[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anesthesia-depth-monitoring\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anesthesia-depth-monitoring":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,46,80,111,135,172],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100640534","comparison-of-hemodynamic-responses-during-anesthesia-induction-using-eleveld-and-schnider-100640534",false,"NCT07586189","Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider","Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider Target-Controlled Infusion Models. A Randomized Trial","Inclusion Criteria:\n\n* Patients scheduled for elective spinal surgery under general anesthesia\n* Patients who will undergo surgery at the Neurosurgery Department of Istanbul University, Istanbul Faculty of Medicine\n* Patients aged 18 years or older\n* Patients who provide written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Patients with uncontrolled hypertension\n* Patients with uncontrolled diabetes mellitus\n* Patients younger than 18 years of age\n* Patients who do not provide informed consent to participate in the study","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","OBSERVATIONAL","This randomized prospective study aims to compare the effects of two target-controlled infusion models, the Schnider and Eleveld models, on anesthetic depth and hemodynamic responses during anesthesia induction in adult patients undergoing spinal surgery.\n\nPatients scheduled for spinal surgery will be randomized into either the Schnider or Eleveld group. Before induction, standard monitoring will be applied, including electrocardiography, peripheral oxygen saturation, invasive arterial blood pressure monitoring, heart rate monitoring, and bispectral index monitoring. Anesthesia induction will be performed with fentanyl 2 mcg\u002Fkg, rocuronium 0.6 mg\u002Fkg, and propofol administered by target-controlled infusion with an effect-site target concentration of 3 mcg\u002FmL according to the allocated pharmacokinetic model.\n\nHemodynamic parameters and bispectral index values will be recorded before induction and at the 1st, 3rd, 5th, and 10th minutes after induction. Additional parameters, including time to BIS below 40, time to delta activity, burst suppression duration, total propofol dose during the first 5 minutes, need for additional propofol, hemodynamic response to intubation, vasopressor requirement within the first 10 minutes, and use of esmolol, will also be documented. The primary aim is to evaluate whether the Schnider and Eleveld models differ in terms of induction-related hemodynamic stability and anesthetic depth during the early induction period.",[24,25,26,27,28],"Spinal (Fusion) Surgery","Total Intravenous Anesthesia","Target Controlled Infusion of Propofol","Anesthesia Depth Monitoring","BIS-EEG",[30,31,32,33],"spinal surgery","total intravenous anesthesia","target controlled infusion","anesthesia depth monitoring","RECRUITING","2026-05-18",{"date":37,"type":38},"2026-05-20","ACTUAL",{"date":35,"type":38},{"date":41,"type":20},"2026-08-30",{"name":43,"class":44},"Istanbul University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":57,"conditions":58,"keywords":64,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":45},"100629097","cognitive-assessment-and-post-operative-complications-after-surgery-linking-anaesthesia-and-risk-100629097","NCT07470216","Cognitive Assessment And Post-Operative Complications After Surgery: Linking Anaesthesia And Risk","CAPSULAR","Inclusion Criteria:\n\n* Age ≥ 70\n* Seen in the Perioperative medicine for Older People undergoing Surgery (POPS) clinic\n* Scheduled for colorectal or urological surgery with expected anaesthesia time over 60 minutes\n\nExclusion Criteria:\n\n* Regional anaesthesia only\n* Planned day surgery or expected hospital stay \\\u003C 24 hours\n* Expected to remain sedated and ventilated for \\> 24 hours postoperatively\n* Participant does not wish to remain in the study if capacity is lost during the study\n\nCO-ENROLMENT\n\n* As this is a non-intervention study, co-enrolment will be permitted in other studies that do not conflict with this protocol.",true,"70 Years",{"count":56,"type":20},40,"Many older people can experience confusion, memory problems, or a decline in their thinking after major surgery. These problems are sometimes called 'postoperative neurocognitive disorders' or PND and can affect recovery and a person's ability to live independently.\n\nThe investigators want to find out the best way to study these problems in older patients undergoing surgery. This is a 'feasibility study', which means we are testing the research methods. The investigators want to see if it is possible to ask participants to do memory tests and give blood samples before and after their operation. The investigators are hoping to include around 40 patients over 2 years in this study.\n\nThe investigators will compare performance in memory (cognitive assessment) findings before and after surgery and link this to data taken from the anaesthetic, including the types of drugs used, duration, brain features from processed electroencephalogram monitoring and standard recommended monitoring. In addition the investigators will link this to blood sample markers of brain health and function (biomarkers).\n\nThe results of this study will help the investigators plan a much larger study in the future, with the ultimate goal of making surgery safer for the brain.",[59,60,61,62,63,27],"Cognitive Impairment","Cognitive Impairment, Mild","Cognitive Impairment, Progressive","Anesthesia","Anesthesia Brain Monitoring",[65,66,67,68,69,33],"cognitive impairment","cognitive impairment, mild","cognitive impairment, progressive","anesthesia","anesthesia brain monitoring","NOT_YET_RECRUITING","2026-05-04",{"date":73,"type":38},"2026-05-08",{"date":75,"type":20},"2026-07-01",{"date":77,"type":20},"2028-03",{"name":79,"class":44},"University of Edinburgh",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":53,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":87,"targetDuration":4,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":45},"100627209","qconqnox-guided-anesthesia-in-patients-undergoing-thyroidectomy-surgery-100627209","NCT07445659","qCON\u002FqNOX-Guided Anesthesia in Patients Undergoing Thyroidectomy Surgery","The Effect of qCON\u002FqNOX-Guided Anesthesia Using the Conox Monitor on Clinical Outcomes in Patients Undergoing Thyroidectomy Surgery","Inclusion Criteria:\n\n* Patients aged 18-70 years\n* Thyroidectomy cases with ASA physical status I-II\n* Patients who have provided written informed consent\n\nExclusion Criteria:\n\n* Skin lesions preventing EEG electrode placement\n* Neurological disorders (e.g., epilepsy)\n* Anticipated difficult airway",{"count":88,"type":20},90,"INTERVENTIONAL",[91],"NA","The aim of this study is to evaluate the effect of using the non-invasive Conox monitor on intraoperative opioid consumption. Additionally, the study aims to assess the impact of Conox monitoring on recovery time, postoperative agitation rate, and pain scores, and to investigate the correlation between qCON and qNOX values and conventional hemodynamic parameters.",[94,95,27],"Thyroid Surgeries","Intraoperative Analgesic Use",[97,98,33,99,100],"thyroid surgery","intraoperative opioid consumption","qCON","qNOX","2026-04-16",{"date":103,"type":38},"2026-04-20",{"date":105,"type":38},"2026-04-10",{"date":107,"type":20},"2026-06-30",{"name":109,"class":110},"Kayseri City Hospital","OTHER_GOV",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":16,"minAge":118,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":89,"phases":122,"briefSummary":123,"conditions":124,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":45},"100629311","peeg-guided-anesthesia-and-behavioral-outcomes-in-children-100629311","NCT07473024","pEEG-Guided Anesthesia and Behavioral Outcomes in Children","Long-Term Behavioral Outcomes After pEEG-Guided Anesthesia in Children: A Follow-Up Study Using the Post-Hospitalization Behavior Questionnaire","Inclusion Criteria:\n\n* Children aged 3-10 years\n* Surgical duration longer than 1 hour\n* Patients undergoing urology, plastic surgery, or pediatric surgery procedures\n* Availability of early postoperative PHBQ data\n* Verbal consent from parents or legal guardians for participation in the follow-up telephone interview\n\nExclusion Criteria:\n\n* Patients with neuromotor developmental abnormalities\n* History of epilepsy or antiepileptic medication use\n* Patients requiring postoperative intensive care unit admission\n* Emergency surgical procedures\n* Inability to contact the family or refusal of verbal consent for the telephone interview\n* Patients who underwent another surgical procedure between the initial surgery and the follow-up period","3 Years","10 Years",{"count":121,"type":20},230,[91],"Post-hospitalization behavioral changes are common in children after surgery and general anesthesia and may persist for varying durations depending on individual and perioperative factors. The Post-Hospitalization Behavior Questionnaire (PHBQ) is a well-validated instrument widely used to evaluate negative postoperative behavioral changes in pediatric patients following hospitalization or surgical procedures. Although early postoperative behavioral disturbances have been extensively studied, most research has focused on short-term outcomes within the first weeks after surgery, while long-term behavioral outcomes remain insufficiently investigated.\n\nProcessed electroencephalography (pEEG) monitoring provides an objective method for assessing anesthetic depth during surgery. Parameters such as the Patient State Index (PSI) and Spectral Edge Frequency 95 (SEF95) allow dynamic evaluation of cortical activity and may help optimize anesthetic administration by preventing excessively deep or inadequate anesthesia. Improved anesthetic depth management may theoretically influence postoperative recovery and behavioral outcomes.\n\nIn the initial randomized study, early postoperative behavioral assessments were obtained within the first postoperative month using the Post-Hospitalization Behavior Questionnaire (PHBQ). In the present follow-up study, children will be contacted again 12-24 months after surgery to evaluate long-term behavioral outcomes. PHBQ scores at long-term follow-up will be compared between children who previously received EEG-guided anesthesia and those managed with standard anesthesia without processed EEG monitoring. By examining both early and long-term behavioral outcomes, this study aims to determine whether intraoperative EEG-guided anesthesia management influences postoperative behavioral changes in the pediatric population.",[62,125,126,27],"Behavior Change","Behavior Child Problems","2026-03-14",{"date":129,"type":38},"2026-03-17",{"date":131,"type":38},"2026-02-02",{"date":133,"type":20},"2026-08-22",{"name":43,"class":44},{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":143,"targetDuration":145,"studyType":21,"phases":4,"briefSummary":146,"conditions":147,"keywords":155,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":45},"100621576","macrophagemonocyte-driven-inflammation-and-anesthetic-sensitivity-in-aging-100621576","NCT07372417","Macrophage\u002FMonocyte Driven Inflammation and Anesthetic Sensitivity in Aging","Role of Macrophage\u002FMonocyte Mediated Inflammatory Response in Diminished Anesthetic Requirements During Aging","MACRO-AGE","Inclusion Criteria:\n\n* Age between 18-30 years or over 60 years old\n* Scheduled for abdominal surgery\n* General anesthesia planned with or without spinal anesthesia\n* Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Chemotherapy or systemic corticosteroid use within the past 2 weeks.\n* Pregnancy.\n* Active sepsis or systemic infection.\n* Emergency surgery.\n* Requirement of ketamine or dexmedetomidine during the first hour of anesthesia.\n* History or diagnosis of: stroke with persistent neurological deficit, dementia, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, central nervous system autoimmune disorders, systemic autoimmune diseases, or infectious diseases of the central nervous system.\n* Current treatment with immunomodulatory medications.\n* Psychiatric disorders with psychotic features.\n* Use of psychoactive or psychotropic recreational drugs within the week prior to surgery.",{"count":144,"type":20},60,"1 Day","The goal of this observational study is to determine whether macrophage\u002Fmonocyte mediated inflammatory signaling contributes to reduced anesthetic requirements in older adults undergoing major abdominal surgery. The main questions it aims to answer are:\n\n* Is there a difference in anesthetic dosing requirements (minimum effective dose) between young and older patients undergoing major abdominal surgery?\n* How do electroencephalographic (EEG) signatures under anesthesia correlate with age and systemic inflammatory markers?\n* Is there an association between age, levels of circulating inflammatory cytokines, and monocyte\u002Fmacrophage phenotypes with anesthetic requirements?\n\nIf there is a comparison group: Researchers will compare older adult patients undergoing major abdominal surgery to younger adult patients undergoing major abdominal surgery to see if macrophage\u002Fmonocyte-mediated inflammatory signaling influences anesthetic sensitivity and the risk of postoperative neurocognitive complications in the older population.\n\nParticipants will:\n\n* Receive general anesthesia for major abdominal surgery, with continuous recording of anesthetic dose requirements.\n* Undergo electroencephalographic (EEG) monitoring during the anesthetic period.\n* Provide blood samples for the measurement of circulating inflammatory cytokines and the assessment of monocyte phenotypes.\n* Provide peritoneal tissue samples (collected during surgery) to evaluate tissue macrophage populations.\n* Provide cerebrospinal fluid (CSF) samples to assess biomarkers of blood-brain barrier permeability.",[148,149,150,151,27,152,153,154],"Aging","Inflammation","Blood-Brain Barrier Permeability","Anesthesia Brain Monitor","Inflammation Biomarkers","Inflammaging","Monocyte",[148,149,156,157,158,159,160,161,162],"General Anesthesia","Anesthetic Sensitivity","Cytokines","Alpha Oscillations","Blood Brain Barrier","Monocyte phenotype","macrophage phenotype","2026-01-19",{"date":165,"type":38},"2026-01-28",{"date":167,"type":20},"2026-01-25",{"date":169,"type":20},"2027-06-15",{"name":171,"class":44},"University of Chile",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":178,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":16,"minAge":180,"maxAge":181,"enrollmentInfo":182,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":184,"conditions":185,"keywords":187,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":45},"100611828","monitoring-the-depth-of-anesthesia-and-nociception-during-the-induction-of-general-anesthesia-in-pediatric-patients-100611828","NCT07245654","Monitoring the Depth of Anesthesia and Nociception During the Induction of General Anesthesia in Pediatric Patients","Monitoring the Depth of Anesthesia and Nociception During the Induction of General Anesthesia in Pediatric Patients: a Prospective Observational Study","ANIGAPP","Inclusion Criteria:\n\n* Pediatric patients (age 1-19 years) indicated for surgery under general anesthesia with airway management (laryngeal mask, orotracheal intubation, nasotracheal intubation)\n* CONOX monitoring available\n\nExclusion Criteria:\n\n* Age out of range\n* Use of ketamine during anesthesia care (premedication, analgesic, anesthetic)\n* Expected duration of surgery less than 30 minutes\n* CONOX monitoring unavailable","1 Year","19 Years",{"count":183,"type":20},100,"Perioperative assessment of adequate depth of anesthesia and analgesia is currently a recommended part of routine anesthesia practice for all surgical procedures. In most cases, it is performed by monitoring and evaluating physiological parameters, which is insufficient, especially for the depth of anesthesia. The depth of anesthesia, when measured with the Conox device, is indicated by the qCON index, the recommended value for anesthesia management is between 40-60. Shallow (above 60) anesthesia may be associated with an increased incidence of perioperative wakefulness episodes, and deeper (below 40) anesthesia may lead to a more frequent occurrence of adverse effects of anesthesia, including emergent delirium in the postoperative period. In addition to assessing the depth of anesthesia, the Conox device also allows for instrumental assessment of analgesia. Inadequate analgesia increases postoperative discomfort and may contribute to an increased incidence of complications in anesthesia and during the postoperative period. Instrumental monitoring of the depth of anesthesia and analgesia increases the safety of anesthesia care. During perioperative care, periods with significant painful stimulation include not only the surgical procedure itself but also airway management during induction of general anesthesia, especially intubation. The hypothesis is - due to the significant painful stimulation during airway management during induction of anesthesia, adequate depth of anesthesia and analgesia may be insufficient and is associated with the patient's clinical response, which may be associated with the occurrence of postoperative delirium.",[186,27],"Anaesthesia",[188,189,190,191,192,193],"depth of anesthesia","pediatric","nociception","awareness","depth of analgesia","airway management","2025-11-17",{"date":196,"type":38},"2025-11-24",{"date":198,"type":38},"2025-11-10",{"date":200,"type":20},"2026-12-31",{"name":202,"class":44},"Brno University Hospital"]