[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anesthesia-brain-monitoring\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anesthesia-brain-monitoring":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100612877","minto-and-eleveld-remifentanil-target-controlled-infusion-tci-models-a-clinical-comparison-100612877",false,"NCT07259291","Minto and Eleveld Remifentanil Target Controlled Infusion (TCI) Models: a Clinical Comparison","Minto and Eleveld Remifentanil Target Controlled Infusion (TCI) Models: a Clinical Comparison Through qNOX and ANIi Reactions to Post-tetanic Count","TCI","Inclusion Criteria:\n\n* Undergo general anaesthesia with Targeted Controlled Infusion of Propofol (Eleveld model) and Remifentanil (Minto or Eleveld model)\n\nExclusion Criteria:\n\n* Neurological disease\n* Psychiatric disease","FEMALE","18 Years","80 Years",{"count":21,"type":22},100,"ESTIMATED","OBSERVATIONAL","Remifentanil is commonly used as an opioid during general anesthesia. In recent years, several pharmacokinetic\u002Fpharmacodynamic (PK\u002FPD) models for target-controlled infusion (TCI) have been developed, with the Eleveld model being one of the most recent and designed for broad applicability.\n\nThe aim of this study is to compare the Eleveld TCI model with the routinely used Minto model, in order to evaluate potential differences in the predicted effect-site concentrations (CeR) required to achieve equivalent analgesia levels, as measured by qNOX (CONOX monitor) and the Analgesia Nociception Index (ANI). Post-Tetanic Count (PTC) was also assessed during the maintenance phase to investigate possible differences in nociceptive index responses between the two TCI models.",[26,27,28],"Propofol","Anesthesia Brain Monitoring","Remifentanil",[30],"Analgesia monitoring","RECRUITING","2026-06-05",{"date":34,"type":35},"2026-06-08","ACTUAL",{"date":37,"type":35},"2025-11-25",{"date":39,"type":22},"2026-12-30",{"name":41,"class":42},"University of Padova","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":52,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":56,"conditions":57,"keywords":63,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":43},"100629097","cognitive-assessment-and-post-operative-complications-after-surgery-linking-anaesthesia-and-risk-100629097","NCT07470216","Cognitive Assessment And Post-Operative Complications After Surgery: Linking Anaesthesia And Risk","CAPSULAR","Inclusion Criteria:\n\n* Age ≥ 70\n* Seen in the Perioperative medicine for Older People undergoing Surgery (POPS) clinic\n* Scheduled for colorectal or urological surgery with expected anaesthesia time over 60 minutes\n\nExclusion Criteria:\n\n* Regional anaesthesia only\n* Planned day surgery or expected hospital stay \\\u003C 24 hours\n* Expected to remain sedated and ventilated for \\> 24 hours postoperatively\n* Participant does not wish to remain in the study if capacity is lost during the study\n\nCO-ENROLMENT\n\n* As this is a non-intervention study, co-enrolment will be permitted in other studies that do not conflict with this protocol.",true,"ALL","70 Years",{"count":55,"type":22},40,"Many older people can experience confusion, memory problems, or a decline in their thinking after major surgery. These problems are sometimes called 'postoperative neurocognitive disorders' or PND and can affect recovery and a person's ability to live independently.\n\nThe investigators want to find out the best way to study these problems in older patients undergoing surgery. This is a 'feasibility study', which means we are testing the research methods. The investigators want to see if it is possible to ask participants to do memory tests and give blood samples before and after their operation. The investigators are hoping to include around 40 patients over 2 years in this study.\n\nThe investigators will compare performance in memory (cognitive assessment) findings before and after surgery and link this to data taken from the anaesthetic, including the types of drugs used, duration, brain features from processed electroencephalogram monitoring and standard recommended monitoring. In addition the investigators will link this to blood sample markers of brain health and function (biomarkers).\n\nThe results of this study will help the investigators plan a much larger study in the future, with the ultimate goal of making surgery safer for the brain.",[58,59,60,61,27,62],"Cognitive Impairment","Cognitive Impairment, Mild","Cognitive Impairment, Progressive","Anesthesia","Anesthesia Depth Monitoring",[64,65,66,67,68,69],"cognitive impairment","cognitive impairment, mild","cognitive impairment, progressive","anesthesia","anesthesia brain monitoring","anesthesia depth monitoring","NOT_YET_RECRUITING","2026-05-04",{"date":73,"type":35},"2026-05-08",{"date":75,"type":22},"2026-07-01",{"date":77,"type":22},"2028-03",{"name":79,"class":42},"University of Edinburgh"]