[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"alveolar-ridge-preservation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:alveolar-ridge-preservation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,51,81,113,135,157,181,213,241,262,286,317,340,362],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100643380","early-phase-1-assessment-of-the-impact-of-neobone-biphasic-calcium-phosphate-on-bone-volume-in-alveolar-ridge-preservation-after-tooth-extraction-100643380",false,"NCT07638358","Assessment of the Impact of Neobone® (Biphasic Calcium Phosphate) on Bone Volume in Alveolar Ridge Preservation After Tooth Extraction","Assessment of Safety and Performance of Neobone®: A Prospective Observational Study in the Field of Dentistry","BCPARPBV","Inclusion Criteria:\n\n* 18 years or older\n* Acceptance of informed consent\n* Type 1 or 2 extraction sockets (Elian et al. 2007)\n\nExclusion Criteria:\n\n* Presence of active infection or severe inflammation in the intervention zone\n* Relevant medical history that contraindicates implant surgery\n* Patients with poor oral hygiene (full-mouth plaque score and full-mouth bleeding score \\>15%) and lack of motivation\n* Uncontrolled diabetes (reported levels of glycated haemoglobin exceeding 7%)\n* Uncontrolled and \u002For untreated periodontal disease\n* Heavy smokers (more than 10 cigarettes per day)\n* Immunosuppression",true,"ALL","18 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"EARLY_PHASE1","The goal of this randomized clinical trial is to assess whether BCP (Biphasic Calcium Phosphate) improves alveolar ridge preservation (ARP) in patients who need tooth extraction. The main question it aims to answer is whether using BCP for alveolar ridge preservation has a positive effect on bone volume compared with natural healing.\n\nThe main questions it aims to answer are:\n\nDoes BCP improve ridge preservation compared with natural healing?\n\nResearchers will compare BCP grafted sockets to natural healing sockets to see if BCP better preserves ridge volume.\n\nParticipants will:\n\nHave a tooth indicated for extraction.\n\nBe assigned to either BCP or natural healing.\n\nUndergo CBCT (Cone Beam Computed Tomography) and intra-oral scanning after extraction and after six months of healing to measure horizontal and vertical resorption and bone density.",[28,29],"Tooth Extraction Site Healing","Alveolar Ridge Preservation",[29,31,32,33,34,35,36,37],"Biphasic Calcium Phosphate","Tooth Extraction","Volumetric Changes","Implant site development","Bone volume","Socket preservation","Ridge augmentation","RECRUITING","2026-06-09",{"date":41,"type":42},"2026-06-11","ACTUAL",{"date":44,"type":42},"2025-12-01",{"date":46,"type":22},"2028-12",{"name":48,"class":49},"Egas Moniz - Cooperativa de Ensino Superior, CRL","OTHER",1,{"id":52,"slug":4,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":50},"100637595","NCT07607314","Rotary Versus Manual Degranulation in Alveolar Ridge Preservation","Efficacy of Manual Versus Rotary Degranulation Techniques on Clinical and Radiographic Outcomes of Alveolar Ridge Preservation: Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients will be recruited from those attending the outpatient clinics of the College of Dentistry.\n* Systemically healthy adults aged 18-65 years who present with teeth indicated for extraction due to chronic periapical pathology (e.g., periapical granuloma or cystic lesion) confirmed clinically and radiographically.\n* All cases must be verified with a tooth-specific, limited field-of-view cone-beam computed tomography (CBCT) scan to minimize radiation exposure and to demonstrate the presence of periapical pathology with intact socket walls and sufficient residual alveolar bone to allow for ridge preservation.\n* Only teeth with single or multi-rooted lesions indicated for atraumatic extraction without excessive bone removal will be considered.\n* Participants must also be capable of providing informed consent, demonstrate adequate oral hygiene, and be willing to return for scheduled follow-up visits.\n\nExclusion Criteria:\n\n* Acute odontogenic infection at the extraction site.\n* Thin buccal bone (\\\u003C 1mm on CBCT).\n* Severe periodontal breakdown with more than 50% bone loss.\n* Grade III mobility.\n* Root morphology that limits instrument accessibility.\n* Uncontrolled systemic diseases (e.g., diabetes, immunocompromised status).\n* Pregnant or lactating women.\n* Medications known to affect bone metabolism such as long-term corticosteroids or bisphosphonates.\n* Self-reported or documented allergy to penicillin or amoxicillin.\n* Poor oral hygiene, inability to maintain adequate postoperative care, or unwillingness to attend scheduled follow-up visits.","65 Years",{"count":59,"type":22},60,[61],"NA","After a tooth is taken out, the empty socket needs to heal. Sometimes unhealthy soft tissue (called granulation tissue) is left behind and can slow down healing. This study compares two ways to clean the socket:\n\n1. Manual method: a hand instrument (curette)\n2. Rotary method: a small rotating dental bur\n\nBoth methods are standard in dental practice. The study will see which method is faster, causes less pain, and leads to better bone healing. After cleaning, all patients will receive a routine bone graft to protect the jawbone for a possible future dental implant.\n\nThe study will measure:\n\n* How long (in seconds) it takes to clean the socket\n* Whether the socket is completely clean, checked with a harmless blue stain (Toluidine Blue)\n* Changes in the bone at 3 and 6 months, measured by a special three-dimensional X-ray (cone-beam computed tomography, CBCT)\n* Pain and swelling reported by patients in the first week after the procedure\n* Any side effects or healing problems\n\nPatients are randomly assigned to one of the two cleaning methods (like flipping a coin). The surgeon knows which method is used, but the person analyzing the X-rays does not, to keep the results fair.\n\nThe study will include 58-60 adult patients who need a tooth removed because of a long-term infection at the root. It is being conducted at the College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.",[64,29],"Chronic Periapical Periodontitis",[66,67,68,69,70,71],"Degranulation","Rotary instrument","Manual curettage","Alveolar ridge preservation","Granulation tissue","Chronic periapical periodontitis","2026-05-31",{"date":74,"type":42},"2026-06-03",{"date":76,"type":42},"2026-06-01",{"date":78,"type":22},"2027-03-01",{"name":80,"class":49},"Imam Abdulrahman Bin Faisal University",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":88,"targetDuration":90,"studyType":91,"phases":4,"briefSummary":92,"conditions":93,"keywords":98,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":50},"100633395","impact-of-alveolar-ridge-preservation-on-the-potential-need-for-sinus-floor-elevation-a-10-year-retrospective-radiographical-study-100633395","NCT07526129","Impact of Alveolar Ridge Preservation on the Potential Need for Sinus Floor Elevation: A 10-year Retrospective Radiographical Study","Impact of Alveolar Ridge Preservation on the Potential Need for Sinus Floor Elevation in Posterior Maxillary Implant Sites: A 10-year Retrospective Radiographical Study","Inclusion Criteria:\n\n* • Patients aged ≥18 years.\n\n  * Patients who underwent alveolar ridge preservation after extraction of maxillary posterior teeth, as a test group.\n  * Patients who underwent extraction of maxillary posterior teeth with unassisted socket healing without alveolar ridge preservation as a control group.\n\nExclusion Criteria:\n\n* • The presence of a clinically symptomatic periapical radiolucency, acute abscesses, or chronic sinus tract, that may falsify the classification of posterior maxillary teeth on 2D radiographs.",{"count":89,"type":22},130,"12 Months","OBSERVATIONAL","This research aims to investigate the influence of alveolar ridge preservation, after extraction of maxillary posterior teeth, on the potential need of sinus floor augmentation procedures (that include lateral or crestal sinus augmentations). From peri-apical radiographs, maxillary posterior teeth will be divided into 4 groups according to the relationship of their apexes with the sinus. Then, the patients will be divided into 2 sub-groups: unassisted socket healing (only extraction) and ARP group (extraction + ARP) and their CBCT scans before implant placement will be collected. The CBCT scans should be at least 4 months post-extraction and ARP. Depending on the residual bone height, patients will be divided into 3 categories, according to the ABC classification:\n\n1. In need of lateral sinus floor augmentation\n2. In need of crestal sinus floor augmentation\n3. No need for sinus floor augmentation, therefore, implant placement.\n\nThese divisions will be conducted, according to:\n\n\\- The residual bone height (RBH) which is the height in mm from the alveolar ridge crest to the lowest point of the maxillary sinus floor.\n\nThe results of the proposed hypothesis are verified and interpreted after statistical analysis.",[94,95,96,97,29],"Alveolar Bone Loss","Sinus Floor Augmentation","Sinus Pneumatization","Alveolar Bone Atrophy",[99,100,101,102,103],"alveolar bone loss","alveolar process atrophy","extraction","tooth socket","sinus floor augmentation","2026-04-06",{"date":106,"type":42},"2026-04-13",{"date":108,"type":42},"2025-01-01",{"date":110,"type":22},"2026-05-30",{"name":112,"class":49},"Saint-Joseph University",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":123,"conditions":124,"keywords":4,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":50},"100625834","clinical-and-radiographic-outcomes-of-alveolar-ridge-preservation-100625834","NCT07427784","Clinical and Radiographic Outcomes of Alveolar Ridge Preservation","Clinical and Radiographic Outcomes of Alveolar Ridge Preservation for Implant-prosthetic Rehabilitation in a Hospital Setting: a Prospective Study","REGSYST","Inclusion Criteria:\n\n* Patients requiring alveolar ridge preservation procedures prior to implant rehabilitation of edentulous sites;\n* Age \\> 18;\n* Achievement of FMPS and FMBS ≤ 15%;\n* Signed written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Uncontrolled diabetes or hypertension;\n* Uncontrolled periodontal disease;\n* Inability to perform consistent and continuous follow-up;\n* Pregnancy or breastfeeding;\n* Inability to provide written informed consent.",{"count":122,"type":22},50,"Dental implants are considered a predictable rehabilitative option following tooth extraction or in cases of missing teeth. In some situations, the inevitable alveolar ridge resorption that occurs after extraction may make the placement of standard-diameter (\\>3.5 mm) or standard-length implants difficult or even impossible without advanced bone augmentation procedures. To counteract post-extraction volumetric bone contraction, alveolar ridge preservation can be performed, consisting of placing a bone graft within the socket walls immediately after tooth extraction. Although this procedure cannot completely prevent dimensional changes, it has been shown to significantly reduce both horizontal and vertical ridge resorption, as reported in the scientific literature. However, there is a lack of clinical and radiographic studies evaluating the outcomes of implant rehabilitation following alveolar ridge preservation with standard-dimension implants in a hospital-based setting.",[29],"NOT_YET_RECRUITING","2026-03-18",{"date":128,"type":42},"2026-03-20",{"date":130,"type":22},"2026-03-01",{"date":132,"type":22},"2031-03-01",{"name":134,"class":49},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":142,"targetDuration":4,"studyType":23,"phases":144,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":50},"100599973","phase-4-biotivity-a-c-membrane-socket-preservation-study-100599973","NCT07091448","Biotivity A-C Membrane Socket Preservation Study","Prospective, Assessment of Alveolar Ridge Preservation Using Biotivity™ Amnion Chorion Membranein Atraumatic Extraction Socket","Inclusion criteria:\n\n1. Provision of informed consent\n2. At least 18 years old\n3. In need of one posterior tooth (premolar or molar), excluding third molars, planned for extraction and replacement with a dental implant\n4. Type I or II extraction socket\u002F ridge identified at the time of enrolment with cone-beam CT scan\n5. At least one retained natural tooth adjacent to the study site\n\nExclusion criteria\n\n1. Insufficient interocclusal or interdental space to allow for an implant- supported prosthesis\n2. Previous interventions performed involving soft and\u002For bone grafting in the study site\n3. Active caries\n4. Uncontrolled periodontal disease present\n5. Evidence of active periapical, radicular, or endodontic lesions on teeth adjacent to study site\n6. History of recent extraction of an adjacent tooth (mesial and distal) to study site within 6 months of enrollment\n7. Current smoker with self-reported history of more than 10 cigarettes or equivalent per day\n8. Self-reported use of smokeless tobacco or e-cigarette\n9. Self-reported history of current alcohol or drug abuse\n10. Systemic or local disease or condition that would compromise bone metabolism, post-operative healing and\u002For osseointegration e.g. uncontrolled diabetes with self-reported most recent HbA1c \\> 8.0 within last six-month13,14\n11. Systemic corticosteroids or any other medication that would influence bone metabolism, post-operative healing, and\u002For osseointegration\n12. Pregnancy, as confirmed by a urine pregnancy test at screening.",{"count":143,"type":22},12,[145],"PHASE4","This is a prospective, randomized controlled pilot clinical trial evaluating the efficacy of a human placental-derived amnion chorion membrane (Biotivity™ A\u002FC Plus Membrane) versus a conventional collagen membrane in alveolar ridge preservation (ARP) following atraumatic extraction of single posterior teeth. A total of 12 subjects will be enrolled at the University of Maryland School of Dentistry. The study aims to assess both soft tissue wound healing and hard\u002Fsoft tissue dimensional changes over a 5-month period prior to dental implant placement.\n\nThroughout the approximately 6-month study duration, participants will undergo oral exams, x-rays, surgical procedures, and follow-up visits. All participants will undergo routine tooth extraction, bone graft material and barrier placement, and dental implant placement.\n\nParticipation in the study is voluntary, and the alternative is to continue routine dental care. Risks include minor discomfort from procedures such as tooth extraction and implant placement. The major benefit of participation in the study is the preservation of jaw dimensions following extraction, which will simplify the placement of a dental implant.",[29],"2026-01-26",{"date":150,"type":42},"2026-01-28",{"date":152,"type":22},"2026-04-01",{"date":154,"type":22},"2028-10-31",{"name":156,"class":49},"University of Maryland, Baltimore",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":17,"sex":18,"minAge":164,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":23,"phases":168,"briefSummary":169,"conditions":170,"keywords":172,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":4},"100621667","clinical-and-radiographic-evaluation-of-delayed-dental-implant-placement-after-socket-preservation-using-injectable-bone-graft-100621667","NCT07373600","Clinical and Radiographic Evaluation of Delayed Dental Implant Placement After Socket Preservation Using Injectable Bone Graft","Clinical and Radiographic Evaluation of Delayed Implant Placement Following Socket Preservation With Injectable Alloplastic Bone Graft. A Randomized Controlled Study.","* Patient aged between 40 and 60 years\n* General good health.\n* Volunteer subjects have to voluntarily sign an informed consent.\n* Patient Indicated for single implant placement in lower posterior area.\n\nInclusion criteria for patients in group I\n\n· Patient with a previously extracted lower posterior tooth and the socket was preserved with injectable bone graft .\n\nExclusion criteria:\n\n* Patient with systemic disease affection bone metabolism .\n* Patients with contraindication to surgical treatment.\n* Patients with uncontrolled medical conditions.","40 Years","60 Years",{"count":167,"type":22},20,[61],"This clinical study aims to evaluate the clinical and radiographic outcomes of delayed dental implant placement following socket preservation using an injectable alloplastic bone graft material.\n\nThe study will include patients who require tooth extraction and are candidates for implant placement.\n\nAfter tooth extraction, the socket will be preserved using the bone graft material, and dental implants will be placed after a healing period.\n\nClinical and radiographic assessments will be performed to evaluate bone quality, bone height, and implant stability.\n\nThe goal of this study is to determine the effectiveness of injectable alloplastic bone grafts in maintaining the alveolar ridge and improving the success of delayed implant placement.",[29,171],"Dental Implant Placement",[171,29],"2026-01-20",{"date":150,"type":42},{"date":176,"type":22},"2026-01",{"date":178,"type":22},"2027-11",{"name":180,"class":49},"Suez Canal University",{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":187,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":165,"enrollmentInfo":189,"targetDuration":4,"studyType":23,"phases":191,"briefSummary":192,"conditions":193,"keywords":195,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":50},"100611571","comparison-of-demineralized-and-mineralized-dentin-grafts-in-ridge-preservation-100611571","NCT07242313","Comparison of Demineralized and Mineralized Dentin Grafts in Ridge Preservation","Comparative Study Between Demineralized and Mineralized Allogeneic Dentin Grafts for Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial","DDG-ARP","Inclusion Criteria:\n\nAdults aged 18 to 60 years.\n\nMedically healthy patients classified as ASA I.\n\nPresence of a single non-restorable tooth indicated for extraction in the posterior maxilla.\n\nAdequate oral hygiene, with plaque and bleeding indices both below 20%.\n\nSufficient bone volume to allow socket preservation without requiring simultaneous augmentation.\n\nPatients willing to participate in the study and able to provide written informed consent.\n\nAbility to commit to follow-up visits for up to 6 months.\n\nExclusion Criteria:\n\nSmokers or tobacco users of any form.\n\nPresence of uncontrolled systemic diseases (e.g., uncontrolled diabetes).\n\nConditions affecting bone metabolism (e.g., osteoporosis, long-term corticosteroid therapy).\n\nPregnant or lactating women.\n\nHistory of radiotherapy in the head and neck region.\n\nActive infection or suppuration at the extraction site.\n\nImmunocompromised patients or those on immunosuppressive therapy.\n\nPatients taking medications known to impair healing (e.g., bisphosphonates).\n\nAllergy or hypersensitivity to any study-related materials.",{"count":190,"type":22},45,[61],"This clinical investigation aims to assess how two different allogeneic dentin graft materials - one de-mineralized and the other mineralized - influence bone preservation following extraction of a single upper posterior tooth. A total of 45 patients will be randomly allocated into three equal groups: a socket-only spontaneous healing group (control), a de-mineralized dentin graft group, and a mineralized dentin graft group. Over a six-month period after extraction, measurements will be taken using CBCT to monitor changes in ridge width, height, and bone density. Secondary outcomes include patient-reported pain, postoperative swelling, satisfaction levels, width of keratinized tissue, and histomorphometric data from biopsy samples at implant placement. Findings from this trial may support evidence-based decisions in alveolar ridge preservation and help clinicians choose the most predictable grafting strategy before implant placement.",[29,194],"Post Extraction Alveolar Bone Resorption",[29,196,197,198,199,200,201,202,203],"Socket Preservation","Post-Extraction Bone Loss","Dentin Graft","Allogeneic Dentin","Demineralized Dentin Matrix","Mineralized Dentin Graft","Bone Regeneration","Histomorphometry","2025-11-21",{"date":206,"type":42},"2025-11-24",{"date":208,"type":42},"2025-10-21",{"date":210,"type":22},"2026-08-31",{"name":212,"class":49},"Kafrelsheikh University",{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":4,"eligibilityCriteria":219,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":220,"enrollmentInfo":221,"targetDuration":4,"studyType":23,"phases":223,"briefSummary":224,"conditions":225,"keywords":226,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":236,"completionDateStruct":237,"leadSponsor":239,"locationsCount":50},"100611331","demineralized-dentin-matrix-versus-mineralized-plasmatic-matrix-on-alveolar-ridge-preservation-in-molar-extraction-sites-100611331","NCT07239193","Demineralized Dentin Matrix Versus Mineralized Plasmatic Matrix on Alveolar Ridge Preservation in Molar Extraction Sites","Effect of Demineralized Dentin Matrix Versus Mineralized Plasmatic Matrix on Alveolar Ridge Preservation in Molar Extraction Sites; A Randomized Clinical Trial.","Inclusion Criteria:\n\n\\- Non-restorable tooth indicated for extraction Multi-rooted teeth Age group of 18 to 55 years Patients free from any systemic disease that may affect bone healing.\n\nExclusion Criteria:\n\n\\- Pregnant females Active infection at extraction site Smokers Systemic conditions affecting healing (e.g. diabetes, medications as bisphosphonates...) Poor oral hygiene. Patient with systemic disease that may affect bone healing. o Uncooperative patient.","55 Years",{"count":222,"type":22},24,[61],"When a tooth is removed, the bone around it (called the alveolar ridge) naturally shrinks. This study compares two bone grafting materials to find out which one better preserves bone after molar extraction:\n\nDemineralized Dentin Matrix (DDM): A material made from the patient's own extracted tooth, treated to remove minerals while keeping bone-forming proteins.\n\nMineralized Plasmatic Matrix (MPM): A mixture of a standard bone substitute and platelet-rich plasma from the patient's blood.",[196,29],[227,228,229,230,231,232],"socket preservation","alveolar ridge preservation","DDM","demineralized dentin matrix","MPM","mineralized plasmatic matrix","2025-11-16",{"date":235,"type":42},"2025-11-20",{"date":44,"type":22},{"date":238,"type":22},"2026-11-01",{"name":240,"class":49},"Cairo University",{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":247,"targetDuration":4,"studyType":23,"phases":248,"briefSummary":249,"conditions":250,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":50},"100537281","mix-of-demineralized-freeze-dried-bone-allograft-and-deproteinized-bovine-bone-mineral-a-possible-solution-for-alveolar-ridge-preservation-100537281","NCT06275789","Mix of Demineralized Freeze-Dried Bone Allograft and Deproteinized Bovine Bone Mineral: a Possible Solution for Alveolar Ridge Preservation?","Inclusion Criteria:\n\n* Patients in good health\n* Require the extraction of at least one premolar or molar with future implant placement\n* Sufficient keratinized gingiva (equal or more than 2mm prior to extraction),\n* No more than 3mm of buccal bone loss\n* Flapless extraction possible\n* Full mouth plaque index of less than 25%\n\nExclusion Criteria:\n\n* Nicotine consumption equivalent to or more than 10 cigarettes per day\n* Electronic cigarette usage\n* A history of irradiation of head and neck area\n* Immunodeficiency disease\n* Uncontrolled systemic health problems (hypertension crisis 180\u002F120, hyperthyroidism, diabetes with HbA1c over 7, recent history of stroke, cancer) History of medications that affect bone remodeling process (bisphosphonates, RANK-L inhibitors)\n* Previous adverse reaction to the biomaterials used\n* Pregnancy\u002Flactation, or those who are trying to become pregnant.\n* Active uncontrolled or untreated periodontal disease\n* Periapical lesions greater than 1 cm and soft tissue pathology",{"count":21,"type":22},[61],"The purpose of the study is to compare a new grafting material for alveolar ridge preservation to a commonly used and well studied material. Alveolar ridge dimensions as well as histology will be compared.",[29,251,252],"Dental Extraction","Bone Graft","2025-09-05",{"date":255,"type":42},"2025-09-12",{"date":257,"type":42},"2024-01-26",{"date":259,"type":22},"2026-06",{"name":261,"class":49},"Nova Southeastern University",{"id":263,"slug":264,"hasResults":11,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":268,"eligibilityCriteria":269,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":270,"targetDuration":4,"studyType":23,"phases":272,"briefSummary":273,"conditions":274,"keywords":4,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":50},"100593046","alveolar-ridge-preservation-versus-spontaneous-healing-100593046","NCT07001345","Alveolar Ridge Preservation Versus Spontaneous Healing","Alveolar Ridge Preservation (ARP) Versus Spontaneous Healing in Large Buccal Bone Defects After Tooth Extraction in the Posterior Mandible","ARP versus SH","Inclusion Criteria:\n\n* A minimum age of 18 years old\n* In need for extraction of a single (pre)molar in the mandible that needs to be replaced by an implant\n* At least one adjacent tooth\n* A buccal bone defect after extraction of 50% or more\n\nExclusion Criteria:\n\n* Active periodontal disease\n* Uncontrolled diabetes mellitus\n* History of or current chemotherapy or radiation in the head and neck area\n* History of or current use of medication related to osteonecrosis of the jaw\n* Heavy and moderate smokers (\\>5 cigarettes a day)\n* Unable to maintain basic oral health (physical and\u002For mental)\n* Pregnancy (in case of pregnancy, the treatment is postponed until after the delivery)",{"count":271,"type":22},66,[61],"Rationale: To determine the effect of alveolar ridge preservation (ARP) versus spontaneous healing (SH) in large buccal bone defects in the posterior mandible.\n\nObjective: To evaluate whether ARP using a xenograft (XG) (Cerabone plus) or an allograft (AG) (Maxgraft granules) covered by a membrane (Jason membrane) reduces the need for additional bone augmentation either prior to or during implant placement in the posterior mandible compared to spontaneous healing Study design: Prospective randomized clinical study with 10-year follow-up.\n\nStudy population:\n\nInclusion criteria: patients are 18 years or older and in need for extraction of a (pre)molar in the posterior mandible with at least one adjacent tooth and a buccal bone defect of \\>50%.\n\nExclusion criteria: the presence of active periodontal disease, uncontrolled diabetes mellitus, a history of or current use of chemotherapy or radiation in the head and neck area, history of or current use of medication related to osteonecrosis of the jaw, smoking (\\> 5 cigarettes a day, disability (physical and\u002For mental), making the patient unable to maintain basic oral health or follow the study protocol, pregnancy (in case of pregnancy, the treatment is postponed until after the delivery).\n\nIntervention (if applicable): Atraumatic extraction of a (pre)molar in the posterior mandible will be performed. Patients will then be included based on the dimensions of the buccal bone defect (buccal bone defect of \\>50%). 66 patients will be randomly divided in either the XG group, the AG group or the SH group (control). In the ARP groups (XG and AG), following tooth extraction, ARP will be performed using either a XG (Cerabone plus) or an AG (Maxgraft granules), both covered by a membrane (Jason membrane). In the control group, the alveolus will be left for spontaneous healing, following tooth extraction. After 4-6 months, a cone bean computed tomography (CBCT) scan will be performed to determine the possibility of implant placement with or without additional augmentation. Implant placement will be performed in all groups with or without guided bone regeneration (GBR).\n\nMain study parameters\u002Fendpoints: Frequency of additional augmentation at implant placement.",[275,29,276],"Dental Implants, Single-tooth","Guided Bone Regeneration","2025-05-23",{"date":279,"type":42},"2025-06-03",{"date":281,"type":22},"2025-06-01",{"date":283,"type":22},"2035-06-01",{"name":285,"class":49},"Erasmus Medical Center",{"id":287,"slug":288,"hasResults":11,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":292,"eligibilityCriteria":293,"healthyVolunteers":11,"sex":18,"minAge":294,"maxAge":295,"enrollmentInfo":296,"targetDuration":4,"studyType":23,"phases":298,"briefSummary":299,"conditions":300,"keywords":305,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":316,"locationsCount":4},"100583657","radiographic-and-histomorphometric-assessment-for-alveolar-ridge-preservation-using-autogenous-tooth-graft-from-extracted-tooth-combined-with-simvastatin-11-versus-autogenous-tooth-graft-100583657","NCT06879171","Radiographic and Histomorphometric Assessment for Alveolar Ridge Preservation Using Autogenous Tooth Graft From Extracted Tooth Combined With Simvastatin 1:1 Versus Autogenous Tooth Graft","Radiographic and Histomorphometric Assessment for Alveolar Ridge Preservation Using Autogenous Tooth Graft From Extracted Tooth Combined With Simvastatin 1:1 Versus Autogenous Tooth Graft: A Randomized Clinical Trial (RCT)","ARP","Inclusion Criteria:\n\n* Patients with badly broken, non-restorable, or periodontally hopeless non molar single rooted teeth.\n* Age from 20-45 years old(6,13). No sex predilection.\n* Medically free from any medical condition that would interfere with bone healing.\n* Patients with status classification (ASA I \\& II) with adequate oral hygiene condition.\n* Alveolar sockets free from any preexisting periapical pathology based on intraoral periapical or panoramic radiograph.\n\nExclusion Criteria:\n\n* Patients with any medical condition that contraindicated the procedure and general contraindications for Implant Surgery(6,13)\n* Patients who are allergic to Simvastatin drug.(6)\n* Presence of active infection around the tooth or remaining root.\n* Psychological reasons that might affect the procedure or the subsequent follow up visits.\n* Heavy smokers\n* Immunosuppressed or Immunocompromised.(13)","20 Years","45 Years",{"count":297,"type":22},26,[61],"This study will be held to overcome the previous limitations related to bone loss after teeth extraction by taking advantages from both Autogenous tooth graft and Simvastatin which will offer a promising synergistic approach for reducing alveolar ridge resorption, enhance bone regeneration and ensuring implant site development for future implant placement. This combination will address the gap in knowledge and offering a novel approach in alveolar ridge preservation. The Autogenous tooth graft will provide a scaffold and growth factor source for bone regeneration while Simvastatin will promotes osteogensis and angiogensis at graft site. So The goal of the present trial aims to evaluate the first-time application of Autogenous tooth graft from extracted tooth combined with Simvastatin with a ratio 1:1(test group) versus Autogenous tooth graft alone (control group) at an extraction socket of non molar single rooted teeth for alveolar ridge preservation and implant site development prior to implant placement.\n\nThe participants will be divided into two groups:\n\nIntervention Group will receive Autogenous tooth graft combine with Simvastatin with a ratio 1:1 Control Group will receive Autogenous tooth graft. with follow up period 4 months.",[29,301,302,303,304],"Horizontal Alveolar Bone Loss","Vertical Alveolar Bone Loss","Delayed Implant","Autogenous Tooth Graft",[306,307,308,228],"autogenous tooth graft","simvastatin","delayed implant","2025-05-19",{"date":311,"type":42},"2025-05-20",{"date":313,"type":22},"2025-06-10",{"date":315,"type":22},"2026-06-10",{"name":240,"class":49},{"id":318,"slug":319,"hasResults":11,"nctId":320,"briefTitle":321,"officialTitle":322,"acronym":323,"eligibilityCriteria":324,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":165,"enrollmentInfo":325,"targetDuration":4,"studyType":23,"phases":327,"briefSummary":330,"conditions":331,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":336,"leadSponsor":338,"locationsCount":50},"100579697","phase-1-clinical-and-radiographic-evaluation-of-allogenic-dentin-grafts-for-alveolar-ridge-preservation-100579697","NCT06827665","Clinical and Radiographic Evaluation of Allogenic Dentin Grafts for Alveolar Ridge Preservation","Clinical and Radiographic Evaluation of Allogenic Dentin Grafts for Alveolar Ridge Preservation: A Prospective Clinical Trial","JUH","Inclusion and Exclusion Criteria for Donors:\n\nInclusion Criteria:\n\n* Students, interns, or residents willing to participate and provide informed consent.\n* No history of systemic diseases such as diabetes, hepatitis, or immune disorders.\n* Negative blood screening for HIV, HBV, and HCV.\n* Non-smokers or individuals who have not smoked within the last six months.\n\nExclusion Criteria:\n\n* History of systemic conditions affecting oral or overall health.\n* Positive blood tests for communicable diseases.\n* Active oral infections or untreated dental caries.\n* Pregnant or lactating individuals.\n* Individuals with a history of smoking or substance abuse within the last six months.\n\nInclusion and Exclusion Criteria for Recipients:\n\nInclusion Criteria:\n\n* Patients aged 18-60 years, requiring extraction of at least three teeth for clinical or therapeutic reasons.\n* Patients in good systemic health without conditions that impair bone healing.\n* Willingness to provide informed consent and participate in follow-ups.\n\nExclusion Criteria:\n\n* Systemic conditions such as diabetes, osteoporosis, or immunodeficiency that could impair bone regeneration.\n* Active oral infections at extraction sites.\n* History of radiation therapy to the head and neck region.\n* Smoking or smoking history within the last six months.\n* Use of medications affecting bone metabolism (e.g., bisphosphonates, steroids).\n* Pregnancy or lactation. Additional Justification for Extraction: Teeth chosen for extraction must meet one or more criteria:\n* Severe periodontal disease.\n* Irreversible pulpitis or structural damage.\n* Non-restorable condition impacting oral health or functionality.",{"count":326,"type":22},10,[328,329],"PHASE1","PHASE2","For the first time, allografts from human-extracted teeth will be prepared and evaluated in a prospective clinical trial to assess their efficacy for alveolar ridge preservation. The reconstruction and preservation of the alveolar ridge after tooth extraction are essential for future prosthetic rehabilitation.\n\nAutogenous bone grafts, while effective, are limited by donor site morbidity and insufficient graft quantity. Allogenic dentin grafts from healthy human donors present a scalable solution. This study aims to evaluate the biocompatibility and effectiveness of two types of allogenic dentin grafts-demineralized dentin allografts (DDA) and whole tooth allografts (WTA)-for alveolar ridge preservation, contributing to innovative, sustainable dental practices.",[29],"2025-02-09",{"date":334,"type":42},"2025-02-14",{"date":108,"type":42},{"date":337,"type":22},"2027-12-30",{"name":339,"class":49},"Jordan University Hospital",{"id":341,"slug":342,"hasResults":11,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":4,"eligibilityCriteria":346,"healthyVolunteers":11,"sex":18,"minAge":294,"maxAge":347,"enrollmentInfo":348,"targetDuration":4,"studyType":23,"phases":350,"briefSummary":351,"conditions":352,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":50},"100526937","2d3d-imaging-to-analyze-the-regeneration-rate-of-autologous-bone-100526937","NCT06141239","2D\u002F3D Imaging to Analyze the Regeneration Rate of Autologous Bone","Using 2D\u002F3D Imaging to Analyze the Regeneration Rate of Autologous Bone During Alveolar Bone Preservation Surgery Using Periodontal Valves to Completely Cover Autologous Tooth Roots, Bone Substitutes, and Vitamin D3 Treatment","Inclusion Criteria:\n\n1. Willing to sign written subject consent\n2. The tooth extraction socket is located in the anterior and posterior areas of the upper and lower jaws.\n3. The area of the extraction socket (bone defect) in the mouth will need to be treated with artificial dental implants in the future.\n4. The patient does not have systemic diseases (such as patients with hypertension, osteoporosis, bone-related diseases, kidney disease, thyroid and parathyroid diseases, etc.).\n\nExclusion Criteria:\n\n1. Patients with potentially weakened healing abilities such as cancer, diabetes, bone infection, tuberculosis, anemia due to heme abnormalities or congenital immune deficiency, cellulitis, acute periodontal cyst, severe cusp disease (cyst size) \\>2mm2) or patients with dental and jaw lesions.\n2. Women who are pregnant or breastfeeding.\n3. Exclude heavy smokers or betel nut chewers who smoke more than one pack of cigarettes per day.\n4. The bone defect in the extraction socket is severe and requires other bone regeneration surgeries (GBR), otherwise it will not be possible to have enough volume to provide artificial dental implants in the future.","70 Years",{"count":349,"type":22},48,[61],"Place a collagen plug (collagen plug) in the lower 2\u002F3 to 1\u002F2 of your tooth extraction site while giving you Vit. The extracted teeth are made into autogenous tooth root thin slices and covered in your tooth extraction cavity, and the skin flap raised by your flap surgery is used to cover the autologous tooth root cover to help the autologous tooth roots stabilize and heal the wound, which is different from traditional surgery. The difference in treatment lies in the local use of autogenous tooth root thin slices and Vit.D3. Collagen plug and Vit.D3 are already qualified medical materials and drugs on the market. However, there is no precedent for making thin autologous tooth root slices. will be a trial of a new medical technology that has not yet been used",[29],"2024-11-27",{"date":355,"type":42},"2024-12-02",{"date":357,"type":42},"2024-06-06",{"date":359,"type":22},"2025-07-31",{"name":361,"class":49},"Chang Gung Memorial Hospital",{"id":363,"slug":364,"hasResults":11,"nctId":365,"briefTitle":366,"officialTitle":366,"acronym":4,"eligibilityCriteria":367,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":164,"enrollmentInfo":368,"targetDuration":4,"studyType":23,"phases":369,"briefSummary":370,"conditions":371,"keywords":4,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":4},"100549571","hard-and-soft-tissue-changes-following-vestibular-socket-preservation-versus-ice-cream-cone-technique-for-management-of-defective-fresh-extraction-sockets-in-the-esthetic-zone-a-randomized-clinical-trial-100549571","NCT06435754","Hard and Soft Tissue Changes Following Vestibular Socket Preservation Versus Ice Cream Cone Technique for Management of Defective Fresh Extraction Sockets in the Esthetic Zone: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Adults from the age of 18 - 40 years\n* Patients with non-restorable maxillary teeth\u002Ftooth indicated for extraction in the area from 2nd premolar to 2nd premolar\n* Type II sockets will be selected as revealed by Cone beam computed tomography (CBCT).\n* Intact gingival tissue with at least 2mm keratinized tissue\n* Absence of any systemic disease or drugs that contraindicate oral surgery using Modified\n* Cornell Medical Index .\n* Patients accepts to provide informed consent\n\nExclusion Criteria:\n\n* Pregnant and lactating females.\n* Smokers as smoking is a contraindication for any plastic periodontal surgery.\n* Patients with BOP\\>15%.\n* Patients with periodontal diseases .\n* Handicapped and mentally retarded patients.\n* Patients undergoing radiotherapy.\n* Presence of systemic disease that would affect wound healing.\n* Presence of active infection with soft tissue communication.",{"count":21,"type":22},[61],"Evaluation of hard and soft tissue changes following vestibular socket preservation versus ice cream cone technique for management of defective fresh extraction sockets in the esthetic zone.",[29],"2024-07-14",{"date":374,"type":42},"2024-07-16",{"date":376,"type":22},"2024-08",{"date":378,"type":22},"2025-11",{"name":240,"class":49}]