[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anemia-postoperative\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anemia-postoperative":52},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":5},"100628352","phase-4-tranexamic-acid-for-bleeding-reduction-during-turp-surgery-100628352",false,"NCT07460518","Tranexamic Acid for Bleeding Reduction During TURP Surgery","Tranexamic Acid for Perioperative Haemostatic Optimisation During Transurethral Resection of the Prostate: A Randomized Quadruple-Blind Placebo-Controlled Trial","TXA-TURP","Inclusion Criteria:\n\n* Male patients aged 50 years or older\n* Diagnosed with benign prostatic hyperplasia (BPH)\n* Scheduled for elective transurethral resection of the prostate (TURP) under spinal anesthesia\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Provided written informed consent\n\nExclusion Criteria:\n\n* History of thromboembolic disease (deep vein thrombosis, pulmonary embolism, stroke)\n* Known hypersensitivity to tranexamic acid\n* Severe renal impairment (creatinine clearance \\\u003C30 mL\u002Fmin)\n* Coagulation disorders\n* Current anticoagulant therapy not appropriately discontinued\n* History of seizure disorder\n* Refusal to participate","MALE","50 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Transurethral resection of the prostate (TURP) is commonly performed in elderly patients and may be associated with perioperative bleeding leading to postoperative anemia and delayed recovery. Tranexamic acid (TXA), an antifibrinolytic agent, may reduce surgical bleeding by inhibiting fibrin degradation.\n\nThis prospective randomized quadruple-blind placebo-controlled clinical trial evaluates whether perioperative administration of intravenous tranexamic acid reduces intraoperative blood loss and preserves postoperative hemoglobin concentration in patients undergoing TURP under standardized spinal anesthesia.\n\nParticipants are randomly assigned to receive either intravenous tranexamic acid or placebo prior to surgery. The primary outcomes assess objective measures of perioperative blood loss and postoperative hemoglobin levels. Secondary outcomes include recovery parameters, perioperative safety, and exploratory hospital-level economic impact.\n\nThe study aims to determine whether anesthesia-led haemostatic optimization using tranexamic acid improves perioperative physiological stability and recovery efficiency within an enhanced recovery framework.",[27,28,29,30],"Benign Prostatic Hyperplasia","Transurethral Resection of the Prostate","Perioperative Bleeding","Anemia, Postoperative",[32,33,34,35,36,37,38,39],"Tranexamic Acid","TURP","Patient Blood Management","Spinal Anesthesia","Randomized Controlled Trial","Hemostasis","Enhanced Recovery After Surgery","Perioperative Medicine","NOT_YET_RECRUITING","2026-03-05",{"date":43,"type":44},"2026-03-10","ACTUAL",{"date":46,"type":21},"2026-03-15",{"date":48,"type":21},"2026-09-01",{"name":50,"class":51},"Hamza Najout","OTHER","Anemia Postoperative"]