[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"amputation-traumaticsurgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:amputation-traumaticsurgery":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,82,111],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100585912","cryo-nerve-block-extremity-amputation-registry-for-post-operative-and-phantom-limb-pain-100585912",false,"NCT06908538","Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain","Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain (VANISH)","VANISH","Inclusion Criteria:\n\n* Patients who have or will have an amputation procedure;\n* Patients who are willing and capable of providing informed consent;\n* Patients whose age is 18 years or above, or of legal age to give informed consent specific to state and national law.\n\nExclusion Criteria:\n\n* Women of childbearing potential who are, or plan to become, pregnant during the time of the study;\n* Other medical, social, or psychological conditions that in the opinion of the Investigator precludes the subject from appropriate consent or adherence to the protocol.","ALL","18 Years",{"count":20,"type":21},2000,"ESTIMATED","5 Years","OBSERVATIONAL","The goal of this Registry is to see how the device is used when freezing nerves during an amputation procedure.",[26,27,28,29,30,31],"Amputation","Amputation of Lower Limb","Amputation of Upper Limb","Amputation, Limb Loss","Amputation, Traumatic\u002FSurgery","Cryo Analgesia","RECRUITING","2026-06-25",{"date":35,"type":36},"2026-06-26","ACTUAL",{"date":38,"type":36},"2025-04-01",{"date":40,"type":21},"2035-04",{"name":42,"class":43},"AtriCure, Inc.","INDUSTRY",5,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":66,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":44},"100586924","pilot-trial-for-woundx-clinical-decision-support-tool-100586924","NCT06921707","Pilot Trial for WounDx™ Clinical Decision Support Tool","SC2i-WounDx-001-WounDx™ Pilot Trial: Proof of Concept Feasibility for the Clinical Operations of WounDx™ in Aiding Clinicians Identify Wounds That Are Ready For Surgical Closure","Inclusion Criteria:\n\n* Wound surface area ≥75cm 2\n* Extremity injury (including shoulder and buttock - without visceral communication)\n* Wound amenable to Negative Pressure Wound Therapy using 3M™ V.A.C. ® canisters without gel pack\n\nExclusion Criteria:\n\n* Insulin Dependent Diabetes\n* Peripheral Vascular Disease\n* Connective Tissue Disorders\n* Preexisting immunosuppressive conditions or immunosuppression therapy\n* Pregnancy\n* Prisoners","65 Years",{"count":54,"type":21},40,"INTERVENTIONAL",[57],"NA","The purpose of this research is to evaluate the overall use of the WounDx medical device in a clinical setting, such as a hospital. The WounDx device is experimental and not yet approved by the United States Food and Drug Administration (FDA). WounDx uses information about a patient's wound to generate a report that a surgeon may use to help determine when to close or not close the wound. The final decision to close the wound remains with the surgeon. The results from this pilot trial will inform a larger pivotal trial.",[60,61,62,63,30,64,65],"Wounds","Wounds and Injuries","Extremity Injury","Traumatic Wounds and Injuries","Amputation, Wound","Open Fracture Wounds",[60,62,67,68,69,70,71],"Clinical Decision Support Tool","Delayed Wound Closure","Cytokine Biomarkers","Wound Effluent","Traumatic Extremity Wounds","2026-04-14",{"date":74,"type":36},"2026-04-17",{"date":76,"type":21},"2026-03-21",{"date":78,"type":21},"2026-09-20",{"name":80,"class":81},"Henry M. Jackson Foundation for the Advancement of Military Medicine","OTHER",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":4},"100600835","comparison-between-digital-nerve-microanastomosis-and-traction-neurectomy-in-post-digital-amputation-pain-100600835","NCT07102654","Comparison Between Digital Nerve Microanastomosis and Traction Neurectomy in Post-Digital Amputation Pain","Comparison Between Digital Nerve Microanastomosis and Traction Neurectomy in Post-Digital Amputation Pain: A Prospective Study","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patients who have undergone a traumatic digital amputation\n* Patients treated with one of the two following techniques: microanastomosis of digital nerves or traction neurectomy\n* Postoperative follow-up of at least 6 months\n\nExclusion Criteria:\n\n* Patients treated with a surgical intervention other than microanastomosis of digital nerves or traction neurectomy for digital amputation\n* Non-traumatic amputations (e.g., cancer or infection)\n* Follow-up of less than 6 months\n* Patients with pre-existing peripheral neuropathy",{"count":90,"type":21},50,"The goal of this prospective observational study is to assess the post-operative pain in adults with digital amputation following two different surgical interventions: microanastomosis of digital nerves or traction neurectomy. The main questions it aims to answer are:\n\n* Which surgical intervention results in less post-operative pain?\n* Which surgical intervention leads to fewer symptoms after six months?\n* Which surgical intervention is associated with fewest post-operative complications? Participants will complete a Visual Analog Scale (VAS) to assess the pain and the Disabilities of the Arm, Shoulder and Hand Questionnaire (DASH) to evaluate the disabilities.\n\nThe researchers will assess post-operative complications during follow-up appointments.",[93,94,30,95],"Amputation Stump","Amputation Neuroma","Amputation, Surgical",[97,98,99,100],"microanastomosis","traction neurectomy","digital amputation","digital nerve","NOT_YET_RECRUITING","2025-09-11",{"date":104,"type":36},"2025-09-15",{"date":106,"type":21},"2025-12-01",{"date":108,"type":21},"2026-07-01",{"name":110,"class":81},"Centre hospitalier de l'Université de Montréal (CHUM)",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":117,"minAge":18,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":55,"phases":121,"briefSummary":124,"conditions":125,"keywords":132,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":154},"100239468","phase-2-human-penile-allotransplantation-100239468","NCT02395497","Human Penile Allotransplantation","Donor Inclusion Criteria:\n\n* Males aged 16 - 65 years.\n* Brain dead meeting the criteria for Determination of Death.\n* Family consent for penile graft donation.\n* Stable donor (i.e., does not require excessive vasopressors to maintain blood pressure).\n* Same blood type as recipient.\n* Negative lymphocytotoxic crossmatch.\n* Accurately matched for skin tone\n\nRecipient Inclusion Criteria:\n\n* Males of any race, color or ethnicity; aged 18-69 years.\n* Recent (≥6 months) or remote (i.e., several decades) penile injury resulting in the loss of ≥75% of the phallus.\n* Penectomy secondary to penile cancer\n* Penile Cancer Survivors \\> 5 years\n* Micropenis associated with congenital\u002Fbirth defect and severely ambiguous male genitalia\n* Must have completed a clinic appointment with one of the study surgeons to discuss all penile reconstructive options.\n* Completes the protocol informed consent form(s).\n* No co-existing medical condition which, in the opinion of the study team, could affect the immunomodulatory protocol, surgical procedure, or functional results (If the condition is amenable to treatment, the study team must agree that said condition should not significantly enhance the surgical risks of penile transplantation.).\n* No co-existing psycho-social problems (i.e., alcoholism, drug abuse).\n* Negative for malignancy for past 5 years.\n* Negative for HIV at transplant.\n* Negative crossmatch with donor.\n* Consents to sample (i.e., skin biopsy) collection and storage and bone marrow infusion as part of the treatment regimen.\n* USA citizen or equivalent.\n* Patient agrees to comply with the protocol and states a dedication to the immunomodulatory treatment regimen.\n\nRecipient and Donor Exclusion Criteria:\n\n* Untreated sepsis.\n* HIV (active or seropositive).\n* Active tuberculosis.\n* Active Hepatitis B infection.\n* Hepatitis C.\n* Viral encephalitis.\n* Toxoplasmosis.\n* Malignancy (within past 5 years).\n* Current\u002Frecent (within 3 months of donation\u002Fscreening consent) IV drug abuse.\n* Paralysis of ischemic or traumatic origin.\n* Inherited peripheral neuropathy.\n* Infectious, post infectious, or inflammatory (axonal or demyelinating) neuropathy.\n* Toxic neuropathy (i.e. heavy metal poisoning, drug toxicity, industrial agent exposure).\n* Mixed connective tissue disease.\n* Severe deforming rheumatoid or osteoarthritis in the limb.\n\nDonor Only Exclusion Criteria:\n\n* Evidence of active herpes simplex virus-2 (HSV-2) infection.\n* Tattoos: non-professional tattoo within the last 6 months, or personally identifiable tattoo (i.e., donor name) on potential transplant.\n\nRecipient Only Exclusion Criteria:\n\n* Conditions that, in the opinion of the study team, may impact the immunomodulatory protocol potentially exposing the recipient to an unacceptable risk under immunosuppressive treatment.\n* Sensitized recipients with high levels (50%) of panel-reactive human leukocyte antigen (HLA) antibodies.\n* Conditions that may impact the success of the surgical procedure or increase the risk of postoperative complications including inherited coagulopathies like Hemophilia, Von-Willebrand's disease, Protein C and S deficiency, Thrombocythemias, Thalassemias, Sickle Cell disease, etc.\n* Conditions that may impact functional outcomes including Lipopolysaccharidosis and amyloidosis (may impact nerve regeneration).\n* Patients considered psychologically\u002Fpsychiatrically unsuitable.","MALE","69 Years",{"count":120,"type":21},60,[122,123],"PHASE2","PHASE3","Injuries to the genitalia are of concern to the military with emphasis placed on the surgical reconstruction and psychological health of these Wounded Warriors. However, despite significant surgical advances in microvascular surgery and autologous free tissue transfer, conventional reconstructions cannot truly replace the complicated structures and functions of the penis including the urethra, erogenous sensation, and erectile corporal bodies. Conventional reconstruction poses several challenges: patients may not have sufficient donor tissue due to other injuries or previous surgery; multiple operations are often needed to restore the neophallus; the final reconstruction only approximates the penis' native form; recreating the urethra is challenging and the new urethra is prone to stricture and fistula formation; the erectile function necessary for sexual intercourse is often lacking; and insufficient protective sensation can lead to penile implant extrusion, infection, subsequent explantation or loss of the reconstruction.\n\nThe investigators propose this clinical trial to determine functional outcomes and quality of life for Wounded Warriors and civilians who choose to undergo penile allotransplantation. The investigators will combine extensive experience performing total penile reconstruction in a large population affected by congenital, traumatic, and therapeutically extirpated Genitourinary deformities and expertise in reconstructive transplantation using an immunomodulatory protocol to for this study. The investigators anticipate penile transplantation can potentially replace \"like with like,\" restoring the appearance, anatomy, and function of the recipient in a manner far superior to autologous reconstruction. This project will establish the ability to perform penile allotransplantation using an immunomodulatory protocol and will compare outcomes with conventional phalloplasty patient results.\n\nStudy Design: This is a non-randomized subject self-controlled clinical trial to implement a cell-based immunomodulatory protocol for penile allotransplantation. An intermediate deliverable is achieving allograft survival and functional return with reduced dosing\u002Ffrequency of maintenance immunosuppression on steroid-free monotherapy (tacrolimus) immunosuppression. The long-term deliverable and goal is to demonstrate superior outcomes when compared to satisfaction and QOL in conventional phalloplasty patients 12-60 months post-transplant.",[26,61,126,127,30,128,129,130,131],"Amputation, Traumatic","Urologic Surgical Procedures, Male","Penis\u002FTransplantation","Penis\u002FSurgery","Penis\u002FInjuries","Congenital Anomaly, Male Genitalia",[133,134,135,136,26,137,138,139,140,141,142,143,144],"Penile Transplant","Vascularized Composite Allotransplantation (VCA)","Composite Tissue Allotransplantation (CTA)","Penis","Immunosuppression","Composite Tissue","Male","Humans","Allotransplantation","Micropenis","Severely Aambiguous Male Genitalia","congenital\u002Fbirth defect","2025-07-03",{"date":147,"type":36},"2025-07-07",{"date":149,"type":36},"2014-06",{"date":151,"type":21},"2039-06",{"name":153,"class":81},"Johns Hopkins University",1]