[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"alzheimer-disease-and-related-dementias\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:alzheimer-disease-and-related-dementias":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,133],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":5},"100579228","home-based-brain-stimulation-for-motoric-cognitive-risk-syndrome-100579228",false,"NCT06821568","Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome","Long-term Home-based Transcranial Electrical Stimulation for Cognitive and Motor Function in Older Adults With an Increased Risk of Dementia: a Randomized Controlled Trial","TDCS4MCR","Inclusion Criteria:\n\n* Men and women\n* Age 65-90 years\n* Subjective cognitive complaints as defined by a 'Yes' response to \"Do you feel that you have more problems with memory than most?\" or a 'No' response to \"is your mind as clear as it used to be?\"\n* Montreal Cognitive Assessment (MoCA) score ≥21\n* Slow gait speed as measured by averaging two 4-Meter walks and defined as a usual walking speed one standard deviation below age and sex-adjusted means.\n* Absence of significant disability as defined by the ability to walk over the instrumented gait mat unassisted (e.g., able to walk without any walking aids for at least 2 minutes non-stop) and preserved activities of daily living as defined by a score of less than 9 on the Functional Activities Questionnaire.\n* Identification of an eligible informant\n* Identification of a willing and able tDCS-administrator; i.e., a study partner to lead the administration of home-based transcranial direct current stimulation (tDCS)\n* Access to reliable WiFi in the participant's home\n\nExclusion Criteria:\n\n* Formal education less than the 8th grade\n* Previous physician diagnosis of dementia\n* Any current diagnosis of a major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depressive disorder)\n* Evidence of moderate-to-severe depressive symptoms defined by a score of ≥9 on the 15-item Geriatric Depression Scale\n* History of head trauma resulting in prolonged loss of consciousness\n* History of fainting spells of unknown or undetermined etiology that might constitute seizures\n* History of seizures, diagnosis of epilepsy, or immediate (first-degree relative) family history of epilepsy except for a single seizure of benign etiology (e.g. febrile seizures) in the judgment of a board-certified neurologist\n* Hospitalization within the past three months due to acute illness, or as the result of a musculoskeletal injury significantly affecting gait or balance\n* Any unstable medical condition or chronic (particularly) uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.) or study complication\n* Substance use disorders within the past six months\n* A hairstyle or headdress that prevents electrode contact with the scalp or would interfere with the stimulation (for example thick braids, hair weave, afro, wig)\n* Chronic vertigo\n* Myocardial infarction within the past 6 months\n* Active cancer for which chemo-\u002Fradiation therapy is being received\n* Legal blindness\n* Visual hallucinations (history or self-report)\n* Pacemaker\n* Contraindications to MRI or tDCS, including unprovoked seizure within the past two years, risk of ferromagnetic objects anywhere in the body, self-reported presence of specific implanted medical devices (e.g., deep brain stimulator, medication infusion pump, cochlear implant, pacemaker, etc.), the presence of any active dermatological condition, such as eczema, on the scalp, etc. as outlined by current recommendations for noninvasive brain stimulation endorsed by the International Federation for Clinical Neurophysiology.\n* History of REM sleep behavior disorder (RBD), often an early sign of Parkinson's disease\n* Medications and medical history will be reviewed by the responsible covering physician and a decision about inclusion will be made based on the participant's past medical history, drug dose, history of recent medication changes or duration of treatment, and combination with other CNS active drugs.","ALL","65 Years","90 Years",{"count":21,"type":22},128,"ESTIMATED","INTERVENTIONAL",[25],"NA","The objective of this study is to determine the effects of a 6-month, home-based personalized transcranial direct current stimulation (tDCS) intervention targeting the left dorsolateral prefrontal cortex on cognitive function, dual task standing and walking, and other metrics of mobility in older adults with motoric cognitive risk syndrome (MCR).",[28,29,30],"Alzheimer Disease and Related Dementias","Cognition","Mobility Disability",[32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120],"Anatomy","Anxiety","Atrophic","Behavioral","Brain","Brain Region","Cephalic","Cognitive","Communities","Dementia","Development","Dose","Double-Blind Method","Electric Stimulation","Enrollment","Evaluation","Exhibits","Exposure to","Frequencies","Future","Gait","Gait Speed","Genetic Crossing Over","Home","Impaired Cognition","Individual","Intervention","Intervention Studies","Magnetic Resonance Imaging","Measurable","Measures","Mood","Motor","Multi-Institutional Clinical Trial","Neuronal Plasticity","Outcome","Participant","Performance","Phase","Pilot Projects","Prefrontal Cortex","Randomized","Randomized Controlled Clinical Trials","Research","Resolution","Rest","Risk","Series","Site","Structure","Testing","Therapeutic","Time","Syndrome","Walking","Work","Arm","cerebral atrophy","Clinically relevant","cognitive task","Cost","Dementia Risk","Design","Executive Function","functional improvement","functional near infrared spectroscopy","Gray Matter","high risk","home test","improved","insight","late life","mental function","neural network","neuroimaging","noninvasive brain stimulation","normal aging","older adult","older men","older women","open label","primary endpoint","response","secondary outcome","smartphone application","transcranial direct current stimulation","trial design","walking speed","Alzheimer's Disease","RECRUITING","2025-09-17",{"date":124,"type":125},"2025-09-22","ACTUAL",{"date":127,"type":125},"2025-09-02",{"date":129,"type":22},"2029-06",{"name":131,"class":132},"Hebrew SeniorLife","OTHER",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":141,"sex":17,"minAge":142,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":23,"phases":145,"briefSummary":146,"conditions":147,"keywords":148,"overallStatus":152,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":162},"100606961","designing-care-management-for-hospice-transitions-for-persons-living-with-advanced-dementia-100606961","NCT07182357","Designing Care Management for Hospice Transitions for Persons Living With Advanced Dementia","ENGAGE-D: Designing Care Management for Hospice Transitions for Persons Living With Advanced Dementia","ENGAGE-D","Inclusion:\n\nCare Partners and PLWD Dyad:\n\n1. Care partners of PLWD who have a diagnosis of moderate to severe dementia.\n2. Able to provide informed consent\n\nHHC Professionals:\n\nCare Managers and Field Nurses:\n\n1. Care managers who regularly engage hospice transitions with care partners of PLWD\n2. Age 18 or older\n\nMedical Providers:\n\n1. Medical providers (e.g., physicians and nurse practitioners) who refer patients for hospice enrollment.\n2. Age 18 or older\n\nHHC Administrators:\n\n1. Home healthcare administrators who work with the Certified Home Health Agency or the Advanced Illness Management Program that refers patients to hospice care\n2. Age 18 or older\n\nExclusion\n\nCare Partner and PLWD Dyad\n\n1. Under age 18\n2. Care partners who are caring for PLWD with Mild Cognitive Impairment\n3. PLWD with Mild Cognitive Impairment\n\nHHC Professionals: Care Managers, Medical Providers, Administrators\n\n1\\. Do not have experience managing hospice transitions for PLWD",true,"18 Years",{"count":144,"type":22},96,[25],"This study will test a care management intervention to guide end-of-life care and hospice transitions for persons with dementia and their care partners receiving home healthcare and ascertain feasibility, acceptability, fidelity, and usability of a dementia care management hospice transitions checklist. This study will also examine hospice enrollment, time to enrollment, and care partner satisfaction with the intervention. The intervention will be delivered within usual care management within a large home healthcare agency.",[28],[149,150,151],"hospice care","care transitions","Alzheimer's disease and related dementias","NOT_YET_RECRUITING","2025-09-11",{"date":155,"type":125},"2025-09-19",{"date":157,"type":22},"2025-10",{"date":159,"type":22},"2028-07-31",{"name":161,"class":132},"New York University",1]