[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anaerobic-power\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anaerobic-power":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,53,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100626821","lower-limb-muscle-mass-and-cardiovascular-and-muscular-performance-in-males-and-females-100626821",false,"NCT07440615","Lower-Limb Muscle Mass and Cardiovascular and Muscular Performance in Males and Females","The Relationship Between Lower-limb Muscle Mass and Cardiovascular and Muscular Performance in Males and Females.","Inclusion Criteria:\n\n* absent of lower body injuries that could impact testing;\n* were moderately physically active\n* did not ingest ergogenic aids or stimulant drugs for at least 6 months prior to the start of the study.\n\nExclusion Criteria:\n\n\\-",true,"ALL","18 Years","30 Years",{"count":21,"type":22},235,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of this study will be to examine the relationship between leg muscle mass and muscle strength, aerobic capacity, anaerobic power, and jumping performance in young adults. In addition, these physical performance measures will be compared between male and female participants.\n\nRecreationally active young adults will be recruited to participate in the study. Body weight and leg muscle mass will be assessed using a body composition analyzer. Participants will perform isokinetic and isometric leg strength tests, an aerobic fitness test (VO₂max), an anaerobic power test (Wingate), and a countermovement jump (CMJ) test.\n\nThis study aims to improve the understanding of the effects of leg muscle mass on physical performance and to identify possible differences between males and females. The findings are expected to contribute to exercise prescription, performance assessment, and future research in sports and health sciences.",[28,29,30,31,32,33],"Physical Performance","Leg Muscle Mass","Muscle Strength","Aerobic Capacity","Anaerobic Power","Jumping Performance in Young Adults",[35,36,37,38,39],"lean mass","isokinetic","isometric","aerobic capacity","force","RECRUITING","2026-06-05",{"date":43,"type":44},"2026-06-09","ACTUAL",{"date":46,"type":44},"2026-02-20",{"date":48,"type":22},"2026-08-15",{"name":50,"class":51},"Uludag University","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":64,"conditions":65,"keywords":72,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":88},"100606658","muscle-architecture-vs-alfredson-protocol-in-achilles-tendinopathy-100606658","NCT07178418","Muscle Architecture vs Alfredson Protocol in Achilles Tendinopathy","The Effects of a Muscle Architecture-Based Exercise Program and the Alfredson Protocol on Muscle-Tendon Architecture and Physical Performance in Subjects With Achilles Tendinopathy","Inclusion Criteria:\n\n* Presence of pain and tenderness in the mid-portion of the Achilles tendon (2-6 cm proximal to the insertion) persisting for at least 3 months\n* Clinical diagnosis of non-insertional Achilles tendinopathy\n* Pain aggravated by physical activity\n* Palpable tenderness localized to the mid-portion of the tendon\n* Voluntary participation in the study with signed informed consent\n\nExclusion Criteria:\n\n* Diagnosis of insertional Achilles tendinopathy\n* History of surgery or fracture in the affected lower limb within the past 12 months\n* Corticosteroid injection to the Achilles tendon within the past month\n* Presence of systemic diseases (e.g., diabetes mellitus, rheumatoid arthritis)\n* Presence of neurological disorders (e.g., peripheral neuropathy, central nervous system disorders)\n* Prior experience with eccentric exercise protocols targeting the Achilles tendon\n* Acute onset of symptoms suggestive of a tendon rupture","60 Years",{"count":62,"type":22},20,[25],"Achilles tendinopathy is a frequent overuse disorder caused by repetitive loading of the tendon, particularly observed in athletes and middle-aged men. It is typically characterized by mid-portion pain, stiffness in the morning, and functional limitations, with structural alterations such as thickening and disrupted collagen alignment. Chronic progression often compromises performance and quality of life.\n\nEccentric training protocols, such as the Alfredson regimen, are commonly prescribed but their standardized nature does not fully address individual variability. Alternative approaches including Heavy Slow Resistance training and progressive loading models (e.g., Silbernagel protocol) have demonstrated clinical effectiveness and higher patient adherence, yet they still apply uniform loading across the triceps surae without accounting for architectural differences.\n\nGiven the heterogeneous structure of the soleus and gastrocnemii, targeted loading strategies may be required to optimize tendon adaptation. To address this, the present study employs a muscle architecture-based exercise program tailored to the functional and structural properties of each muscle. Ultrasound imaging will be used to evaluate muscle-tendon morphology, while isokinetic dynamometry and functional performance tests will quantify outcomes. Pain (VAS) and functional capacity (VISA-A) will also be assessed.\n\nThis randomized controlled trial aims to compare the effectiveness of an architecture-specific program with the Alfredson protocol on tendon remodeling, strength, endurance, functional performance, and symptom reduction in individuals with non-insertional Achilles tendinopathy.",[66,67,68,69,70,71,32],"Achilles Tendinopathy (AT)","Eccentric Exercise Training","Muscle Architecture","Isokinetic Test","Ultrasound","Balance",[73,74,75,76,77],"Achilles tendinopathy","muscle architecture","isokinetic strength","Alfredson protocol","tendon architecture","NOT_YET_RECRUITING","2025-09-10",{"date":81,"type":44},"2025-09-17",{"date":83,"type":22},"2025-10-15",{"date":85,"type":22},"2026-12-31",{"name":87,"class":51},"Halic University",2,{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":96,"enrollmentInfo":97,"targetDuration":4,"studyType":23,"phases":99,"briefSummary":100,"conditions":101,"keywords":105,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":52},"100603009","molecular-hydrogen-inhalation-effects-on-health-exercise-capacity-and-inflammatory-response---in-vivoin-vitro-studies-100603009","NCT07130942","Molecular Hydrogen Inhalation: Effects on Health, Exercise Capacity and Inflammatory Response - in Vivo\u002Fin Vitro Studies","The Effect of Inhalation Using a Molecular Hydrogen Generator on the Level of Exercise Capacity and Inflammatory Response, Anti-cancer Potential of Human Blood Serum in the Light of in Vivo\u002Fin Vitro Studies","Inclusion Criteria:\n\nThe study will be used purposeful selection of the following criteria:\n\n* age 18-25,\n* not taking medicines during the study,\n* negative history of cardiovascular disorders,\n* negative history of autonomic nervous system disorders,\n* negative history of mental disorders,\n* negative history of cerebrospinal traumas,\n* negative history of other diseases that may directly affect obtained results,\n* good health status (no concurrent injuries),\n* no drugs intake,\n* no supplements consumption,\n\nIn the study as a not training grope age and morphologically appropriate participation will take part. Participants will be recruited basing on a voluntary letter of intent. All representatives of the analysed group participating in the pre-qualification research will fill in the physical activity sheet - Global Health Activity Questionnaire - World Health Organization in Polish adaptation. This will allow to eliminate people who report high levels of physical activity (similar to the level of sport training individuals).\n\nExclusion Criteria:\n\n* taking medicines during the study,\n* history of cardiovascular disorders,\n* history of autonomic nervous system disorders,\n* history of mental disorders,\n* history of cerebrospinal traumas,\n* history of other diseases that may directly affect obtained results,\n* concurrent injuries,\n* drugs intake,\n* supplements consumption.","49 Years",{"count":98,"type":22},250,[25],"Summary To comprehensively address the research aims and explore the state of knowledge of the mechanisms of biochemical response to specific tissue affecting method in form of a molecular hydrogen inhalation and will allow to determine its role on the post-exercise response in form of changes in biochemical markers secretion, expression of selected trophic factors and changes in iron metabolism in this process.\n\nMoreover, this project will try to take into account the role of hepcidin, vitamin D and cfDNA. Additionally, the present project may contribute to the determination of the role of presented inhalation procedure on cells proliferation, as example of anty-tumor proprieties, regulation of the expression of genes related to the stress response (HSF-1, NF-kB, TNF-dependent pathway), muscle cell growth (e.g. myostatin gene), energy pathways (e.g. GAPDH, LDH) and the membrane transport and the hedgehog pathway ls (including Gli1), Hif-1-alpha and NF-kB.\n\n1.1. Primary Objectives\n\n1. Demonstration relationship between post-exercise oxidative stress parameters, and two weeks of daily inhalation with the use of a molecular hydrogen generator.\n2. Indicate of whether and how daily inhalation with the use of a molecular hydrogen generator will affect BDNF and hepcidin, erytropheron (ERFE) and erythropoietin (EPO).\n3. Show how daily inhalation with the use of a molecular hydrogen generator and physical activity procedures effects human serum anti-tumor potential, and is it associated with Vitamin D status and Iron metabolism.\n\n1.2. Secondary Objectives\n\n1. Examine the relationship between two weeks of daily inhalation using a molecular hydrogen generator and the expression of genes related to the stress response (HSF-1, NF-kB, TNF-dependent pathway).\n2. Show the relationship between the expression of genes related to muscle cell growth (e.g. myostatin gene), intracellular metabolism, energy pathways (e.g. GAPDH, LDH) and the effect of molecular hydrogen inhalation?\n3. Show the molecular hydrogen inhalation effects on the expression of genes responsible for membrane transport and the hedgehog pathway in muscle cells (including Gli1), expression of transcription factors: Hif-1-alpha (hypoxia-inducible factor) and NF-kB and selected genes dependent on their activity.\n\n1.3. Hypotheses\n\nIn the project on the basis of current knowledge, the following hypotheses are stated:\n\n1. Daily inhalation with the use of a molecular hydrogen will increase the concentration of BDNF, which will correlate with higher skeletal muscle resistance to damage;\n2. Two week daily inhalation with the molecular hydrogen will increase the concentration of BDNF, which will persist over a longer period compering to a single inhalation with the molecular hydrogen session;\n3. Daily inhalation with the molecular hydrogen and physical activity effects on vitamin D binding protein, megalin, cubilin concentration changes.\n4. Daily inhalation with the molecular hydrogen protects muscles and reduces oxidative stress induced by physical exercise and protects against oxidative stress induced by high Iron concentration (lower inflammation process and cfDNA concentration).\n5. Daily inhalation with the molecular hydrogen effects human serum anti-tumor potential against human LNCaP prostate cancer cells.\n\nIII. Research project methodology In order to achieve the objectives of the study 80 people will be recruited, then randomly divided into two groups: Experimental ((N=40) and Control (N=40). Furthermore, groups will be divided into subgroups to implement the assumptions of one-time and 10-time inhalation with the use of a molecular hydrogen generator on the level of induced muscle damage and the level of maximum anaerobic and aerobic capacity. The whole study will be carried out using the assumptions of the experiment - a blind test (inhalation with normal air but under the use of H2 generator (switched of), and in accordance with the principles of the experiment.\n\nIn the study an experiment based on an ex post facto research plan will be used, due to the lack of manipulation of the grouping variable. Study will be based on comparative analysis and regression analysis. In the independent variable test, the group (non-trainees), variables dependent on molecular hydrogen inhalation and the anaerobic\u002Faerobic performance characteristics, biochemical blood indicators. Minimal (40 people each) sample size was calculated according to Kirby et all (2002) and Kadam and Bhalerao (2010).\n\nIV. The study will consist of twelve parts. For anaerobic power of the lower limbs measurement of double Wingate anaerobic test (WAnT) will be conducted on a cycle ergometer,\n\n* For the measurement of Aerobic Components of Fitness and post-aerobic exercises response Bruce Treadmill Test will be performed.\n* The blood collection for diagnostic tests will be strictly dependent on the requirements of a particular designation,",[102,103,31,32,104],"Physiological Adaptations","Sport Performance","Sport Recovery",[106,107,108,109,110],"molecular hydrogen","anti-cancer potential","inflammatory response","exercise capacity","inhalation","2025-08-18",{"date":113,"type":44},"2025-08-19",{"date":115,"type":22},"2025-10-01",{"date":117,"type":22},"2030-12-31",{"name":119,"class":51},"Gdansk University of Physical Education and Sport"]