[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"alzheimers-disease-diagnosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:alzheimers-disease-diagnosis":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100609468","early-phase-1-mild-cognitive-impairment-community-screening-and-early-intervention-via-stem-cell-therapy-and-wearable-brain-computer-interface-device-100609468",false,"NCT07214974","Mild Cognitive Impairment Community Screening and Early Intervention Via Stem Cell Therapy and Wearable Brain Computer Interface Device.","Mild Cognitive Impairment Community Screening, Early Detection, and Therapeutic Intervention to Slow Down, or Stop the Progression of the Cognitive Impairment.","MCITestCare","Inclusion Criteria:\n\nAdults aged 55 years and older Residents of U.S. urban or suburban communities Able to provide informed consent Willing to participate in 3-year follow-up assessments Able to complete cognitive screening assessments Access to transportation for community-based appointments No prior formal diagnosis of dementia\n\nExclusion Criteria:\n\nAdults under 55 years of age Current diagnosis of moderate to severe dementia Severe psychiatric disorders that would interfere with assessment validity Active substance abuse disorders Severe visual or hearing impairments that cannot be corrected and would prevent assessment completion Terminal illness with life expectancy less than 3 years Current participation in other cognitive intervention research studies Inability to attend follow-up assessments due to geographic relocation plans Significant neurological conditions (stroke, traumatic brain injury, Parkinson's disease) that could confound cognitive assessment Institutionalized individuals (nursing home residents)",true,"ALL","55 Years",{"count":21,"type":22},600,"ESTIMATED","INTERVENTIONAL",[25],"EARLY_PHASE1","This study aims to evaluate the efficacy of community-based early detection and targeted interventions, including stem cell therapy and wearable non-invasive brain-computer interface (BCI) devices, for Mild Cognitive Impairment (MCI) in adults aged 55 years and older residing in U.S. urban and suburban communities. Primary objectives include assessing improvements in MCI detection rates, cognitive outcomes, and progression delay compared to standard care.",[28,29,30,31,32,33,34,35,36,37],"Mild Cognitive Impairment (MCI)","Early Stages of Cognitive Decline","Alzheimer's Disease Dementia","Alzheimer's Disease Diagnosis","Alzheimer's Disease and Related Dementias","Parkinson's Disease","Parkinson's Disease (PD)","Parkinson's Disease With Wearing-off Motor Fluctuations","Dementia (Diagnosis)","Dementia MCI (Mild Cognitive Impairment)","NOT_YET_RECRUITING","2026-03-06",{"date":41,"type":42},"2026-03-10","ACTUAL",{"date":44,"type":22},"2026-09-01",{"date":46,"type":22},"2030-01-03",{"name":48,"class":49},"Noah Tech, Corp.","INDUSTRY",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":63,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":50},"100440847","modelling-tau-distribution-from-dti-with-generative-adversarial-network-for-alzheimers-disease-diagnosis-100440847","NCT05020626","Modelling Tau Distribution From DTI With Generative Adversarial Network for Alzheimer's Disease Diagnosis","Modelling Tau Deposition and Distribution From Diffusion Tensor Imaging With Generative Adversarial Network for Alzheimer's Disease Diagnosis","Inclusion Criteria:\n\n* With the age of 55 years and above\n* With brain MRI taken within ±6 months from the date of clinically confirmed diagnosis of AD, MCI or normal cognition.\n\nExclusion Criteria:\n\n* AD with mixed dementia\n* Non-AD dementia\n* History of severe traumatic brain injury, severe depression, stroke, brain tumors, and incident major systemic illness",{"count":59,"type":22},250,"OBSERVATIONAL","The most significant impact of this project is to propose for the first time a novel generative adversarial network (GAN), as one kind of deep learning architecture, to automatically generate synthetic PET images reflecting tau deposition, from brain DTI images. If successful, this framework will become the most state-of-the-art approach to simulate the stereotypical pattern of intracerebral tau accumulation and distribution in vivo.\n\nSynthetic tau-PET images via DTI, possessing overwhelming superiority in radiation-free, non-invasiveness and cost-effectiveness, will potentially serve as one of alternative modalities of PET in detecting tau-load and probably outperform PET on accessibility, generalizability, and availability in future, making it much more attractive in clinical application. A big conceptual shift may occur preferring a fire-new tau-PET simulated via DTI.\n\nThe DTI data-driven deep learning framework to be created in this project will constitute an accurate, robust, clinically applicable and explainable tool to efficiently categorize the subjects into tau-burden positive and tau-burden negative cases, which will undoubtedly contribute to both clinical and research activities.",[31],[64,65,66],"Generative Adversarial Network","Tau","Diffusion Tensor Imaging","RECRUITING","2024-08-21",{"date":70,"type":42},"2024-08-22",{"date":72,"type":42},"2021-06-30",{"date":74,"type":22},"2025-12-31",{"name":76,"class":77},"Chinese University of Hong Kong","OTHER"]