[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"amnestic-mild-cognitive-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:amnestic-mild-cognitive-disorder":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,88],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100473568","phase-2-pathways-relating-amnestic-mci-to-a-mild-traumatic-brain-injury-history-100473568",false,"NCT05446584","Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History","PATH","Inclusion Criteria:\n\n1. Active diagnosis of amnestic mild cognitive impairment\n2. Presence of an mTBI history for the mTBI+ group; absence of an mTBI history for a control sample\n3. Female and male subjects\n4. All races\u002Fethnicities\n5. Age 55 years and older\n6. Fluent in English\n\nExclusion Criteria:\n\n1. Mild traumatic brain injury within past year\n2. Lifetime history of moderate or severe brain injury\n3. Lifetime major neurologic syndromes (e.g., stroke, epilepsy, brain tumor)\n4. Lifetime major cardiovascular conditions (e.g., heart attack, heart failure)\n5. Current substance use disorder\n6. Current major psychiatric disorders (e.g., major depressive disorder, bipolar disorder)\n7. Current vision or hearing impairment that interferes with testing\n8. Any electronic and or metallic implants in the skull or brain\n9. Current medication use known to alter HD-tDCS reactivity","ALL","55 Years",{"count":19,"type":20},75,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools. Participants who Do as well as those who Do Not have a history of mTBI will be enrolled in the study.",[26,27,28,29,30],"Mild Cognitive Impairment","Amnestic Mild Cognitive Disorder","Amnestic Mild Cognitive Impairment","Mild Traumatic Brain Injury","Concussion, Brain",[32,33,34,35,36],"MCI","TBI","memory","biomarker","Alzheimer","RECRUITING","2026-05-05",{"date":40,"type":41},"2026-05-06","ACTUAL",{"date":43,"type":41},"2023-04-20",{"date":45,"type":20},"2027-05-31",{"name":47,"class":48},"University of Texas Southwestern Medical Center","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":21,"phases":62,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":49},"100471336","low-intensity-focused-ultrasound-for-mild-cognitive-impairment-and-mild-alzheimers-disease-100471336","NCT05417555","Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease","Modulation of Hippocampal Circuitry and Memory Function With Focused Ultrasound in Amnestic MCI","LIFUP-MCIAD","Inclusion Criteria\n\n* Amnestic MCI or Mild Alzheimer's diagnosis\n* Age 50-90\n* English-speaking\n* Ability to provide informed consent\n* Normal or corrected-to-normal hearing and vision\n\nExclusion Criteria\n\nGENERAL\n\n* Participation in another clinical trial\n* Active use of immunotherapeutic medications for cognition (Aduhelm, Leqembi, Kisunla)\n* Moderate to Severe Alzheimer's\n* Inability to provide informed consent\n\nMRI-Related:\n\n* Weight exceeding 275 pounds\n* Pregnancy, suspicion of pregnancy, or attempting to become pregnant\n* Claustrophobia\n* Difficulties during previous MRIs\n* Top permanent retainer (bottom only is okay), 5 or more non-removable gold-teeth, metal braces, top spacers, and\u002For palate expanders\n* Any of the following implants: Cardiac Pacemaker, Aneurysm clips, Cochlear implants, Defibrillator, Electrodes or wires, Magnetically-activated device, Spinal cord stimulator, Infusion or insulin pumps, Implanted drug infusion device, Deep brain stimulation device\n* Non-removable hairpieces, hairpiece extensions, and\u002For piercings\n* Facial tattoos or permanent makeup\n* Metal implants that are MR-incompatible, or where participant is unable to provide sufficient information to determine MR compatibility\n* Previous injury by metallic foreign body (e.g., bullet, BB, shrapnel) where the object entered the body and participant lacks doctor's confirmation that it was fully removed\n\nMedical:\n\n* Diagnosis of one or more of the following neurological disorders: Parkinson's disease, Lou Gehrig's disease (ALS), Multiple sclerosis, Cerebral Palsy\n* Diagnosis of one or more of the following genetic disorders: Cystic Fibrosis, Sickle Cell Disease\n* Diagnosis of one or more of the following psychiatric disorders: Bipolar, Psychosis\n* Psychiatric illness that has not been controlled for at least two months (if controlled \\>2 months, with or without medication, they are not exclusionary)\n* Severe lung, liver, heart, and\u002For kidney disease\u002Fs (e.g., heart failure, liver failure, and etc...)\n* Diagnosis of thyroid disorder or change of thyroid medication dose within the last 3 months\n* Cancer treatment\u002Fs with chemotherapy and\u002For radiation to head and neck, or stage 4 (metastatic) cancer\n* Autoimmune disorder or viral infection such as HIV, COVID 19, or hepatitis C that has caused current problems with cognition\u002Fmemory\n* History of substance abuse in the past year\n* History of stroke (Transient ischemic attack \u002F mini-stroke not exclusionary if symptoms lasted \\\u003C1 week)\n* History of 2 or more seizures or diagnosis of epilepsy, unless the seizures occurred prior to age 5 alongside a fever.\n* History of brain tumor, brain aneurysm, brain hemorrhage, or subdural hematoma (transient ischemic attack not exclusionary)\n* Head injury that resulted in loss of consciousness lasting \\>30 minutes, cognitive issues lasting \\>18 months, and\u002For brain abnormalities visible in CT or MRI scan\n* Uncontrolled high blood pressure or diabetes\n* Heart attack within the last year","50 Years","90 Years",{"count":61,"type":20},144,[63],"NA","The goal of this study is to investigate whether Low Intensity Focused Ultrasound Pulsation (LIFUP) targeting a part of the brain involved in memory will have an affect on brain activity and whether it may improve memory in people with Mild Cognitive Impairment and Mild Alzheimer's Disease.\n\nThe main questions the study seeks to answer are:\n\n1. Can LIFUP increase brain activity in the targeted area?\n2. Can LIFUP improve memory in people with MCI and mild AD?\n3. Can LIFUP improve connectivity of memory networks in the brain?\n\nParticipants in this study will complete MRIs and memory testing, and receive Low Intensity Focused Ultrasound to a part of their brain involved in memory (the entorhinal cortex).",[26,27,66,67],"Deep Brain Stimulation","Mild Alzheimer's Disease",[69,70,34,71,72,73,74,75,76,77,78],"deep brain stimulation (DBS)","transcranial focused ultrasound stimulation (tFUS)","low-intensity focused ultrasound pulsation (LIFUP)","fMRI","mild cognitive impairment","mci","noninvasive brain stimulation (NIBS)","ultrasound","Alzheimer's Disease","Mild Alzheimer's","2026-04-13",{"date":81,"type":41},"2026-04-16",{"date":83,"type":41},"2022-09-01",{"date":85,"type":20},"2026-07-31",{"name":87,"class":48},"University of California, Los Angeles",{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":16,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":4,"studyType":21,"phases":99,"briefSummary":100,"conditions":101,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":49},"100550245","modified-ketogenic-diet-in-amnestic-mild-cognitive-impairments-100550245","NCT06444568","Modified Ketogenic Diet in Amnestic Mild Cognitive Impairments","Efficacy of Modified Ketogenic Diet in Amnestic Mild Cognitive Impairments","Inclusion Criteria:\n\n* Having been diagnosed with \"amnestic mild cognitive impairment\u002Fdisorder (aMCI)\" by the clinician after the evaluation of cognitive functions according to the neuropsychological evaluation method (0.5 according to the Clinical Dementia Rating Scale (CDR).)\n* Having at least 6 years of education.\n\nExclusion Criteria:\n\n* Under the age of 65 or over the age of 80.\n* Diagnosis of neurological (other than MCI) or psychological diseases.\n* GDS-15 score \\> 5 (baseline)\n* Kidney\u002Fpancreas\u002Fliver diseases or dysfunctions, Type 1 diabetes (and Type II diabetic patients receiving insulin replacement therapy), cancer, metabolic diseases (fatty acid oxidation defect, etc.), thyroid dysfunction, pulmonary or autoimmune diseases, head trauma, history of any cardiovascular event (i.e., stroke, myocardial infarction) in the last year.\n* Hypercholesterolemia (fasting T-C \\>300 mg\u002FdL or LDL-C \\>200 mg\u002FdL), non-reference B12 or folate levels according to biochemical tests performed in the last year.\n* Nutritional risks (chewing\u002Fswallowing difficulties, history of involuntary weight loss in the last 6 months, body mass index \\\u003C 22 kg\u002Fm2).\n* Use of internal device\u002Fimplant (pacemaker or hearing aid, etc.).\n* Medication use (individuals using anticholinergic, antidementia, and opioid class drugs will be excluded; individuals using antidepressant class drugs will be included in the study on the condition that it has been continued for at least 3 months and there is no change in drug type and dose during the study protocol.)","65 Years","80 Years",{"count":98,"type":20},36,[63],"This clinical study aims to examine the effectiveness of a 12-week modified ketogenic diet (MKD) intervention, especially on cognitive functions, in individuals diagnosed with amnestic-mild cognitive impairment (aMCI) and to compare the effects of control groups (passive or active).\n\nAccordingly, a sample of 36 older adults aged 65-80 years diagnosed with aMCI will be randomized into 3 different groups: passive control (without any intervention), active control (MIND: Mediterranean-DASH Intervention for Neurodegenerative Delay diet) or intervention (MKD). They will be monitored according to targeted criteria throughout the 12-week study protocol.\n\nThe main questions this study aims to answer are:\n\n* Does a 12-week MKD intervention improve cognitive functions in aMCI?\n* Does the effectiveness of the 12-week MKD intervention in aMCI (i.e., in terms of cognitive function, physical and functional measures, or metabolic\u002Finflammatory biomarkers) differ from control groups?\n\nExpected from participants during the study protocol:\n\n* Participants assigned to the passive control arm are expected to come to the research center at the beginning (week 0) and end (week 12) of the protocol and participate in evaluations.\n* Participants assigned to the active control (MIND diet) or intervention (MKD) arm are expected to adhere to assigned dietary therapy, keep a weekly food diary, and have weekly phone calls or online meetings with the dietitian to follow up on the diet. These participants assigned to the diet groups are expected to come to the research center at weeks 0, 4, 8, and 12 to participate in the evaluations.",[27,28],"2024-11-20",{"date":104,"type":41},"2024-11-25",{"date":106,"type":41},"2024-05-20",{"date":108,"type":20},"2025-03-01",{"name":110,"class":48},"Saglik Bilimleri Universitesi"]