[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"analgesia-epidural\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:analgesia-epidural":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,82,105],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100436511","neuraxial-labor-analgesia-and-offspring-neurodevelopment-100436511",false,"NCT04964206","Neuraxial Labor Analgesia and Offspring Neurodevelopment","Impact of Maternal Neuraxial Labor Analgesia on Offspring Neurodevelopment. A Multicenter, Prospective, Longitudinal Cohort Study","Inclusion Criteria:\n\n1. Primiparae between 18 and 35 years of age with term single cephalic pregnancy;\n2. Undergo regular prenatal examination in the study centers;\n3. Preparing to deliver vaginally.\n\nExclusion Criteria:\n\n1. History of psychiatric diseases (indicate those that are diagnosed before or during pregnancy by psychiatrists);\n2. History of diseases involving the hypothalamic-pituitary-adrenal axis;\n3. Presence of contraindications to epidural analgesia, which includes: (1) History of infectious disease of the central nervous system (poliomyelitis, cerebrospinal meningitis, encephalitis, etc.); (2) History of spinal or intra-spinal disease (trauma or surgery of spinal column, intra-spinal canal mass, etc.); (3) Systemic infection (sepsis); (4) Skin or soft tissue infection at the site of epidural puncture; (5) Coagulopathy.\n4. Presence of contraindications to vaginal delivery;\n5. Other reasons that are considered unsuitable for study participation.","FEMALE","18 Years","35 Years",{"count":20,"type":21},4645,"ESTIMATED","24 Months","OBSERVATIONAL","How perinatal factors affect the long-term development of children has always been an issue of much concern. This study is designed to explore the potential impact of maternal neuraxial labor analgesia exposure on offspring neurodevelopment.",[26,27,28,29,30],"Pregnant Women","Labor Pain","Analgesia, Epidural","Infants","Neurodevelopmental Disorders",[32,33,34,29,35],"Pregnant women","Labor pain","Neuraxial labour analgesia","Neurodevelopmental disorders","RECRUITING","2026-06-05",{"date":39,"type":40},"2026-06-09","ACTUAL",{"date":42,"type":40},"2022-10-14",{"date":44,"type":21},"2028-12",{"name":46,"class":47},"Dong-Xin Wang","OTHER",2,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100623384","comparing-pieb-and-cei-for-labor-pain-relief-100623384","NCT07395934","Comparing PIEB and CEI for Labor Pain Relief","Comparison of Continuous Epidural Infusion vs. Programmed Intermittent Epidural Bolus Combined With Patient-Controlled Epidural Analgesia for Labor Pain Relief: A Randomized Controlled Trial","COPILOT","Inclusion Criteria:\n\n* Parturients indicated for labor analgesia for vaginal delivery via epidural anesthesia.\n* Age from 18 to 40 years.\n* Physical status: ASA II.\n* Singleton pregnancy, full-term, vertex presentation in labor.\n* Indication for vaginal delivery.\n* No contraindications to epidural anesthesia.\n* Agreement to participate in the research and signed written informed consent.\n\nExclusion Criteria:\n\n* Contraindications to epidural analgesia.\n* History of allergy to local anesthetics (Ropivacaine) or opioids (Fentanyl).\n* High-risk pregnancies: Preeclampsia, placenta previa, placental abruption.\n* Fetal distress or fetal abnormalities.\n* Chronic use of analgesic drugs or neurological\u002Fpsychiatric disorders.\n* Parturients who refuse to participate or request to withdraw from the research.","40 Years",{"count":59,"type":21},60,"INTERVENTIONAL",[62],"NA","The purpose of this randomized controlled trial is to compare the efficacy and safety of two epidural analgesia maintenance methods for labor pain relief: Programmed Intermittent Epidural Bolus (PIEB) and Continuous Epidural Infusion (CEI), both combined with Patient-Controlled Epidural Analgesia (PCEA). The study aims to evaluate which technique provides superior analgesia while minimizing anesthetic consumption and preserving maternal motor function. A total of 60 parturients at Family Hospital, Da Nang, will be randomly assigned to either the PIEB or CEI group. Outcomes including pain intensity (VAS scores), total drug consumption, maternal satisfaction, and neonatal Apgar scores will be assessed.",[27,28,65,66],"Analgesia, Obstetrical","Labor, Obstetric",[68,69,70,71],"Programmed Intermittent Epidural Bolus (PIEB)","Continuous Epidural Infusion (CEI)","Patient-Controlled Epidural Analgesia (PCEA)","Visual Analog Scale (VAS)","2026-01-31",{"date":74,"type":40},"2026-02-09",{"date":76,"type":40},"2025-07-30",{"date":78,"type":21},"2026-08-30",{"name":80,"class":47},"Da Nang Family General Hospital",1,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":60,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":48},"100568529","the-impact-of-local-anesthetic-solution-temperature-on-epidural-related-maternal-fever-100568529","NCT06682416","The Impact of Local Anesthetic Solution Temperature on Epidural-related Maternal Fever","Inclusion Criteria:\n\n1. Requesting epidural analgesia;\n2. Aged 18 or older;\n3. At least 37 weeks of gestation;\n4. Those delivering vaginally.\n\nExclusion Criteria:\n\n1. Contraindications to epidural analgesia;\n2. Pre-existing fever (≥38°C) before labor;\n3. Use of NSAIDs or other types of antipyretics before labor;\n4. Multiple pregnancy (carrying more than one fetus);\n5. Fetal demise (stillbirth);\n6. Severe preeclampsia;\n7. Women who refuse to participate.",{"count":89,"type":21},424,[62],"This study investigates how the temperature of local anesthetics affects maternal fever related to epidural analgesia during childbirth. The research is a prospective, randomized controlled trial involving 424 participants from two hospitals. The primary objective is to investigate the impact of local anesthetic solution temperature on intrapartum fever in parturients. Secondary goals include assessing the impact on the efficacy of epidural analgesia and various maternal and neonatal outcomes. Participants will receive either 37°C or 23°C anesthetic solutions, and data will be collected on fever rates, pain scores, and other health indicators. The study runs from January 2024 to December 2026.",[93,28,94,95],"Epidural Related Maternal Fever","Fever","Intrapartum Fever","2025-09-10",{"date":98,"type":40},"2025-09-11",{"date":100,"type":40},"2024-11-30",{"date":102,"type":21},"2027-10-01",{"name":104,"class":47},"The First Affiliated Hospital of Soochow University",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":60,"phases":114,"briefSummary":116,"conditions":117,"keywords":4,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":81},"100584434","phase-4-comparison-of-safety-and-efficacy-between-pieb-and-cei-for-labour-epidural-analgesia-100584434","NCT06889285","Comparison of Safety and Efficacy Between PIEB and CEI for Labour Epidural Analgesia","Comparison of Safety and Efficacy Between Programmed Intermittent Epidural Bolus (PIEB) and Continuous Epidural Infusion (CEI) for Labour Epidural Analgesia: a Randomized Controlled Trial","Inclusion Criteria:\n\n* age \\> 18 years old\n* ASA 2 \\& 3w\n\nExclusion Criteria:\n\n* patient refusal\n* significant comorbiddities, eg patient with heart disease, kidney diseae, neurological disoder\n* contraindicated to neuraxial blockade\n* allergic to local anesthetic agent or opioid\n* obstetric complications, eg pre-eclampsia, leaking liqour, suspicious CTG\n* morbid obesity, BMI \\> 40\n* grandmultiparous ( \\> 5biths at \\> 20 weeks gestation)\n* combined spinal epidural technique for labour epidural analgesia\n* height \\\u003C 145cm",{"count":113,"type":21},76,[115],"PHASE4","The goal of this clinical trial is to compare safety and efficacy of programmed intermittent epidural bolus (PEIB) and continuous epidural infusion (CEI) in parturients during active phase of labour.\n\nThe main questions aimed to answer are:\n\n* Will parturient using PIEB+PCEA has lower incidence of motor block as compared to CEI during labour?\n* Will parturient using PIEB + PCEA has lower local anaesthetic consumption (in mg\u002Fhr) as compared to CEI during labour?\n* Will parturient using PIEB + PCEA has shorter duration of second stage labour as compared to CEI?\n* Will parturient using PIEB + PCEA has better satisfaction score when compared to CEI during labour?\n\nParticipants will be randomised into PIEB group and CEI group after informed consent taken\n\n* All participants will be taken baseline demographic data, vital signs, Bromage score, cardiotocograph prior intervention\n* Labour epidural will be inserted and started on PIEB protocol or CEI protocol based on randomisation\n* Participants vital signs and Bromage score will be recorded hourly till baby delivery\n* In the end of delivery, total LA consumption and duration of second stage will be recorded\n* Within 24 hours, participants will be interviewed on their satisfaction score on labour epidural analgesia.\n\nResearchers will compare PIEB and CEI to see if PIEB has better safety and efficacy as compared to CEI in labour epidural analgesia.",[28],"NOT_YET_RECRUITING","2025-03-15",{"date":121,"type":40},"2025-03-21",{"date":123,"type":21},"2025-04-01",{"date":125,"type":21},"2025-12-30",{"name":127,"class":47},"Hospital Universiti Sains Malaysia"]