[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aml-adult-recurrent\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aml-adult-recurrent":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,72,105],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100636507","phase-1-dose-finding-study-to-evaluate-the-safety-of-bsb-2002-in-relapsed-or-refractory-acute-myeloid-leukemia-aml-patients-with-npm1-mutation-100636507",false,"NCT07566585","Dose Finding Study to Evaluate the Safety of BSB-2002 in Relapsed or Refractory Acute Myeloid Leukemia (AML) Patients With NPM1 Mutation","A Phase 1 Multicenter Dose Finding Study to Evaluate the Safety of BSB-2002 in Relapsed or Refractory Acute Myeloid Leukemia (AML) Patients With NPM1 Mutation","Inclusion Criteria:\n\n1. Male or female patients, ages 18 years or older,\n2. AML diagnosed per ELN criteria1 which has been treated with at least two lines of therapy,\n\n   1. which is relapsed (after previously complete remission, CR, CRh or CRi), or\n   2. refractory (failed to achieve complete remission) to the last treatment\\*, \\*Primary refractory patients should have received at least two cycles of induction treatment\n3. Patients who are MRD positive by NGS for NPM1 after being MRD negative following the last treatment\n4. HLA-A\\*02:01,\n5. Positive for NPM1 mutation type A, D, G or H (see Appendix 3)2\n6. Adequate venous access for apheresis or agree to use of a central line for apheresis collection,\n7. Willing and able to provide informed consent and adhere to all study requirements.\n\nExclusion Criteria:\n\n1. Leukemic blast count of \\>20,000\u002Fμl. If the blast count can be maintained below the threshold with hydroxyurea, the patient would be eligible.\n2. Patients with extramedullary only AML.\n3. Patients that are candidates for hematopoietic stem cell transplant.\n4. Patients that are eligible to receive an approved targeted therapy.\n5. Treatment with other investigational agents within 5 half-lives of the planned dosing of BSB-2002 (day 1).\n6. Subject has had hematopoietic stem cell transplant (HSCT) and has any of the following:\n\n   1. Is within 3 months of transplant;\n   2. Has clinically significant graft-versus-host disease requiring systemic treatment;\n   3. Has ≥ Grade 2 persistent non-hematological toxicity related to the transplant.\n7. Other malignancy that requires treatment.\n8. Uncontrolled bacterial, viral, or fungal infections at time of enrollment.\n9. Active Hepatitis B or C infection.\n10. Seropositive for Human Immunodeficiency Virus-1 or -2.\n11. CNS involvement refractory to intrathecal chemotherapy and\u002For standard cranial- spinal radiation.\n12. Subject has congestive heart failure NYHA class 3 or 4, or subject with a history of congestive heart failure NYHA class 3 or 4 in the past, unless an echocardiogram performed within 3 months prior to study entry results in a left ventricular ejection fraction that is ≥ 45%.\n13. Renal insufficiency, with estimated creatinine clearance of \\\u003C 40 ml\u002Fmin\u002F1.73m2 by the Cockcroft-Gault equation with adjustment if the weight is ≥ 125% of ideal body weight OR inadequate renal function defined by serum creatinine \\> 1.6 mg\u002FdL\n14. Total bilirubin \\> 2x upper limit of normal (unless attributed to Gilbert's Syndrome).\n15. AST or ALT \\> 3x upper limit of normal.\n16. Pregnant or lactating women.\n17. Eastern Cooperative Oncology Group (ECOG) performance status \\>2.\n18. Ongoing treatment with chronic immunosuppressants (e.g., cyclosporine or systemic steroids at any dose)\n19. Women of childbearing potential (WOCBP) and men who are fertile and are unwilling to use an effective birth control method or abstinence for 12 months. Effective forms of birth control are listed in the Contraception section.\n20. Any condition, in the judgement of the Investigator, that would interfere with study participation, pose a significant risk to the patient, or interfere with study data interpretation.","ALL","18 Years",{"count":19,"type":20},19,"ESTIMATED","INTERVENTIONAL",[23],"PHASE1","The goal of this clinical trial is to test BSB-2002 which is a new type of cellular therapy to treat blood cancer (AML). It will evaluate the safety of BSB-2002 and also determine whether it works to prevent relapse of your cancer.",[26,27,28],"AML - Acute Myeloid Leukemia","AML With Mutated NPM1","AML, Adult Recurrent",[30,31],"TCR","T-cell therapy","RECRUITING","2026-04-27",{"date":35,"type":36},"2026-05-05","ACTUAL",{"date":38,"type":36},"2026-04-21",{"date":40,"type":20},"2027-09",{"name":42,"class":43},"BlueSphere Bio, Inc","INDUSTRY",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},"100570200","phase-1-bsb-1001-in-patients-undergoing-hla-matched-allogenic-hematopoietic-stem-cell-transplant-for-aml-all-or-mds-100570200","NCT06704152","BSB-1001 in Patients Undergoing HLA-Matched Allogenic Hematopoietic Stem Cell Transplant for AML, ALL or MDS","A Phase 1\u002F2a Multicenter Ascending Dose Study to Evaluate the Safety of HA-1 Minor Histocompatibility Antigen-Reactive TCR-Modified T Cells (BSB-1001) in Patients Undergoing HLA-Matched Allogenic Hematopoietic Stem Cell Transplant for AML, ALL or MDS","Inclusion Criteria:\n\n1. Male or female patients, ages 18 - 70 years inclusive, undergoing alloHCT.\n2. Any of the following high-risk hematologic malignancies:\n\n   1. AML diagnosed which has been treated with at least two lines of therapy\\* Refractory or relapsed (CR, CRh or CRi,), including myeloblasts up to 25% OR MRD positive OR persistent disease-defining cytogenetic abnormality OR MRD-negative, but with high-risk disease For patients in remission meeting criteria a, consolidation regimens would be considered another line of therapy of eligibility purposes\n   2. ALL which has been with abnormal lymphoblasts ≥5% and up to 25% in bone marrow OR persistent disease-defining cytogenetic abnormality or MRD positive\n   3. MDS after at least one line of therapy, which includes hypomethylating agent(s) and must be high or very high risk by Revised International Prognostic Scoring System (IPSS-R), monosomy, or complex karyotype or TP53 mutation.\n   4. In the expansion phase AML patients diagnosed which has been treated with at least two lines of therapy, and refractory or relapsed (CR, CRh or CRi,), including myeloblasts up to 25% OR MRD positive OR persistent disease-defining cytogenetic abnormality OR MRD-negative, but with high- risk disease\n3. HLA-A\\*02:01 AND HA-1 positive (either H\u002FH or H\u002FR).\n4. Suitable for one of the approved conditioning regimens as defined in the protocol.\n5. Patient must have an identified donor that is HA 1-negative with 10\u002F10 matched related or unrelated donor\n\nExclusion Criteria:\n\n1. Weight \\> 100 kg.\n2. Prior history of allogeneic stem cell transplantation\n3. Prior history of autologous stem cell transplantation within 1 year prior to the planned dosing of BSB-1001 (day 0)\n4. Previous genetically engineered chimeric antigen receptor T Cell therapy (CAR-T), approved or investigational, within 2 years of screening, with the exception of patients with ALL previously treated with an autologous CAR-T product.\n5. Treatment with other investigational agents within 5 half-lives of the planned dosing of BSB-1001 (day 0).\n6. History of treatment with checkpoint inhibitor therapy within 3 months of transplantation.\n7. Other malignancy with life expectancy \\\u003C 1year.\n8. Pregnant or lactating women.\n9. Uncontrolled bacterial, viral, or fungal infections at time of enrollment.\n10. Past or current viral infections as defined in the protocol.\n11. CNS involvement refractory to intrathecal chemotherapy and\u002For standard cranial- spinal radiation. 12 Karnofsky Performance Score \\\u003C 60%.\n\n13\\. Inadequate organ function as defined in protocol.","70 Years",{"count":54,"type":20},38,[23,56],"PHASE2","The goal of this clinical trial is to test BSB-1001 which is a new type of cellular therapy to treat blood cancers (AML, ALL and MDS). It will evaluate the safety of BSB-1001 and also determine whether it works to prevent relapse of your cancer.",[28,59,60],"ALL, Recurrent, Adult","MDS",[62],"TCR, T-cell therapy","2025-09-17",{"date":65,"type":36},"2025-09-18",{"date":67,"type":36},"2025-02-04",{"date":69,"type":20},"2029-03",{"name":42,"class":43},6,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":21,"phases":84,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":44},"100548366","phase-1-sequential-car-t-cells-targeting-cd33cd123-in-patients-with-acute-myelocytic-leukemia-aml-100548366","NCT06420063","Sequential CAR-T Cells Targeting CD33\u002FCD123 in Patients With Acute Myelocytic Leukemia AML","Sequential CAR-T Cell Infusion Targeting CD33 and CD123 for Refractory\u002FRelapsed Acute Myeloid Leukaemia","BAH244","Inclusion Criteria:\n\n* Subjects with acute myeloid leukemia who voluntarily signed informed consent and met the following criteria:\n* Age older than 6 months.\n* Confirmed expression of CLL-1, CD123 and\u002For CD33 in blast AML by immuno-histochemical staining or flow cytometry.\n* Karnofsky performance status (KPS) score is higher than 80 and life expectancy \\> 3 months.\n* Adequate bone marrow, liver and renal function as assessed by the following laboratory requirements: cardiac ejection fraction ≥ 50%, oxygen saturation ≥ 90%, creatinine ≤ 2.5 × upper limit of normal, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 × upper limit of normal, total bilirubin ≤ 2.0mg\u002FdL.\n* Hgb≥80g\u002FL.\n* No cell separation contraindications.\n* Abilities to understand and the willingness to provide written informed consent.\n\nExclusion Criteria:\n\n* Severe illness or medical condition, which would not permit the patient to be managed according to the protocol, including active uncontrolled infection.\n* Active bacterial, fungal or viral infection not controlled by adequate treatment.\n* Known HIV, hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.\n* Pregnant or nursing women may not participate.\n* Use of glucocorticoid for systemic therapy within one week prior to entering the trial.\n* Patients, in the opinion of investigators, may not be able to comply with the study.","6 Years","90 Years",{"count":83,"type":20},85,[23,56],"This is an open, single-arm, clinical study to evaluate the efficacy and safety of chimeric antigen receptor T cell immunotherapy (CAR-T) targeting CD33 or CD123 or both sequentially in the treatment of Acute Myelocytic Leukemia.",[87,88,28,89],"AML","Acute Myeloid Leukemia","AML, Adult",[91,92,93,94],"aml","cd33","cd123","CAR-T","2024-11-10",{"date":97,"type":36},"2024-11-12",{"date":99,"type":36},"2024-07-10",{"date":101,"type":20},"2026-12-28",{"name":103,"class":104},"Essen Biotech","OTHER",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":21,"phases":114,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":127},"100497543","phase-1-a-phase-i-study-of-euthare-155008eth-155008-in-aml-and-nhl-patients-100497543","NCT05758610","A Phase I Study of Euthare-155008(ETH-155008) in AML and NHL Patients","A Phase I Clinical Study of Safety, Tolerability, Pharmacokinetics, and Initial Efficacy of ETH-155008 Tablets in Patients With Relapsed or Refractory Acute Myeloid Leukemia and Non-Hodgkin's Lymphoma","Inclusion Criteria:\n\n1. Be at least 18 years of age and \\\u003C 80 years old.\n2. Must sign an informed consent form (ICF) indicating that he or she understands the purpose of and procedures required for the trial and are willing to participate in the trial prior to any other trial-related assessments or procedures, and can communicated with investigators and are willing to comply with the protocol.\n3. Has histologically or cytologically confirmed relapsed and\u002For refractory acute myelocytic leukemia(AML) or non-Hodgkin's lymphoma(NHL) with no available standard therapy or is not a candidate for available standard therapy, and for whom, in the opinion of the investigator, experimental therapy with ETH-155008 may be beneficial. In addition, the following disease-specific criteria outlined below must be met.\n\n   1. For all indolent NHL (Follicular Lymphoma\\[FL\\], Marginal Zone Lymphoma\\[MZL\\] and Waldenström Macroglobulinemia\\[WM\\]), previously treated with at least 2 prior lines of systemic therapy with at least 1 line being an anti-cluster of differentiation antigen 20(anti-CD20) antibody-containing combination regimen. For chronic lymphocytic leukemia\u002Fsmall lymphocytic lymphoma (CLL\u002FSLL), prior treatment with at least 2 lines of systemic therapy, including Bruton's tyrosine kinase(BTK) inhibitors or B-cell lymphoma-2(BCL-2) inhibitors, is required.\n   2. For mantle cell lymphoma(MCL), prior treatment with at least 2 lines of systemic therapy (including a combination regimen of anti-CD20 antibodies and BTK inhibitors) and no other approved therapy considered more appropriate by the investigators.\n   3. For aggressive B-NHL (diffuse large B cell lymphoma\\[DLBCL\\], highly malignant B-cell lymphoma\\[HGBCL\\], and primary mediastinal large B-cell lymphoma\\[PMBCL\\]), patients who can tolerate intensive therapy or autologous hematopoietic stem cell transplantation are required to have received standard second-line therapy in the past but have failed or relapsed. If patients cannot tolerate intensive therapy or autologous hematopoietic stem cell transplantation, they must have received standard first-line therapy in the past, but therapy failed or relapsed.\n   4. For T-NHL, it is required to have been adequately treated with a systemic standard dose of drugs in the past without remission or recurrence.\n   5. For AML, relapsed\u002Frefractory AML diagnosed according to the World Health Organization (WHO) classification in 2016, for which no standard treatment is available or for which standard treatment is not tolerated; According to Chinese Guidelines for the Diagnosis and Treatment of Relapsed and Refractory acute myeloid Leukemia (2021 Edition), the definition of relapsed and refractory is as follows:\n\n   \u003C!-- -->\n\n   1. Recurrent AML: recurrence of leukemia cells in peripheral blood or original cells in bone marrow ≥ 5% after CR (except for other reasons such as bone marrow regeneration after consolidation chemotherapy) or extramedullary leukemia cell infiltration.\n   2. Refractory AML: initial patients who failed to respond to 2 courses of treatment with standard protocols; Patients with CR relapse within 12 months after consolidation and intensive treatment; Patients who relapse after 12 months but fail to respond to conventional chemotherapy; Patients with two or more relapses; Extramedullary leukemia persists.\n4. For NHL, measurable lesions that meet the efficacy evaluation criteria for Lugano lymphoma (Cheson 2014) are required(at least one intranodular lesion longest diameter (LDi)﹥1.5 cm, or at least 1 extranodal lesion LDi﹥1 cm). For WM patients, immunoglobulin M(IgM) should be greater than 5g\u002FL. For chronic lymphocytic leukemia(CLL) patients, monoclonal B lymphocytes greater than 5×109\u002FL are required. For patients with AML, bone marrow primordial cells at baseline are required to be at least 5%.\n5. Eastern Cooperative Oncology Group (ECOG) performance status grade of 0 or 1 (dose escalation cohorts) or ≤2 (dose expansion cohorts).\n6. For NHL, hematology laboratory parameters must be within the following ranges. Values must be without transfusions or growth factors for at least 7 days prior to the first dose of study drug ,\n\n   1. Hemoglobin (HB) ≥80g\u002FL; In case of bone marrow invasion, hemoglobin ≥60g\u002FL is required (red blood cell infusion is allowed prior to initial administration).\n   2. Platelet (PLT) count ≥75×10\\^9\u002FL; In case of bone marrow invasion, platelet count ≥50×10\\^9\u002FL (50,000\u002FμL) is required.\n   3. Absolute count of neutrophil granulocyte (ANC) ≥1.0×10\\^9\u002FL; Absolute neutrophil count ≥0.75×10\\^9\u002FL (750\u002FμL) is required if bone marrow invasion is present.\n7. For AML, there is no upper limit on white blood cell count (WBC) at screening, but it is required before the first administration of the investigational drug WBC﹤25×10\\^9\u002FL. Note: Subjects with excess primitive cells may be treated with hydroxyurea until 2 days prior to initial administration of the study drug to reduce WBC.\n8. Blood biochemical test results must be within the following range:\n\n   1. Aspartate aminotransferase (AST), alanine aminotransferase (ALT) ≤2.5×upper limit of normal (ULN). If the subject has primary liver invasion, ALT, AST ≤5×ULN is required.\n   2. Total bilirubin(TBIL) ≤1.5×ULN. If the subject has primary liver invasion, TBIL ≤3×ULN is required.\n   3. Creatinine clearance rate(CCr)≥45 ml\u002Fmin (Cockcroft-Gault formula).\n   4. Prothrombin time(PT) and activated partial thromboplastin time(aPTT) ≤1.5×ULN.\n9. Life expectancy of at least 3 months.\n10. A woman of childbearing potential must have a negative serum beta-human chorionic gonadotropin (beta-hCG) at screening and prior to the first dose of study drug.\n11. Women must be: a. Not of childbearing potential b. Of childbearing potential and - Practicing a highly effective, preferably user-independent method of contraception (failure rate of \\\u003C1% per year when used consistently and correctly) and agrees to remain on a highly effective method while receiving study drug and until 90 days after last dose.\n12. In addition to the user-independent, highly effective method of contraception, a male or female condom is required. Male condoms and female condoms should not be used together (due to risk of failure with friction).\n13. A man who is sexually active with a woman of childbearing potential and has not had a vasectomy must agree to use a barrier method of birth control, e.g., either condom with or partner with occlusive cap (diaphragm or cervical\u002Fvault caps).\n14. Men or women must agree not to donate sperm or eggs (ova, oocytes) for the purposes of assisted reproduction during the study and for at least 3 months after the last study drug administration.\n15. Must be willing and able to adhere to the requirements and restrictions specified in the ICF and this protocol.\n\nExclusion Criteria:\n\n1. Acute promyelocytic leukemia, acute mixed phenotypic leukemia, acute myeloid leukemia with Philadelphia chromosome (Ph chromosome) positive.\n2. AML with myeloid sarcoma.\n3. The central nervous system (CNS) is known to be involved.\n4. Previous solid organ transplantation.\n5. Previously received allogeneic hematopoietic stem cell transplantation.\n6. The patient received autologous hematopoietic stem cell transplantation (HSCT) within 3 months prior to initial administration of ETH-155008.\n7. Have an active autoimmune disease within the past 2 years that requires treatment with systemic immunosuppressive drugs (i.e., long-term corticosteroids, methotrexate, or tacrolimus).\n8. Toxicities from previous anti-cancer therapies have not resolved to baseline levels or to Grade 1 or less except for alopecia and peripheral neuropathy.\n9. Has known past or current malignancy other than inclusion diagnosis, except for:\n\n   1. Cervical carcinoma of Stage ⅠB or less.\n   2. Non-invasive basal cell or squamous cell skin carcinomas.\n   3. Non-invasive, superficial bladder cancer.\n   4. Prostate cancer with a current prostate-specific antigen(PSA) level \\\u003C 0.1 ng\u002FmL.\n   5. malignancy which in the opinion of the investigator, with concurrence with the sponsor's medical monitor, is considered cured with minimal risk of recurrence within 1 year before the first dose of study drug.\n   6. Any curable cancer with a complete response(CR) of \\> 2 years duration.\n10. Prior treatment with a cyclin dependent kinase 4 and 6(CDK4\u002F6) or Pim inhibitor.\n11. Known allergies, hypersensitivity, or intolerance to ETH-155008 or its excipients.\n12. Prior chemotherapy or targeted therapy within 2 weeks(Or five half-lives, which is the longer) prior to first dosing treatment, or treatment with an investigational anticancer agent or radiotherapy (including investigational vaccines) within 4 weeks before the first administration of ETH-155008. For investigational agents where half-life is known, there should be a treatment-free window of at least 2 weeks or 5 half-lives.\n13. Prior chimeric antigen receptor T-Cell(CAR-T) immunotherapy within 12 weeks before the first administration of ETH-155008.\n14. Corticosteroids \\>10 mg daily prednisone equivalents:\n\n    a. A short course (ie, \\>10 mg daily prednisone equivalents for less than 7 days) of corticosteroids is permitted. Inhaled or topical steroids, and adrenal replacement doses ≤10 mg daily prednisone equivalents, are permitted in the absence of active autoimmune disease.\n15. History of clinically significant cardiovascular disease within the 6 months prior to the first dose of study drug including, but not limited to:\n\n    1. Corrected QT interval (QT interval corrected using Fridericia formula \\[QTcF\\]) female﹥470ms, male﹥450ms.\n    2. Myocardial infarction\n    3. Severe or unstable angina\n    4. Clinically significant cardiac arrhythmias\n    5. Uncontrolled (persistent) hypertension: systolic blood pressure \\>159 mmHg; diastolic blood pressure \\>99 mmHg\n    6. Stroke or transient ischemic attack\n    7. Venous thromboembolic events (i.e., pulmonary embolism) within 1 month prior to the first dose of study drug\n    8. Congestive heart failure (New York Heart Association class III-IV)\n    9. Pericarditis or clinically significant pericardial effusion\n    10. Myocarditis\n    11. Endocarditis\n16. Clinically significant pulmonary compromise, particularly the need for supplemental oxygen to maintain adequate oxygenation.\n17. Unable to swallow capsules or tablets or malabsorption syndrome, disease significantly affecting GI function, or resection of the stomach or small bowel, symptomatic inflammatory bowel disease or ulcerative colitis, or partial or complete bowel obstruction. If any of these conditions exist, the site should discuss with the sponsor to determine subject eligibility.\n18. Evidence of active viral, bacterial, or uncontrolled systemic fungal infection requiring parenteral treatment within 2 weeks before the first dose of study drug.\n19. Active or chronic hepatitis B or hepatitis C infection.\n\n    1. Hepatitis B infection is defined by a positive test for hepatitis B surface antigen (HBsAg)\n    2. Or HBsAg negative and positive for anti-hepatitis B core antigen (HBc) with hepatitis B virus(HBV) DNA﹥ULN\n    3. Hepatitis C infection is defined by a positive hepatitis C virus (HCV) ribonucleic acid (RNA).\n20. Tested HIV positive at screening.\n21. Syphilitic antibody positive.\n22. Trauma or major surgery (e.g., requiring general anesthesia) within 28 days prior to the first dose of study drug. Note: Subjects with planned surgical procedures to be conducted under local anesthesia may participate.\n23. Any serious underlying medical or psychiatric condition (e.g., alcohol or drug abuse), dementia or altered mental status; or any issue that would impair the ability of the subject to receive or tolerate the planned treatment at the investigational site, to understand informed consent, or that in the opinion of the investigator would contraindicate the participation in the study or confound the protocol-specified assessments or results of the study.\n24. Requires a prohibited medication that cannot be discontinued or substituted, or temporally interrupted during the study.\n25. A drug used as a substrate for cytochrome P450 3A4(CYP3A4) within 1 week (or 5 half-lives, whichever was longer) prior to initial treatment.\n26. Overactive CYP3A4 or P-glycoprotein inducers or inhibitors were used within 1 week (or 5 half-lives, if older) prior to initial treatment.\n27. A woman who is pregnant or breastfeeding.\n28. Other patients judged by the investigator to be unsuitable for inclusion.",{"count":113,"type":20},60,[23],"This Trial is an open-label, multicenter trial to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of ETH-155008 in subjects with AML and NHL who previously received standard treatment or are ineligible for standard treatment options.",[117,28],"NHL, Adult","2024-05-06",{"date":120,"type":36},"2024-05-08",{"date":122,"type":36},"2022-11-04",{"date":124,"type":20},"2026-06",{"name":126,"class":43},"Shengke Pharmaceuticals (Jiangsu) Limited, China",2]