[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"amputation-of-lower-limb\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:amputation-of-lower-limb":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,78,106],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100585912","cryo-nerve-block-extremity-amputation-registry-for-post-operative-and-phantom-limb-pain-100585912",false,"NCT06908538","Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain","Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain (VANISH)","VANISH","Inclusion Criteria:\n\n* Patients who have or will have an amputation procedure;\n* Patients who are willing and capable of providing informed consent;\n* Patients whose age is 18 years or above, or of legal age to give informed consent specific to state and national law.\n\nExclusion Criteria:\n\n* Women of childbearing potential who are, or plan to become, pregnant during the time of the study;\n* Other medical, social, or psychological conditions that in the opinion of the Investigator precludes the subject from appropriate consent or adherence to the protocol.","ALL","18 Years",{"count":20,"type":21},2000,"ESTIMATED","5 Years","OBSERVATIONAL","The goal of this Registry is to see how the device is used when freezing nerves during an amputation procedure.",[26,27,28,29,30,31],"Amputation","Amputation of Lower Limb","Amputation of Upper Limb","Amputation, Limb Loss","Amputation, Traumatic\u002FSurgery","Cryo Analgesia","RECRUITING","2026-06-25",{"date":35,"type":36},"2026-06-26","ACTUAL",{"date":38,"type":36},"2025-04-01",{"date":40,"type":21},"2035-04",{"name":42,"class":43},"AtriCure, Inc.","INDUSTRY",5,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":77},"100580976","personalized-prosthetic-foot-prescription-and-rehabilitation-for-veterans-with-lower-limb-loss-100580976","NCT06844305","Personalized Prosthetic Foot Prescription and Rehabilitation for Veterans With Lower Limb Loss","A Personalized, Patient-Centered Prosthetic Foot Prescription and Rehabilitation Strategy to Maximize Mobility and Satisfaction in Veterans With Lower Limb Loss","OPORP","Inclusion Criteria:\n\n* Unilateral transtibial amputation;\n* At least 6 months post-amputation;\n* A comfortable-fitting prosthetic socket that can be used with endoskeletal components;\n* Sufficient walking abilities to safely complete study activities.\n\nExclusion Criteria:\n\n* Major contralateral limb amputation LLL on the contralateral limb;\n* Currently receiving physical therapy related to gait training or prosthesis use.",{"count":54,"type":21},50,"INTERVENTIONAL",[57],"NA","The goal of clinical trial is to assess an integrated, patient-centered strategy combining user preference-based prosthetic foot prescription and subsequent targeted physical therapy to maximize satisfaction and mobility outcomes for Veterans and others with lower limb loss. The main aims it will address are:\n\n* Assess the effect of prosthetic foot selection based on experiential preference as determined using a variable stiffness foot on mobility and satisfaction\n* Assess the effect of a targeted physical therapy intervention following preference-based foot selection on mobility, balance, and satisfaction? Participants will walk with an emulator prosthetic foot to experience three different conditions that emulate different commercial feet to determine their most- and least-preferred foot. Participants' satisfaction, perceived mobility, and functional mobility will be measured and compared between their most- and least-preferred feet using the corresponding commercial feet. Participants will then be randomly assigned to receive either the standard-of-care (control group) or personalized physical therapy intervention for eight weeks using that preferred prosthetic foot. Participants' satisfaction, mobility, and balance will be measured pre- and post-intervention.",[27],[61,62,63,64,65],"amputation","prosthesis","prescription","physical therapy","personalized","NOT_YET_RECRUITING","2026-06-09",{"date":69,"type":36},"2026-06-10",{"date":71,"type":21},"2026-12",{"date":73,"type":21},"2029-05",{"name":75,"class":76},"Northwestern University","OTHER",1,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":55,"phases":87,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":105},"100606450","evaluating-methods-to-replicate-stumbles-and-slips-during-walking-100606450","NCT07175714","Evaluating Methods to Replicate Stumbles and Slips During Walking","Inclusion Criteria:\n\n* 40 kg \\\u003C body weight \\\u003C 136kg\n* Cognitive ability to understand all instructions and questionnaires in the study\n* Willing and able to participate in the study and following the protocol\n* Age ≥ 18 years\n* Able to walk independently without the use of assistive device such as a cane or walker\n* Able-bodied subjects OR Regular prosthesis users for at least 1 year with unilateral lower limb amputation at or below the transfemoral level (or equivalent level limb deficiency)\n\nExclusion Criteria:\n\n* Subjects with pain which can affect their mobility\n* Users with socket comfort score less than 7\n* Subjects with cognitive impairment\n* Pregnant subjects\n* Musculoskeletal disorders or neurological conditions that affect motor function, gait or balance\n* Use of medications that are known to impair balance and coordination\n* Any other conditions deemed by the investigator to make participation unsafe",true,{"count":86,"type":21},20,[57],"This protocol outlines a study designed to investigate three different methodologies for inducing gait perturbations.\n\nSubjects will be divided into two groups: prosthetic users and able-bodied individuals.\n\nEach group will undergo a series of tests where controlled perturbations are applied using up to three methodologies with the number depending on factors such as time and fatigue. These methodologies may include mechanical, visual, or auditory perturbations designed to mimic unexpected obstacles or changes in terrain.",[90,91,27],"Fall Prevention","Balance, Falls",[61,93,94,95],"falls","fall prevention","balance","2026-02-10",{"date":98,"type":36},"2026-02-13",{"date":100,"type":36},"2025-05-26",{"date":102,"type":21},"2026-12-31",{"name":104,"class":43},"Össur Iceland ehf",2,{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":55,"phases":115,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":105},"100565947","limber-unileg-rapid-on-demand-and-scaled-up-manufacturing-of-customized-transtibial-prosthetic-legs-for-amputees-100565947","NCT06648798","LIMBER UniLeg: Rapid, On-demand, and Scaled-up Manufacturing of Customized Transtibial Prosthetic Legs for Amputees","Inclusion Criteria:\n\n1. Provision of signed and dated informed consent form.\n2. Stated willingness to comply with all study procedures and availability for the duration of the study.\n3. Persons, aged 18 to 75\n4. In good general health as determined by clinical site monitor\n5. Weight \\\u003C 125kg\n6. Are not diabetic (self reported)\n7. Be a unilateral transtibial amputee of more than 1 year since amputation\n8. Have an existing prosthetic device(s) that does not use sensors or motors (is passive)\n9. Live in the Southern California region (within 50 miles of UCSD)\n10. Has sufficient sensation in residual limb as tested by the clinical site monitor\n11. Agreement to adhere to Lifestyle Considerations throughout study duration 11a. Use the testing device (EPD or UniLeg) only during the testing periods. 11b. Walk at least 14,000 steps per week (average of 1 mile per day). 11c. Maintain a similar diet and activity level throughout study duration (no abrupt changes of weight, activity, etc.)\n\nExclusion Criteria:\n\n1. Not currently using a prosthetic device\n2. Prosthetic device with active motors, sensors, etc.\n3. Pregnancy (due to fall risk)\n4. Diabetic (due to poor limb sensation), self reported\n5. No under 18 (due to inability to consent)\n6. No over 75 (due to fall risk)\n7. Poor proprioception or sensation at the residual limb","75 Years",{"count":114,"type":21},30,[57],"The LIMBER UniLeg, a 3D printed single-piece transtibial prosthetic limb, is sufficiently equivalent to traditional passive prosthetic limbs (no motors or sensors), while reducing the cost and time of manufacturing and enabling global reach through the use of digital technologies to solve the worldwide prosthetic accessibility crisis. This is a single-site, Phase I, Clinical Research Study to test the effectiveness and safety of the LIMBER UniLeg. One study group of 30 participants involved for two months using a non-inferiority design in which the participant will be assessed using their normal device (1 month) and the study device (1 month).",[27,118,119],"Prosthesis","Non-inferiority Trial of Prothesis",[118,121,122,123],"Trans-tibial amputation","Limber Unileg","3D Printed","2024-11-25",{"date":126,"type":36},"2024-11-26",{"date":128,"type":36},"2023-12-20",{"date":130,"type":21},"2026-10-31",{"name":132,"class":43},"LIMBER Prosthetics & Orthotics Inc"]