[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anesthesia-endotracheal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anesthesia-endotracheal":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100545310","opioid-free-anesthesia-as-an-alternative-to-general-anesthesia-in-abdominal-surgery-100545310",false,"NCT06380244","Opioid-free Anesthesia as an Alternative to General Anesthesia in Abdominal Surgery","Inclusion Criteria:\n\n* Adults aged 18-75 years scheduled for elective urological surgery under general anesthesia: laparoscopic or robotic nephrectomy, laparoscopic or robotic prostatectomy, or laparoscopic or robotic cystectomy.\n* Ability to operate a patient-controlled analgesia (PCA) pump postoperatively.\n* Ability to understand and use the Numeric Rating Scale (NRS) for pain assessment.\n* Written informed consent.\n\nExclusion Criteria:\n\n* Patient's refusal to participate.\n* Inability to operate the PCA pump.\n* Inability to understand the NRS pain scale.\n* Known hypersensitivity to any of the study drugs (anesthetics, ketamine, dexmedetomidine, ropivacaine, oxycodone, metamizole, paracetamol, ibuprofen).\n* Second- or third-degree atrioventricular block, or symptomatic bradycardia.\n* Chronic opioid use.\n* Contraindication to the planned regional anesthesia technique (e.g. coagulopathy or therapeutic anticoagulation, infection at the puncture site).","ALL","18 Years","75 Years",{"count":19,"type":20},600,"ESTIMATED","INTERVENTIONAL",[23],"NA","Opioid-free anesthesia (OFA) is a multimodal technique that eliminates intraoperative opioids by combining dexmedetomidine, ketamine, lidocaine, NSAIDs, and regional analgesia. Growing evidence suggests OFA reduces postoperative opioid consumption, opioid-related adverse effects, and may have favorable oncological implications in cancer surgery.\n\nThis randomized controlled trial compares OFA with opioid-based anesthesia (remifentanil) in patients undergoing elective urological surgery: laparoscopic nephrectomy, robotic nephrectomy, laparoscopic prostatectomy, robotic prostatectomy, laparoscopic cystectomy, and robotic cystectomy.\n\nThe PRIMARY OBJECTIVE is to compare the total postoperative oxycodone dose (mg) administered via patient-controlled analgesia (PCA) during the first 24 hours after surgery between the OFA and remifentanil groups.\n\nSECONDARY OBJECTIVES include: postoperative pain intensity (NRS) at 1, 2, 6, 12, and 24 hours; incidence of postoperative nausea and vomiting (PONV); change in serum creatinine from baseline to postoperative day 1; change in white blood cell (WBC) count from baseline to postoperative day 1; and the ratio of demanded to delivered PCA boluses.\n\nPRE-SPECIFIED SUBGROUP ANALYSES will compare outcomes by surgical procedure type: laparoscopic nephrectomy, robotic nephrectomy, laparoscopic prostatectomy, robotic prostatectomy, laparoscopic cystectomy, and robotic cystectomy. Subgroup-by-treatment interaction tests will be performed and reported as forest plots.\n\nPlanned enrollment: approximately 600 patients (300 per arm). Follow-up: 24 hours postoperatively.",[26,27,28],"Analgesics, Opioid","Anesthesia, Endotracheal","Anesthesia, General","RECRUITING","2026-06-18",{"date":32,"type":33},"2026-06-24","ACTUAL",{"date":35,"type":33},"2024-03-10",{"date":37,"type":20},"2026-12-31",{"name":39,"class":40},"Jagiellonian University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":41},"100533862","endotracheal-tube-ett-180-stylet-loaded-endotracheal-tube-rotation-before-insertion-100533862","NCT06231342","Endotracheal Tube (ETT) 180: Stylet-loaded Endotracheal Tube Rotation Before Insertion","Endotracheal Tube (ETT) 180: Stylet-loaded Endotracheal Tube Rotation Before Insertion to Decrease the Risk of Postoperative Sore Throat: a Randomized Double-Blind Prospective Trial.","Inclusion Criteria:\n\n* ASA I - III\n* Ambulatory patients undergoing general anesthesia with an Endotracheal Tube (ETT) placement\n* Admitted patients undergoing general anesthesia an Endotracheal Tube (ETT) placement\n* Age \\> 18 and \\\u003C 90 years old\n* BMI \\\u003C 50\n\nExclusion criteria:\n\n* Age \\\u003C 18 years old or age \\> 90 years old\n* Pregnant women\n* Prisoners\n* Any surgery involving the pharynx, larynx, vocal cords, trachea that will create confounding factors related to postoperative sore throat\n* History of difficult airway\n* Critically ill patients requiring intensive care","90 Years",{"count":51,"type":20},357,[23],"The main objective of the proposed study is to clarify whether rotating a stylet-loaded endotracheal tube (ETT) 180 degrees prior to intubation will decrease the incidence of postoperative throat soreness, when compared to standard technique used in Standard of Care.",[27],"2026-04-23",{"date":57,"type":33},"2026-04-29",{"date":59,"type":33},"2023-05-31",{"date":61,"type":20},"2027-05-31",{"name":63,"class":40},"Ohio State University"]