[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anastomotic-leak\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anastomotic-leak":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,56,81,114,146,172,201,222,255,282,302,328],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":38,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100619934","post-market-study-of-the-signia-circular-stapler-with-tri-staple-technology-in-left-sided-colon-sigmoid-and-rectal-resections-100619934",false,"NCT07351071","Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections","A Prospective, Multicenter, Single-arm, Post Market Study to Evaluate the Safety and Performance of the Signia™ Circular Stapler With Tri-Staple™ Technology in Elective Open or Minimally Invasive Left-sided Colon, Sigmoid, and Rectal Resections (SECURE)","SECURE","Preoperative Inclusion Criteria:\n\n1. Subject is competent and willing to provide documented informed consent to participate in this clinical study\n2. Subject is intended to undergo an elective left sided colon\u002Fcolorectal procedure where a creation of an anastomosis will be completed with the Signia™ circular stapler\n3. Subject is ≥ 18 years of age at time of consent\n\nPreoperative Exclusion Criteria:\n\n1. Subject is unable or unwilling to comply with the study requirements or follow-up schedule\n2. Subject with ASA classification ≥ IV\n3. Subject is pregnant (as determined by standard site practices)\n4. The procedure is an emergency procedure\n5. The procedure is a revision\u002Freoperation for the same indication\n6. The subject has a documented confounding medical condition which in the opinion of the investigator, will not be appropriate for the study, or the subject has an estimated life expectancy of less than 6 months\n7. Subject has participated or plans to participate in an investigational drug or device research study that would interfere with the results of this study\n8. Subject will undergo multiple synchronous colon resections\n9. Subject with a bleeding disorder or is undergoing anticoagulant treatment that has not been reversed (anticoagulant prophylaxis prescribed as part of the surgical protocol is allowed)\n10. Subject has undergone chemotherapy or received biologics within 6 weeks prior to the day of the procedure\n11. Subject has history of chronic corticosteroid use (used greater than 3 months within a year prior to the index procedure)\n12. Subject has chronic immunosuppression therapy (used greater than 3 months within a year prior to the index procedure)\n13. Any subject undergoing an ileal-anal pouch anastomosis surgery\n\nIntraoperative Exclusion Criteria\n\n1. Anastomosis not attempted with the Signia™ circular stapler\n2. Any subject for which the device is intended to be used outside the instructions for use (IFU)","ALL","18 Years",{"count":20,"type":21},137,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to evaluate the safety and performance of the Signia™ power handle, Signia™ circular adapter, and Signia™ Tri-Staple™ 2.0 circular reloads (hereafter referred to as Signia™ circular stapler) in patients undergoing left sided colon, sigmoid, or rectal resections in a post market setting.",[27,28,29,30,31,32,33,34,35,36,37],"Colorectal Anastomosis","Left-sided Colon Resection","Anastomotic Leak","Anastomotic Complication","Digestive System Diseases","Gastrointestinal Diseases","Colonic Diseases","Intestinal Diseases","Rectal Diseases","Postoperative Complications","Anastomotic Leaks",[27,28,39,29,40,41,42],"Circular stapler","Rectal cancer","Low anterior resection","Powered stapler","RECRUITING","2026-06-11",{"date":46,"type":47},"2026-06-12","ACTUAL",{"date":49,"type":47},"2025-12-30",{"date":51,"type":21},"2027-02-28",{"name":53,"class":54},"Medtronic - MITG","INDUSTRY",9,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":67,"conditions":68,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100603165","leakage-rate-of-ileo-colic-sutured-anastomosis-after-right-hemicolectomy-100603165","NCT07132970","Leakage Rate of Ileo-COlic Sutured Anastomosis After Right Hemicolectomy","Assessment of the Leakage Rate of Ileo-colic Sutured Anastomoses Using a Polydioxanone Based Suture Material After Laparoscopic or Open Right Hemicolectomy to Treat Malignancy","LICOSARH","Inclusion Criteria:\n\n* Patients undergoing a primary, elective either open or laparoscopic right hemicolectomy or right extended hemicolectomy due to malignancy with the creation of an intracorporeal or extracorporeal ileo-colic anastomosis.\n* Either complete hand-sewn anastomosis or partial sutured anastomosis (e.g. combination of stapling and suturing)\n* Open or laparoscopic as well as conversion from open to laparoscopic surgery\n* Absence of peritoneal carcinomatosis\n* Absence of vascular, nervous or bone infiltration\n* Age ≥ 18 years\n* Written data protection declaration (Written Informed consent)\n\nExclusion Criteria:\n\n* Left hemicolectomy or left extended hemicolectomy or sigma resection\n* Inflammatory bowel disease (e.g. Crohn´s disease)\n* Emergency surgery\n* Previous abdominal surgery with bowel resection\n* Re-operation of an anastomosis (anastomosis revision surgery)\n* Need for stoma creation\n* Non-compliant patients\n* Participation in an interventional randomized controlled study (RCT)",{"count":65,"type":21},249,"OBSERVATIONAL","The primary aim of the study is to show that the ileo-colic anastomosis leakage rate until the first 30 days after surgery using MonoPlus® suture material for anastomosis construction after right hemicolectomy is not inferior to the anastomosis leakage rate published in the literature for totally handsewn or stapled-handsewn ileo-colic anastomosis.",[29,69,70],"Colon Cancer","Right Hemicolectomy","2026-06-08",{"date":73,"type":47},"2026-06-09",{"date":75,"type":47},"2026-01-26",{"date":77,"type":21},"2028-03",{"name":79,"class":54},"Aesculap AG",4,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":89,"enrollmentInfo":90,"targetDuration":92,"studyType":66,"phases":4,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":113},"100604066","anastomotic-leakage-after-colorectal-surgery-100604066","NCT07144683","Anastomotic Leakage After Colorectal Surgery.","Risk Factors for Anastomotic Leakage After Colorectal Surgery.","AL","Inclusion Criteria:\n\n* Aged ≥18 years\n* Undergoing elective or emergency colorectal resection with primary anastomosis (e.g., ileocolic, colocolic, colorectal, coloanal)\n* Providing written informed consent\n\nExclusion Criteria:\n\n* Colorectal resection without anastomosis (e.g., end stoma)\n* Inflammatory bowel disease (Crohn's, ulcerative colitis)\n* History of previous colorectal surgery involving anastomosis\n* Pregnancy\n* Unable to provide informed consent or comply with follow-up","80 Years",{"count":91,"type":21},430,"1 Year","Anastomotic leakage (AL) is a severe complication after colorectal surgery, with incidence rates of 2-30%. This prospective, single-center observational cohort study aims to identify and quantify independent risk factors for AL, determine its incidence and impact on outcomes, and develop a predictive model. Approximately 430 patients undergoing colorectal resection with anastomosis will be enrolled from August 2025 to August 2026. Risk factors will be assessed preoperatively, intraoperatively, and postoperatively. AL will be defined and graded per the International Study Group of Rectal Cancer (ISGRC) criteria.",[29,95,96],"Colorectal Cancer","Diverticulitis",[98,99,100,101,102],"Anastomotic leakage","Colorectal surgery","Risk factors","Postoperative complications","Predictive model","2026-05-17",{"date":105,"type":47},"2026-05-19",{"date":107,"type":47},"2025-08-25",{"date":109,"type":21},"2026-09-25",{"name":111,"class":112},"Minia University","OTHER",1,{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":122,"targetDuration":4,"studyType":22,"phases":124,"briefSummary":125,"conditions":126,"keywords":131,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":113},"100628665","crp-point-of-care-testing-trajectory-a-predictive-factor-for-anastomotic-leak-in-elective-colorectal-surgery-100628665","NCT07464600","CRP Point-of-care Testing Trajectory, a Predictive Factor for Anastomotic Leak in Elective Colorectal Surgery","CRP Point-of-care Testing Trajectory, a Predictive Factor for Anastomotic Leak in Elective Colorectal Surgery? A Key to Early Rehabilitation?","CRP","Inclusion Criteria:\n\n* Patients undergoing elective (non-emergency) colorectal surgery, regardless of the approach (laparotomy, laparoscopy, robotic) and whether there is a protective ileostomy.\n\nExclusion Criteria:\n\n* No anastomosis\n* Urgent surgery\n* Pregnancy or breast-feeding\n* Patients under guardianship or trusteeship\n* Minor patients",{"count":123,"type":21},500,[24],"In colorectal surgery, one of the most feared complications is anastomotic leak (AL). To limit the consequences of AL, it must be diagnosed as early as possible, before it becomes symptomatic. Digestive surgeons use a variety of pre-, per- and post-operative techniques to reduce the rate of anastomotic fistula, but the risk persists, with a rate of 7% reported in the literature. It has been shown that the value of CRP between D1 and D5 correlates with the risk of AL, and that the trajectory between two consecutive days (D1 to D5 post-op) is the most discriminating element in predicting the risk of AF. This assay requires repeated intravenous sampling, which is the opposite of simplifying care. CRP point-of-care testing (POCT) is used in clinical practice, notably in pediatrics and outpatient medicine (in children and adults) to help prescribe probabilistic antibiotic therapy, as the instantaneousness of the result has an impact on patient management. For the diagnosis of AL, CRP POCT assessment could reduce the number of blood samples taken, shorten the time between sampling and medical management in cases of suspected AL, and thus improve the patient's post-operative experience.",[127,128,129,130,29],"Colorectal Surgery","Enhanced Recovery","CRP Point-of-care Testing Trajectory","Post-operative Complication",[132,133,134,135,136],"colorectal surgery","enhanced recovery","CRP point-of-care testing trajectory","post-operative complication","anastomotic leak","2026-03-06",{"date":139,"type":47},"2026-03-11",{"date":141,"type":47},"2025-09-17",{"date":143,"type":21},"2029-02",{"name":145,"class":112},"Centre Hospitalier Universitaire, Amiens",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":153,"targetDuration":92,"studyType":66,"phases":4,"briefSummary":155,"conditions":156,"keywords":158,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":171},"100627482","registry-study-of-people-who-are-having-an-esophagectomy-and-are-at-high-risk-of-anastomotic-leak-100627482","NCT07449208","Registry Study of People Who Are Having an Esophagectomy and Are at High Risk of Anastomotic Leak","Gastric Preconditioning by Percutaneous Angioembolization Before Esophagectomy in Patients With a High Risk of Anastomotic Leak","Inclusion Criteria:\n\n* Documentation of Disease\n\n  * Patients must have pathologically confirmed esophageal malignancy requiring esophagectomy.\n  * Patients must also have risk factors for anastomotic leak:\n  * Previous foregut or bariatric surgery (gastric sleeve or gastric bypass), but excluding fundoplication-only surgery OR\n  * Salvage esophagectomy OR\n  * Planned cervical anastomosis OR\n  * Two or more comorbidities:\n  * Diabetes, obesity, coronary artery disease, vascular disease (including celiac stricture or atherosclerosis, significant aortic disease, or any previous diagnosis of peripheral arterial disease), steroid use, hypertension, current or former smoker, renal insufficiency, and heart failure.\n* Definition of Disease\n\n  * Patients must have pathologically confirmed esophageal malignancy requiring esophagectomy and risk factors for anastomotic leak, as described above.\n  * Patients must be candidate and have agreed to receive gastric preconditioning procedure\n* Prior Treatment\n\n  o There are no requirements with regard to prior treatment.\n* Age ≥ 18\n* ECOG Performance Status of ≤ 2 (See Appendix I for performance status criteria)",{"count":154,"type":21},40,"The main purpose of this study is to look at how often anastomotic leaks happen in participants who are at high risk of these leaks and are eligible to receive gastric preconditioning by percutaneous angioembolization before an esophagectomy.",[157,29],"Esophageal Malignant Neoplasm Primary",[159,160,136,161,162],"esophageal malignancy","esophagectomy","Memorial Sloan Kettering Cancer Center","26-045","2026-02-27",{"date":165,"type":47},"2026-03-04",{"date":167,"type":47},"2026-02-25",{"date":169,"type":21},"2029-02-25",{"name":161,"class":112},7,{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":179,"enrollmentInfo":180,"targetDuration":4,"studyType":22,"phases":182,"briefSummary":183,"conditions":184,"keywords":188,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":113},"100511746","comparison-of-postoperative-anal-function-between-parks-and-bacon-techniques-in-low-rectal-cancer-100511746","NCT05943444","Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal Cancer","Comparison of Postoperative Anal Function Between Different Anastomosis Techniques(Parks Versus Bacon) in Low Rectal Cancer: A Prospective, Multicentric and Randomized Controlled Study","Inclusion Criteria:\n\n1. Men or women, aged between 18 and 75 years;\n2. Pathological diagnosis of rectal cancer before operation, with the distance from the lower edge of the tumor to the dentate line ≤ 3cm by MR imaging;\n3. No local complications (including complete\u002F incomplete obstruction, active bleeding, local invasion of sphincter or levator ani, etc.) before operation;\n4. Suitable for anal preservation surgery discussed by MDT;\n5. Adequate bone marrow, liver, renal and cardiac function meeting the requirements of surgery and anesthesia;\n6. R0 resection is expected technically;\n7. Provision of written informed consent.\n\nExclusion Criteria:\n\n1. Previous history of malignant colorectal tumors;\n2. Complications such as obstruction and gastrointestinal bleeding that need an emergency operation;\n3. Unachievable R0 resection due to invasion of adjacent organs by primary tumor;\n4. Multiple primary tumors;\n5. History of other malignancy;\n6. Participation in other clinical trials within the previous 4 weeks of enrollment;\n7. ASA physical status score ≥ IV level and\u002For ECOG performance status ≥ 2;\n8. Intolerance of surgery due to liver, renal, cardiopulmonary or coagulation dysfunction, or underlying diseases;\n9. History of serious mental disorders;\n10. Women in pregnancy or lactation period;\n11. Uncontrolled infection before operation;\n12. Unsuitable to be included due to other clinical and laboratory conditions by the judgement of investigators.","75 Years",{"count":181,"type":21},256,[24],"The goal of this study is to compare the postoperative anal function of patients with ultra-low rectal cancer after Parks operation (colon anal anastomosis) and Bacon operation (colon anal pull-out anastomosis), which may provide clinical evidence for the improvement of anal function and quality of life.\n\nThe main questions it aims to answer are: the difference of anal function 1 year after surgery type of study: clinical trial participant population: patients with low rectal cancer Participants will receive Parks operation of Bacon operation If there is a comparison group: Researchers will compare Parks and Bacon operation to see if the anal function 1 year after surgery is different.",[185,186,29,187],"Rectal Neoplasms","Low Anterior Resection Syndrome","Quality of Life",[189,190,191],"anal function","Parks technique","Bacon technique","2025-12-11",{"date":194,"type":47},"2025-12-18",{"date":196,"type":47},"2023-08-08",{"date":198,"type":21},"2027-08-08",{"name":200,"class":112},"Sixth Affiliated Hospital, Sun Yat-sen University",{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":4,"eligibilityCriteria":207,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":89,"enrollmentInfo":208,"targetDuration":4,"studyType":22,"phases":210,"briefSummary":211,"conditions":212,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":113},"100595756","parlar-02-trialmodified-transanal-drainage-tube-use-for-preventing-anastomotic-leakage-100595756","NCT07036588","PARLAR-02 Trial：Modified Transanal Drainage Tube Use for Preventing Anastomotic Leakage","Modified Transanal Drainage Tube Use for Preventing Anastomotic Leakage After Low Anterior Resection in Patients With Rectal Cancer: A Randomized Clinical Trial(PALARC 02)","Inclusion Criteria:\n\n* Rectal adenocarcinoma (confirmed by pathology);\n* Tumor location: The lower edge is ≤10 cm from the anal verge;\n* Age: ≥18 and ≤80 years old;\n* ASA ≤3 ;\n* After assessment, laparoscopic\u002Frobotic sphincter - preserving surgery for rectal cancer is feasible;\n* T2 - 4N0 - 3M0\\~T0 - 1N1 - 3M0 \\& non- local recurrence;\n* Signed informed consent form;\n* Able to understand the risks of participating in the trial.\n\nExclusion Criteria:\n\n* Emergency surgery;\n* Presence of multiple primary colorectal cancers;\n* History of long - term use of immunosuppressants or corticosteroids;\n* Patients with severe mental illness or uncontrolled infection before surgery;\n* Pregnant or breastfeeding women;\n* Bowel obstruction before surgery.",{"count":209,"type":21},968,[24],"Surgical resection remains the primary treatment for rectal cancer, but the postoperative incidence of anastomotic leakage (AL) is relatively high. AL not only increases the medical burden on patients, prolongs hospital stays, raises the need for secondary surgery, and elevates perioperative mortality, but also increases the long-term risk of local recurrence and reduces survival rates. There is an urgent need for a simple, effective treatment method that minimizes the burden on patients to prevent anastomotic leakage.\n\nThe preoperative placement of a transanal drainage tube (TDT) is believed to effectively drain gas and feces from the intestinal lumen, thereby reducing intestinal pressure and alleviating tension at the anastomotic site, thus preventing AL. Previous studies have shown that traditional drainage tubes cannot effectively prevent leakage. Given the limitations of existing research on traditional TDTs, we plan to use a modified TDT (which allows postoperative irrigation and utilizes a balloon to block feces from adversely affecting the anastomosis) to conduct a randomized, parallel-controlled trial. This study aims to further investigate the role of the modified TDT in preventing and treating anastomotic leakage following rectal surgery",[29],"2025-06-16",{"date":215,"type":47},"2025-06-25",{"date":217,"type":21},"2025-07-01",{"date":219,"type":21},"2030-12-31",{"name":221,"class":112},"Third Military Medical University",{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":4,"eligibilityCriteria":228,"healthyVolunteers":11,"sex":17,"minAge":229,"maxAge":230,"enrollmentInfo":231,"targetDuration":4,"studyType":22,"phases":233,"briefSummary":234,"conditions":235,"keywords":241,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":113},"100585739","resumption-of-enteral-feeding-after-bowel-anastomosis-100585739","NCT06906289","Resumption of Enteral Feeding After Bowel Anastomosis","Comparison of Early Versus Late Resumption of Enteral Feeding After Small Bowel Anastomosis.","Inclusion Criteria:\n\n* All patients undergoing small bowel anastomosis for any indication in elective setting\n* Patients of age between 15 to 65 years.\n* All genders\n\nExclusion Criteria:\n\n* Patient using glucocorticoids or other immunosuppressive drugs\n* non conseting individuals\n* Patient having history of gastrectomy","15 Years","65 Years",{"count":232,"type":21},204,[24],"Resumption of oral feeding after small intestine surgery is a matter of controversy .Some surgeons advocate early resumption while others don't.early feeding is initiated as soon as the patient recovers from effects of anaesthesia, while late resumption is started after 24-48 hours after surgery.Recent studies and guidelines suggest early feeding. The aim of this study is to compare the early and late resumption of oral feeding.",[236,237,238,239,29,240],"Enhanced Recovery After Surgery","Hospital Stay, Length of Stay in Hospital From Time of Surgery Till Discharge","Defecation","Vomiting, Postoperative","Flatus",[242,243,244,245],"Enhanced Recover After Surgery","Hospital Stay","Postoperative vomiting","Anastomotic leak","2025-03-25",{"date":248,"type":47},"2025-04-02",{"date":250,"type":47},"2024-10-01",{"date":252,"type":21},"2025-12",{"name":254,"class":112},"Khyber Teaching Hospital",{"id":256,"slug":257,"hasResults":11,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":261,"eligibilityCriteria":262,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":263,"targetDuration":4,"studyType":22,"phases":265,"briefSummary":266,"conditions":267,"keywords":270,"overallStatus":273,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":280,"locationsCount":113},"100556204","evaluating-the-effective-and-safe-use-of-stream-platform-100556204","NCT06522061","Evaluating the Effective and Safe Use of Stream™ Platform","Evaluating the Effective and Safe Use of Stream™ Platform by a Lay User in a Simulated Environment","Home-Stream","Inclusion Criteria:\n\n* Age ≥ 18 years - male or female.\n* Subject\u002FSDM understands and has voluntarily signed and dated Informed Consent Form (ICF).\n* Subject underwent colorectal surgery with anastomosis.\n* Subjects must be willing to comply with trial requirements.\n* Subject has a prophylactic abdominal\u002Fpelvic drain after colorectal surgery.\n\nExclusion Criteria:\n\n* Subjects\u002Fcaregiver is unwilling or unable to comply with the requirements of the protocol.\n* 24 hours or more have passed since the end of the subject's surgery and consent was not attained.\n* The subject had already developed an anastomotic leak at the time of screening and underwent surgery for treatment of the complication.\n* Plans that the subject will be discharged in less than 3 days post-surgery.\n* Subject has reported that they are pregnant.\n* Subject has a permanent end stoma.\n* Subject is delirious.\n* Subject has severe dementia.\n* Subject was involved in the planning and conduct of the clinical investigation.\n* Origin™ is not compatible with the drain used on the subject.\n* Subject and\u002For caregiver is\u002Fare not capable of conducting the calibrations for Stream™ Platform (this can be self-reported or determined by the CRC\u002FHCP\u002Fother research staff).\n* The subject and\u002For caregiver is\u002Fare unable to understand the instructions provided for the management and calibration of Stream™ Platform (this can be self-reported or determined by the CRC\u002Finvestigator\u002Fother research staff).",{"count":264,"type":21},25,[24],"The study aims to demonstrate the potential for at-home monitoring using Stream™ Platform, through simulated-use testing. Lay users, defined as subjects or nonprofessional caregivers, will be asked to operate Stream™ Platform. Safety, efficacy, and usability data will be collected to ensure that users are able to comply with prescribed device use.\n\nAdditionally, clinical testing will be conducted to identify correlations between measurements from Stream™ Platform and standard laboratory, radiological, and clinical assessments used for leak detection as part of the current standard of care (SOC) that may be skipped if the subject is discharged early.",[268,29,127,269],"User-Centered Design","Artificial Intelligence",[29,269,127,271,272],"ERAS","Stream Platform","NOT_YET_RECRUITING","2025-02-26",{"date":276,"type":47},"2025-02-28",{"date":278,"type":21},"2025-03-15",{"date":49,"type":21},{"name":281,"class":54},"FluidAI Medical",{"id":283,"slug":284,"hasResults":11,"nctId":285,"briefTitle":286,"officialTitle":287,"acronym":4,"eligibilityCriteria":288,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":289,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":291,"conditions":292,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":294,"startDateStruct":296,"completionDateStruct":298,"leadSponsor":300,"locationsCount":113},"100558603","anastomotic-leakage-in-right-colectomy-100558603","NCT06553261","Anastomotic Leakage in Right Colectomy","Open Versus Laparoscopic Right Colectomy: Does the Initial Approach Impact on Management and Outcome in Anastomotic Leakage? A Multicenter Cohort Study","Inclusion Criteria:\n\n* Patients with benign or malignant diseases in the right portion of the colon.\n* elective surgery\n\nExclusion Criteria:\n\n* emergent surgery",{"count":290,"type":21},3446,"Data of patients undergoing elective right colectomy for benign and malignant disease using an open or laparoscopic approach are to be collected in seven colorectal units among Austria for the period between January 2010 and December 2019. Demographic, peri- and postoperative data of patients were analyzed retrospectively.",[29],"2024-08-11",{"date":295,"type":47},"2024-08-14",{"date":297,"type":21},"2024-08-12",{"date":299,"type":21},"2024-12-12",{"name":301,"class":112},"Barmherzige Brüder Vienna",{"id":303,"slug":304,"hasResults":11,"nctId":305,"briefTitle":306,"officialTitle":307,"acronym":4,"eligibilityCriteria":308,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":309,"targetDuration":311,"studyType":66,"phases":4,"briefSummary":312,"conditions":313,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":113},"100485880","endoscopic-vacuum-therapy-for-transmural-defects-in-the-upper-gastrointestinal-tract-100485880","NCT05606822","Endoscopic Vacuum Therapy for Transmural Defects in the Upper Gastrointestinal Tract","Endoscopic Vacuum Therapy for Anastomotic Leakage After Upper Gastrointestinal Surgery \u002F Endoscopic Vacuum Therapy for Esophageal Perforation: A Multicenter Retrospective Cohort Study","Inclusion Criteria:\n\n* Treated with EVT for anastomotic leakage after esophago-gastric surgery\n* Signed informed consent form\n* 18 years or older\n\nExclusion Criteria:\n\n* No signed informed consent",{"count":310,"type":21},200,"6 Months","The goal of this observational study is to learn about the best indications and techniques regarding endoscopic vacuum therapy (EVT) in patients with a transmural defect in the upper gastrointestinal (GI) tract (e.g. anastomotic leakage, Boerhaave syndrome, iatrogenic perforation, other). The main questions it aims to answer are:\n\n* What is the success rate of EVT for transmural defects in the upper GI tract?\n* What are the best indications for EVT in the upper GI tract? (e.g. etiology, patient characteristics, defect characteristics)\n* What are the best techniques for EVT in the upper GI tract? (e.g. EsoSponge, VACStent, vacuum pressure, intraluminal\u002Fintracavitary) Participants will be asked for informed consent to retrospectively and prospectively collect data on EVT.",[314,29,315,316,317,318],"Endoscopic Vacuum Therapy","Esophageal Perforation","Esophageal Perforation, Traumatic","EsoSponge","VACStent","2024-07-19",{"date":321,"type":47},"2024-07-23",{"date":323,"type":47},"2021-10-01",{"date":325,"type":21},"2030-10-01",{"name":327,"class":112},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",{"id":329,"slug":330,"hasResults":11,"nctId":331,"briefTitle":332,"officialTitle":333,"acronym":334,"eligibilityCriteria":335,"healthyVolunteers":336,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":337,"targetDuration":92,"studyType":66,"phases":4,"briefSummary":339,"conditions":340,"keywords":4,"overallStatus":273,"whyStopped":4,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":342,"startDateStruct":344,"completionDateStruct":346,"leadSponsor":348,"locationsCount":113},"100487503","quantification-of-anastomostic-blood-flow-with-fluorescence-imaging-in-low-anterior-resection-for-rectal-cancer-100487503","NCT05627934","Quantification of Anastomostic Blood Flow With Fluorescence Imaging in Low Anterior Resection for Rectal Cancer","Quantification of Anastomotic Blood Flow With Fluorescence Imaging in Low Anterior Resection for Rectal Cancer, FILAR. -Can we Identify Cut-off Values to Diminish the Risk of Anastomotic Leakage. A Prospective Multicentre Study","FILAR","Inclusion Criteria:\n\n* Patients, older than 18, undergoing laparoscopic or robotic surgery for rectal cancer, with or without combination with trans-anal approach.\n\nExclusion Criteria:\n\n* Allergy of iodide. Terminal renal disease. Pregnancy. Lactation. Previous left side colon resection or major surgery on intraabdominal vessels.",true,{"count":338,"type":21},168,"A serious and life-threatening complication to rectal surgery is anastomotic leakage, AL. In Denmark, approximately 800 patients every year, are operated for rectal cancer, 50% of these with resection and anastomosis.\n\nThe registered leakage rate for rectal anastomosis is 10-15%. AL can be life threatening and has long-term adverse effects for the patients, with reduced quality of life, due to a poor functional result of the neo-rectum known as low anterior rectal syndrome (LARS). Fistulas to the vagina or urinary tract are other severe complications. Furthermore, AL is associated with an increased risk of reccurence1. Finally, the AL-associated morbidity is also a significant economic burden to the health care system due to prolonged hospital stay, medicine, and reoperations.\n\nDuring surgery it is important to ensure optimal healing conditions for the anastomosis. The blood flow is evaluated by colour and pulsation in the mesentery.\n\nStudies suggest that it might be easier to evaluate the perfusion using fluorescent dye. This evaluation is a subjective evaluation, based mostly on the surgeon's experience.\n\nAssessing fluorescence by computer-based software, qICG, has been developed. But cut-off values for sufficient blood flow to diminish the risk of leakage, has not yet been defined.\n\nAim:\n\nPrimary objective: To establish cut-off values of qICG, where blood flow assumes sufficient for healing, and thereby reduce the risk of leakage.\n\nSecondary objective: To identify which long-term complications grade A, B and C leakages entails on Quality of Life.",[29],"2022-11-17",{"date":343,"type":47},"2022-11-28",{"date":345,"type":21},"2023-03-01",{"date":347,"type":21},"2027-03-01",{"name":349,"class":112},"Odense University Hospital"]