[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"amniotic-fluid-embolism\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:amniotic-fluid-embolism":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,38],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":20,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100500094","the-establishment-of-a-registry-and-a-biorepository-of-patients-with-suspected-amniotic-fluid-embolism-afe-100500094",false,"NCT05791786","The Establishment of a Registry and a Biorepository of Patients With Suspected Amniotic Fluid Embolism (AFE)","AFE","Inclusion Criteria for participants of the AFE registry and biorepository include affected individuals diagnosed with AFE (see below).\n\n* All subjects or their next of kin must be able to provide a signed and dated informed consent form.\n* In the case of lethal AFE, the surviving family member or next of kin must be able to provide a signed and dated informed consent form with an accompanying death certificate and proof of legal kinship.\n* Participants are expected to be willing to permit collection of data about their affected pregnancy, previous and future pregnancies, and their current and future health conditions.\n* Providing biological samples is not required for enrollment.\n* Any maternal death in the Hermann Hospital System suspected of having an AFE within 24 hours of childbirth between 1\u002F2012 and 1\u002F2023 will also be included for data analysis and biospecimen studies\n* Medical records will be abstracted into a comprehensive case report form and then reviewed by a team of three experts with consensus to determine case classification of three categories, according to criteria previously reported and based on data generated from the previously existing registry:\n\n  (1) Classic AFE is defined by the following indicators:\n* Acute hypotension or cardiac arrest,\n* Acute hypoxia, defined as dyspnea, cyanosis, or respiratory arrest,\n* Coagulopathy, defined as laboratory evidence of intravascular consumption or fibrinolysis or severe clinical hemorrhage in the absence of other explanations,\n* Onset of the above during labor, cesarean section, or dilation and evacuation or within 30 minutes post-partum, and\n* Absence of any other significant confounding condition or potential explanation for the signs and symptoms observed.\n\n  (2) Not AFE:\n* Anything that clinically appears to be a likely result of another pathophysiology, e.g., delayed treatment of postpartum hemorrhage from uterine atony.\n\n  (3) Atypical AFE:\n* Subjective determination by the chart reviewer that lies between \"classic\" and \"not,\" e.g., the patient presents some of the registry criteria and no other explanation.\n\n  (4) Indeterminate: There is not sufficient information to classify in 1-3 above.\n\nThe classification of AFE is for research purposes only.\n\nExclusion Criteria:\n\n* The inability of an individual to provide a signed and dated informed consent form or those who do not wish to participate.","ALL",{"count":18,"type":19},400,"ESTIMATED","2 Weeks","OBSERVATIONAL","To establish a clinical registry of suspected cases of AFE. The existing registry will be migrated to a new platform,",[24],"Amniotic Fluid Embolism","RECRUITING","2026-05-04",{"date":28,"type":29},"2026-05-08","ACTUAL",{"date":31,"type":29},"2022-07-05",{"date":33,"type":19},"2031-12-31",{"name":35,"class":36},"The University of Texas Health Science Center, Houston","OTHER",1,{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":42,"acronym":43,"eligibilityCriteria":44,"healthyVolunteers":45,"sex":46,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":37},"100592327","analysis-of-factors-associated-with-the-occurrence-of-amniotic-fluid-entry-in-patients-undergoing-caesarean-section-100592327","NCT06991985","Analysis of Factors Associated With The Occurrence of Amniotic Fluid Entry in Patients Undergoing Caesarean Section","AOFAWTOOAFEIPU","Inclusion Criteria:\n\n* Approved consent and informed consent of the patient by the Ethics Committee of the Second Hospital of Shanxi Medical University;\n* ASA classification of I-III;\n* Age 20-50 years old;\n* No previous history of psychiatric diseases or psychotropic drugs;\n\nExclusion Criteria:\n\n* Suffer from diseases of the cardiorespiratory system;\n* Those with communication difficulties who were unable to complete the screening questionnaire;",true,"FEMALE","20 Years","50 Years",{"count":50,"type":19},120,"To compare serum STN （Neuraminic acid-N-acetylgalactose）antigen concentrations in patients undergoing cesarean section and to study the factors associated with amniotic fluid entry.Compare the serum complement C4 concentration in patients in the amniotic fluid admission group with those in the non-admission group to study whether amniotic fluid admission triggers the body's immune response.To record the patients' blood pressure, heart rate, blood oxygen, and the occurrence of related symptoms and adverse reactions at the time of admission, at the time of blood collection, at the time of discharge from the room, and at the time of the occurrence of haemodynamic changes.",[24],"NOT_YET_RECRUITING","2025-05-19",{"date":56,"type":29},"2025-05-28",{"date":58,"type":19},"2025-05-20",{"date":60,"type":19},"2025-12-31",{"name":62,"class":36},"Second Hospital of Shanxi Medical University"]