[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"analgesia-obstetrical\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:analgesia-obstetrical":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,82,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100623384","comparing-pieb-and-cei-for-labor-pain-relief-100623384",false,"NCT07395934","Comparing PIEB and CEI for Labor Pain Relief","Comparison of Continuous Epidural Infusion vs. Programmed Intermittent Epidural Bolus Combined With Patient-Controlled Epidural Analgesia for Labor Pain Relief: A Randomized Controlled Trial","COPILOT","Inclusion Criteria:\n\n* Parturients indicated for labor analgesia for vaginal delivery via epidural anesthesia.\n* Age from 18 to 40 years.\n* Physical status: ASA II.\n* Singleton pregnancy, full-term, vertex presentation in labor.\n* Indication for vaginal delivery.\n* No contraindications to epidural anesthesia.\n* Agreement to participate in the research and signed written informed consent.\n\nExclusion Criteria:\n\n* Contraindications to epidural analgesia.\n* History of allergy to local anesthetics (Ropivacaine) or opioids (Fentanyl).\n* High-risk pregnancies: Preeclampsia, placenta previa, placental abruption.\n* Fetal distress or fetal abnormalities.\n* Chronic use of analgesic drugs or neurological\u002Fpsychiatric disorders.\n* Parturients who refuse to participate or request to withdraw from the research.","FEMALE","18 Years","40 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this randomized controlled trial is to compare the efficacy and safety of two epidural analgesia maintenance methods for labor pain relief: Programmed Intermittent Epidural Bolus (PIEB) and Continuous Epidural Infusion (CEI), both combined with Patient-Controlled Epidural Analgesia (PCEA). The study aims to evaluate which technique provides superior analgesia while minimizing anesthetic consumption and preserving maternal motor function. A total of 60 parturients at Family Hospital, Da Nang, will be randomly assigned to either the PIEB or CEI group. Outcomes including pain intensity (VAS scores), total drug consumption, maternal satisfaction, and neonatal Apgar scores will be assessed.",[28,29,30,31],"Labor Pain","Analgesia, Epidural","Analgesia, Obstetrical","Labor, Obstetric",[33,34,35,36],"Programmed Intermittent Epidural Bolus (PIEB)","Continuous Epidural Infusion (CEI)","Patient-Controlled Epidural Analgesia (PCEA)","Visual Analog Scale (VAS)","RECRUITING","2026-01-31",{"date":40,"type":41},"2026-02-09","ACTUAL",{"date":43,"type":41},"2025-07-30",{"date":45,"type":22},"2026-08-30",{"name":47,"class":48},"Da Nang Family General Hospital","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":62,"conditions":63,"keywords":69,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":49},"100622648","phase-4-intrathecal-versus-epidural-morphine-for-post-cesarean-analgesia-100622648","NCT07386353","Intrathecal Versus Epidural Morphine for Post-Cesarean Analgesia","Intrathecal Versus Epidural Morphine for Post-Cesarean Analgesia: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Pregnant women scheduled for elective cesarean section;\n* Age \\> 18 years;\n* Willingness to participate in the study, as demonstrated by signed informed consent.\n\nExclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status classification \\> III;\n* Chronic kidney disease with a glomerular filtration rate \\\u003C 60 mL\u002Fmin;\n* Relevant drug allergies (particularly to protocol medications);\n* Opioid tolerance;\n* Contraindication to neuraxial anesthetic techniques.",true,{"count":59,"type":22},120,[61],"PHASE4","Cesarean section is one of the most commonly performed surgical procedures worldwide, making effective management of acute postoperative pain a key issue in obstetric anesthesiology. Post-cesarean analgesia should promote rapid maternal recovery, support newborn care, and consider the pharmacological implications for breastfeeding.\n\nAccording to recent PROSPECT® guidelines from ESRA, neuraxial opioids play a central role in post-cesarean analgesia and are at least as effective as other techniques, such as continuous local anesthetic infusion. However, the optimal route of opioid administration remains unclear. While earlier studies favored epidural morphine, more recent evidence suggests that intrathecal morphine may provide superior analgesia. Due to limited and conflicting data, no definitive conclusion can be drawn. Given that epidural morphine remains standard practice at Hospital Central do Funchal, a randomized clinical trial is proposed to compare the analgesic efficacy of intrathecal versus epidural morphine after elective cesarean section.",[64,65,66,67,68],"Analgesia Obstetrical","Analgesia","Post Operative Pain","Patient Satisfaction","Cesarean Section Pain",[70,71,72],"Post-Cesarean Analgesia","Epidural Morphine","Intrathecal Morphine","2026-01-27",{"date":75,"type":41},"2026-02-04",{"date":77,"type":41},"2024-05-20",{"date":79,"type":22},"2026-07-31",{"name":81,"class":48},"Hospital Central do Funchal",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":57,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":23,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":4},"100600231","phase-4-comparison-of-intrathecal-bupivacaine-with-and-without-morphine-for-post-operative-analgesia-in-parturients-undergoing-elective-cesarean-section-a-randomized-controlled-trial-100600231","NCT07094802","Comparison of Intrathecal Bupivacaine With and Without Morphine for Post-operative Analgesia in Parturients Undergoing Elective Cesarean Section: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Parturients undergoing elective caesarean section under Spinal anesthesia\n* ASA PS II, III\n* \\> 18 years\n\nExclusion Criteria:\n\n* Refusal to Participate\n* Contraindications to spinal anaesthesia and adjuvants INR ≥ 1.5 Plateletes \\\u003C 1,00,000\u002Fcumm Severe aortic stenosis, and\u002For severe mitral stenosis Infection at lumbar puncture site Known allergy to local anesthetics and opioids\n* Communication barrier\n* Height \\\u003C150 cm",{"count":89,"type":22},92,[61],"The goal of this clinical trial is to compare intrathecal bupivacaine with or without morphine for postoperative analgesia in patients undergoing elective cesarean section. The main questions it aims to answer are:\n\nIs intrathecal bupivacaine with morphine superior to intrathecal bupivacaine alone for postoperative analgesia for parturients undergoing cesarean section? What is the duration of analgesia in the two groups? Researchers will compare drug intrathecal bupivacaine with morphine to a iintrathecal bupivacaine alone to see if intrathecal morphine has benefits for psotoperative analgesia .\n\nParticipants will:\n\nGet intrathecal bupivacaine with Morphine or intrathecal bupivacaine alone during spinal anesthesia for cesarean section.\n\nThey will be followed up for NRS pain scores and side effects for 24 hours. Time to need of first rescue analgesic will be noted",[93,94,30],"Postoperative Pain","Cesarean Delivery","NOT_YET_RECRUITING","2025-07-23",{"date":43,"type":41},{"date":99,"type":22},"2025-10-15",{"date":101,"type":22},"2026-08-15",{"name":103,"class":48},"Tribhuvan University Teaching Hospital, Institute Of Medicine.",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":115,"conditions":116,"keywords":118,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":4},"100514351","intrathecal-catheter-placement-versus-resiting-epidural-catheter-after-dural-puncture-in-obstetric-patients-100514351","NCT05977361","Intrathecal Catheter Placement Versus Resiting Epidural Catheter After Dural Puncture in Obstetric Patients","Intrathecal Catheter Placement Versus Resiting Epidural Catheter After Dural Puncture in Obstetric Patients: a Multicenter Randomized Controlled Trial","ItaREVI","Inclusion Criteria:\n\n* Confirmed diagnosis of UDP during labour\n* Written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* History of PDPH",{"count":113,"type":22},181,[25],"Epidural anesthesia represents the most popular method for pain relief during labour. Unintentional dural puncture (UDP) occurs in 0.4-1.5% of labour epidural analgesia, representing therefore the most common complication. Up to 80% of patients with a UDP may develop a post-dural puncture headache (PDPH).\n\nWhen a UDP occurs, two possible strategies have been proposed in order to ensure analgesia during labour: either resiting the epidural catheter in a different intervertebral space, or inserting an intrathecal catheter. Both strategies proved to equally provide analgesia during labour, but their relative contribution in preventing PDPH is still not known.\n\nThe primary aim of this multicenter randomized controlled trial is therefore to compare these two strategies in the occurrence of PDPH at 24 hours from the UDP.",[30,117],"Post-Dural Puncture Headache",[28,119,29],"Obstetric Labor Complications","2024-04-24",{"date":122,"type":41},"2024-04-25",{"date":124,"type":22},"2024-04-26",{"date":126,"type":22},"2026-11-30",{"name":128,"class":48},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS"]