal area of each patient will be performed. To isolate and expand hASCs from the lipoaspirate, specific cell culture protocols will be followed, resulting in cultured viable cells and their conditioned medium (CM). Cells and CM will be then separated by a sequence of filters and centrifugation, and isolated CM will be frozen. ELISA will analyze the presence of chemokines and their concentration in CM before grafting. Following pre-op surgical planning, both maxillary sinuses of each patient will be grafted internally applying a lateral window to each sinus. The bony floor of the test maxillary sinus will be augmented with synthetic bone substitute (BoneCeramic™ 1-2 mm) mixed with 10 to 15 ml of CM (test). The control site will receive bone substitute with saline. Lateral windows in both sinuses will be then closed with a collagen membrane (Bio-Gide™). After 6 months, first-stage implant surgery will be performed placing 6 implants in each patient. Registration of implant stability by manual torque wrench will be performed. Also, bone biopsies from each drilled implant site will be collected for histology, histomorphometry and immunohistochemistry (RT-PCR). Tomographic evaluation of the bone formation will include cone beam computed tomographies (CBCTs) at pre-operative \\[Baseline\\], 90 \\[T1\\] and 180 \\[T2 = implant placement\\] days for bone 3D image analysis.",[490,491,27,256,492],"Bone Loss, Osteoclastic","Bone Loss, Alveolar","Grafting Bone",[494,495,496,497,498,499,500],"bone","bone formation","bone graft","tissue engineering","stem cell","exosome","cell-free therapy","2025-06-02",{"date":503,"type":36},"2025-06-05",{"date":505,"type":21},"2025-12-15",{"date":218,"type":21},{"name":508,"class":43},"Pontificia Universidade Católica do Rio Grande do Sul",{"id":510,"slug":511,"hasResults":12,"nctId":512,"briefTitle":513,"officialTitle":514,"acronym":515,"eligibilityCriteria":516,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":517,"enrollmentInfo":518,"targetDuration":4,"studyType":22,"phases":520,"briefSummary":521,"conditions":522,"keywords":525,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":529,"lastUpdatePostDateStruct":530,"startDateStruct":532,"completionDateStruct":534,"leadSponsor":536,"locationsCount":4},"100588070","rgd-with-minimally-invasive-non-surgical-technique-in-treatment-of-periodontal-intrabony-defect-100588070","NCT06936605","RGD With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defect","The Use of Integrin Binding Domain Loaded Hydrogel (RGD) With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defect (Randomized Clinical Trial Study)","MINST + RGD","Inclusion Criteria:\n\n* • All patients included will have moderate to advanced periodontitis.\n\n  * Patients included in this study will be free from any systemic diseases according to criteria of Modified Cornell Medical Index(10).\n  * Patients who had not undergone any type of regenerative periodontal therapy six months prior to the initial examination.\n\nExclusion Criteria:\n\n* • Patients with systemic diseases, smokers, pregnant (female).\n\n  * Patients received antibiotics or non-steroidal anti-inflammatory drugs six months before the beginning of the study.","55 Years",{"count":519,"type":21},45,[24],"Periodontal regeneration is a complex process that involves coordinated activities and interactions of many cell types, extracellular matrix, cytokines, and specific growth factors to restore tissue integrity. The most important challenge facing periodontal regeneration is cellular insufficiency. Periodontal defects usually have a limited regenerative capacity due to their bounded surface area which is supposed to provide the wound area with a limited number of viable cells and a limited amount of biologic mediators. Cell recruitment and adhesion into the defect area are essential for cells to survive and secrete collagen.\n\nApoptosis is initiated when failure in adhesion in many different cell types occurs. Some periodontal treatment options failed in the reconstruction of the defect due to failure in wound stabilization and subsequent cell adhesion. Many treatment options have been developed to enhance defect stability and cellular recruitment including the use of GTM and different biologics. However, the treatment outcomes vary considerably depending on the level of the defect cellularity and the degree of cell recruitment into the defect area. For maximum outcomes, enhanced stability, vascularity, and biologics-sustained delivery were suggested. The minimally invasive surgical technique (MIST) suggested by Cortellini et al. offers a suitable level of tissue preservation that could help in defect stability and cellular adhesion. It was suggested to promote flap stability, maintain space, and maintain a greater amount of blood supply at the alveolar crest and papillary levels.",[523,524,27],"Intrabony Defect","Periodontal Diseases",[526,527,528],"MINST","RGD","intrabony defect","2025-04-17",{"date":531,"type":36},"2025-04-20",{"date":533,"type":21},"2025-04-15",{"date":535,"type":21},"2025-10-20",{"name":537,"class":43},"Minia University",{"id":539,"slug":540,"hasResults":12,"nctId":541,"briefTitle":542,"officialTitle":543,"acronym":4,"eligibilityCriteria":544,"healthyVolunteers":53,"sex":17,"minAge":280,"maxAge":545,"enrollmentInfo":546,"targetDuration":4,"studyType":22,"phases":547,"briefSummary":548,"conditions":549,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":550,"lastUpdatePostDateStruct":551,"startDateStruct":553,"completionDateStruct":555,"leadSponsor":557,"locationsCount":44},"100540328","composite-plug-vs-d-ptfe-membrane-in-socket-preservation-100540328","NCT06315413","Composite Plug Vs D-PTFE Membrane in Socket Preservation","Evaluation of Socket Seal Using Flowable Composite Above Xenograft Compared to Dense Polytetrafluoroethylene (d-PTFE) Membrane in Ridge Preservation Procedures: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients having single non-adjacent hopeless maxillary tooth in the esthetic zone that are indicated for extraction.\n* Patients with healthy systemic condition.\n* Patients aged from 20 to 70 years old.\n* Good oral hygiene.\n* Accepts 4 months follow-up period (cooperative patients).\n\nExclusion Criteria:\n\n* Systemic diseases or medications that might affect bone metabolism, increase surgical risk or complicate post-operative healing.\n* Previous bone augmentation to implant site.\n* Untreated periodontal diseases.\n* Para-functional habits such as bruxism and clenching.\n* History of radiation therapy to the head and neck.\n* Heavy smokers (≥ 10 cigarettes per day).\n* Pregnant or lactating females.\n* Alcoholism or drug abuse.\n* Psychiatric problems.","70 Years",{"count":438,"type":21},[24],"The aim of the current study is to compare the effect socket sealing with flowable resin composite compared to dense polytetrafluoroethylene membrane after filling the extraction site with xenograft particles in terms of soft and hard tissue changes, procedural time, post operative pain, patients' satisfaction, and cost effectiveness.",[27],"2025-03-22",{"date":552,"type":36},"2025-03-26",{"date":554,"type":21},"2025-05",{"date":556,"type":21},"2025-10",{"name":193,"class":43},{"id":559,"slug":560,"hasResults":12,"nctId":561,"briefTitle":562,"officialTitle":563,"acronym":4,"eligibilityCriteria":564,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":565,"enrollmentInfo":566,"targetDuration":4,"studyType":22,"phases":568,"briefSummary":569,"conditions":570,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":572,"lastUpdatePostDateStruct":573,"startDateStruct":575,"completionDateStruct":577,"leadSponsor":578,"locationsCount":44},"100555637","non-surgical-treatment-of-peri-implantitis-with-ultrasonic-carbon-tip-100555637","NCT06514677","Non-Surgical Treatment of Peri-Implantitis With Ultrasonic Carbon Tip","A Comparison of Two Different Mechanical Interventions in Non-Surgical Peri-implantitis Treatment","Inclusion criteria:\n\n1. Adult patients (≥18 years old)\n2. Systemically healthy (ASA class 1 and ASA class 2)\n3. Full-mouth plaque scores ≤20%\n4. Implant had been in function for more than 6 months\n5. Absence of plaque around the implant\n6. Consent to complete all follow-up visits\n\nExclusion criteria:\n\n1. Mobile implant\n2. Overhanging restorations that prevent access to the implant for clinical measurements\n3. Unresolvable technical complications that can cause peri-implantitis\n4. Presence of active periodontal disease\n5. Implants with a history of peri-implantitis treated using graft materials\n6. Use of drugs that cause gingival hyperplasia\n7. Systemic antibiotic use in the last 3 months\n8. Acute and chronic medical conditions that prevent the patient from participating in the study\n9. Presence of uncontrolled severe peri-implantitis from neighbouring implants\n10. History of radiotherapy in the head and neck region\n11. Receiving acute chemotherapy\n12. Current corticosteroid therapy","99 Years",{"count":567,"type":21},60,[24],"As the frequency of dental implants increases, the incidence of complications and peri-implant diseases also increases. Early diagnosis and treatment of the disease is important to prevent consequences up to implant loss. Non-surgical treatment is the recommended treatment in the first stage due to its shorter duration and low morbidity rate. Non-surgical treatment of peri-implantitis provides clinical improvements such as reduced bleeding on probing (20-50%) and, in some cases, reduced pocket depth (≤ 1 mm). This study aims to clinically and radiographically compare two different mechanical treatments in patients with mild and moderate peri-implantitis.",[571,27],"Peri-Implantitis","2025-03-09",{"date":574,"type":36},"2025-03-12",{"date":576,"type":36},"2023-12-01",{"date":76,"type":21},{"name":579,"class":43},"Kutahya Health Sciences University",{"id":581,"slug":582,"hasResults":12,"nctId":583,"briefTitle":584,"officialTitle":585,"acronym":4,"eligibilityCriteria":586,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":587,"targetDuration":4,"studyType":22,"phases":589,"briefSummary":590,"conditions":591,"keywords":592,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":596,"lastUpdatePostDateStruct":597,"startDateStruct":599,"completionDateStruct":601,"leadSponsor":603,"locationsCount":44},"100566952","effectiveness-of-alveolar-bone-preservation-in-alveoli-with-infectious-process-100566952","NCT06661863","Effectiveness of Alveolar Bone Preservation in Alveoli With Infectious Process","Effectiveness of Autologous Bone and Bioactive Glass for Alveolar Preservation in Alveoli With Infectious Process","Inclusion Criteria:\n\n* Patients over 18 years of age\n* Patients with indicated tooth extractions\n* Patients who have accepted the conditions of the study\n\nExclusion Criteria:\n\n* Pregnant patients, breastfeeding or using oral contraceptives\n* Smoking patients\n* Patients with uncontrolled systemic diseases\n* History of autoimmune disease\n* Previous traumatic extraction\n* Patients taking bisphosphonates or anticoagulants\n* Patients who are or have undergone chemotherapy and radiotherapy",{"count":588,"type":21},28,[24],"Alveolar ridge preservation (ARP) is a surgical technique that aims to minimize the degree of dimensional changes following extraction. In the healing period after extraction, the alveolar bone (AB) undergoes morphological changes during the remodeling process. The changes become evident immediately after tooth extraction, with greater resorption changes observed during the first two months, and these dimensional changes can be observed 1 year after surgery.",[27],[593,594,595,62],"Alveolar Resorption","Alveolar process","Bone Substitutes","2024-10-25",{"date":598,"type":36},"2024-10-28",{"date":600,"type":21},"2024-11-15",{"date":602,"type":21},"2029-12-15",{"name":604,"class":43},"Universidad de Especialidades Espiritu Santo",{"id":606,"slug":607,"hasResults":12,"nctId":608,"briefTitle":609,"officialTitle":610,"acronym":4,"eligibilityCriteria":611,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":436,"enrollmentInfo":612,"targetDuration":4,"studyType":22,"phases":614,"briefSummary":615,"conditions":616,"keywords":4,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":618,"lastUpdatePostDateStruct":619,"startDateStruct":621,"completionDateStruct":623,"leadSponsor":625,"locationsCount":4},"100557529","socket-preservation---a-randomized-clinical-implementation-in-a-student-setting-100557529","NCT06539299","Socket Preservation - A Randomized Clinical Implementation in a Student Setting","Socket Preservation - How Successful is the Method for Inexperienced Practitioners? A Randomized Clinical Implementation in a Student Setting","Inclusion Criteria:\n\n* Study participants have signed patient information and consent form\n* Age between 18-65 years, all genders included\n* Study participants who are considering a planned extraction of a mandibular posterior tooth with subsequent treatment with an implant\n* Study participants with medical and anatomical conditions that correspond to the applicable instructions for use\n* Study participants agree to student treatment\n\nExclusion Criteria:\n\n* Study participants under 18 years of age\n* Study participants with allergies or undesirable reactions to the materials used - Patients with uncontrolled diabetes mellitus (HbA1C value \\>8%)\n* Heavy smokers (\\>10 cigs\u002Fday)\n* Previous general medical conditions that influence bone metabolism (Bone metabolic diseases such as osteopetrosis, osteomalacia, Paget's disease, metabolic diseases such as hyperthyroidism, renal osteopathy, oophorectomy, uncontrolled diabetes mellitus type 2), malignant neoplasms, chemotherapy\u002Fradiation therapy in the head and neck area and immunocompromised patients)\n* which can be determined clinically or radiologically pathological symptoms in the oral cavity or on the alveolar processes or the adjacent regions, untreated acute or chronic disease of the periodontium, untreated disease of the oral mucosa - drug abuse, alcohol disease or abuse",{"count":613,"type":21},51,[24],"Preserving the ridge dimension after tooth extraction aims to avoid the need for bone augmentation procedures before implant placement. This study aims to show that socket preservation procedure is a safe, easy and predictable method that stabilizes the bone situation when late implantation is planned.",[27,29,617],"Bone Augmentation","2024-08-01",{"date":620,"type":36},"2024-08-06",{"date":622,"type":21},"2024-09-01",{"date":624,"type":21},"2027-03-01",{"name":626,"class":43},"Sigmund Freud PrivatUniversitat",{"id":628,"slug":629,"hasResults":12,"nctId":630,"briefTitle":631,"officialTitle":632,"acronym":4,"eligibilityCriteria":633,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":634,"enrollmentInfo":635,"targetDuration":4,"studyType":22,"phases":636,"briefSummary":638,"conditions":639,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":640,"lastUpdatePostDateStruct":641,"startDateStruct":643,"completionDateStruct":645,"leadSponsor":646,"locationsCount":44},"100555511","phase-4-evaluation-of-erythropoietin-on-alveolar-ridge-preservation-100555511","NCT06513039","Evaluation of Erythropoietin on Alveolar Ridge Preservation","Evaluation of Erythropoietin on Alveolar Ridge Preservation: (A Randomized Controlled Clinical Trial With Histomorphometric Assessment)","Inclusion Criteria:\n\n1. Age range (18-40).\n2. Hopeless teeth indicated for extraction such as root fractures, caries, internal root resorption, external root resorption, endodontic failures.\n3. Systemically free patients using Cornell Medical Index-Health Questionnaire \\[36\\].\n4. Patients diagnosed with intact surrounding alveolar bone (socket type I) \\[37\\].\n5. Maxillary anterior teeth and\u002For premolars indicated for extraction.\n6. Enough zone of keratinized tissue (≥2 mm).\n\nExclusion Criteria:\n\n1. Smokers\n2. Occlusal trauma at the site of the graft\n3. Pregnancy and lactation\n4. Bad compliance with the plaque control instructions following initial therapy.","40 Years",{"count":339,"type":21},[637],"PHASE4","regenerative materials would help in decreasing post-extraction resorption in sites indicated for placement of a conventional bridge or prosthetically driven implant. Erythropoietin (EPO) is a growth factor that promotes angiogenesis and bone regeneration by stimulating osteoblastic differentiation and by inhibiting osteoclastic resorption. Post-extraction alveolar ridge resorption creates morphological and volumetric changes. These changes can be considered of clinical value that may threaten the placement of a conventional bridge or an implant-supported crown. Atwood et al. \\[1\\] in a cephalometric study categorized factors influencing the rate of alveolar ridge resorption into 4 types: anatomic, metabolic, functional, and prosthetic. As stated by Tan et al. \\[2\\] in a systematic review of alveolar hard and soft tissue dimensional changes in humans post-extraction, they found that alveolar ridge resorption occurs to a greater extent in a horizontal direction than vertical. Therefore, alveolar ridge preservation (ARP) procedures were introduced in an attempt to prevent hard and soft tissue dimensional changes following extraction.",[27],"2024-07-19",{"date":642,"type":36},"2024-07-22",{"date":644,"type":36},"2024-01-01",{"date":267,"type":21},{"name":647,"class":43},"Ain Shams University",{"id":649,"slug":650,"hasResults":12,"nctId":651,"briefTitle":652,"officialTitle":653,"acronym":4,"eligibilityCriteria":654,"healthyVolunteers":12,"sex":17,"minAge":280,"maxAge":465,"enrollmentInfo":655,"targetDuration":4,"studyType":22,"phases":656,"briefSummary":657,"conditions":658,"keywords":659,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":662,"lastUpdatePostDateStruct":663,"startDateStruct":665,"completionDateStruct":667,"leadSponsor":668,"locationsCount":44},"100550704","radiographic-and-histological-assessment-of-autogenous-onlay-block-versus-cortical-shell-on-anterior-maxilla-100550704","NCT06450535","Radiographic and Histological Assessment of Autogenous Onlay Block Versus Cortical Shell on Anterior Maxilla","Radiographic and Histological Assessment of Retromolar Autogenous Onlay Bone Block Versus Cortical Shell for Augmentation of Horizontally Deficient Anterior Maxilla: (Randomized Clinical Trial).","Inclusion Criteria:\n\n* Patients in both sex with partial edentulism of the maxilla and requiring horizontal ridge augmentation\n* The ages of the patients ranged from 20 to 60 years.\n* The residual ridge width in these patients are less than 4.m\n* Sufficient bone in intra-oral donor sites are available (external oblique ridge)\n* Patients free from any systemic conditions and bone metabolism diseases that might interfere with the surgical intervention, soft tissue or hard tissue healing.\n* The vertical level should be in a favourable esthetic appearance with normal inter-arch space\n* The minimum number of missing teeth in the anterior maxilla alveolar ridge is one single extracted teeth\n\nExclusion Criteria:\n\n* Subjected to irradiation in the head and neck area less than 1 year before implantation.\n* Poor oral hygiene and motivation.\n* Uncontrolled diabetes.\n* Pregnant or nursing.\n* Substance abuse.\n* Psychiatric problems or unrealistic expectations.\n* Severe bruxism or clenching.\n* Immunosuppressed or immunocompromised.",{"count":467,"type":21},[24],"Two groups of patient with horizontally deficient anterior maxilla indicated for bone augmentation ,one will be subjected to autogenous onlay bone block from retromolar bone and the other to cortical shell from retromolar bone also.",[27],[660,661],"Autogenous onlay bone block","Cortical shell technique","2024-06-07",{"date":664,"type":36},"2024-06-10",{"date":666,"type":21},"2024-07-01",{"date":76,"type":21},{"name":193,"class":43}]