[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"alveolar-ridge-augmentation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:alveolar-ridge-augmentation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,71,100,130],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100633040","evaluation-of-guided-tissue-regeneration-with-autogenous-bone-chips-and-cgf-during-implant-placement-100633040",false,"NCT07521514","Evaluation of Guided Tissue Regeneration With Autogenous Bone Chips and CGF During Implant Placement","Clinical and Radiographic Evaluation of Guided Tissue Regeneration Using Autogenous Bone Chips and Concentrated Growth Factors Membranes With Simultaneous Implant Placement. (Case Series)","CGF","inclusion criteria:\n\n* A medical history that contraindicates oral surgical treatment such as (uncontrolled\u002Funtreated diabetes mellitus, immuno-compromised status, radio or chemotherapy of the oral and maxillofacial region, treatment with oral and\u002For intravenous bisphosphonates).\n* Presence of active or untreated periodontal disease.\n* Vertical root fractures involving the buccal aspect.\n* Tooth \u002Fteeth with horizontal fractures below bone level.\n* Tooth \u002Fteeth with external or internal resorption.\n* Patients with destructive oral habits such as smoking, chewing tobacco, bruxism,etcetera(Chrcanovic et al., 2014).\n\nexclusion criteria: A medical history that contraindicates oral surgical treatment such as (uncontrolled\u002Funtreated diabetes mellitus, immuno-compromised status, radio or chemotherapy of the oral and maxillofacial region, treatment with oral and\u002For intravenous bisphosphonates).\n\n* Presence of active or untreated periodontal disease.\n* Vertical root fractures involving the buccal aspect.\n* Tooth \u002Fteeth with horizontal fractures below bone level.\n* Tooth \u002Fteeth with external or internal resorption.\n* Patients with destructive oral habits such as smoking, chewing tobacco, bruxism, etcetera(Chrcanovic et al., 2014).","ALL","18 Years",{"count":20,"type":21},8,"ESTIMATED","INTERVENTIONAL",[24],"NA","CGF membranes will be prepared using a swing-lock centrifuge. A full-thickness mucoperiosteal flap will be elevated in a narrow alveolar ridge. Implants will be inserted. Autologous bone chips will be harvested via bone scraping and used for augmentation, CGF membranes will be placed over the grafted area. Suturing of the mucoperiosteal flap. Radiographic evaluation of the bone density and tissue thickness will be performed by CBCT preoperatively, immediate postoperative and after the procedure by 4 months. Clinical evaluation of the tissue thickness using periodontal probe preoperatively, immediate postoperatively and after the procedure by 4 months",[27,28,29],"Alveolar Bone Loss","Alveolar Ridge Augmentation","Dental Implant",[15,31,32,33,34],"autogenous bone graft","gingival biotype","dental implant","guided tissue regeneration","NOT_YET_RECRUITING","2026-04-08",{"date":38,"type":39},"2026-04-13","ACTUAL",{"date":41,"type":21},"2026-04-16",{"date":43,"type":21},"2026-10",{"name":45,"class":46},"Cairo University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":47},"100552389","vallomix-socket-preservation-study-100552389","NCT06472453","Vallomix Socket Preservation Study","Prospective Comparative Evaluation of Alveolar Ridge Preservation: Mixing Allograft With Xenograft VS. Allograft Alone in Atraumatic Extraction Sockets","Inclusion criteria:\n\n1. Provision of informed consent\n2. At least 18 years old\n3. In need of one posterior tooth (premolar or molar), excluding third molar molars, planned for extraction and replacement with a dental implant\n4. Type I or II extraction socket\u002F ridge identified at the time of enrolment with cone-beam CT scan\n5. At least one retained natural tooth adjacent to the study site\n\nExclusion criteria\n\n1. Insufficient interocclusal or interdental space to allow for an implant- supported prosthesis\n2. Previous interventions performed involving soft and\u002For bone grafting in the study site\n3. Active treated caries\n4. Uncontrolled periodontal disease present\n5. Evidence of active periapical, radicular, or endodontic lesions on teeth adjacent to study site\n6. History of recent extraction of an adjacent tooth (mesial and distal) to study site within 6 months of enrollment\n7. Current smoker with self-reported history of more than 10 cigarettes or equivalent per day\n8. Self-reported use of smokeless tobacco or e-cigarette\n9. Self-reported history of current alcohol or drug abuse\n10. Systemic or local disease or condition that would compromise bone metabolism, post-operative healing and\u002For osseointegration e.g. uncontrolled diabetes with self-reported most recent HbA1c \\> 8.0 within last six-month\n11. Systemic corticosteroids or any other medication that would influence bone metabolism, post-operative healing, and\u002For osseointegration",true,{"count":57,"type":21},24,[24],"This research aims to compare the effectiveness of two bone grafting materials on preserving jawbone integrity after tooth extraction. Following extraction, the jawbone surrounding the removed tooth can shrink, affecting future implant placement. By placing a bone graft material in the extraction socket, we aim to maintain adequate jawbone space for future implants. This study compares how well the mixture of vallos®f (human source bone) and Bio-Oss (animal source bone) \\[test\\], and vallos® only \\[control\\] grafting materials work.\n\nParticipants with at least one tooth planned for extraction and subsequent implant placement are sought for this study. Participants will be randomly assigned to either the mixture of vallos®f and Bio-Oss (test) group or the vallos® only (control) group.\n\nThroughout the approximately 2-year study duration, participants will undergo oral exams, x-rays, surgical procedures, and follow-up visits. All participants will undergo routine tooth extraction, bone graft material placement, and dental implant placement. After the crown is placed on the implant, participants will attend follow-up visits.\n\nParticipation in the study is voluntary, and the alternative is to continue routine dental care. Risks include minor discomfort from procedures such as tooth extraction and implant placement. The major benefit of participation in the study is the preservation of jaw dimensions following extraction, which will simplify the placement of a dental implant.",[28],"RECRUITING","2026-02-06",{"date":64,"type":39},"2026-02-10",{"date":66,"type":39},"2025-01-13",{"date":68,"type":21},"2028-06",{"name":70,"class":46},"University of Maryland, Baltimore",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":55,"sex":17,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":47},"100619392","comparative-analysis-of-2-bone-graft-materials-in-socket-preservation-100619392","NCT07344025","Comparative Analysis of 2 Bone Graft Materials in Socket Preservation","Comparative Analysis of Healing Outcomes Between Two Bone Graft Materials in Socket Preservation Procedure","Inclusion Criteria:\n\n* • Systemically healthy individuals\n\n  * Non-smokers\n  * Age between 21 and 50 years\n  * Indicated for tooth extraction and socket preservation\n  * Good oral hygiene (full-mouth plaque score \\\u003C20%)\n  * Willingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* • Stage III or IV periodontitis\n\n  * Active periodontal or periapical infection\n  * Severely resorbed sockets (buccal bone height \\\u003C5 mm)\n  * Smoking more than 10 cigarettes per day\n  * Pregnancy\n  * Systemic conditions or medications affecting bone metabolism","21 Years","50 Years",{"count":81,"type":21},18,[24],"Socket preservation procedures after tooth extraction have been designed and implemented to maintain the volume of the bone and gingival tissues, which can decrease following the extraction of the teeth. In this clinical trial we will compare clinically and histologically the effectiveness of two distinct bovine bone graft materials; an allograft and a xenograft, in alveolar ridge preservation procedures following tooth extraction .",[85,28,86],"Socket Preservation","Dental Implants",[88,89,90],"Alveolar ridge preservation","Allograft","Bovine xenograft","2026-01-15",{"date":93,"type":39},"2026-01-20",{"date":95,"type":21},"2026-01",{"date":97,"type":21},"2026-04",{"name":99,"class":46},"Pharos University in Alexandria",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":55,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":116,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":47},"100615722","antibiotic-prophylaxis-versus-placebo-in-alveolar-bone-grafting-a-randomized-controlled-trial-100615722","NCT07296302","Antibiotic Prophylaxis Versus Placebo in Alveolar Bone Grafting: A Randomized Controlled Trial","Randomized Clinical Trial Comparing Prophylactic Antibiotic Therapy and Placebo in Intraoral Alveolar Bone Grafting Procedures.","ABXGRAFT","Inclusion Criteria:\n\n* Age between 18 and 65 years.\n\nGenerally healthy individuals classified as American Society of Anesthesiologists (ASA) physical status I or II ( ASA I or ASA II).\n\nIndication for tooth extraction followed by alveolar bone grafting in a fresh socket.\n\nAbsence of active infection at the surgical site.\n\nWillingness to take amoxicillin or, in cases of β-lactam antibiotic allergy, azithromycin.\n\nNo use of antibiotics in the previous 30 days.\n\nAgreement to participate and signature of the informed consent form (ICF).\n\nExclusion Criteria:\n\n* Presence of uncontrolled systemic diseases or chronic use of immunosuppressive medications.\n\nPregnancy or breastfeeding.\n\nSevere liver disease.\n\nSmoking more than 10 cigarettes per day.\n\nKnown allergy to macrolides (azithromycin).\n\nPrior use of antibiotics within the last 30 days.\n\nConcomitant use of medications with known risk of QT interval prolongation.\n\nSigns of acute infection at the extraction site.","65 Years",{"count":110,"type":21},150,[24],"Tooth extraction sites often require alveolar bone grafting to preserve ridge dimensions and improve conditions for future implant placement. Although systemic antibiotic prophylaxis is commonly prescribed after grafting procedures, there is limited evidence supporting its necessity in healthy patients undergoing intraoral bone grafting. This randomized, double-blind, placebo-controlled clinical trial aims to compare the effects of prophylactic amoxicillin versus placebo on postoperative outcomes in alveolar bone graft procedures using Plenum® Oss HP biomaterial, a synthetic biphasic bioceramic composed of hydroxyapatite and beta-tricalcium phosphate (HA\u002Fβ-TCP; 70:30 ratio).\n\nParticipants will be randomly assigned to receive either amoxicillin 500 mg every 8 hours for 7 days or a matching placebo. Clinical parameters, postoperative complications, and patient-reported outcomes will be assessed. The study seeks to determine whether antibiotic prophylaxis provides measurable clinical benefits or whether placebo yields comparable results, contributing to more rational antibiotic use and supporting antimicrobial stewardship in oral surgery.",[28,114,115],"Bone Grafting","Antibiotic Prophylaxis",[117,118,115,119,120],"Ridge Preservation","Alveolar Bone Graft","Synthetic Bone Graft","Biphasic Calcium Phosphate","2025-12-20",{"date":123,"type":39},"2025-12-29",{"date":125,"type":21},"2026-02",{"date":127,"type":21},"2027-08",{"name":129,"class":46},"Agnaldo Rocha de Souza Junior",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":55,"sex":17,"minAge":137,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":22,"phases":141,"briefSummary":142,"conditions":143,"keywords":144,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":47},"100576312","pepticol-ezgraft-in-the-extraction-socket-preservation-process-after-tooth-extraction-100576312","NCT06783660","PeptiCol EZgraft in the Extraction Socket Preservation Process After Tooth Extraction","A Multicenter, Open-label, Randomized, Independent Evaluation, Confirmatory Clinical Trial to Evaluate the Safety and Efficacy of the Periodontal Tissue Inducing Photoresponsive PeptiCol EZgraft in the Extraction Socket Preservation Process After Tooth Extraction.","Inclusion Criteria:\n\n1. Adults aged 19 to 75 years.\n2. Systemically healthy or with mild systemic disease, classified as ASA I or II.\n3. Planning to place implants in the maxilla or mandible after extraction, or having such plans for the future. If there are multiple extraction sockets, only one socket will be included in the trial, and other areas will follow spontaneous healing or treatment plans.\n4. The extraction socket area must have more than 50% of the alveolar bone wall remaining.\n5. Willing to maintain good oral hygiene during the clinical trial.\n6. Voluntarily decided to participate in the trial and signed the informed consent form.\n7. Willing to participate for the entire duration of the clinical trial and comply with trial procedures.\n\nExclusion Criteria:\n\n1. Extensive alveolar bone absorption observed in the extraction socket area.\n2. Severe periodontal disease or acute periodontal abscess.\n3. Poor oral hygiene.\n4. History of bone grafts or implants in the area of the medical device application.\n5. Mucosal diseases due to autoimmune disorders.\n6. History of hypersensitivity to collagen preparations.\n7. Smoking more than 10 cigarettes per day.\n8. Alcohol or drug addiction.\n\n   \\*The alcohol addiction screening will be conducted using AUDIT-K.\n9. Use of drugs affecting bone formation within 2 weeks prior to screening (e.g., steroids, bisphosphonates).\n10. Use of oral or injectable rheumatic medications, including immunosuppressants, within 2 weeks prior to screening.\n11. History of or current use of oral or injectable bisphosphonates for osteoporosis for more than 12 weeks.\n12. Uncontrolled bleeding disorders or use of medications affecting blood coagulation.\n13. Uncontrolled diabetes or hypertension.\n14. Clinically significant cardiovascular, gastrointestinal, respiratory, endocrine, or central nervous system diseases observed at screening.\n15. Immune disorders including acquired immunodeficiency syndrome.\n16. Pregnant or breastfeeding women\n17. During the clinical trial period, female and male participants who are of childbearing potential must agree to use appropriate contraception from the date of signing the informed consent form until the end of the clinical trial (16 weeks post-procedure). If a female participant becomes pregnant during the trial period, her participation will be discontinued.","19 Years","75 Years",{"count":140,"type":21},114,[24],"This clinical trial aims to compare the efficacy and safety of applying \"PeptiCol EZgraft\" in extraction socket preservation procedures against \"Regenomer,\" in terms of reducing the amount of alveolar bone change during the healing process following tooth extraction.",[28],[145,146,147,148],"socket preservation","collagen sponge","collagen gel","Peptide","2025-10-02",{"date":151,"type":39},"2025-10-03",{"date":153,"type":39},"2025-01-08",{"date":155,"type":21},"2026-02-28",{"name":157,"class":158},"NIBEC Co., Ltd.","INDUSTRY"]