[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anesthesia-induction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anesthesia-induction":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,43,66,90,116,137,163,184],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100054244","phase-4-the-ed95-of-ciprofol-for-laryngeal-mask-airway-insertion-with-fentanyl-in-children-a-biased-coin-dose-finding-trial-100054244",false,"NCT07697404","The ED95 of Ciprofol for Laryngeal Mask Airway Insertion With Fentanyl in Children: A Biased-Coin Dose-Finding Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status I or II\n* Aged 1 to 12 years\n* Scheduled for elective surgery requiring general anesthesia with laryngeal mask airway (LMA) insertion (e.g., ophthalmic surgery, skin lesion excision, minor abdominal or urological procedures, with expected surgical duration ≤ 2 hours)\n* Written informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to ciprofol, fentanyl, or any study-related drugs\n* Intellectual disability, cognitive-affective disorders, psychiatric or neurological diseases\n* Inability to cooperate with peripheral intravenous cannulation\n* History of reactive airway disease or suspected difficult airway\n* Body mass index (BMI) ≥ 30 kg\u002Fm² or ≤ 15 kg\u002Fm²\n* History of sedative medication use\n* Inability to understand the study protocol or participation in another clinical trial within the past 30 days","ALL","1 Year","12 Years",{"count":19,"type":20},180,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","Ciprofol is a novel intravenous anesthetic with a pharmacological profile similar to propofol but with a lower incidence of injection pain, hypotension, and respiratory depression. For pediatric day-case surgeries, laryngeal mask airway (LMA) insertion without neuromuscular blockers is increasingly preferred. While opioids are often combined with hypnotics to optimize insertion conditions, the optimal bolus dose of ciprofol when co-administered with a standard dose of fentanyl for LMA insertion in children remains unknown. This study aims to determine the 95% effective dose (ED95) of a single intravenous bolus of ciprofol, combined with a fixed dose of fentanyl (1 μg\u002Fkg), for successful LMA insertion in children aged 1-12 years during general anesthesia induction.",[26,27,28,29],"Pediatric","Anesthesia Induction","Ciprofol","Laryngeal Mask Airway","RECRUITING","2026-07-10",{"date":33,"type":34},"2026-07-13","ACTUAL",{"date":36,"type":34},"2026-06-15",{"date":38,"type":20},"2028-12-01",{"name":40,"class":41},"Huazhong University of Science and Technology","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":15,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":42},"100527162","phase-4-induction-in-the-dark-100527162","NCT06144177","Induction in the Dark","Induction in the Dark: a Prospective Randomized Control Trial for Perioperative Pediatric Anxiety","Inclusion Criteria\n\n* Age 2 to 6 years old\n* American Society of Anesthesiologists physical status I-II\n* Outpatient elective surgical procedures\n* Undergoing general anesthesia\n* Parent or guardian willing to be present during induction\n\nExclusion Criteria\n\n* History of previous surgery\n* Fear of the dark\n* Contraindication to inhalational mask induction of general anesthesia such as allergy to inhalation medication, NPO violation, active nausea or vomiting, severe GERD, etc.\n* Severe developmental delay\n* Severe obvious, preoperative anxiety\n* Patients currently using psychiatric medications\n* Non-English speaking","2 Years","6 Years",{"count":53,"type":20},240,[23],"This study will enroll children ages 2-6 who are undergoing an elective outpatient surgical procedure under general anesthesia. They will be randomized to one of the following groups and assessed for preoperative anxiety, mask acceptance, and behavioral changes in the following week.\n\n1. darkened room and star projector with parental presence;\n2. preoperative midazolam 0.5 mg\u002Fkg by mouth and parental presence; or\n3. parental presence alone.",[27],"2026-06-17",{"date":59,"type":34},"2026-06-22",{"date":61,"type":34},"2024-04-16",{"date":63,"type":20},"2027-05-22",{"name":65,"class":41},"Medical University of South Carolina",{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":15,"minAge":73,"maxAge":4,"enrollmentInfo":74,"targetDuration":4,"studyType":21,"phases":76,"briefSummary":78,"conditions":79,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":86,"leadSponsor":88,"locationsCount":42},"100643520","ondansetron-versus-lidocaine-for-preventing-pain-on-propofol-injection-100643520","NCT07632144","Ondansetron Versus Lidocaine for Preventing Pain on Propofol Injection.","Ondansetron Versus Lidocaine for Preventing Pain on Propofol Injection: a Randomized Controlled Trial.","Inclusion Criteria:\n\n* The study included patients who met all of the following criteria:\n\nAged 18 years or older; Classified as ASA physical status I-III (Appendix 1); Provided written informed consent to participate in the study; Scheduled for elective surgery requiring general anesthesia with propofol induction.\n\nExclusion Criteria:\n\n* Patients were not eligible for inclusion if they:\n\nHad received analgesics or antiemetics within 12 hours before surgery; Had communication difficulties or were unable to assess pain adequately (e.g., language barrier, dementia, impaired consciousness); Had a known allergy to ondansetron, lidocaine, or propofol; Did not receive propofol for anesthetic induction; Were pregnant or breastfeeding; Suffered from chronic pain or regularly used opioid medications; Did not have a 20-gauge intravenous catheter inserted on the dorsum of the hand; Declined participation in the study.\n\nPatients were excluded from the study if they experienced any complication during anesthetic induction, including:\n\nAnaphylactic shock or allergic reaction to study medications; Hemodynamic or respiratory instability.\n\nPatients who subsequently withdrew their consent were also excluded from the study.","18 Years",{"count":75,"type":20},156,[77],"NA","This is a prospective, single-center, randomized, double-blind controlled trial involving patients scheduled for elective surgery requiring general anesthesia with propofol induction. Participants are randomly assigned to one of three groups: the ondansetron group (8 mg IV), the lidocaine group (40 mg IV), or the control group (0.9% normal saline placebo). Study medications are administered intravenously over 5 minutes, ending 1 minute before anesthetic induction.\n\nthe goal: To assess the efficacy of intravenous ondansetron versus lidocaine and placebo in reducing the incidence and intensity of pain associated with propofol injection in patients undergoing general anesthesia.",[27,80],"Propofol Pain Injection","NOT_YET_RECRUITING","2026-06-02",{"date":84,"type":34},"2026-06-08",{"date":84,"type":20},{"date":87,"type":20},"2026-08-15",{"name":89,"class":41},"Mongi Slim Hospital",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":15,"minAge":98,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":21,"phases":101,"briefSummary":102,"conditions":103,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":42},"100621032","frequency-of-electrical-acupoint-stimulation-on-hypotension-in-tavr-patients-100621032","NCT07365345","Frequency of Electrical Acupoint Stimulation on Hypotension in TAVR Patients","The Influence of Electrical Acupoint Stimulation at Different Frequencies on Hemodynamics During Anesthesia Induction in Patients Undergoing TAVR Surgery","FRESH-T","Inclusion Criteria:\n\n* The age of the patients is 60 years or older;\n* Patients who are scheduled to undergo TAVR surgery under general anesthesia;\n\nExclusion Criteria:\n\n* Body mass index less than 18 kg\u002Fm2 or greater than 30 kg\u002Fm2;\n* Hemodynamic instability (severe arrhythmia, decompensated heart failure);\n* Hypotension after admission requiring intervention with vasoactive drugs;\n* Severe liver or kidney dysfunction;\n* Those who are contraindicated for electrical stimulation, including those with local skin damage, infection, or having implanted electrophysiological devices in the body.","60 Years",{"count":100,"type":20},150,[77],"Within 30 minutes before anesthesia, acupoint electrical stimulation at different frequencies were applied at Neiguan, Jian Shi, and Baihui. The changes in blood pressure during the anesthesia induction period were compared between the high-frequency group and the low-frequency group.",[104,105,27,106],"Transcatheter Aortic Valve Replacement (TAVR)","Hemodynamic Stability","Electro-acupuncture","2026-03-22",{"date":109,"type":34},"2026-03-25",{"date":111,"type":34},"2026-01-30",{"date":113,"type":20},"2026-12-31",{"name":115,"class":41},"Air Force Military Medical University, China",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":15,"minAge":73,"maxAge":4,"enrollmentInfo":124,"targetDuration":4,"studyType":21,"phases":126,"briefSummary":127,"conditions":128,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":136,"locationsCount":4},"100618287","crystalloid-vs-colloid-for-hemodynamics-during-anesthesia-induction-in-tavr-patients-100618287","NCT07329660","Crystalloid vs Colloid for Hemodynamics During Anesthesia Induction in TAVR Patients","The Impact of Different Preload Strategies on Hemodynamics During Anesthesia Induction in TAVR Patients","CHAIN-T","Inclusion Criteria:\n\n* Age ≥ 18 years;\n* Patients scheduled to undergo elective TAVR under general anesthesia;\n\nExclusion Criteria:\n\n* Allergy to hydroxyethyl starch, its components, and\u002For sodium lactate Ringer's solution, or a history of colloidal allergy;\n* Severe cardiac dysfunction (ejection fraction\\[EF\\] \\\u003C 35%);\n* Severe renal dysfunction (creatinine \\> 132 μg\u002FL and\u002For requiring renal replacement therapy);\n* Morbid obesity (body mass index\\[BMI\\] \\> 37.5 kg\u002Fm² or \\> 32.5 kg\u002Fm² with metabolic diseases);\n* Severe hepatic dysfunction ;\n* Severe electrolyte disturbances ;\n* Patients with preoperative intracranial hypertension requiring dehydration therapy;\n* Expected postoperative hospital stay \\\u003C 24 hours;\n* Patients scheduled for multiple surgeries during this hospitalization.",{"count":125,"type":20},116,[77],"The purpose of this study is to evaluate whether the administration of 5 ml\u002Fkg of colloid solution prior to anesthesia induction, compared with 5 ml\u002Fkg of lactated Ringer's solution, can reduce hemodynamic fluctuations during the induction period (defined as the first 15 minutes after induction) in patients undergoing Transcatheter Aortic Valve Replacement (TAVR).",[129,105,27],"Transcatheter Aortic Valve Replacement","2026-02-25",{"date":132,"type":34},"2026-02-27",{"date":134,"type":20},"2026-02-16",{"date":113,"type":20},{"name":115,"class":41},{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":145,"sex":15,"minAge":73,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":21,"phases":149,"briefSummary":150,"conditions":151,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":162},"100581979","reinforcement-learned-automatic-anesthesia-system-during-painless-gastrointestinal-endoscopy-100581979","NCT06857344","Reinforcement Learned Automatic Anesthesia System During Painless Gastrointestinal Endoscopy","Automated Anesthesia System-Gastrointestinal Endoscopy (AAS-GE): a Reinforcement Learning Based Control for Anesthesia During Gastrointestinal Endoscopy","AAS-GE","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status class I-II\n* Expected operation duration less than 1 hour\n\nExclusion Criteria:\n\n* History of cardiac, hepatic, renal, or metabolic disorders (e.g., diabetes, hypertension, sleep apnea)\n* Known allergy to opioids or ciprofloxacin components\n* Cachexia\n* Hypothermia; history of narcotic abuse; chronic alcoholism; obesity (BMI \\>30); patients with apnea\n* Current pregnancy or lactation\n* History of substance abuse or alcohol dependence\n* Participation in any other drug clinical trial within the past 3 months\n* Obesity (BMI \\>30 kg\u002Fm²)\n* Procedure termination due to gastric retention or inadequate bowel preparation",true,"65 Years",{"count":148,"type":20},164,[77],"The goal of this clinical trial is to compare the performance difference between trained model and clinical professionals in anesthesia control during gastrointestinal endoscopy. The participants would include adults aged between 18-65 years old with ASA scores I-II. The main questions it aims to answer are:\n\n* Can AI model successfully and safely perform anesthesia during gastrointestinal endoscopy?\n* Researchers hypothesis that anesthesia performed by professionals is not inferior to those performed by AI model.\n\nThe researchers will compare the results of the AI group with the traditional group to see if both groups have similar success rates in performing anesthesia.\n\nParticipants will fast for 8 hours before the procedure, and drinking water will be prohibited for 2 hours after taking the intestinal purgatives.",[27],"2025-08-12",{"date":154,"type":34},"2025-08-15",{"date":156,"type":34},"2025-05-01",{"date":158,"type":20},"2025-10-01",{"name":160,"class":161},"Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd.","INDUSTRY",5,{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":15,"minAge":73,"maxAge":4,"enrollmentInfo":169,"targetDuration":4,"studyType":21,"phases":171,"briefSummary":172,"conditions":173,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":180,"leadSponsor":182,"locationsCount":42},"100580785","the-impact-of-ultrasound-guided-superficial-and-deep-paravertebral-nerve-blocks-at-the-superior-costotransverse-ligament-on-hemodynamics-during-the-induction-phase-of-thoracoscopic-lung-lobectomy-a-multicenter-double-blind-randomized-controlled-trial-100580785","NCT06841822","The Impact of Ultrasound-Guided Superficial and Deep Paravertebral Nerve Blocks at the Superior Costotransverse Ligament on Hemodynamics During the Induction Phase of Thoracoscopic Lung Lobectomy: A Multicenter, Double-Blind, Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients scheduled for elective two-port video-assisted thoracoscopic lobectomy\n* Age: ≥18 years\n* ASA classification: I-III\n* BMI: 18-30 kg\u002Fm²\n\nExclusion Criteria:\n\n* Severe hypertension (SBP ≥180 mmHg or DBP ≥110 mmHg)\n* MAP \\\u003C70 mmHg before anesthesia induction\n* Emergency surgery\n* Severe cardiovascular disease, including history of cerebral or thoracic\u002Fabdominal aortic aneurysm\n* Congestive heart failure (New York Heart Association class III or IV)\n* Untreated or unstable ischemic heart disease\n* Severe aortic or mitral valve disease\n* Pregnancy or lactation\n* Coagulation disorders\n* Bacteremia, sepsis, or infection at the puncture site\n* Allergy to study-related drugs\n* Severe liver and kidney dysfunction\n* Neurological disorders, spinal disease (deformity or trauma), history of spinal surgery, or abnormal skin sensation in the thoracic or back region\n* Existing or anticipated difficult airway management\n* Other conditions deemed unsuitable for inclusion by the investigators Forty patients who required CT (3D) imaging technology to observe drug diffusion after the implementation of the two methods were included as follows: patients who were scheduled to undergo double-hole thoracoscopic lobectomy, aged ≥18 years, ASA grade I to III, BMI 18 to 30kg\u002Fm2, and required preoperative CT localization. Exclusion criteria In addition to the above conditions, patients with a history of anaphylaxis induced by contrast agents should be excluded.",{"count":170,"type":20},168,[77],"This study aims to determine whether performing a paravertebral nerve block at the superficial surface of the superior costotransverse ligament (SCTL) (without needle penetration of the SCTL) is more effective in maintaining hemodynamic stability during the induction phase of thoracoscopic lung lobectomy compared to the deep surface of the SCTL (with needle penetration of the SCTL).\n\nThis is a multicenter, double-blind, randomized controlled trial enrolling a total of 168 participants across five hospitals. To investigate the effects of different nerve block methods on hemodynamics during induction, participants will be allocated to either the deep plane SCTL block group (T group) or the superficial plane SCTL block group (S group) using a stratified randomization scheme. The stratification accounts for a 40% proportion of hypertensive patients within each treatment group at each center.\n\nThirty minutes before surgery, patients will receive either an ultrasound-guided deep SCTL block (needle penetrating the SCTL) or a superficial SCTL block (needle not penetrating the SCTL) in the pre-anesthesia room. The target vertebral levels for the block are T4 and T6, and 20 mL of 0.375% ropivacaine hydrochloride solution will be injected slowly at each site. Researchers will document whether subpleural compression is observed on ultrasound imaging and monitor for complications such as hemothorax, pneumothorax, local hematoma, local anesthetic toxicity, epidural anesthesia, or total spinal anesthesia during the procedure.\n\nAnother investigator, blinded to the group allocation, will evaluate patients after the nerve block procedure, recording any occurrences of hemothorax, pneumothorax, local hematoma, local anesthetic toxicity, epidural block, or total spinal anesthesia. Cold sensitivity tests using the temperature method will be conducted at the midaxillary line within the corresponding blocked regions at 5, 10, 20, and 30 minutes post-block, and the sensory blockade level will be recorded.\n\nThirty minutes after the block, anesthesia induction will be performed using target-controlled infusion (TCI) of propofol and remifentanil, along with rocuronium (0.6 mg\u002Fkg). Heart rate (HR), mean arterial pressure (MAP), stroke volume (SV), cardiac index (CI), and stroke volume index (SVI) will be measured every minute from induction until 5 minutes after intubation. Hypotension is defined as a MAP decrease of 20% or an absolute MAP \\\u003C 65 mmHg, while severe hypotension is defined as a MAP decrease of 30% or an absolute MAP \\\u003C 55 mmHg. Hemodynamic stability will be maintained using vasoactive medications as needed.\n\nThe study will record intraoperative consumption of propofol and remifentanil, anesthesia duration, intraoperative intravenous fluid volume, urine output, blood loss, and extubation time. Postoperative assessments will include resting and movement-evoked (coughing) VAS scores at 4 and 24 hours, opioid consumption within 24 hours (oxycodone usage, first demand time, number of effective and actual demands), and additional analgesic requirements. The QOR-15 score at 24 hours and puncture-related complications within 72 hours postoperatively will be documented, along with a patient satisfaction survey at 72 hours.\n\nFor the imaging study evaluating drug diffusion following each block method using CT (3D) imaging, 40 patients will be recruited at Nanjing First Hospital. Patients requiring preoperative CT-guided localization and puncture will receive an ultrasound-guided deep SCTL block (T group) or superficial SCTL block (S group) 30 minutes before the procedure, with 10 patients in each group. The block sites will be at the surgical side T4 and T6 levels, using 20 mL of a nerve block solution containing 0.375% ropivacaine mixed with 2 mL of iohexol (total 20 mL).\n\nFollowing the nerve block, patients will be placed in the supine position, and after 30 minutes, a blinded investigator will assess sensory loss using cold stimulation at the anterior chest wall (midclavicular line), lateral chest wall (posterior axillary line), and posterior chest wall (paravertebral region). Subsequently, patients will undergo routine CT-guided lesion localization and 3D imaging technology will be used to evaluate drug diffusion patterns for the two block techniques.\n\nAny adverse events occurring during the trial will be managed according to the study protocol and recorded accordingly.",[174,27,175],"Thoracic Paravertebral Block","Hypotension on Induction","2025-05-21",{"date":178,"type":34},"2025-05-25",{"date":178,"type":20},{"date":181,"type":20},"2026-06-30",{"name":183,"class":41},"Nanjing First Hospital, Nanjing Medical University",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":190,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":15,"minAge":73,"maxAge":192,"enrollmentInfo":193,"targetDuration":4,"studyType":21,"phases":195,"briefSummary":196,"conditions":197,"keywords":201,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":42},"100565250","preoperative-blood-volume-optimization-using-transthoracic-echocardiography-100565250","NCT06639737","Preoperative Blood Volume Optimization Using Transthoracic Echocardiography","Effect of Preoperative Stroke Volume Optimization Using Transthoracic Echocardiography on Arterial Hypotension Following Induction of Intravenous Anesthesia. A Prospective, Double Blinded Randomized Study.","EchOptimal","Inclusion Criteria:\n\n* Patient aged 18 years or older,\n* Affiliated with social security,\n* Informed about the study and having signed the informed consent form,\n* Requires surgical intervention under general anesthesia,\n* Intermediate or high risk of cardiovascular events within 30 days,\n* ASA phyiscal status Classification 3 or 4\n\nExclusion Criteria:\n\n\\- Pregnant or breastfeeding women,\n\n* Patients under guardianship, curatorship, judicial protection, or legal protection,\n* Minors,\n* Patients with contraindications to intravenous induction with Propofol and Remifentanil,\n* Patients not fasting at the time of surgery,\n* Patients with an immediate life-threatening emergency or requiring surgery without delay to ensure survival,\n* Patients with contraindications for placing an arterial pressure catheter in the radial artery: bilateral negative Allen's test indicating absence of ulnar collateral circulation, Raynaud's syndrome, Buerger's disease, severe dyslipidemias,\n* Patients with characteristics making the measurement of ITVSAo uninterpretable: atrial fibrillation, non-sinus electrocardiogram, severe valvulopathy, documented right or left heart failure,\n* Patients under general anesthesia before arrival in the operating room,\n* Patients receiving aminergic support before anesthetic induction,\n* Patients requiring rapid sequence induction,\n* Patients treated with ACE inhibitors\u002FARBs who have not discontinued the treatment on the day of the procedure","99 Years",{"count":194,"type":20},220,[77],"Immediately following the induction of general anesthesia, arterial hypotension may occur with an incidence of about 40% in patients classified as ASA 3 or 4. Perioperative arterial hypotension is associated with increased perioperative morbidity and mortality. The increased mortality associated with perioperative arterial hypotension has been reported up to 30 and 90 days after surgery. This association appears to be both dose-dependent and time-dependent (severity and duration of arterial hypotension).\n\nEchOptimal study aims to determine whether non invasive preoperative stroke volume optimization using transthoracic echocardiography (TTE) can reduce the incidence and severity arterial hypotension following induction of general anesthesia.\n\nThis is prospective, randomized, controlled, double blinded study approved by ethics comittee.\n\nThe primary objective of this study is to compare the incidence of arterial hypotension (mean arterial pressure \\\u003C 65 mmHg) within the first 15 minutes following the induction of general anesthesia, between 2 groups :\n\n* standard current care (stroke volume optimized after induction of general anesthesia using oesophageal doppler) and\n* preopertaive stroke volume optimization using transthoracic echocardiography measument of subaortic velocity time integral.",[198,199,27,200],"Anesthesia","Anesthesia Complication","Arterial Hypotension",[202,203,204,205,206],"preoperative stroke volume optimization echocardiography","arterial hypotension","general anesthesia","transoesophageal doppler","sub aortic velocity time integral","2024-10-10",{"date":209,"type":34},"2024-10-15",{"date":211,"type":34},"2024-10-04",{"date":213,"type":20},"2027-12-30",{"name":215,"class":41},"University Hospital, Caen"]