[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"amputation-congenital\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:amputation-congenital":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100554592","to-assess-the-utility-of-the-point-mini-in-a-clinical-take-home-study-100554592",false,"NCT06501092","To Assess the Utility of the Point Mini in a Clinical Take-home Study","Inclusion Criteria:\n\n* Unilateral or bilateral partial hand limb differences\n* Fluent in English or Spanish\n* Ability to follow simple directions\n* Age between 3 and 17 years\n\nExclusion Criteria:\n\n* Patients with any unhealed wounds on their residual limb(s)\n* Significant cognitive deficits as determined upon clinical evaluation\n* Inability to follow simple directions\n* Significant physical deficits including pain and scarring impacting the design and fitting of the Point Mini prosthesis\n* Other psychosocial, personal, and medical co-morbidities expressed by the subject, family or study personnel","ALL","3 Years","17 Years",{"count":19,"type":20},14,"ESTIMATED","INTERVENTIONAL",[23],"NA","The objective of this study is to evaluate the efficacy of the Point Mini system as compared to the subject's existing prosthetic treatment, which may include a prosthesis, other assistive device, or no device. This study will be a single subject crossover design where one group of 14 children with partial hand deficiencies will be evaluated on several metrics using their existing prosthetic treatment for one month and the Point Mini system for two months. Metrics include: in-clinic functional measures, subjective assessments, bilateral hand use, and prosthesis wear time.",[26,27],"Amputation; Traumatic, Hand","Amputation, Congenital","RECRUITING","2026-06-23",{"date":31,"type":32},"2026-06-26","ACTUAL",{"date":34,"type":32},"2025-06-18",{"date":36,"type":20},"2027-07-31",{"name":38,"class":39},"Point Designs","INDUSTRY",2,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":15,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":75},"100519436","cns-changes-following-upper-limb-loss-100519436","NCT06043518","CNS Changes Following Upper Limb Loss","Functional, Structural, and Metabolic Central Nervous System Changes Following Damage of the Central Nervous System","Inclusion Criteria - Patients:\n\n* Age 18-75\n* Upper-limb congenital amputees with complete absence of a hand\n* Signed informed consent\n\nExclusion Criteria - Patients:\n\n* Contraindications to magnetic resonance imaging\n* Neurological impairment of body function impairments not induced by spinal cord injury\n* BMI \\> 40\n* Pregnancy\n* Claustrophobia\n\nInclusion Criteria - Healthy subjects:\n\n* Age 18-75\n* Signed Informed consent\n\nExclusion Criteria - Healthy subjects:\n\n* Contraindications to magnetic resonance imaging\n* Pregnancy\n* Neurological illness\n* Impairment of body function induced by a congenital upper-limb amputation\n* Claustrophobia\n* BMI \\> 40",true,"18 Years","75 Years",{"count":52,"type":20},70,"OBSERVATIONAL","The objective of this study is to better understand the structural and functional changes that the central nervous system (CNS) undergoes following congenital upper limb loss. The focus is on the brain's sensory processing and how neuronal changes may relate to clinical measures. By doing so, the hope is to gain insight into the contribution of critical periods to the plasticity of the sensorimotor processing stream. Both macroscopic and microscopic changes of the brain will be examined in individuals with upper limb amelia and compared to healthy controls. fMRI will be combined with behavioural testing to understand which clinical and behavioural determinants drive somatosensory representations along the entire somatosensory processing stream. Using advanced imaging techniques, the aim is to investigate the contribution of brainstem reorganisation to plasticity observed at the cortical level and, by doing so, gain a better understanding of the mechanistic underpinnings of functional reorganisation. Overall, the hope is to provide the first mechanistic insight into whether early life experiences are crucial for the development of the relay nuclei in the central nervous system and how these changes relate to clinical measures such as adaptive behaviours or pain.",[27,56],"Upper Limb; Amelia",[58,59,60,61,62,63,64],"Plasticity","Congenital amputee","Upper limb amelia","Somatotopy","Functional MRI","Hand","Reorganisation","2025-11-14",{"date":67,"type":32},"2025-11-19",{"date":69,"type":32},"2023-07-05",{"date":71,"type":20},"2027-06-30",{"name":73,"class":74},"University of Zurich","OTHER",1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":15,"minAge":49,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":86,"conditions":87,"keywords":93,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":40},"100593821","effects-of-myoelectric-channel-count-and-targeting-for-upper-limb-prosthetic-control-100593821","NCT07011420","Effects of Myoelectric Channel Count and Targeting for Upper Limb Prosthetic Control","Evaluation of Functional Performance of Persons With Limb Differences to Optimize Pattern Recognition Control of Powered Upper Limb Prosthesis","Inclusion Criteria:\n\n* Unilateral transradial level limb absence\n* Current or past user of myo-electric controlled prostheses\n* Six months or more post-amputation\n* Have adequate limb length such that a wrist rotation device can fit in the check socket\n* Well-fitting socket as determined by a Socket-Comfort Score of 6 or above\n* Capable of wearing and operating a prosthesis with a wrist rotator and multi-articulating hand\n* Capable of understanding and following multi-step instructions and completing the tasks as described\n* English speaking\n\nExclusion Criteria:\n\n* Significant new injury that would prevent use of a prosthesis: The ability to consistently wear a prosthesis and perform activities of daily living and specific performance tasks is necessary to evaluate the relative benefits of the interventions.\n* Cognitive impairment sufficient to adversely affect understanding of or compliance with study requirements, ability to communicate experiences, or ability to give informed consent: The ability to understand and comply with requirements of the study is essential for the study to generate useable, reliable data. The ability to obtain relevant user feedback through questionnaires and informal discussion adds significant value to this study.",{"count":84,"type":20},32,[23],"The goal of this clinical trial is to systematically evaluate whether or not two commonly held fundamental assumptions for pattern recognition control translates to functional performance when tested on individuals aged 18 years or older with upper limb absence at the transradial level while wearing a physical prosthesis.\n\nThe specific aims of this study are:\n\n1. To evaluate the effect of changing untargeted myoelectric channel count on the functional performance of transradial prosthesis users wearing a fully functional prosthesis via functional outcomes measures such as the Box and Blocks test.\n2. To evaluate the effect of changing myoelectric channel targeting of a fixed number of myoelectric channels on the functional performance of transradial prosthesis users wearing a fully functional prosthesis via functional outcomes measures such as the Box and Blocks test.\n\nResearchers will perform a randomized crossover study to compare system configurations with different number of sensor channels and with various strategies for sensor placement on the limb. Participants will be assigned to a random test sequence that includes the following four different EMG channel conditions:\n\nCondition A: 4 untargeted channels Condition B: 8 untargeted channels Condition C: Up to 16 untargeted channels Condition D: 8 targeted channels\n\nResearchers will evaluate the effects of changing myoelectric channel counts on the functional prosthesis performance of individuals with transradial limb loss via functional outcome measures.\n\nParticipants will:\n\n* Attend up to 5 in-lab sessions that are expected to last 4 hours.\n* Conduct site visits every 1-2 weeks to complete functional and self reported outcome measures with each condition.\n* Play virtual games with the Coapt Cuff for 15 minutes a day, 3 days a week in between visits.",[88,89,27,90,91,92],"Amputation","Amputation, Traumatic","Prosthesis User","Upper Limb Amputation Below Elbow (Injury)","Amputation; Traumatic, Arm: Forearm, Between Elbow and Wrist",[94,95,96,97,98],"amputee","upper limb amputee","transradial amputee","prosthetic arm","upper limb prosthesis user","2025-09-02",{"date":101,"type":32},"2025-09-03",{"date":103,"type":20},"2025-10",{"date":105,"type":20},"2026-06",{"name":107,"class":39},"Liberating Technologies, Inc."]