[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"amputation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:amputation":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,66,0,25,[9,46,76,103,130,161,189,215,246,268,291,322,354,382,409,430,453,483,504,525,553,575,608,642,666],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100585912","cryo-nerve-block-extremity-amputation-registry-for-post-operative-and-phantom-limb-pain-100585912",false,"NCT06908538","Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain","Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain (VANISH)","VANISH","Inclusion Criteria:\n\n* Patients who have or will have an amputation procedure;\n* Patients who are willing and capable of providing informed consent;\n* Patients whose age is 18 years or above, or of legal age to give informed consent specific to state and national law.\n\nExclusion Criteria:\n\n* Women of childbearing potential who are, or plan to become, pregnant during the time of the study;\n* Other medical, social, or psychological conditions that in the opinion of the Investigator precludes the subject from appropriate consent or adherence to the protocol.","ALL","18 Years",{"count":21,"type":22},2000,"ESTIMATED","5 Years","OBSERVATIONAL","The goal of this Registry is to see how the device is used when freezing nerves during an amputation procedure.",[27,28,29,30,31,32],"Amputation","Amputation of Lower Limb","Amputation of Upper Limb","Amputation, Limb Loss","Amputation, Traumatic\u002FSurgery","Cryo Analgesia","RECRUITING","2026-06-25",{"date":36,"type":37},"2026-06-26","ACTUAL",{"date":39,"type":37},"2025-04-01",{"date":41,"type":22},"2035-04",{"name":43,"class":44},"AtriCure, Inc.","INDUSTRY",5,{"id":47,"slug":48,"hasResults":12,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":75},"100548355","prosthetic-performance-enhancement-trial-100548355","NCT06419920","Prosthetic Performance Enhancement Trial","PROSPER","Inclusion Criteria:\n\n* lower limb amputation at ankle (Symes) level and above\n* age 18+ years\n* fitted with a walking prosthesis and use it regularly for home and\u002For community ambulation\n* good socket fit, assessed by a score of 8-10 on the socket fit comfort scale\n* able to walk for three minutes at a time with or without an assistive device\n\nExclusion Criteria:\n\n* leg\u002Ffoot ulcer or other conditions that cause pain during weight-bearing\n* poor skin integrity that could cause tissue breakdown by walking\n* cardiovascular, respiratory or other critical health conditions that preclude moderate physical activity\n* unilateral or bilateral upper limb absence or loss at the wrist and above that precludes use of handrails bilaterally, or would require asymmetrical adaptation to body posture for use.\n* pregnancy",{"count":54,"type":22},35,"INTERVENTIONAL",[57],"NA","The purpose of this research is to determine the feasibility of an uneven terrain walking program for lower limb prosthesis users. The training is designed to induce step-to-step variability during walking within a safe environment, with the aim of improving walking skill and confidence.",[27,60,61,62,63,64],"Lower Limb Amputation Below Knee (Injury)","Lower Limb Amputation Above Knee (Injury)","Lower Limb Amputation at Ankle (Injury)","Lower Limb Amputation Knee","Lower Limb Amputation at Hip (Injury)","2026-06-18",{"date":67,"type":37},"2026-06-23",{"date":69,"type":37},"2025-06-26",{"date":71,"type":22},"2027-07",{"name":73,"class":74},"University of Nevada, Las Vegas","OTHER",1,{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":18,"minAge":19,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":55,"phases":86,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":75},"100643041","evaluation-of-a-powered-ankle-prosthesis-capable-of-bidirectional-control-via-neural-recording-and-cutaneous-stimulation-in-free-space-and-walking-tasks-100643041","NCT07645729","Evaluation of a Powered Ankle Prosthesis Capable of Bidirectional Control Via Neural Recording and Cutaneous Stimulation in Free-Space and Walking Tasks","Inclusion Criteria:\n\n* Male or Female age 18-70. The patient must have a unilateral transtibial amputation . The patient must have the ability to ambulate at variable cadence (an expected lower extremity prosthesis functional level of K3 or above).\n\nThe patient must have adequate socket to support the device.\n\nExclusion Criteria:\n\n* Women who are pregnant. Severe co morbidity, atypical skeletal anatomy, or poor general physical\u002Fmental health that, in the opinion of the Investigator, will not allow the subject to be a good study candidate (i.e. other disease processes, mental capacity, substance abuse, shortened life expectancy, vulnerable patient population, BMI \\>40, etc.).",true,"70 Years",{"count":85,"type":22},10,[57],"The purpose of this study is to evaluate the performance of a powered ankle prosthesis capable of bidirectional control via neural recording and cutaneous stimulation, during free-space and walking tasks. This research aims to assess the sense of embodiment with the device, gait symmetry, and stability of a person with lower-extremity amputation walking with a powered ankle and their prescribed prosthesis. Findings from this study will inform future developments in bionic ankle design with optimal integration with the human body, with the goal of improving prosthetic integration into daily life.",[27],[90,91,92,93],"prosthesis","neuroprosthesis","osseointegration","amputation","2026-06-11",{"date":96,"type":37},"2026-06-12",{"date":98,"type":37},"2025-10-21",{"date":100,"type":22},"2031-09-30",{"name":102,"class":74},"Massachusetts Institute of Technology",{"id":104,"slug":105,"hasResults":12,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":113,"conditions":114,"keywords":116,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":75},"100565659","usability-of-the-smart-hallway-system-in-clinical-setting-100565659","NCT06645054","Usability of the Smart Hallway System in Clinical Setting","Smart Hallway for Gait Assessment","SmartHallway","Inclusion Criteria:\n\n* ability to walk at least 10 metres without help of a person,\n* no severe cognitive problems (able to answer questionnaires),\n* native Slovenian speakers,\n* wiling to participate (signed informed consent)\n\nExclusion Criteria:\n\n* severe cognitive impairment,\n* not being able to walk with or without a prosthesis or orthosis.",{"count":112,"type":22},100,"The aim of the study is to examine suitability of data and processed reports acquired from the Smart Hallway system for clinical settings in terms of user acceptability and accuracy for use in clinical practice.",[27,115],"Gait Disorders, Neurologic",[117,118,119,120,121],"Gait analysis","Computerised assessment","Rehabilitation","Lower limb loss","Prosthetics and orthotics",{"date":123,"type":37},"2026-06-15",{"date":125,"type":37},"2024-03-24",{"date":127,"type":22},"2026-09",{"name":129,"class":74},"University Rehabilitation Institute, Republic of Slovenia",{"id":131,"slug":132,"hasResults":12,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":55,"phases":140,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":160},"100492978","phase-3-po-vs-iv-antibiotics-for-the-treatment-of-infected-nonunion-of-fractures-after-fixation-100492978","NCT05699174","PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation","PO Versus IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation","POvIV2","Inclusion Criteria:\n\n1. 1\\. Bone fracture (proximal to and including the tarsal\u002Fmetatarsal joint (Lisfranc) or proximal to the carpal joints (includes distal radius fractures), excluding pelvis and spine) that has previously undergone fixation and has not healed and requires fixation to be retained or replaced at least until bone union. Fractures that have not healed and require revision fixation are also eligible.\n2. Infection as determined by either\n\n   1. FRI criteria\n   2. CDC criteria (without the timeframe) This includes the possibility of culture negative, but determined to be infection by treating surgeon\n3. Systemic antibiotic treatment regimen scheduled for at least 6 weeks\n\nExclusion Criteria:\n\n1. Patients with a high risk of amputation based on the initial managing physician\n2. Patients undergoing treatment of any other investigational therapy within the month preceding infection treatment or planned within the 12 months following infection treatment\n3. Incarcerated or institutionalized patients\n4. Patients who are unable to return for required follow-up visits and\u002For medical co-morbidities which preclude treatment with a general anesthetic\n5. Patients with a prior history of chronic infection at the index site before fracture fixation\n6. Patients with pathological fractures from a neoplastic process\n7. History of Paget's Disease\n8. The patient, or a designated proxy, unwilling to provide consent\n9. The patient must be available for follow-up for at least 12 months following infection treatment",{"count":139,"type":22},250,[141],"PHASE3","This is a Phase III clinical randomized control trial to investigate differences between patient with an infected nonunion treated by PO vs. IV antibiotics. The study population will be 250 patients, 18 years or older, being treated for infected nonunion after internal fixation of a fracture with a segmental defect less than one centimeter. Patients will be randomly assigned to either the treatment (group 1) PO antibiotics for 6 weeks or the control group (group 2) IV antibiotics for 6 weeks. The primary hypothesis is that the effectiveness of oral antibiotic therapy is equivalent to traditional intravenous antibiotic therapy for the treatment of infected nonunion after fracture internal fixation, when such therapy is combined with appropriate surgical management. Clinical effectiveness will be measured as the primary outcome as the number of secondary re-admissions related to injury and secondary outcomes of treatment failure (re-infection, nonunion, antibiotic complications) within the first one year of follow-up, as defined by specified criteria and determined by a blinded data assessment panel. In addition, treatment compliance, the cost of treatment, the number of surgeries required, the type and incidence of complications, and the duration of hospitalization will be measured.",[144,145,146,147,27,148,149,150,151],"Infections","Infected Wound","Nonunion of Fracture","Injury Leg","Internal Fixation; Complications, Infection or Inflammation","Fracture","Lower Extremity Fracture","Antibiotic Side Effect","2026-06-09",{"date":94,"type":37},{"date":155,"type":37},"2023-05-30",{"date":157,"type":22},"2028-09-29",{"name":159,"class":74},"Major Extremity Trauma Research Consortium",13,{"id":162,"slug":163,"hasResults":12,"nctId":164,"briefTitle":165,"officialTitle":165,"acronym":4,"eligibilityCriteria":166,"healthyVolunteers":82,"sex":18,"minAge":19,"maxAge":167,"enrollmentInfo":168,"targetDuration":4,"studyType":55,"phases":170,"briefSummary":172,"conditions":173,"keywords":176,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":75},"100358467","phase-2-autologous-volar-fibroblast-injection-into-the-stump-site-of-amputees-100358467","NCT03947450","Autologous Volar Fibroblast Injection Into the Stump Site of Amputees","Inclusion Criteria:\n\nPatients interested in study participation must meet all of the following inclusion criteria:\n\n* May be male or female\n* Must be between 18 years and 65 years of age\n* Must have a below the knee amputation.\n* Must be using a prosthetic for the vicinity of 3 months or have had osteo-integration of a prosthetic in place for 1 month.\n* In the opinion of the investigator, must be medically able to undergo the administration of study material determined by laboratory tests obtained within 7 days before baseline for which the investigator identified no clinically significant abnormality.\n* Be able to comprehend the informed consent document and provide consent for participation\n* Females of childbearing potential must:\n\n  * have a negative pregnancy test at screening\n  * agree to not become pregnant or breastfeed for the period of the study through 1 month after completion of the study\n  * be willing to use a reliable form of contraception during the study\n* Be willing and able to comply with the scheduled visits, biopsy\u002Finjection procedures, wound care instructions treatment plan, and other study procedures for the duration of the study.\n\nExclusion Criteria:\n\nPatients meeting any of the following criteria will be ineligible for study participation:\n\n* A skin erosion deeper than the skin dermis.\n* Having received any investigational drug within 30 days prior to study entry\n* An allergy history to any study materials including local anesthetic, dimethyl sulfoxide, human albumin, or bovine constituents, hetastarch, or EMLA (lidocaine 2.5% and prilocaine 2.5%).\n* Pregnant, lactating, or trying to become pregnant\n* A history of keloid formation\n* Having a significant medical history that the investigator feels is not safe for study participation (for example, some forms of autoimmune conditions, metastatic cancer, infectious diseases such as HIV, HTLV I\u002FII, Hepatitis B, Hepatitis C). Biopsies taken from individuals with infections that are not allowed to enter the cell therapy core will make it such that these individuals cannot participate.\n* Specifically we will exclude those with autoimmune diseases affecting the skin such as lupus.\n* Presence of necrotic ischemic tissue on any stump ulcers, and\u002For capillary refill on stump skin of greater than 3 seconds\n* Active infection of the residual limb.\n* Active smoker during the study\n* We will also exclude those who are on chronic immunosuppressive therapies such as oral steroids, but also those on chronic topical steroids in the area of investigation.\n* Recent amputee who has not yet been approved to use a prosthetic.\n* Use of a prosthetic for less than 3 months.\n* Amputees with neuromas of the terminal limb within the last 3 months.\n* Known bleeding disorder.\n* For those receiving Bellafill\u002Fcollagen skin test: history of serious allergy, such as anaphylaxis.\n* For whole stump injections: Have a history of congenital or idiopathic methemoglobinemia, glucose-6-phosphate deficiencies, or use of medications associated with drug-induced methemoglobinemia. (specifically: Sulfonamides, Acetaminophen, Acetanilid, Aniline dyes, Benzocaine, Chloroquine, Dapsone, Naphthalene, Nitrates and Nitrites, Nitrofurantoin, Nitroglycerin, Nitroprusside, Pamaquine, Para-aminosalicylic acid, Phenacetin, Phenobarbital, Phenytoin, Primaquine, or Quinine.)","65 Years",{"count":169,"type":22},50,[171],"PHASE2","This study is a clinical trial testing the safety and efficacy of volar fibroblast (skin cells from the palm or sole) injections for thickening the epidermal (skin) layer at the stump site in people with below the knee amputations. The study will enroll adults seen at Johns Hopkins.",[27,174,175],"Skin Wound","Stem Cell",[93,177,178,179,180],"stem cells","autologous fibroblast","skin wound","skin breakdown","2026-06-08",{"date":152,"type":37},{"date":184,"type":37},"2019-09-05",{"date":186,"type":22},"2028-04-01",{"name":188,"class":74},"Johns Hopkins University",{"id":190,"slug":191,"hasResults":12,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":4,"eligibilityCriteria":195,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":196,"targetDuration":4,"studyType":55,"phases":198,"briefSummary":199,"conditions":200,"keywords":202,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":214},"100598711","comparing-the-attentional-demands-and-functional-outcomes-in-people-with-transradial-amputation-100598711","NCT07075042","Comparing the Attentional Demands and Functional Outcomes in People With Transradial Amputation","Comparing the Attentional Demands and Functional Outcomes of Pattern Recognition and Direct Myoelectric Control in People With Transradial Amputation","Inclusion Criteria:\n\n* 18 years of age or older\n* Unilateral transradial limb loss\n* At least 6 months since loss\n* Previous or current use of a myoelectric device for 3 months or longer\n* Use of a prosthesis at least 4 days each week\n* Ability to read, write, and understand English\n* Willingness to use each control strategy as primary device for 3 months each (6 months commitment total)\n\nExclusion Criteria:\n\n* Any health condition that would prevent safely completing trial activities\n* Discontinued use of a myoelectric prosthesis due to non-financial reasons",{"count":197,"type":22},32,[57],"Different ways of controlling an upper-limb prosthesis can affect how easy it is to use and how helpful it is in everyday activities. One common method, called direct control, uses signals from two muscles and can make switching between movements difficult. Another clinically available option, called pattern recognition control, uses signals from several muscles to better understand the user's intended movement and may feel more natural to use. This study compares these two control methods to see how they affect function for adults with below-the-elbow limb loss.",[27,201],"Prosthesis Use",[203,204,205],"Transradial Amputation","Direct Myoelectric Control","Pattern Recognition Controller (PRC)","2026-06-05",{"date":181,"type":37},{"date":209,"type":22},"2026-07",{"date":211,"type":22},"2027-12",{"name":213,"class":74},"Virginia Commonwealth University",2,{"id":216,"slug":217,"hasResults":12,"nctId":218,"briefTitle":219,"officialTitle":219,"acronym":220,"eligibilityCriteria":221,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":222,"enrollmentInfo":223,"targetDuration":225,"studyType":24,"phases":4,"briefSummary":226,"conditions":227,"keywords":229,"overallStatus":237,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":244,"locationsCount":75},"100640874","the-association-between-amputation-level-and-chronic-low-back-pain-after-combat-related-amputation-100640874","NCT07626294","The Association Between Amputation Level and Chronic Low Back Pain After Combat-Related Amputation","LEVEL-BACK","Inclusion Criteria:\n\n* Age ≥18 years\n* Combat-related lower limb amputation\n* Transtibial, transfemoral, or bilateral lower limb amputation\n* Time since amputation ≥3 months\n* Current or planned prosthesis use\n* Ability to participate in rehabilitation assessment\n* Ability to report low back pain intensity\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Traumatic spinal injury related to the initial combat trauma\n* Previous spinal surgery before amputation\n* Known severe spinal deformity\n* Active spinal infection or malignancy\n* Severe neurological disorder affecting mobility\n* Non-combat-related amputation\n* Inability to complete follow-up assessments\n* Refusal or inability to provide informed consent","50 Years",{"count":224,"type":22},300,"6 Months","Patients with combat-related lower limb amputations frequently experience chronic low back pain during long-term rehabilitation and prosthetic use. Altered biomechanics, asymmetric loading, gait disturbances, and changes in spinal alignment after limb loss may contribute to the development of persistent back pain. The severity and characteristics of low back pain may vary according to the level of amputation.\n\nThe LEVEL-BACK Study is a prospective observational study designed to evaluate the relationship between amputation level and chronic low back pain after combat-related amputation.\n\nParticipants with different levels of lower limb amputation will undergo clinical assessment of low back pain intensity, functional limitations, prosthesis use, and rehabilitation outcomes during follow-up.\n\nThe goal of the study is to improve understanding of how amputation level influences chronic low back pain after combat-related limb loss and to identify patients at increased risk for persistent spinal pain during rehabilitation.",[228,27],"Low Back Pain",[230,231,232,233,234,235,236,119],"Chronic low back pain","Combat-related amputation","Amputation level","Transtibial amputation","Transfemoral amputation","Bilateral amputation","Prosthesis use","NOT_YET_RECRUITING","2026-05-30",{"date":240,"type":37},"2026-06-04",{"date":242,"type":22},"2026-09-15",{"date":242,"type":22},{"name":245,"class":74},"Ukrainian Society of Regional Anesthesia and Pain Therapy",{"id":247,"slug":248,"hasResults":12,"nctId":249,"briefTitle":250,"officialTitle":250,"acronym":4,"eligibilityCriteria":251,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":252,"enrollmentInfo":253,"targetDuration":4,"studyType":55,"phases":254,"briefSummary":255,"conditions":256,"keywords":257,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":75},"100622755","assessing-ambulatory-and-non-ambulatory-community-mobility-in-people-with-lower-limb-amputation-100622755","NCT07387744","Assessing Ambulatory and Non-ambulatory Community Mobility in People With Lower Limb Amputation","Inclusion Criteria:\n\n* Unilateral or bilateral major lower limb amputation (e.g., proximal to or through the ankle joint)\n* \\>6 months since LLA Fitted with a prosthetic limb\n* Fitted with a prosthetic limb\n* Use a wheelchair or scooter for mobility for part of a day at least once per week\n\nExclusion Criteria:\n\n* Unstable heart condition (including unstable angina, uncontrolled cardiac dysrhythmia, acute myocarditis, hypertension, and acute pericarditis)\n* Acute systemic infection Prisoner or institutionalized such that self-determined mobility is restricted\n* Prisoner or institutionalized such that self-determined mobility is restricted\n* Decisionally challenged individuals (Modified Telephone Interview for Cognitive Status score ≤24)\n* Undergoing active cancer treatment\n* Participating in prosthetic rehabilitation\n* Clinical discretion of the principal investigator to exclude patients who are determined to be unsafe and\u002For inappropriate to participate in the protocol\n* Inability to communicate verbally in English","85 Years",{"count":169,"type":22},[57],"Mobility is a fundamental aspect of daily life, enabling individuals to participate in social, occupational, and recreational activities. Community mobility, defined as movement in environments outside the home, is particularly important for quality-of-life. Following lower limb amputation (LLA), mobility limitations are common and persistent. With rehabilitation and prosthetic training, many regain the ability to ambulate but results vary as only 25 - 58% of patients regain ambulatory ability and less than half of those who become ambulatory achieve sufficient ability to walk in community settings. As a result, \\~40% of people with LLA are ambulatory but also use wheeled mobility (e.g., wheelchair, scooter) for some or all of their community mobility tasks. To date, the complementary role of wheeled and ambulatory mobility in maximizing community mobility has been overlooked, with clinical research overwhelmingly focused on assessing and improving ambulatory ability despite its impracticality for many community settings.",[27],[258,259],"Lower Limb Amputation (LLA)","Global Positioning System (GPS)","2026-05-27",{"date":262,"type":37},"2026-05-29",{"date":264,"type":22},"2026-06-21",{"date":266,"type":22},"2027-08",{"name":213,"class":74},{"id":269,"slug":270,"hasResults":12,"nctId":271,"briefTitle":272,"officialTitle":272,"acronym":4,"eligibilityCriteria":273,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":274,"targetDuration":4,"studyType":55,"phases":276,"briefSummary":277,"conditions":278,"keywords":280,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":284,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":75},"100557578","regulatory-clearance-of-the-glide-control-strategy-for-upper-limb-prostheses-100557578","NCT06539936","Regulatory Clearance of the Glide Control Strategy for Upper Limb Prostheses","Inclusion Criteria:\n\n* Trans-radial unilateral limb loss\n* Candidate for a multi-articulated myoelectric hand prosthesis as determined by the study prosthetist\n* Minimal residual limb length for myoelectric control as determined by the clinical team\n* Age of 18 years or greater\n\nExclusion Criteria:\n\n* Patients with a residual limb that is unhealed from the amputation surgery\n* Patients with easily damaged or sensitive skin who would not tolerate EMG electrodes\n* Unhealed wounds\n* Significant cognitive deficits as determined upon clinical evaluation\n* Significant neurological deficits as determined upon clinical evaluation\n* Significant physical deficits of the residual limb impacting full participation in the study as determined upon clinical evaluation\n* Uncontrolled pain or phantom pain impacting full participation in the study as determined upon clinical evaluation\n* Serious uncontrolled medical problems as judged by the project therapist",{"count":275,"type":22},7,[57],"The investigators will test the following hypothesis: Use of Glide results in improved functional performance, satisfaction, and usage metrics as compared to use of a standard Direct Control (DC) prosthesis.\n\nThis study will compare the use of Glide \\[Experimental\\] prosthesis with a DC \\[Standard\\] prosthesis in a clinical setting and in unsupervised daily activity. We will follow a multiple baseline design, specifically an AB design. Each of the subjects will use the Experimental and Standard systems over a total of 24-weeks. The A phase is the baseline phase where the DC prosthesis will be used, and the B phase will be the treatment phase where the Glide prosthesis will be used. Participants will undergo an A phase of either 10-weeks, 12-weeks, or 14-weeks duration, with the remaining 14-, 12-, or 10-weeks of the study being dedicated to the B phase.",[27,279],"Upper Limb",[93,281,282,90,283],"upper limb","myoelectric control","glide",{"date":262,"type":37},{"date":286,"type":37},"2024-09-16",{"date":288,"type":22},"2027-03-31",{"name":290,"class":44},"Infinite Biomedical Technologies",{"id":292,"slug":293,"hasResults":12,"nctId":294,"briefTitle":295,"officialTitle":296,"acronym":297,"eligibilityCriteria":298,"healthyVolunteers":12,"sex":18,"minAge":299,"maxAge":83,"enrollmentInfo":300,"targetDuration":4,"studyType":55,"phases":302,"briefSummary":303,"conditions":304,"keywords":307,"overallStatus":237,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":75},"100637147","bio-leg-advancing-mobility-100637147","NCT07613502","Bio Leg: Advancing Mobility","Adaptive Mobility Technology: A Comparative Study of C-Leg and Bio Leg","BAM","Inclusion Criteria:\n\n* Adults 40 to 70 years of age\n* Unilateral transfemoral amputation \\> 1 year\n* K3 or K4 ambulator and able to walk with no greater assistances than a single point cane\n* Current microprocessor-controlled prosthesis (C-leg) user with \\> 6 months experience and able to walk without a device of using a single point cane\n* Able to give informed consent\n\nExclusion Criteria:\n\n* Severe cardiovascular condition or other disease limiting study participation\n* Skin lesions or wounds, acute or unstable fracture, diagnosis of osteoarthritis or bone impairments affecting safe participation in walking activities\n* Residual limb dysfunction (i.e. joint contracture) limiting mobility or study participation\n* Pain that limits walking of participation in walking activities\n* Current participation in rehabilitation to address walking function","40 Years",{"count":301,"type":22},12,[57],"Following transfemoral amputation, regaining functional mobility, particularly the ability to navigate curbs, ramps, long distances, and the ability to stand is challenging and often unattainable. Use of advanced prosthetic limb technology can dramatically influence mobility outcomes. The purpose of this study is to compare walking function in individuals with transfemoral amputations who are current users of the C-leg (current clinical standard) to function achieved when using the Bio Leg powered micro-processor prosthetic knee.",[305,306,27],"Amputation of Lower Limb Above Knee","Amputee",[27,308,309,310,311,312,313,306],"Above Knee Amputation","AKA","Prosthetic Use","Prostheses","C-leg","BioLeg","2026-05-21",{"date":262,"type":37},{"date":317,"type":22},"2026-06-01",{"date":319,"type":22},"2028-07",{"name":321,"class":74},"University of Florida",{"id":323,"slug":324,"hasResults":12,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":4,"eligibilityCriteria":328,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":329,"targetDuration":4,"studyType":55,"phases":331,"briefSummary":332,"conditions":333,"keywords":340,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":347,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":214},"100638631","personalizing-thromboprophylaxis-for-patients-with-peripheral-artery-disease-100638631","NCT07613840","Personalizing Thromboprophylaxis for Patients With Peripheral Artery Disease","Personalizing Post Surgical Thromboprophylaxis for Patients With Peripheral Artery Disease","Inclusion Criteria:\n\n* Patients with a named arterial extremity injury or named vessel revascularization for atherosclerosis requiring open and\u002For closed revascularization.\n* Patients at the age of 18 or older\n\nExclusion Criteria:\n\n* Patients who are younger than 18 years old\n* Known pregnancy (females of childbearing potential will have a pregnancy test prior to surgery as per standard of care)\n* Prisoners, defined as those who have been directly admitted from a correctional facility.\n* No atherosclerosis\n* Subject has active stomach ulcers\n* Subject has severe hepatic impairment\n* Subject has a recent history of intracranial hemorrhage. If the patient has a history of cerebral hemorrhage with no new central nervous system disease of \\>1 year, the study team will consult with the",{"count":330,"type":22},484,[57],"The goal of this clinical trial is to determine whether a personalised blood clot prevention plan is more effective than standard treatment in adults with peripheral artery disease (PAD) who have undergone a procedure to restore blood flow to their legs.\n\nThe main questions it aims to answer are:\n\n* Does the personalized plan lower the rate of blood clots in the treated leg one year after the procedure?\n* Does the personalized plan lower rates of amputation, repeat procedures, bleeding, and death compared to standard treatment?\n\nResearchers will compare the personalized TARGET plan which uses a blood test to tailor each person's blood clot prevention medication to the standard treatment to see if the personalized approach works better.\n\nParticipants will:\n\n* Be randomly assigned to either the personalized TARGET plan or standard treatment after their procedure\n* Have blood tests at 1 week and at 1, 3, 6, 9, and 12 months after their procedure\n* Have medications adjusted based on blood test results if assigned to the TARGET group",[334,27,335,336,337,338,339],"Peripheral Arterial Disease (PAD)","Thrombosis","Thrombosis (Stent Thrombosis)","Platelet Aggregation Inhibitors","Thromboelastography (TEG)","PRU(Platelet Reactivity Unit)",[341,342,343,344,345,346],"Peripheral Artery Disease Thromboprophylaxis","Personalizing Blood Thinners","Clopidogrel Resistance","Thromboelastography with Platelet Mapping (TEG-PM)","Graft\u002F Stent Thrombosis","Platelet Inhibition",{"date":262,"type":37},{"date":349,"type":37},"2025-04-29",{"date":351,"type":22},"2027-06-30",{"name":353,"class":74},"Massachusetts General Hospital",{"id":355,"slug":356,"hasResults":12,"nctId":357,"briefTitle":358,"officialTitle":358,"acronym":4,"eligibilityCriteria":359,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":360,"enrollmentInfo":361,"targetDuration":4,"studyType":55,"phases":363,"briefSummary":364,"conditions":365,"keywords":366,"overallStatus":237,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":75},"100613399","influence-of-a-slope-adaptive-foot-on-participation-of-veterans-with-lower-limb-amputations-100613399","NCT07266077","Influence Of A Slope Adaptive Foot On Participation Of Veterans With Lower-Limb Amputations","Inclusion Criteria:\n\n* US military Veterans willing to travel to the Minneapolis VA Health Care System\n* Unilateral, below-knee amputation\n* Use of a definitive prosthesis for at least 12 months (limb volume has stabilized and has accommodated to prosthesis use post-amputation)\n* Medicare Functional Classification Level K3 ambulator (unlimited community ambulator)\n* Well-fitting and well-aligned prosthesis\n* Uses a prescribed energy storage and return foot (ESAR)\n* Blessed Orientation-Memory-Concentration (Short Blessed) test score between 0-6 (no cognitive impairment)\n* Access to computer, tablet, or smartphone and internet for video conferencing and REDCap data collection\n\nExclusion Criteria:\n\n* Residual-limb skin problems\n* Not a regular prosthesis user\n* Mass over 125 kg (275 lbs)\n* Residual limb too long to accommodate the study feet (104 mm of build height)\n* Has used a hydraulic foot previously as part of clinical care or a research study\n* Documented major neurocognitive disorder (i.e., dementia) with evidence of impact on activities of daily living and\u002For instrumental activities of daily living\n* Baseline PROMIS-APSRA or PROMIS-SSRA scores at the maximum levels (no room for improvement on primary outcomes)","89 Years",{"count":362,"type":22},30,[57],"Veterans with below-knee amputations are limited by prosthetic feet that cannot adapt to sloped and uneven terrain. This limitation results in reduced mobility, reduced balance confidence, and a higher risk of falls among some individuals who use below-knee prostheses, which have been shown to negatively impact participation in daily and recreational activities. The investigative group has designed a novel Slope Adaptive Foot (SAF) that is mechanically passive, capable of slope adaption on every step of walking, and maintains high levels of energy storage and return. Pilot testing of the SAF with Veterans has generated excellent results to date, with comments suggesting potential improvements in participation. This study will evaluate the extent to which participation and fall-related health outcomes are influenced by using the SAF versus a typical hydraulic foot in a cross-over randomized controlled trial. Using mixed-methods, the investigators will also collect long-term data of Veterans using their preferred foot to inform the development of evidence-based education materials for use in clinical decision making.",[27],[367,27,368,369,370,371,372],"Artificial Limbs","Leg Prosthesis","Ankle","Community Participation","Social Participation","Falls",{"date":374,"type":37},"2026-05-26",{"date":376,"type":22},"2026-07-01",{"date":378,"type":22},"2029-08-01",{"name":380,"class":381},"VA Office of Research and Development","FED",{"id":383,"slug":384,"hasResults":12,"nctId":385,"briefTitle":386,"officialTitle":387,"acronym":4,"eligibilityCriteria":388,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":389,"enrollmentInfo":390,"targetDuration":4,"studyType":55,"phases":392,"briefSummary":393,"conditions":394,"keywords":396,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":407,"locationsCount":75},"100537242","regenerative-peripheral-nerve-interface-for-control-of-lower-limb-prostheses-100537242","NCT06275282","Regenerative Peripheral Nerve Interface for Control of Lower Limb Prostheses","Regenerative Peripheral Nerve Interfaces to Enhance Function and Sensation in People With Transfemoral Amputation","Inclusion Criteria:\n\n* Unilateral amputation of the leg proximal to the knee at least 6 months prior to enrollment.\n* Low surgical risk (American Society of Anesthesiologists Class I and II).\n* For participants without existing RPNI grafts (at the time of enrollment), the residual limb must have sufficient soft tissue quality to support performance of the RPNI operative procedures. Participants sustaining severe crushing or avulsion injuries with substantial superficial and deep scarring may not be appropriate candidates for inclusion in the study.\n* Amputee Mobility Predictor with prosthesis (AMPPRO) score of at least 37 (Gailey et al. 2002).\n* Sufficient clearance to a motorized prosthetic leg without the necessity for shoe lifts or extenders on the contralateral limb.\n\nExclusion Criteria:\n\n* Severe pain syndrome including complex regional pain syndrome or severe phantom pain. All of these conditions would suggest pathological activity of the nerve and would exclude the participant from participation.\n* Untreated mental health disorders and if they have any DSM-5 diagnoses, they must receive approval to participate from their mental health professional.\n* Any medical conditions that, in the opinion of the Principal Investigator, would place them at high risk for a surgical procedure including recent myocardial infarction, cerebrovascular accidents, deep venous thrombosis, pulmonary embolus, uncontrolled diabetes, or end stage renal disease.\n* Participants must not have used tobacco for at least one month prior to enrollment in the study.\n* Participants must agree to not use tobacco for the duration of the study.\n* Pregnancy.\n* No other indwelling electronic implants like pacemakers, implantable cardioverter defibrillators, implantable neurostimulators, body worn insulin pumps, or body worn patient monitoring devices.\n* Severe peripheral vascular occlusive disease, venous hypertension of the extremity, or severe lymphedema of the extremity.\n* An autoimmune condition which is not well controlled by medication.\n* A significant injury of the contralateral limb.\n* Significant, uncorrected vision problems.\n* Impaired mental capacity that negatively impacts verbal communication with the clinicians and research team or requires a Legally Authorized Representative to facilitate communication.","75 Years",{"count":391,"type":22},3,[57],"Individuals with an above-knee lower limb amputation are known to walk more slowly, expend more energy, have a greater risk of falling, and have reduced quality of life compared to individuals without amputation and those with below knee amputation. One of the driving factors behind these deficits is the lack of active function provided by above-knee prostheses with prosthetic knees and ankles. While many prosthetic devices have been developed for functional restoration after major lower extremity amputation, there remains no stable interface to facilitate reliable, long-term volitional control of an advanced robotic limb capable moving multiple joints. Moreover, there is no existing interface that provides useful sensory feedback that in turn enhances the functional capabilities of the prosthesis. To achieve both greater signal specificity and long-term signal stability, we have developed a biologic interface known as the Regenerative Peripheral Nerve Interface (RPNI). An RPNI consists of a peripheral nerve that is implanted into a free muscle graft that would otherwise go unused in the residual limb. As the nerve grows, it reinnervates the free muscle graft which undergoes a predictable sequence of revascularization and regeneration.\n\nThe main questions it aims to answer are:\n\n1. Can the amplitude, movement specificity and stability of sciatic nerve RPNI electromyography (EMG) signals be detected up to one year post RPNI surgery?\n2. Do RPNIs contain information to enable control of a physical motorized prosthetic leg with multiple degrees of freedom?\n3. Does stimulation of sciatic nerve RPNIs provides meaningful sensory feedback?\n\nConsenting participants with unilateral transfemoral amputation (TFA) will:\n\n1. Undergo RPNI surgery and electrode implantation in the residual limb.\n2. Attend regular follow-up visits following surgery to assess the health and signal strength of the RPNIs and their ability to use a prescribed prosthesis between 3- and 12-months following implantation.\n3. Undergo explantation of electrodes following the conclusion of data collection.",[27,395],"Prostheses and Implants",[397,398,399],"RPNI","Regenerative Peripheral Nerve Interface","Implanted Electrodes","2026-05-18",{"date":402,"type":37},"2026-05-19",{"date":404,"type":37},"2025-02-13",{"date":406,"type":22},"2027-09-30",{"name":408,"class":74},"University of Michigan",{"id":410,"slug":411,"hasResults":12,"nctId":412,"briefTitle":413,"officialTitle":413,"acronym":414,"eligibilityCriteria":415,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":416,"targetDuration":4,"studyType":55,"phases":418,"briefSummary":419,"conditions":420,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":421,"lastUpdatePostDateStruct":422,"startDateStruct":424,"completionDateStruct":426,"leadSponsor":428,"locationsCount":75},"100420141","early-evaluation-of-the-introduction-of-pre--and-post-operative-psychological-and-physiotherapeutic-follow-up-in-vascular-surgery-in-amputee-patients-100420141","NCT04750876","Early Evaluation of the Introduction of Pre- and Post-operative Psychological and Physiotherapeutic Follow-up in Vascular Surgery in Amputee Patients","EPKIVA","Inclusion Criteria:\n\n* Patient over the age of majority, no age limit\n* Amputation related to obliterative arteriopathy of the lower limbs\n* Trans-tibial or trans-femoral amputation\n* Patient with an indication of discharge to a rehabilitation and re-education service\n* Patient with the ability to understand the protocol\n* Patient who has agreed to participate in the study and has given express oral consent\n* Patient receiving social security cover or entitled to it\n\nExclusion Criteria:\n\n* Trauma related amputation\n* Amputation of upper limb, trans-metatarsal or one or more toes\n* Amputation of comfort in a palliative care setting\n* Patient leaving home after surgery\n* Patient undergoing psychological or psychiatric treatment\n* Pregnant or breastfeeding woman, or a woman who is able to procreate without effective contraception\n* Patient unable to follow the protocol as judged by the investigator\n* Patient participating in another interventional research protocol involving a drug or medical device\n* Patient under guardianship, curators or legal protection measure",{"count":417,"type":22},40,[57],"An amputation represents a real ordeal for the person who will have to overcome the loss of a limb and face long months of rehabilitation. It is most often carried out following arterial insufficiency.\n\nAs paramedical professionals, we see in our daily practice a physical and psychological suffering for amputee patients. In spite of our skills acquired through training and professional experience, we are unable to offer comprehensive care for these patients and therefore feel that we are offering incomplete care. A multidisciplinary care, including a medical and paramedical team, would seem to us to be more appropriate for patients with lower limb amputations.\n\nFollowing this observation, we would like to highlight the interest for the patient and the care team to include a psychologist and a physiotherapist in the care offer to evaluate the improvement of the physical and emotional state of the amputee patient.",[27],"2026-05-12",{"date":423,"type":37},"2026-05-15",{"date":425,"type":37},"2021-04-08",{"date":427,"type":22},"2027-10-18",{"name":429,"class":74},"Centre Hospitalier Departemental Vendee",{"id":431,"slug":432,"hasResults":12,"nctId":433,"briefTitle":434,"officialTitle":435,"acronym":4,"eligibilityCriteria":436,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":167,"enrollmentInfo":437,"targetDuration":4,"studyType":55,"phases":438,"briefSummary":439,"conditions":440,"keywords":441,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":444,"lastUpdatePostDateStruct":445,"startDateStruct":447,"completionDateStruct":449,"leadSponsor":451,"locationsCount":75},"100478095","can-an-array-of-micro-electrodes-implanted-in-a-human-nerve-record-neural-signals-and-provide-feedback-100478095","NCT05505513","Can an Array of Micro-electrodes Implanted in a Human Nerve Record Neural Signals and Provide Feedback?","Can an Array of Micro-electrodes Implanted in a Human Nerve Record Neural Signals and Provide Sensory Feedback Useful for Controlling a Prosthetic Device?","Inclusion Criteria:\n\n* at least 18 years of age and less than 65 years of age\n* unilateral and bilateral traumatic or elective upper extremity amputations at the transradial level\n\nExclusion Criteria:\n\n* incarceration\n* pregnancy\n* inability to consent\n* psychiatric comorbidity\n* medical conditions that significantly increase the risk of adverse effects of general anesthesia",{"count":391,"type":22},[57],"The investigators will investigate the device feasibility of human peripheral nerves and muscles recording and stimulation using percutaneous Utah Slanted Electrode Arrays (pUSEAs) implanted into residual peripheral arm nerves and EMG electrodes implanted in the residual muscles of patients with limb amputations in order to determine the ability of the HAPTIX (Hand Proprioception and Touch Interfaces) System to control an upper-extremity prosthesis, and to provide a sense of cutaneous touch and muscle proprioceptive feedback to the amputee.",[27],[442,27,443],"Micro-Electrodes","Prosthetic Device","2026-05-08",{"date":446,"type":37},"2026-05-13",{"date":448,"type":37},"2020-12-21",{"date":450,"type":22},"2028-12",{"name":452,"class":74},"University of Utah",{"id":454,"slug":455,"hasResults":12,"nctId":456,"briefTitle":457,"officialTitle":457,"acronym":458,"eligibilityCriteria":459,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":460,"targetDuration":4,"studyType":55,"phases":462,"briefSummary":464,"conditions":465,"keywords":469,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":474,"lastUpdatePostDateStruct":475,"startDateStruct":477,"completionDateStruct":479,"leadSponsor":481,"locationsCount":75},"100613235","phase-1-influence-of-prosthetic-foot-stiffness-on-transtibial-osseointegrated-bone-anchored-limb-outcomes-100613235","NCT07263945","Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes","TBAL","Inclusion Criteria:\n\n* Unilateral transtibial amputation due to traumatic, congenital, or cancer-related causes\n* \\> 12-months bone-anchored limb implantation surgery (Bone Anchored Limb group)\n* \\> 12-months limb amputation (Socket Control group)\n* Non-vascular amputation etiology\n* Low profile prosthetic foot (nominal)\n* Can walk unassisted for 5-minutes\n* \\> 18 years old\n\nExclusion Criteria:\n\n* Major amputation on contralateral limb\n* Vascular amputation etiology\n* Neurologic pathology that impairs coordination\u002Fbalance\n* Regular assistive device use required for community ambulation\n* Inflammatory diseases or diabetes\n* Pregnancy or breastfeeding",{"count":461,"type":22},60,[463],"PHASE1","A clinical trial utilizing cross-over study design in which individuals with transtibial amputation using either a bone-anchored limb or standard socket prosthesis will perform activities of daily living with varying prosthetic foot stiffness categories to complete the following 4 Specific Aims: 1) Determine the influence of prosthetic foot stiffness on dynamic bone-implant loading, 2) Determine how prosthetic foot stiffness influences function, pain, and multi-joint biomechanics outcomes, 3) Establish how prosthetic foot stiffness influences osseoperception and fall risk, and 4) Establish target ranges of optimal foot stiffness based on the sensitivity biomechanical outcomes to variability in foot stiffness.",[27,466,467,468],"Transtibial Amputation - Unilateral","Bone Anchored Devices","Osseointegration",[93,470,92,471,472,473],"bone anchored limb","transtibial amputation","below knee amputation","prosthetics","2026-04-20",{"date":476,"type":37},"2026-04-21",{"date":478,"type":37},"2025-11-25",{"date":480,"type":22},"2030-05-31",{"name":482,"class":74},"University of Colorado, Denver",{"id":484,"slug":485,"hasResults":12,"nctId":486,"briefTitle":487,"officialTitle":487,"acronym":488,"eligibilityCriteria":489,"healthyVolunteers":82,"sex":18,"minAge":19,"maxAge":490,"enrollmentInfo":491,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":493,"conditions":494,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":495,"lastUpdatePostDateStruct":496,"startDateStruct":498,"completionDateStruct":500,"leadSponsor":502,"locationsCount":75},"100576104","quantification-of-motor-compensation-following-biomechanical-proprioceptive-and-physiological-alterations-post-lower-limb-amputation-100576104","NCT06780943","Quantification of Motor Compensation Following Biomechanical, Proprioceptive and Physiological Alterations Post-lower Limb Amputation.","QAMPA","Inclusion Criteria:\n\n* The patient must have given their free and informed consent and signed the consent form\n* The patient must be a member or beneficiary of a health insurance plan\n* Persons with unilateral transtibial or transfemoral amputees followed in the MPR department at the Nîmes University Hospital, RRL department, Grau du Roi University Rehabilitation Hospital.\n* All etiologies: vascular, traumatic and septic.\n* Adapted equipment validated by the rehabilitation doctor.\n* Able to walk for 5 minutes on a treadmill without technical assistance\n\nInclusion criteria specific to healthy volunteers:\n\n* Adults (\\>18 years old) and under 40 years old\n* Able to walk for 5 minutes on a treadmill without technical assistance.\n* Body mass index between 18 and 25\n\nExclusion Criteria:\n\n* The patient is participating in an interventional or a drug\u002Fmedical device study, or is in a period of exclusion determined by a previous study\n* The patient unable to express consent\n* It is impossible to give the patient informed information\n* The patient is under safeguard of justice or state guardianship\n* Patient who has already been included in this study.\n* Pregnant, parturient or breastfeeding patient.\n* Appearance of a stump wound during the study requiring unloading.\n* Patient for whom the implementation of vibration stimulation is not possible\n\nExclusion criteria for amputee patients:\n\n* Patient suffering from uncorrected or untreated visual disorders.\n* Patient with major cognitive disorders (MoCA \\\u003C23).\n* Patient with vestibular disorders or uncontrolled epilepsy.\n* Patient with an unhealed amputation stump.\n* Patient with a weight \\> 135kg or \\\u003C 20kg\n* Patients with a FAC of 1 (i.e. patients who need firm and continuous assistance from a person to support their weight and maintain balance) or less.\n* Sensory impairment that makes it impossible to perceive stimulation\n* Significantly reduced bone density\n* Patient in whom it is impossible to correctly adjust the GRAIL System harness to the corresponding body part due to:\n\n  * Body shape\n  * Colostomy bags\n  * Skin lesions that cannot be adequately protected.\n  * Any other reason that prevents a good, painless adjustment of the harness.\n* Patient in whom it is impossible to correctly adjust the CON-TREX System:\n\n  * Body shape\n  * Colostomy bags\n  * Skin lesions that cannot be adequately protected.\n  * Any other reason that prevents a good, painless adjustment of the support systems.\n\nExclusion criteria for healthy volunteers:\n\n* History of significant injury or surgery affecting the lower limbs (such as hip or knee replacement or knee\u002Fankle ligament reconstruction) that could impact walking\n* History of neurological or psychiatric disorders that could affect locomotion or the processing of sensorimotor information.\n* Drug treatments affecting locomotion: drugs likely to alter walking or balance, such as sedatives, muscle relaxants or neuroleptics.","80 Years",{"count":492,"type":22},75,"Lower limb amputation causes segmental loss that alters locomotor organization. The human body, designed to function in a multisegmental manner, must adapt to this new configuration where segments are missing, depending on the level of amputation. These adaptations are directly linked to the biomechanical, physiological and proprioceptive alterations caused by the loss of the amputated segments. Without mechanoreceptive afferents essential for regulating locomotion, the sensory system uses alternative information to maintain efficient locomotor function. The prosthesis partially compensates, but remains limited on the biomechanical and proprioceptive levels. Current prosthetic technologies, inspired by biomimicry, aim to imitate evolutionary solutions to restore walking, although current algorithms do not allow real-time modulation. This research aims to characterize post-amputation locomotor adaptations through biomechanical, physiological and proprioceptive exploration to develop a \"locomotor characterization\" model.\n\nThe study authors hypothesize that the post-amputation alterations are exacerbated in contexts of continuous and discontinuous constraints (e.g., ascent\u002Fdescent and destabilization), and that the addition of a prosthesis, although inspired by biomimicry, only restores partial compensation of locomotor functions.",[27],"2026-04-10",{"date":497,"type":37},"2026-04-15",{"date":499,"type":37},"2025-05-06",{"date":501,"type":22},"2026-11",{"name":503,"class":74},"Centre Hospitalier Universitaire de Nīmes",{"id":505,"slug":506,"hasResults":12,"nctId":507,"briefTitle":508,"officialTitle":509,"acronym":4,"eligibilityCriteria":510,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":360,"enrollmentInfo":511,"targetDuration":4,"studyType":55,"phases":513,"briefSummary":514,"conditions":515,"keywords":516,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":518,"lastUpdatePostDateStruct":519,"startDateStruct":521,"completionDateStruct":523,"leadSponsor":524,"locationsCount":75},"100485499","impact-of-improving-footwear-options-100485499","NCT05601869","Impact of Improving Footwear Options","Impact of Improving Footwear Options for Women Veterans With Amputations","Inclusion Criteria:\n\n* US military Veterans that identify as women\n* Transtibial (below-knee) amputation\n* Using a definitive prosthesis for at least 6 months (limb has accommodated to prosthesis use post-amputation)\n* Well fitting and well aligned prosthesis\n* Blessed Orientation-Memory-Concentration (Short Blessed) score between 0-6\n* Access to computer, tablet, or smart phone and internet for video conferencing and RedCap data collection\n\nExclusion Criteria:\n\n* Residual limb skin problems\n* Residual limb too long to accommodate the RECOVER prosthetic ankle-feet system\n* Unable or unwilling to travel to Minneapolis\n* Not a regular prosthesis user\n* Mass over 125 kg\n* Documented neurocognitive disorder (e.g., dementia) with evidence of impact on activities of daily living and\u002For instrumental activities of daily living\n* Baseline ABIS-R or PROMIS-APSRA scores at the maximum levels (no room for improvement on primary outcomes)",{"count":512,"type":22},18,[57],"Veterans with leg amputations have limited footwear options because their artificial feet do not change shapes for different shoes. Studies have shown that women with amputations receive more frequent prosthetics care than men, but are less satisfied with the fit, comfort, and appearance of their prostheses. The investigators' previous research indicates that women Veterans would like to be able to wear a broader variety of footwear, and those who perceive more footwear limitations tend to have poorer body image and community participation. A new prosthesis designed by the investigators' group allows Veterans with amputations to use their footwear of choice using 3D-printed artificial feet with a single ankle. The novel prosthesis will be tested in this project with women Veterans with amputations to determine the impact of improving footwear options on body image and community participation.",[27],[367,27,368,517,370,371],"Body Image","2026-04-01",{"date":520,"type":37},"2026-04-07",{"date":522,"type":37},"2023-09-01",{"date":288,"type":22},{"name":380,"class":381},{"id":526,"slug":527,"hasResults":12,"nctId":528,"briefTitle":529,"officialTitle":530,"acronym":531,"eligibilityCriteria":532,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":533,"enrollmentInfo":534,"targetDuration":225,"studyType":24,"phases":4,"briefSummary":535,"conditions":536,"keywords":540,"overallStatus":237,"whyStopped":4,"lastUpdateSubmitDate":544,"lastUpdatePostDateStruct":545,"startDateStruct":547,"completionDateStruct":549,"leadSponsor":551,"locationsCount":75},"100631563","evacuation-time-and-tourniquet-use-as-risk-factors-for-ptsd-in-combat-related-amputation-100631563","NCT07502313","Evacuation Time and Tourniquet Use as Risk Factors for PTSD in Combat-Related Amputation","Evacuation Time and Tourniquet Use as Risk Factors for PTSD in Combat-Related Amputation: A Prospective Cohort Study","EVAC-PTSD Stud","Inclusion Criteria:\n\n* Ukrainian veterans with combat-related injury (post-February 2022)\n* Single limb amputation\n* Admission to rehabilitation within 2-4 months post-injury\n* Age ≥18 years\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Prior PTSD diagnosis before current injury\n* Multiple amputations\n* Rehabilitation duration \\>3 months\n* Return to active military duty before follow-up completion","60 Years",{"count":224,"type":22},"This study aims to evaluate the relationship between evacuation time, tourniquet use, and the development of post-traumatic stress disorder (PTSD) in patients with combat-related amputations. In the context of modern warfare, prolonged evacuation times and extended tourniquet application may contribute not only to physical injury but also to psychological trauma. The study will prospectively follow patients over 18 months to identify key predictors of PTSD and to assess their interaction.",[27,537,538,539],"PTSD","Combat Posttraumatic Stess Disorder","Combat Trauma",[541,539,27,542,543],"Post-Traumatic Stress Disorder","Tourniquet Use","Evacuation Time","2026-03-30",{"date":546,"type":37},"2026-04-03",{"date":548,"type":22},"2026-03-15",{"date":550,"type":22},"2026-11-15",{"name":552,"class":74},"Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)",{"id":554,"slug":555,"hasResults":12,"nctId":556,"briefTitle":557,"officialTitle":558,"acronym":4,"eligibilityCriteria":559,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":83,"enrollmentInfo":560,"targetDuration":4,"studyType":55,"phases":561,"briefSummary":562,"conditions":563,"keywords":564,"overallStatus":237,"whyStopped":4,"lastUpdateSubmitDate":567,"lastUpdatePostDateStruct":568,"startDateStruct":570,"completionDateStruct":571,"leadSponsor":573,"locationsCount":4},"100630741","prosthetic-socket-fit-testing-system-100630741","NCT07491614","Prosthetic Socket Fit Testing System","Evaluation of a Prototype Socket Fit Testing System to Assess Coupling of the Prosthetic Socket in Individuals With Lower Limb Amputation","Inclusion Criteria:\n\n* be between 18 and 70 years old\n* have a unilateral transfemoral amputation\n* be at least 12 months post-amputation\n* have a residual limb that is free of open wounds or infections\n* wear a prosthesis for a minimum of four hours per day\n* be able to ambulate short distances with a prosthesis\n* be able to stand on the intact leg for brief periods\n* be able to hold onto parallel bars with the arms for balance\n* have pain-free range of motion at the hip on the amputated side\n* have no back problems that make standing or hip movement difficult\n* have corrected vision that is sufficient to see the cursors on the screen\n* be able to follow simple instructions in English\n\nExclusion Criteria:\n\n* residual limb issues (e.g. sensitive or frail skin) that may be made worse by testing\n* a prosthetic socket that cannot be disconnected from the distal prosthetic components\n* unable to read and speak English",{"count":512,"type":22},[57],"Ensuring a well fitting prosthetic socket is a major challenge in the care of people with amputation. Poor fit causes pain, skin issues, reduced mobility, and lower satisfaction, affecting daily activity and quality of life. Current prosthetic socket fit assessment relies on prosthesis user feedback, prosthetist experience or intrusive equipment. The investigators have developed a non-invasive prototype socket fit testing system that attaches externally to the end of any prosthetic socket and uses two air cylinders to apply resistance and track motion. During testing, socket motion is mapped to a cursor on a screen. Participants perform a test where they move their leg and socket to randomly presented targets. Movement duration and accuracy provide measures of how well the socket and leg move together. This pilot study will assess feasibility and validity of the socket fit testing system performance for above-the-knee prosthesis users.",[27],[90,565,566],"assessment","socket fit","2026-03-18",{"date":569,"type":37},"2026-03-24",{"date":518,"type":22},{"date":572,"type":22},"2027-02-28",{"name":574,"class":74},"University of Washington",{"id":576,"slug":577,"hasResults":12,"nctId":578,"briefTitle":579,"officialTitle":579,"acronym":4,"eligibilityCriteria":580,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":581,"targetDuration":4,"studyType":55,"phases":583,"briefSummary":584,"conditions":585,"keywords":586,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":599,"lastUpdatePostDateStruct":600,"startDateStruct":602,"completionDateStruct":604,"leadSponsor":606,"locationsCount":75},"100317169","feasibility-of-neural-feedback-for-lower-limb-amputees-100317169","NCT03409133","Feasibility of Neural Feedback for Lower Limb Amputees","Inclusion Criteria:\n\n* Adults age 18 or greater\n* Chronic, medically stable ( \\> 3 months) trans-tibial or trans-femoral amputation at the time of implant surgery.\n* Potential user of trans-tibial or trans-femoral prostheses for standing or walking\n* Viable target nerves in the lower extremity as determined by standard-of-care clinical tests of nerve conduction, response to stimulation, sensory evoked potentials and the like\n* Good skin integrity and personal hygiene\n* Absence of autoimmune deficiencies, seizure disorders or cardiac abnormalities contraindicating stimulation\n* Sufficient social support and personal ability to tolerate study procedures and comply with follow-up schedule\n\nExclusion Criteria:\n\n* Uncontrolled diabetes to a degree that would preclude surgery\n* Significant vascular disease\n* Chronic skin ulcerations\n* Significant history of poor wound healing\n* Significant history of uncontrolled infections\n* Active infection\n* Significant pain in the residual or phantom limb\n* Pregnancy\n* Inability to speak English\n* Expectation that MRI will be required at any point for the duration of study or while percutaneous leads are in place\n* Severe neurological conditions that significantly impair balance or mobility to an extent that independent ambulation is impossible without assistance ( as determined by a healthcare provider)\n* Appropriate body habitus (height and weight within acceptable limits as determined by study physician)\n* Poor surgical candidate\n* Psychiatric or cognitive conditions that could affect cooperation or understanding of instructions and willingness to undergo psychological evaluation, if recommended by study surgeons or investigators.",{"count":582,"type":22},15,[57],"The purpose of this study is to evaluate the effectiveness of providing sensation of the missing limb to individuals with lower limb loss, including above and below knee amputees. The approach involves delivering small electrical currents directly to remaining nerves via implanted stimulating electrodes. These small electrical currents cause the nerves to generate signals that are then transferred to your brain similar to how information about the foot and lower limb used to be transferred to your brain prior to the amputation.\n\nIndividuals also have the option to have recording electrodes implanted within muscles of the lower limb(s) in an attempt to develop a motor controller that would enable the user to have intuitive control of a robotic prosthetic leg.",[27],[587,588,589,90,590,93,591,592,91,593,594,595,596,597,598],"prosthesis user","phantom sensation","sensory feedback","amputee","limb loss","robotic prosthesis","sensory restoration","robotic","electromyography","EMG","sensation","myoelectric","2026-03-04",{"date":601,"type":37},"2026-03-06",{"date":603,"type":37},"2015-11-05",{"date":605,"type":22},"2027-09-01",{"name":607,"class":381},"Louis Stokes VA Medical Center",{"id":609,"slug":610,"hasResults":12,"nctId":611,"briefTitle":612,"officialTitle":612,"acronym":613,"eligibilityCriteria":614,"healthyVolunteers":82,"sex":18,"minAge":615,"maxAge":83,"enrollmentInfo":616,"targetDuration":4,"studyType":55,"phases":618,"briefSummary":619,"conditions":620,"keywords":625,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":633,"lastUpdatePostDateStruct":634,"startDateStruct":635,"completionDateStruct":637,"leadSponsor":639,"locationsCount":214},"100481386","studies-into-touch-in-healthy-humans-to-provide-sensory-feedback-in-prostheses-100481386","NCT05548322","Studies Into Touch in Healthy Humans to Provide Sensory Feedback in Prostheses","TACTHUM","Inclusion Criteria:\n\n* Men and women aged between 20 and 70.\n* Be a member of a social security scheme, or a beneficiary of such a scheme\n* Be calm enough to sit still for four hours.\n* Specific for people participating in Arm 7 on amputees: People with an upper or lower limb amputation (unilateral) of more than 2 years.\n\nExclusion Criteria:\n\n* Have peripheral neuropathy (diabetes, Raynaud's disease) or chronic muscle and\u002For sensory pain.\n* Have a neurological or psychiatric history.\n* Be subject to epilepsy.\n* Be pregnant (declared) or breastfeeding, having given birth within the last year.\n* Be afraid of injections.\n* Being under dermatological treatment.\n* Have a pacemaker.\n* Not being able to understand the information leaflet and the consent form or sign it.\n* Be subject to a legal protection measure (declarative)\n* Be a protected adult (curatorship or guardianship)","20 Years",{"count":617,"type":22},210,[57],"Our sense of touch is essential to explore our environment and experience life and is based on signals from receptors in the body that are sensitive to different types of stimulation. The TACTHUM projects aims to investigate the fundamental firing of mechanoreceptors in the body to various external stimuli, with an end-aim to better understand the human somatosensory system and to apply this knowledge to provide comprehensive sensory feedback in prosthetics. We have a vast system of peripheral receptors in the skin and muscles that provide us with exquisitely detailed information about our everyday interactions. When there is injury to a body part, such as in amputation, there is a significant loss of somatosensory input. Prosthetic devices have greatly developmed in the past few years, especially with the introduction of useful sensory feedback. However, there is a lot to discover both about the workings of the somatosensory system and how to recreate this to give feedback in a prosthetic device.\n\nThe main objective of the TACTHUM project is to understand how to recover and apply useful somatosensory feedback in prostheses for amputees. There are a number of other sub-objectives, to:\n\n1. Determine how tactile mechanoreceptors encode the texture of natural surfaces during passive and active exploration.\n2. Investigate how our sense of touch varies with emotional state.\n3. Explore what happens to our sense of touch when we explore surfaces at different temperatures.\n4. Understand the origin of our perception of humidity.\n5. Investigate differences in the encoding of tactile information with age.\n6. Determine the perceptions generated by the stimulation of single tactile afferents.\n7. Study changes in spontaneous activity and responses to tactile stimulation on the residual limb of amputees.\n\nTo accomplish these objectives, we will primarily use the technique of microneurography, in vivo recordings from peripheral nerves, to gain direct information about the firing of peripheral neurons in humans. In conjunction with this, we will use a variety of mechanical and thermal stimuli to excite somatosensory fibers and register the activity of other physiological and perceptual measures. This will allow us to gain a fuller understanding of how the incoming somatosensory signals are interpreted and processed. Overall, we aim to explore how more naturalistic tactile interactions are encoded and how these can be translated to provide realistic prosthetic feedback.",[621,27,622,623,624],"Somatosensory Disorders","Tactile Disorders","Aging","Prosthesis User",[626,627,628,629,630,631,632],"Touch","Temperature","Somarosensation","Prosthetics","Microneurography","Tactile","Mechanoreceptor","2026-03-03",{"date":599,"type":37},{"date":636,"type":37},"2024-04-15",{"date":638,"type":22},"2034-11-02",{"name":640,"class":641},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV",{"id":643,"slug":644,"hasResults":12,"nctId":645,"briefTitle":646,"officialTitle":647,"acronym":648,"eligibilityCriteria":649,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":650,"enrollmentInfo":651,"targetDuration":4,"studyType":55,"phases":652,"briefSummary":653,"conditions":654,"keywords":656,"overallStatus":237,"whyStopped":4,"lastUpdateSubmitDate":658,"lastUpdatePostDateStruct":659,"startDateStruct":661,"completionDateStruct":662,"leadSponsor":664,"locationsCount":4},"100626910","toe-study-treatment-and-gait-analysis-following-an-excised-lesser-toe-100626910","NCT07441772","TOE Study: Treatment and Gait Analysis fOllowing an Excised Lesser Toe","A Feasibility Randomised Controlled Study to Examine the Effect of Otoform Toe Dividers in the Treatment of Patients With Diabetes Mellitus Following a Lesser Toe Amputation","TOE","Inclusion Criteria:\n\n1. Participants over the age of 18.\n2. Participants with DM and a lesser toe amputation.\n3. Participants who wish to take part and provide informed written consent\n4. Participants who are mobile (including those who use walking aids).\n\nExclusion Criteria\n\n1. Participants under the age of 18.\n2. Participants who do not have DM.\n3. Participants who have active ulcerations or surgical sites.\n4. Participants who had had a 1st toe and\u002For ray amputation.\n5. Participants with neuroarthropathy or other marked foot deformities.\n6. Participants who already wear a toe divider.\n7. Participants who have a known allergy to the silicone or catalyst being used.\n8. Participants who are immobile.","105 Years",{"count":362,"type":22},[57],"Summary of study\n\nThe study will examine patients with Diabetes Mellitus (DM) who have had a lesser toe amputations (LTA) (toes 2nd3rd,4th or 5th). It is currently not understood how this affects the way patients walk and foot function. No previous studies have been undertaken to examine this and its potential for causing further ulceration risk.\n\nThis study is a feasibility study. It is designed to see if it is possible to undertake a large, randomised trial. It will explore how participants are recruited, kept in the study and how easy it is to follow the study protocol.\n\nAim of the study\n\nEstablish the feasibility of a corresponding full scale investigation into to the effectiveness of a toe divider made from Otoform for patients with DM following an LTA.\n\nStudy Design\n\n1. Participants will be recruited from Mid Yorkshire NHS teaching Hospital.\n2. Participants will be randomised to receive either standard care or an otoform toe divider.\n3. Participants age, gender, medical history, medication and blood sugar levels will be recorded.\n4. Vascular and neurological assessments, foot posture and toe deformities will be undertaken and recorded.\n5. All participants will have pressures measured on the plantar aspects of both feet.\n6. Follow up visits will be arranged every 6 weeks for12 months for all participants to monitor foot health and changes in walking pattern and pressure redistribution.\n7. If an ulceration or other foot complication occurs, the participants will be removed from the study and appropriate treatment given (the rescue arm of the study).",[655,27],"Diabetes Mellitus",[657],"Diabetes Mellitus, Lesser Toe Amputation","2026-02-27",{"date":660,"type":37},"2026-03-02",{"date":518,"type":22},{"date":663,"type":22},"2028-07-31",{"name":665,"class":74},"University of Huddersfield",{"id":667,"slug":668,"hasResults":12,"nctId":669,"briefTitle":670,"officialTitle":671,"acronym":672,"eligibilityCriteria":673,"healthyVolunteers":12,"sex":18,"minAge":674,"maxAge":83,"enrollmentInfo":675,"targetDuration":4,"studyType":55,"phases":676,"briefSummary":677,"conditions":678,"keywords":680,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":684,"lastUpdatePostDateStruct":685,"startDateStruct":686,"completionDateStruct":688,"leadSponsor":690,"locationsCount":75},"100498326","evaluation-of-myoelectric-implantable-recording-array-mira-in-participants-with-transradial-amputation-100498326","NCT05768802","Evaluation of Myoelectric Implantable Recording Array (MIRA) in Participants With Transradial Amputation","Evaluation of an Implantable Intramuscular Device to Control a Myoelectric Prosthesis","MIRA","Inclusion Criteria:\n\n1. Subjects must have a unilateral transradial amputation or wrist disarticulation.\n2. Subjects must demonstrate independent voluntary control of muscles in the flexor and extensor compartments of the forearm\n3. Subjects must be over 1-year post-amputation at time of implantation.\n4. Subjects must be between the ages of 22 and 70 years old. Subjects outside this age range may be at an increased surgical risk and increased risk of fatigue during prosthetic training.\n5. Subjects must be able to communicate with the investigators in English because of the need to follow the instructions of the study team.\n6. Subjects must show an understanding of the study goals and have the ability to follow simple directions as judged by the investigators.\n7. Subjects must pass a neuropsychological and psychosocial assessment.\n8. Documentation of informed consent must be obtained from the subject.\n\nExclusion Criteria:\n\n1. Subjects must be able to function without the use of a prosthesis, or have access to assistance, for a period of 6 weeks following implantation and explantation surgeries.\n2. Subjects must not have visual impairment such that extended viewing of a computer monitor would be difficult even with ordinary corrective lenses.\n3. Subjects who have another serious disease(s) or disorder(s) that could affect their ability to participate in this study (verified during pre-op anesthesia evaluation to determine surgical risk status) will be excluded.\n4. Subjects must not have phantom limb pain that is self-reported to be severe (options are no pain, mild pain, moderate pain, severe pain).\n5. Subjects must not have any type of implantable generator such as a pacemaker, spinal cord stimulator, cochlear implant, deep brain stimulator (DBS) or DBS leads, vagus nerve stimulator, or defibrillator.\n6. Female subjects of childbearing age must not be pregnant, lactating, or plan to become pregnant during the next 25 months.\n7. Subjects must have no history of peripheral vascular disease that could impact wound healing.\n8. Subjects who require routine MRI, therapeutic ultrasound, or diathermy as part of their ongoing care will be excluded.\n9. Subjects must not have osteomyelitis.\n10. Subjects must have no history of intractable clinically relevant cardiac arrhythmias.\n11. Subjects must have no active infection(s) or unexplained fever(s) (verified during pre-op anesthesia evaluation to determine surgical risk status).\n12. Subject must have no history of ongoing untreated alcoholism.\n13. Subject must not be receiving chronic oral or intravenous steroids or immunosuppressive therapy.\n14. Subjects must not be receiving medications that affect blood coagulation.\n15. Subjects must not have had active cancer within the past year (other than adequately treated basal cell or squamous cell skin cancer) or require chemotherapy.\n16. Subjects must not have uncontrolled insulin dependent diabetes mellitus.\n17. Subjects who have had a seizure in the last two years will be excluded.\n18. Subjects who have attempted suicide in the past 12 months will be excluded.\n19. Subjects who are immunosuppressed or who have conditions that typically result in immunocompromise (including, but not limited to: ataxia-telangiectasia, cancer, Chediak-Higashi syndrome, combined immunodeficiency disease, complement deficiencies, DiGeorge syndrome, HIV\u002FAIDS, hypogammaglobulinemia, Job syndrome, leukocyte adhesion defects, malnutrition, panhypogammaglobulinemia, Bruton disease, congenital agammaglobulinemia, selective deficiency of IgA and Wiscott-Aldrich syndrome) will be excluded.\n20. Subjects with active psychiatric concerns, including but not limited to major depression, bipolar disorder, schizophrenia or other psychotic disorder and post-traumatic stress disorder. Individuals undergoing effective treatment for any of these disorders will not be excluded, but will be evaluated by a rehabilitation psychologist.\n21. Subjects who report use of controlled, non-prescribed substances other than cannabis\u002Fmarijuana will be excluded. If a subject reports use of cannabis, we will use the DAST-10 questionnaire to screen for level of abuse. An individual may be included if the score is 5 or less and if the neuropsychologist deems that they are eligible. Subjects reporting use of cannabis will also undergo a urine drug test to screen for other nonprescribed drugs. Subjects will be excluded if they test positive for any non-prescribed substance other than cannabis.","22 Years",{"count":45,"type":22},[57],"The purpose of this research study is to see how well a new type of myoelectric prosthesis works. A myoelectric prosthesis is a robotic limb for amputees that is controlled by sensing the activity of muscles in the body above the amputation level. This study involves a medical procedure to implant the Myoelectric Implantable Recording Array (MIRA) in the residual limb. The procedure will be performed under sedation by a physician. When muscles contract, they generate an electrical signal that can be sensed by MIRA and used to control the prosthetic limb. Myoelectric prosthetic limbs normally use electrodes that are placed on the surface of the skin to control different movements. However, MIRA is implanted under the skin, which could improve the ability to control the myoelectric prosthesis. After the MIRA is implanted, training will occur to learn how to control the prosthesis using the muscles in the residual limb. The device can stay implanted for up to one year. The device will be removed (explanted) by a physician.",[27,679],"Amputation; Traumatic, Hand",[681,682,683],"hand amputation","wrist amputation","transradial amputation","2026-02-25",{"date":658,"type":37},{"date":687,"type":37},"2026-01-16",{"date":689,"type":22},"2030-12",{"name":691,"class":74},"Boninger, Michael, MD"]