[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"analgetic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:analgetic":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100609345","phase-2-high-dose-dexamethasone-to-reduce-postoperative-pain-after-video-assisted-thoracoscopic-surgery-lobectomy-segmentectomy-100609345",false,"NCT07213375","High Dose Dexamethasone to Reduce Postoperative Pain After Video-Assisted Thoracoscopic Surgery Lobectomy \u002FSegmentectomy","High Dose Dexamethasone In High-Pain Responders Undergoing Enhanced Recovery Video-Assisted Thoracoscopic Surgery Lobectomy and Segmentectomy - A Randomized Double-Blinded Controlled Trial","DEXTER","Inclusion Criteria:\n\n* Age ≥ 18 year\n* Able to understand written and spoken Danish language\n* PCS ≥20\n* Signed written informed consent form.\n* Patient planned to elective VATS lobectomy\u002Fsegmentectomy\n\nExclusion Criteria:\n\n* Patients undergoing systemic glucocorticoid or other immunosuppressive therapies, ex-cluding inhaled steroids.\n\n  * Individuals with diabetes requiring insulin treatment.\n  * Pregnant or breastfeeding patients.\n  * Patients with known allergies to the study drug.\n  * Individuals with mental disabilities that may impair their capacity to provide informed consent or compromise the validity of data collection.\n  * Patients with diagnosed schizophrenia, active psychosis, bipolar disorder, or a history of ongoing treatment with antipsychotic and\u002For antidepressant medications.\n  * Individuals with altered pain perception due to other conditions or injuries, such as spi-nal cord or brain injuries, severe polyneuropathies, or neurological disorders.\n  * Regular users of opioid medications.\n  * Patients requiring reoperation within the first two postoperative days.\n  * Individuals undergoing conversion to a surgical procedure other than VATS lobecto-my\u002Fsegmentectomy.","ALL","18 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE2","PHASE3","The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg\u002Fkg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to \"High-pain-responders\" in patients undergoing VATS lobectomy\u002Fsegmentectomy.\n\nThe hypothesis is that a high dose of Dexamethasone can lower pain when coughing in the morning after VATS lobectomy\u002Fsegmentectomy, in patients scoring as \"High-pain-responders\" on the Pain-Catastrophizing-Scale",[28,29,30,31],"Analgetic","Lung Cancer (NSCLC)","Video Assisted Thoracic Surgery (VATS)","Glucocorticoid",[33,34,35,36,37],"Pain catastrophizing","ERAS","VATS","Lung cancer","Minimizing pain","RECRUITING","2026-01-05",{"date":41,"type":42},"2026-01-07","ACTUAL",{"date":44,"type":42},"2025-09-01",{"date":46,"type":21},"2026-11",{"name":48,"class":49},"Rigshospitalet, Denmark","OTHER"]