[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"amputee\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:amputee":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100637147","bio-leg-advancing-mobility-100637147",false,"NCT07613502","Bio Leg: Advancing Mobility","Adaptive Mobility Technology: A Comparative Study of C-Leg and Bio Leg","BAM","Inclusion Criteria:\n\n* Adults 40 to 70 years of age\n* Unilateral transfemoral amputation \\> 1 year\n* K3 or K4 ambulator and able to walk with no greater assistances than a single point cane\n* Current microprocessor-controlled prosthesis (C-leg) user with \\> 6 months experience and able to walk without a device of using a single point cane\n* Able to give informed consent\n\nExclusion Criteria:\n\n* Severe cardiovascular condition or other disease limiting study participation\n* Skin lesions or wounds, acute or unstable fracture, diagnosis of osteoarthritis or bone impairments affecting safe participation in walking activities\n* Residual limb dysfunction (i.e. joint contracture) limiting mobility or study participation\n* Pain that limits walking of participation in walking activities\n* Current participation in rehabilitation to address walking function","ALL","40 Years","70 Years",{"count":21,"type":22},12,"ESTIMATED","INTERVENTIONAL",[25],"NA","Following transfemoral amputation, regaining functional mobility, particularly the ability to navigate curbs, ramps, long distances, and the ability to stand is challenging and often unattainable. Use of advanced prosthetic limb technology can dramatically influence mobility outcomes. The purpose of this study is to compare walking function in individuals with transfemoral amputations who are current users of the C-leg (current clinical standard) to function achieved when using the Bio Leg powered micro-processor prosthetic knee.",[28,29,30],"Amputation of Lower Limb Above Knee","Amputee","Amputation",[30,32,33,34,35,36,37,29],"Above Knee Amputation","AKA","Prosthetic Use","Prostheses","C-leg","BioLeg","NOT_YET_RECRUITING","2026-05-21",{"date":41,"type":42},"2026-05-29","ACTUAL",{"date":44,"type":22},"2026-06-01",{"date":46,"type":22},"2028-07",{"name":48,"class":49},"University of Florida","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":17,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":23,"phases":64,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":50},"100588998","evaluation-of-the-biomechanics-of-crowding-and-the-energetic-cost-of-endurance-runners-unilateral-transtibial-amputees-100588998","NCT06948695","Evaluation of the Biomechanics of Crowding and the Energetic Cost of Endurance Runners Unilateral Transtibial Amputees.","Evaluation of the Biomechanics of Crowding and the Energetic Cost of Endurance Runners Unilateral Transtibial Amputees According to the Stiffness of the Race-specific Prothesis.","BLADENDURUN","Inclusion Criteria:\n\n* Male or female,\n* Weighing less than 110 kg, in accordance with C-blade recommendations,\n* Subjects who have undergone a unilateral transtibial amputation,\n* Have been running with a sports blade for at least 3 months, over several sessions of at least 3 kilometers.\n* Subjects who have signed a written consent form,\n* Subjects affiliated or entitled to a social security scheme.\n\nExclusion Criteria:\n\n* Subjects whose amputation is due to complications related to diabetes or atherosclerosis.\n* Subjects with chronic or central neurological pathologies\n* Subjects with cardiovascular disorders\n* Subjects with alcohol or drug dependency.\n* Pregnant or breast-feeding women\n* Subjects under court protection.",true,"18 Years","65 Years",{"count":63,"type":22},24,[25],"Transtibial amputation accounts for 3,700 cases per year in France. Athletes can use sport blades made of carbon plate for improved energy restitution.\n\nSports blades are adjusted according to the manufacturer's recommendations and the subjective experience of the ortho-prosthetist and patient. These adjustments are designed to optimize performance and comfort while reducing the risk of injury. This risk is all the greater when asymmetries between the healthy and affected limbs are large, exposing the healthy limb to large and repeated reaction forces.",[29,35,67],"Healthy Volunteers",[69,70],"Unilateral transtibial amputees","Endurance runners","RECRUITING","2025-08-04",{"date":74,"type":42},"2025-08-05",{"date":76,"type":42},"2025-04-23",{"date":78,"type":22},"2026-11-01",{"name":80,"class":49},"Centre Hospitalier Universitaire de Saint Etienne"]