[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anaplastic-oligoastrocytoma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anaplastic-oligoastrocytoma":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100270475","phase-2-super-selective-intra-arterial-repeated-infusion-of-cetuximab-erbitux-with-reirradiation-for-treatment-of-relapsedrefractory-gbm-aa-and-aoa-100270475",false,"NCT02800486","Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed\u002FRefractory GBM, AA, and AOA","Phase II Trial of Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed\u002FRefractory Glioblastoma Multiforme, Anaplastic Astrocytoma, and Anaplastic Oligoastrocytoma","Inclusion Criteria:\n\n* Male or female patients of ≥18 years of age\n* Patients with a documented histologic diagnosis of relapsed or refractory glioblastoma multiforme (GBM), anaplastic astrocytoma (AA) or anaplastic oligoastrocytoma (AOA)\n* Patients with pathology confirmed histologic EGFR overexpression\n* Patients must have at least one confirmed and evaluable tumor site.∗\n\n  \\*A confirmed tumor site is one in which is biopsy-proven\n* Patients must have a Karnofsky performance status ≥60% and an expected survival of ≥ three months.\n* No chemotherapy for two weeks prior to treatment under this research protocol and no external beam radiation for eight weeks prior to treatment under this research protocol\n* Patients must have adequate hematologic reserve with WBC≥3000\u002Fmm3, absolute neutrophils ≥1500\u002Fmm3 and platelets ≥100,000\u002F mm3. Patients who are on Coumadin must have a platelet count of ≥150,000\u002F mm3\n* Pre-enrollment chemistry parameters must show: bilirubin\\\u003C1.5X the institutional upper limit of normal (IUNL); AST or ALT\\\u003C2.5X IUNL and creatinine\\\u003C1.5X IUNL\n* Pre-enrollment coagulation parameters (PT and PTT) must be ≤1.5X the IUNL\n* Patients must agree to use a medically effective method of contraception during and for a period of three months after the treatment period. A pregnancy test will be performed on each premenopausal female of childbearing potential immediately prior to entry into the research study\n* Patients must be able to understand and give written informed consent. Informed consent must be obtained at the time of patient screening\n\nExclusion Criteria:\n\n* Women who are pregnant or lactating.\n* Women of childbearing potential and fertile men will be informed of the potential unknown risk of conception while participating in this research trial and will be advised that they must use effective contraception during and for a period of three months after the treatment period\n* Patients with significant intercurrent medical or psychiatric conditions that would place them at increased risk or affect their ability to receive or comply with treatment or post-treatment clinical monitoring\n* Patients with radiological evidence of leptomeningeal disease\n* Patients with history of allergic reaction to CTX\n* Patients who completed chemo\u002FRT less than 6 months prior to enrollment\n* Patients who have not failed standard Stupp protocol","ALL","18 Years",{"count":19,"type":20},37,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","Primary brain tumors are typically treated by surgery, radiation therapy and chemotherapy, either individually or in combination. Present therapies are inadequate, as evidenced by the low 5-year survival rate for brain cancer patients, with median survival at approximately 12 months. Glioma is the most common form of primary brain cancer, afflicting approximately 7,000 patients in the United States each year. These highly malignant cancers remain a significant unmet clinical need in oncology. GBM often has a high expression of EFGR (Epidermal Growth Factor Receptor), which is associated with poor prognosis. Several methods of inhibiting this receptor have been tested, including monoclonal antibodies, vaccines, and tyrosine kinase inhibitors. The investigators hypothesize that in patients with recurring GBM, intracranial superselective intra-arterial infusion of Cetuximab (CTX), at a dose of 250mg\u002Fm2 in conjunction with hypofractionated radiation, will be safe and efficacious and prevent tumor progression in patients with recurrent, residual GBM.",[26,27,28,29,30,31,32,33,34],"Glioblastoma","Anaplastic Astrocytoma","Anaplastic Oligoastrocytoma","Glioma","Brain Neoplasm","Brain Cancer","Brain Tumor","Brain Tumor, Recurrent","Brain Neoplasm, Malignant","RECRUITING","2026-04-08",{"date":38,"type":39},"2026-04-13","ACTUAL",{"date":41,"type":39},"2016-05",{"date":43,"type":20},"2036-05",{"name":45,"class":46},"Northwell Health","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":47},"100410394","phase-2-chemotherapy-and-radiation-therapy-for-the-treatment-of-idh-wildtype-gliomas-or-non-histological-molecular-glioblastomas-100410394","NCT04623931","Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas","Phase II Trial of Treatment Intensification for IDH Wildtype, Non-Histological Glioblastoma, Gliomas (IDH Wildtype Lower Grade Glioma Treatment Intensification)","Inclusion Criteria:\n\n* Historical grade II and III gliomas IDH wildtype gliomas by including; diffuse astrocytoma, anaplastic astrocytoma, oligodendroglioma, anaplastic oligodendroglioma, oligoastrocytoma, anaplastic oligoastrocytoma\n* IDH wildtype gliomas (molecularly defined high grade glioma or molecularly defined glioblastoma \\[GBM\\])\n* History \\& physical exam, and Karnofsky performance status (KFS) of \\>= 70 within 30 days prior to enrollment\n* Post-operative magnetic resonance imaging (MRI) with contrast is mandatory and necessary for radiation therapy (RT) planning\n* Thin-slice (\\\u003C 1.5 mm) three-dimensional (3D) T1 pre and post contrast and axial T2\u002Ffluid-attenuated inversion recovery (FLAIR) sequences for planning purposes are highly encouraged to obtain.\n* Absolute neutrophil count (ANC) \\>= 1,500 cells\u002Fmm\\^3 (within 60 days prior to registration)\n* Platelets \\>= 100,000 cells\u002Fmm\\^3 (within 60 days prior to registration)\n* Hemoglobin \\>= 10.0 g\u002Fdl (within 60 days prior to registration) (Note: The use of transfusion or other intervention to achieve hemoglobin \\[Hgb\\] \\>= 10.0 g\u002Fdl is acceptable)\n* Bilirubin =\\\u003C 1.5 upper limit of normal (ULN) (within 60 days prior to registration)\n* Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =\\\u003C 3 x ULN (within 60 days prior to registration)\n* Blood urea nitrogen (BUN) \\\u003C 30 mg\u002Fdl (within 60 days prior to registration)\n* Serum creatinine \\\u003C 1.5 mg\u002Fdl (within 60 days prior to registration)\n\nExclusion Criteria:\n\n* Definitive clinical or radiologic evidence of metastatic disease; if applicable\n* Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years. (For example, carcinoma in situ of the breast, oral cavity or cervix are permissible)\n* Prior cranial radiotherapy or radiotherapy to the head and neck where potential field overlaps would exist\n* Prior chemotherapy or radiotherapy for any brain tumor\n* Histologic diagnosis of gliosarcoma World Health Organization (WHO grade IV) or pilocytic astrocytoma (WHO grade I)\n* Multicentric glioblastoma\n* Leptomeningeal disease\n* Inability to undergo MRI with and without contrast\n* Severe, active co-morbidity defined as follows:\n\n  * Unstable angina or congestive heart failure requiring hospitalization within 6 months prior to enrollment\n  * Transmural myocardial infarction within the last 6 months prior to registration. Evidence of recent myocardial infarction or ischemia by the findings of S-T elevations of \\>= 2 mm using the analysis of an electrocardiogram (EKG) performed within 28 days prior to registration. (Note: EKG to be performed only if clinical suspicion of cardiac issue)\n\n    • New York Heart Association grade II or greater congestive heart failure requiring hospitalization within 12 months prior to registration\n  * Serious and inadequately controlled arrhythmia at step 2 registration\n  * Serious or non-healing wound, ulcer or bone fracture or history of abdominal fistula, intra-abdominal abscess requiring major surgical procedure, open biopsy or significant traumatic injury within 28 days prior to registration, with the exception of the craniotomy for surgical resection\n  * Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration\n  * Hepatic insufficiency resulting in clinical jaundice and\u002For coagulation defects; note, however, that laboratory tests for coagulation parameters are not required for entry into this protocol\n  * Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration\n  * Human immunodeficiency virus (HIV) positive with CD4 count \\\u003C 200 cells\u002Fmicroliter. Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that HIV testing is not required for entry into this protocol. The need to exclude patients with AIDS from this protocol is because the treatments involved in this protocol may be significantly immunosuppressive with potentially fatal outcomes in patients already immunosuppressed\n* Any other severe immunocompromised condition\n* Active connective tissue disorders, such as lupus or scleroderma that in the opinion of the treating physician may put the patient at high risk for radiation toxicity\n* End-stage renal disease (i.e., on dialysis or dialysis has been recommended)\n* Any other major medical illnesses or psychiatric treatments that in the investigator's opinion will prevent administration or completion of protocol therapy",{"count":56,"type":20},40,[23],"This phase II trial studies how well temozolomide and radiation therapy work in treating patients with IDH wildtype historically lower grade gliomas or non-histological molecular glioblastomas. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving chemotherapy with radiation therapy may kill more tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The goal of this clinical research study is to compare receiving new radiation therapy doses and volumes to the prior standard treatment for patients with historically grade II or grade III IDH wild-type gliomas, which may now be referred to as IDH wildtype molecular glioblastomas at some institutions. Receiving temozolomide in combination with radiation therapy may also help to control the disease.",[60,28,61,62,26,63,64,65,66],"Anaplastic Astrocytoma, IDH-Wildtype","Anaplastic Oligodendroglioma","Diffuse Astrocytoma, IDH-Wildtype","Oligoastrocytoma","Oligodendroglioma","WHO Grade II Glioma","WHO Grade III Glioma","2026-01-12",{"date":69,"type":39},"2026-01-14",{"date":71,"type":39},"2020-01-30",{"date":73,"type":20},"2026-12-31",{"name":75,"class":46},"M.D. Anderson Cancer Center"]