[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"amputation-traumatic-hand\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:amputation-traumatic-hand":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,66,95,121],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100603394","to-evaluate-the-clinical-impact-of-the-point-powered-system-100603394",false,"NCT07135947","To Evaluate the Clinical Impact of the Point Powered System","Inclusion Criteria:\n\n* Partial unilateral hand loss with at least index and\u002For middle fingers amputated at the MCP level\n* Intact thumb with full range of motion\n* Fluent in English\n* Age of 18 years or older\n\nExclusion Criteria:\n\n* Patients with a residual limb that is unhealed from the amputation surgery\n* Unhealed wounds\n* Significant cognitive deficits as determined upon clinical evaluation\n* Significant neurological deficits as determined upon clinical evaluation\n* Significant physical deficits of the residual limb impacting full participation in the study as determined upon clinical evaluation\n* Uncontrolled pain or phantom pain impacting full participation in the study as determined upon clinical evaluation\n* Serious uncontrolled medical problems as judged by the project therapist","ALL","18 Years",{"count":18,"type":19},10,"ESTIMATED","INTERVENTIONAL",[22],"NA","The objective of this study is to evaluate the efficacy of the Point Powered system as compared to the patient's standard-of-care treatment. This study will be a single subject crossover design where one group of 10 adult partial hand amputees will be evaluated on several metrics on their existing prosthetic treatment (Treatment 1) and the Point Powered system (Treatment 2) over a period of three months using standard two-site myoelectric control. Metrics include: in-clinic functional measures, subjective assessments, bilateral hand use, and prosthesis wear time.",[25],"Amputation; Traumatic, Hand",[27,28,29,30],"Prosthesis","Myoelectric","Digits","Fingers","NOT_YET_RECRUITING","2026-06-23",{"date":34,"type":35},"2026-06-26","ACTUAL",{"date":37,"type":19},"2026-09-01",{"date":39,"type":19},"2027-04-01",{"name":41,"class":42},"Point Designs","INDUSTRY",3,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":15,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":20,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":59,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":65},"100554592","to-assess-the-utility-of-the-point-mini-in-a-clinical-take-home-study-100554592","NCT06501092","To Assess the Utility of the Point Mini in a Clinical Take-home Study","Inclusion Criteria:\n\n* Unilateral or bilateral partial hand limb differences\n* Fluent in English or Spanish\n* Ability to follow simple directions\n* Age between 3 and 17 years\n\nExclusion Criteria:\n\n* Patients with any unhealed wounds on their residual limb(s)\n* Significant cognitive deficits as determined upon clinical evaluation\n* Inability to follow simple directions\n* Significant physical deficits including pain and scarring impacting the design and fitting of the Point Mini prosthesis\n* Other psychosocial, personal, and medical co-morbidities expressed by the subject, family or study personnel","3 Years","17 Years",{"count":53,"type":19},14,[22],"The objective of this study is to evaluate the efficacy of the Point Mini system as compared to the subject's existing prosthetic treatment, which may include a prosthesis, other assistive device, or no device. This study will be a single subject crossover design where one group of 14 children with partial hand deficiencies will be evaluated on several metrics using their existing prosthetic treatment for one month and the Point Mini system for two months. Metrics include: in-clinic functional measures, subjective assessments, bilateral hand use, and prosthesis wear time.",[25,57],"Amputation, Congenital","RECRUITING",{"date":34,"type":35},{"date":61,"type":35},"2025-06-18",{"date":63,"type":19},"2027-07-31",{"name":41,"class":42},2,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":15,"minAge":72,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":20,"phases":75,"briefSummary":77,"conditions":78,"keywords":79,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":94},"100418168","phase-4-prospective-study-on-the-role-of-intravenous-unfractionated-heparin-following-digital-replantation-and-revascularization-100418168","NCT04725201","Prospective Study on the Role of Intravenous Unfractionated Heparin Following Digital Replantation and Revascularization","Inclusion Criteria:\n\n* All replantation and revascularization patients who are accepted into the CEVARMU program at the Centre hospitalier de l'Université de Montréal\n\nExclusion Criteria:\n\n* Patients on anticoagulants, other than ASA, prior to admission (i.e. Coumadin, Eliquis, Pradaxa, Plavix, or similar medications)\n* Patients with a contraindication for heparin (e.g. coagulopathy, acute ulcers, thrombocytopenia, severe liver damage, shock)\n* Patients who suffered an amputation in the level of the carpal tunnel and proximal to it\n* Patients who experienced a degloving injury","14 Years",{"count":74,"type":19},188,[76],"PHASE4","The purpose of this study is to determine the effectiveness of therapeutic dose intravenous heparin at improving replantation\u002Frevascularization success and its indications (if any) in participants who have suffered traumatic digital amputation. Digital replantation\u002Frevascularization success will be assessed in participants who receive continuous intravenous drip of thromboprophylactic heparin at a therapeutic dose (i.e. modifies INR to the desired range) contrasted to those who do not receive therapeutic dose heparin (i.e. does not modify INR to the desired range). In the study, replantation\u002Frevascularization success is defined as a clearly viable digit at the time of discharge. Secondary objectives include assessing postoperative complications associated with heparin use, such as bleeding, hematoma or heparin induced thrombocytopenia. The investigators would also assess the impact of categorical variables such as smoking status, mechanism of injury and comorbidities, on digital survival.",[25],[80,81,82,83],"Replantation","Revascularization","Unfractionated heparin","Finger","2026-03-27",{"date":86,"type":35},"2026-04-02",{"date":88,"type":35},"2021-05-24",{"date":90,"type":19},"2027-05-01",{"name":92,"class":93},"Centre hospitalier de l'Université de Montréal (CHUM)","OTHER",1,{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":20,"phases":104,"briefSummary":105,"conditions":106,"keywords":107,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":94},"100285324","dexterous-hand-control-through-fascicular-targeting-deft---human-subjects-100285324","NCT02994160","DExterous Hand Control Through Fascicular Targeting (DEFT) - (Human Subjects)","Criteria for Inclusion of Subjects:\n\nHand, forearm and arm amputees:\n\n1. Male or female, age 18 and older, of any race or ethnicity\n2. Able and willing to sign Consent\n3. Able and willing to participate in all study activities including implantation, testing and explantation of the study device.\n4. Able to communicate effectively in English without an interpreter\n\nAfter preliminary screening subjects will be assessed for the following inclusion criteria:\n\nOverall and phantom pain are well-controlled and not incapacitating\n\nCriteria for Exclusion of Subjects:\n\n1. If MR neurogram and EMG\u002FNCS study show nerve or muscle dysfunction\u002Finjury at a higher level than anticipated based on the appearance of the physical amputation stump, the subject may be excluded from the study due to adverse neuromuscular anatomy which would preclude use of the proposed experimental electrode implants. The radiographs will be used to confirm suitability of the amputation stump configuration. If the bony anatomy of the amputation stump is found to be unsuitable, the patient may be excluded from the study.\n2. Subjects who have a history of cardiac arrhythmia will be excluded from the study.","95 Years",{"count":103,"type":19},25,[22],"Our goal is to temporarily implant the following groups for 540 +\u002F- 30 days:\n\n1. Forearm FAST electrodes\n\n   1. Five human partial hand amputees (amputated at the level of the hand) with 2 FAST electrodes in the ulnar nerve and 2-5 FAST electrodes in the median nerve.\n   2. Five human hand and forearm amputees (amputated at the level of the forearm) with 2 FAST electrodes in the ulnar nerve and 2-5 FAST electrodes in the median nerve .\n2. Arm FAST electrodes\n\n   1. Five human partial hand amputees (amputated at the level of the hand) with 2 FAST electrodes in the ulnar nerve and 2-5 FAST electrodes in the median nerve.\n   2. Five human hand and forearm amputees (amputated at the level of the forearm) with 2 FAST electrodes in the ulnar nerve and 2-5 FAST electrodes in the median nerve.\n   3. Five human hand, forearm and arm amputees (amputated at the level of the arm) with 2 FAST electrodes in the ulnar nerve and 2-5 FAST electrodes in the median nerve.",[25],[108,109,110,111],"peripheral nerve","intraneural electrode","hand amputation","forearm amputation","2026-03-03",{"date":114,"type":35},"2026-03-05",{"date":116,"type":4},"2015-06",{"date":118,"type":19},"2028-03",{"name":120,"class":93},"University of Texas Southwestern Medical Center",{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":127,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":15,"minAge":129,"maxAge":130,"enrollmentInfo":131,"targetDuration":4,"studyType":20,"phases":132,"briefSummary":133,"conditions":134,"keywords":136,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":94},"100498326","evaluation-of-myoelectric-implantable-recording-array-mira-in-participants-with-transradial-amputation-100498326","NCT05768802","Evaluation of Myoelectric Implantable Recording Array (MIRA) in Participants With Transradial Amputation","Evaluation of an Implantable Intramuscular Device to Control a Myoelectric Prosthesis","MIRA","Inclusion Criteria:\n\n1. Subjects must have a unilateral transradial amputation or wrist disarticulation.\n2. Subjects must demonstrate independent voluntary control of muscles in the flexor and extensor compartments of the forearm\n3. Subjects must be over 1-year post-amputation at time of implantation.\n4. Subjects must be between the ages of 22 and 70 years old. Subjects outside this age range may be at an increased surgical risk and increased risk of fatigue during prosthetic training.\n5. Subjects must be able to communicate with the investigators in English because of the need to follow the instructions of the study team.\n6. Subjects must show an understanding of the study goals and have the ability to follow simple directions as judged by the investigators.\n7. Subjects must pass a neuropsychological and psychosocial assessment.\n8. Documentation of informed consent must be obtained from the subject.\n\nExclusion Criteria:\n\n1. Subjects must be able to function without the use of a prosthesis, or have access to assistance, for a period of 6 weeks following implantation and explantation surgeries.\n2. Subjects must not have visual impairment such that extended viewing of a computer monitor would be difficult even with ordinary corrective lenses.\n3. Subjects who have another serious disease(s) or disorder(s) that could affect their ability to participate in this study (verified during pre-op anesthesia evaluation to determine surgical risk status) will be excluded.\n4. Subjects must not have phantom limb pain that is self-reported to be severe (options are no pain, mild pain, moderate pain, severe pain).\n5. Subjects must not have any type of implantable generator such as a pacemaker, spinal cord stimulator, cochlear implant, deep brain stimulator (DBS) or DBS leads, vagus nerve stimulator, or defibrillator.\n6. Female subjects of childbearing age must not be pregnant, lactating, or plan to become pregnant during the next 25 months.\n7. Subjects must have no history of peripheral vascular disease that could impact wound healing.\n8. Subjects who require routine MRI, therapeutic ultrasound, or diathermy as part of their ongoing care will be excluded.\n9. Subjects must not have osteomyelitis.\n10. Subjects must have no history of intractable clinically relevant cardiac arrhythmias.\n11. Subjects must have no active infection(s) or unexplained fever(s) (verified during pre-op anesthesia evaluation to determine surgical risk status).\n12. Subject must have no history of ongoing untreated alcoholism.\n13. Subject must not be receiving chronic oral or intravenous steroids or immunosuppressive therapy.\n14. Subjects must not be receiving medications that affect blood coagulation.\n15. Subjects must not have had active cancer within the past year (other than adequately treated basal cell or squamous cell skin cancer) or require chemotherapy.\n16. Subjects must not have uncontrolled insulin dependent diabetes mellitus.\n17. Subjects who have had a seizure in the last two years will be excluded.\n18. Subjects who have attempted suicide in the past 12 months will be excluded.\n19. Subjects who are immunosuppressed or who have conditions that typically result in immunocompromise (including, but not limited to: ataxia-telangiectasia, cancer, Chediak-Higashi syndrome, combined immunodeficiency disease, complement deficiencies, DiGeorge syndrome, HIV\u002FAIDS, hypogammaglobulinemia, Job syndrome, leukocyte adhesion defects, malnutrition, panhypogammaglobulinemia, Bruton disease, congenital agammaglobulinemia, selective deficiency of IgA and Wiscott-Aldrich syndrome) will be excluded.\n20. Subjects with active psychiatric concerns, including but not limited to major depression, bipolar disorder, schizophrenia or other psychotic disorder and post-traumatic stress disorder. Individuals undergoing effective treatment for any of these disorders will not be excluded, but will be evaluated by a rehabilitation psychologist.\n21. Subjects who report use of controlled, non-prescribed substances other than cannabis\u002Fmarijuana will be excluded. If a subject reports use of cannabis, we will use the DAST-10 questionnaire to screen for level of abuse. An individual may be included if the score is 5 or less and if the neuropsychologist deems that they are eligible. Subjects reporting use of cannabis will also undergo a urine drug test to screen for other nonprescribed drugs. Subjects will be excluded if they test positive for any non-prescribed substance other than cannabis.","22 Years","70 Years",{"count":5,"type":19},[22],"The purpose of this research study is to see how well a new type of myoelectric prosthesis works. A myoelectric prosthesis is a robotic limb for amputees that is controlled by sensing the activity of muscles in the body above the amputation level. This study involves a medical procedure to implant the Myoelectric Implantable Recording Array (MIRA) in the residual limb. The procedure will be performed under sedation by a physician. When muscles contract, they generate an electrical signal that can be sensed by MIRA and used to control the prosthetic limb. Myoelectric prosthetic limbs normally use electrodes that are placed on the surface of the skin to control different movements. However, MIRA is implanted under the skin, which could improve the ability to control the myoelectric prosthesis. After the MIRA is implanted, training will occur to learn how to control the prosthesis using the muscles in the residual limb. The device can stay implanted for up to one year. The device will be removed (explanted) by a physician.",[135,25],"Amputation",[110,137,138],"wrist amputation","transradial amputation","2026-02-25",{"date":141,"type":35},"2026-02-27",{"date":143,"type":35},"2026-01-16",{"date":145,"type":19},"2030-12",{"name":147,"class":93},"Boninger, Michael, MD"]