[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"analgesic-efficacy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:analgesic-efficacy":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,71,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100634234","analgesic-efficacy-of-quadro-iliac-plane-block-versus-erector-spinae-plane-in-total-hip-arthroplasty-100634234",false,"NCT07537036","Analgesic Efficacy of Quadro-Iliac Plane Block Versus Erector Spinae Plane in Total Hip Arthroplasty","Analgesic Efficacy of Quadro-Iliac Plane Block Versus Erector Spinae Plane in Total Hip Arthroplasty: A Randomized Non-Inferiority Trial","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status I-III.\n* Undergoing total hip arthroplasty (THA) under spinal anesthesia.\n\nExclusion Criteria:\n\n* History of allergies to local anesthetics.\n* Opioid dependency.\n* Body mass index (BMI) \\> 35 kg\u002Fm2.\n* Cognitive impairment.\n* Bleeding or coagulation disorders.\n* Psychiatric and neurological disorder.\n* Local infection at the site of injection.\n* Severe heart, lung, liver, and renal dysfunction.\n* Emergency surgery.","ALL","18 Years",{"count":19,"type":20},76,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to compare the Quadro-Iliac Plane Block versus Erector Spinae Plane Block after total hip arthroplasty.",[26,27,28,29],"Analgesic Efficacy","Quadro-Iliac Plane Block","Erector Spinae Plane Block","Total Hip Arthroplasty","RECRUITING","2026-06-22",{"date":33,"type":34},"2026-06-23","ACTUAL",{"date":36,"type":34},"2026-04-18",{"date":38,"type":20},"2026-11-30",{"name":40,"class":41},"Tanta University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":42},"100633325","phase-3-suzetrigine-frame-trial-comparing-suzetrigine-and-acetaminophen-100633325","NCT07525219","Suzetrigine Frame Trial Comparing Suzetrigine and Acetaminophen","A Randomized Controlled Trial Comparing Suzetrigine and Acetaminophen for Reducing Pain During Local Anesthetic Infiltration and Head Frame Application","Inclusion Criteria:\n\n* Patients scheduled for a standard of care procedure requiring a stereotactic head frame to be placed\n\nExclusion Criteria:\n\n* Patients not scheduled for a standard of care procedure requiring a stereotactic head frame to be placed will not be approached","21 Years",{"count":52,"type":20},80,[54],"PHASE3","Local anesthetic infiltration is a primary source of acute pain during stereotactic procedures.",[26],[58,59,60],"procedural prophylaxis","anesthetic infiltration","stereotactic head frame","NOT_YET_RECRUITING","2026-04-22",{"date":64,"type":34},"2026-04-23",{"date":66,"type":20},"2026-07",{"date":68,"type":20},"2027-07",{"name":70,"class":41},"Wake Forest University Health Sciences",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":21,"phases":80,"briefSummary":82,"conditions":83,"keywords":89,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":42},"100598327","phase-4-continuous-vs-bolus-administration-of-nsaids-after-laparoscopic-surgery-for-multimodal-analgesia-100598327","NCT07070050","Continuous vs. Bolus Administration of NSAIDs After Laparoscopic Surgery for Multimodal Analgesia","Continuous vs. Bolus Administration of NSAIDs After Laparoscopic Surgery for Multimodal Analgesia: Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Age \\> 18 years old\n* Elective laparoscopic surgery\n* General anesthesia\n* Signed informed consent from the patient to participate in the study\n* RASS scale from -2 to +1 on admission to a surgical department or ICU\n\nExclusion Criteria:\n\n* History of ibuprofen allergy\n* Active erosive or ulcerative lesions of the gastrointestinal tract\n* Chronic use of opioid analgesics or NSAIDs prior to enrollment\n* Chronic kidney disease ≥ 3b stage according to the KDIGO classification\n* Liver dysfunction (three times exceeding the upper reference limit of ALT or AST)\n* A history of bronchial asthma\n* A history of hereditary coagulopathies\n* A history of use of anticoagulants",{"count":79,"type":20},100,[81],"PHASE4","Currently the prevalent approach to perioperative management of patients is ERAS (Enhanced Recovery After Surgery) concept. This approach includes numerous aspects, among which the perioperative use of multimodal analgesia takes one of the leading places. Within the ERAS guidelines all sorts of minimization of opioid analgesics use in schemes of postoperative analgesia are appreciated. Thus, new pharmacological approaches are being actively developed currently in order to achieve adequate analgesia and to minimize the use of this group of drugs.\n\nOne of the most perspective trends within the multimodal analgesia concept is continuous infusion of non-steroidal anti-inflammatory drugs (NSAID). Up to date there are papers that both confirm the effectiveness of this method for maintaining adequate postoperative analgesia and show its limitations and deny the advantages of the continuous use of NSAID.\n\nUp to this time the main attention of the medical community was paid for such drugs as paracetamol and ketoprofen. Nevertheless, one of the most common and safe NSAID is ibuprofen. In spite of this, there are no studies that explore the effectiveness of the continuous infusion of this drug. Thus, the lack of even low-quality evidence led to setting up a study of effectiveness and safety of continuous infusion of ibuprofen in comparison to its bolus injection.",[84,85,26,86,87,88],"Analgesic Drugs","Analgesic, Nonopioid","Analgetic Consumption","Postoperative Care","Pain Management",[90,91,92,93,94],"NSAID","pain management","analgesia","postoperative care","analgesic drug","2025-07-07",{"date":97,"type":34},"2025-07-17",{"date":99,"type":34},"2025-05-05",{"date":101,"type":20},"2026-11-20",{"name":103,"class":41},"Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":21,"phases":114,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":125,"leadSponsor":127,"locationsCount":42},"100561018","analgesic-efficacy-of-external-oblique-intercostal-block-vs-subcostal-transversus-abdominis-plane-block-in-open-surgical-nephrectomy-100561018","NCT06584695","Analgesic Efficacy of External Oblique Intercostal Block vs Subcostal Transversus Abdominis Plane Block in Open Surgical Nephrectomy","Analgesic Efficacy of External Oblique Intercostal Block Versus Subcostal Transversus Abdominis Plane Block in Open Surgical Nephrectomy","Inclusion Criteria:\n\n* Age (18-65) year.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) class II and III.\n* Cancer patients candidate for open nephrectomy .\n\nExclusion Criteria:\n\n* Patient refusal.\n* Skin lesions or infection at the site of proposed needle insertion.\n* Cognitive disorders.\n* History of psychiatric disorders or drug abuse.\n* Patients allergic to medication used.\n* ASA class IV.\n* Coagulopathy.\n* Body mass index (BMI) more than 35.","65 Years",{"count":113,"type":20},63,[23],"To compare the efficacy of unilateral ultrasound-guided oblique subcostal transversus abdominis plane block with unilateral ultrasound-guided external oblique intercostal plane block in providing intraoperative and postoperative analgesia in cancer patients undergoing open nephrectomy.",[26,117,118,119,120],"External Oblique Intercostal Block","Subcostal Transversus Abdominis Plane Block","Open","Nephrectomy","2024-09-05",{"date":123,"type":34},"2024-09-19",{"date":121,"type":34},{"date":126,"type":20},"2025-12-01",{"name":128,"class":41},"Cairo University"]