[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"amantadine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:amantadine":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100390741","influenza-vaccination-acei-and-arb-in-the-evolution-of-sars-cov2-infection-100390741",false,"NCT04367883","Influenza Vaccination, ACEI and ARB in the Evolution of SARS-CoV2 Infection","Evaluation of Influenza Vaccination and Treatment With ACEI and ARB in the Evolution of SARS-CoV2 Infection","Inclusion Criteria:\n\n* Hospital Admissions at the Hospital of Terrassa from March 1, 2020 for any cause.\n\nExclusion Criteria:\n\n* None.\n* For comparison of percentage of Influenza vaccination, ACEI and ARB vs general population, patients from outside the reference area of the Terrassa Health Consortium would be excluded.","ALL",{"count":18,"type":19},3000,"ESTIMATED","OBSERVATIONAL","Some authors have proposed the use of the flu vaccine to reduce the severity of COVID-19 cases, while some have proposed the use of ACE Inhibitors (ACEI) or Angiotensin Receptor blockers (ARB), since this virus shares hemagglutinin as a transmission mechanism and acts on the ACE2 enzyme during infection.\n\nOther authors described how none of the elderly patients receiving antihistamines and azythromycin in two nursing homes in Toledo -Spain- during the first wave died or needed hospital admission, even considering that 100% of residents had a positive serological test after that wave. Other authors have described a positive evolution in patients receiving amantadine for their Parkinson's disease.\n\nThe aim is to evaluate whether the admitted patients who are previously vaccinated or those who were already receiving these treatments showed a better evolution.",[23,24,25,26,27,28],"COVID19","Influenza Vaccination","ACE Inhibitors","ARB","Antihistamine Allergy","Amantadine","RECRUITING","2026-03-23",{"date":32,"type":33},"2026-03-25","ACTUAL",{"date":35,"type":33},"2020-03-01",{"date":37,"type":19},"2028-02-24",{"name":39,"class":40},"Consorci Sanitari de Terrassa","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":67,"leadSponsor":69,"locationsCount":41},"100625345","adding-amantadine-or-duloxetine-to-pregabalin-on-occurrence-of-post-mastectomy-pain-syndrome-100625345","NCT07421427","Adding Amantadine or Duloxetine to Pregabalin on Occurrence of Post Mastectomy Pain Syndrome","The Effect of Adding Amantadine or Duloxetine to Pregabalin on Occurrence of Post Mastectomy Pain Syndrome; Randomized Controlled Study","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* American society of anesthesiologists (ASA) Physical status II, III.\n* Body mass index (BMI): (20-40) kg\u002Fm2.\n* Type of surgery: patients undergoing modified radical mastectomy for breast cancer.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Patients with Known sensitivity or contraindication to drug used in the study.\n* History of psychological disorders and\u002For chronic pain and drug abuse patients.\n* Previous administration of antidepressants, anticonvulsants, or opioids before surgery.\n* Severe respiratory or cardiac disorders.\n* Advanced liver or kidney disease.\n* Previous breast surgery","FEMALE","18 Years","65 Years",{"count":53,"type":19},150,"INTERVENTIONAL",[56],"NA","This study aims to evaluate the additive effect of Amantadine or Duloxetine to Pregabalin on development of post mastectomy pain syndrome",[28,59,60,61,62],"Duloxetine","Pregabalin","Mastectomy","Pain Syndrome","2026-02-21",{"date":65,"type":33},"2026-02-24",{"date":63,"type":33},{"date":68,"type":19},"2027-01-01",{"name":70,"class":40},"Cairo University"]