[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anesthesia-local\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anesthesia-local":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,23,0,[8,48,69,98,124,145,175,203,226,247,280,305,330,349,365,389,406,424,449,470,493,529,556],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100556683","effects-of-erector-spinae-plane-block-on-postoperative-pain-following-lumbar-fusion-surgery-100556683",false,"NCT06528288","Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery","Opioid Usage and Patient Reported Outcome Comparison Following Erector Spinae Plane Block or Subcutaneous Anesthetic in Spinal Fusion Procedures","Inclusion Criteria:\n\n* The individual has signed and dated a study specific informed consent form approved by the Institutional Review Board at UMMHC.\n* The individual is at least 18 years of age.\n* The individual is skeletally mature (over the age of 18).\n* The patient is scheduled for a one or two level lumbar spinal fusion.\n\nExclusion Criteria:\n\n* Patients unable to consent for themselves.\n* Pregnant women.\n* Non-English speaking subjects.\n* Prisoners.\n* Spinal fusion procedures for a diagnosis of fracture, tumor, and\u002For infection.\n* Patients who have used greater than 150 morphine milligram equivalents of opioids in the month prior to their operation.\n* Patients with a body mass index (BMI) of 40 or greater.","ALL","18 Years",{"count":19,"type":20},66,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this study is to determine if the method for injecting local anesthesia affects patients' pain and opioid usage after surgery. The investigators will compare subcutaneous anesthesia, injections of anesthesia under the skin, to a method called erector spinae plane block (ESPB). An ESPB injection involves placing local anesthesia along the muscles and bones in the back, using a special type of x-ray called fluoroscopy for guidance. The Investigators will use patient reported outcomes (PROs) and track subjects' opioid usage to find out if there is a difference between ESPB and subcutaneous anesthesia. The investigators hypothesize that patients who get ESPB injections will use less opioids and report less pain after lumbar fusion surgery compared to patients who receive subcutaneous anesthesia injections.",[26,27,28,29],"Fusion of Spine, Lumbar Region","Anesthesia, Local","Pain, Postoperative","Opioid Use",[31,32,33,34],"Erector Spinae Plane Block","Spinal Fusion","Patient Reported Outcomes","Opioid Usage","RECRUITING","2026-03-12",{"date":38,"type":39},"2026-03-16","ACTUAL",{"date":41,"type":39},"2024-09-13",{"date":43,"type":20},"2027-07-01",{"name":45,"class":46},"University of Massachusetts, Worcester","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":47},"100502249","effect-of-fasting-on-patient-outcomes-after-wide-awake-local-anesthesia-only-no-tourniquet-walant-procedures-100502249","NCT05819801","Effect of Fasting on Patient Outcomes After Wide-Awake, Local Anesthesia-only, No Tourniquet (WALANT) Procedures","Inclusion Criteria:\n\n* Patients undergoing wide-awake, local anesthetic-only, no-tourniquet (WALANT) procedures with the lead researcher.\n\nExclusion Criteria:\n\n* Patients with insulin-dependent diabetes or allergy to local anesthesia, \\\u003C 18 years of age, patients unable to follow up.",{"count":55,"type":20},134,[23],"The purpose of this study is to determine whether eating solid food prior to undergoing a wide awake local-only no tourniquet (WALANT) procedure reduces anxiety in patients or has any effect on outcomes. Patients will be split randomly into two groups and told whether to eat or fast before their procedure. We will then compare levels of anxiety and nausea on the day of the procedure as well as satisfaction with the procedure and other outcome measures at follow-up visits. Our hypothesis is that patients who are instructed to eat before their WALANT procedure will have less anxiety, nausea, and overall higher satisfaction compared to those who are instructed to fast prior to their procedure.",[59,27,60],"Surgery","Fasting","2026-03-11",{"date":36,"type":39},{"date":64,"type":39},"2024-02-22",{"date":66,"type":20},"2026-09",{"name":68,"class":46},"University of California, Irvine",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":21,"phases":79,"briefSummary":81,"conditions":82,"keywords":83,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100627145","phase-4-targeted-nerve-injection-to-the-knee-nerve-to-vastus-medialis-comparing-two-adductor-canal-block-approaches-100627145","NCT07444827","Targeted Nerve Injection to the Knee (Nerve to Vastus Medialis): Comparing Two Adductor Canal Block Approaches","Study of Targeted Injection of Nerves to the Knee-A Volunteer Trial Evaluating Nerve to Vastus Medialis","Inclusion Criteria:\n\n* Age ≥18 years\n* Able to provide written informed consent\n* Able and willing to comply with study procedures and \\~6-hour visit\n* American Society of Anesthesiologists (ASA) Physical Status 1 or 2\n* Weight \\>70 kg\n\nExclusion Criteria:\n\n* BMI \\>35 kg\u002Fm²\n* Use of analgesics within 24 hours before the procedure\n* History of thigh trauma or surgery\n* Pregnant or planning pregnancy\n* Lower extremity deformities\u002Ftattoos interfering with block performance\n* Systemic neuromuscular disease\n* Contraindications to regional anesthesia (e.g., infection, allergy, challenging sonoanatomy)\n* Other health conditions that would affect safe participation",true,{"count":78,"type":20},25,[80],"PHASE4","This randomized, double-blinded volunteer study compares two ways of performing the adductor canal (AC) nerve block at the mid-thigh to see which approach more reliably numbs the anteromedial knee. One approach is the traditional AC block placed near the saphenous nerve; the other separately targets the nerve to vastus medialis (NVM) in addition to the saphenous nerve. Healthy adult participants receive both blocks in one visit (one on each leg), with the order randomized. The primary outcome is change in quadriceps strength (a proxy for vastus medialis anesthesia) measured by load-cell dynamometry. Secondary outcomes include cutaneous sensory mapping (pinprick and cold) and the percentage of a standardized, marked knee-incision line covered by sensory block. The study uses ultrasound guidance and a standard dose of chloroprocaine, with routine monitoring to minimize risks.",[27],[84,85,86,87],"Adductor canal block","Nerve to vastus medialis","Chloroprocaine","Knee joint","NOT_YET_RECRUITING","2026-02-25",{"date":91,"type":39},"2026-03-03",{"date":93,"type":20},"2026-07-01",{"date":95,"type":20},"2027-12-01",{"name":97,"class":46},"Duke University",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":76,"sex":16,"minAge":105,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":21,"phases":109,"briefSummary":110,"conditions":111,"keywords":113,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":47},"100513355","effect-of-silver-diamine-fluoride-on-local-anesthesia-in-hypomineralized-molars-100513355","NCT05964387","Effect of Silver Diamine Fluoride on Local Anesthesia in Hypomineralized Molars","Effect of Silver Diamine Fluoride on Local Anesthesia Efficacy in Molar Incisor Hypomineralization-affected Molars in Children: A Randomized Clinical Trial","Inclusion Criteria:\n\n* At least one hypomineralized first permanent molar with a primary cavitated caries lesion(s) or a cavitated tooth defect requiring restorative dental care with local anesthesia\n* American Society of Anesthesiologists (ASA) Physical Status Classification I or II (healthy children or those with mild systemic disease)\n* English speaking\n* Subjects for which basic behavior guidance (non-pharmacological or nitrous oxide\u002Foxygen) is indicated\n\nExclusion Criteria:\n\n* Teeth with irreversible pulpitis and pulp necrosis\n* Patients requiring advanced behavior management such as moderate sedation, general anesthesia, and\u002For active or passive restraint\n* Inability of the child to cooperate due to special needs or other conditions\n* Allergy to SDF, local anesthetic or other material component\n* Subjects with ulcerative gingivitis or stomatitis\n* Subjects with known sensitivity to silver or other heavy-metal ions\n* Subjects showing abnormal skin sensitization in daily circumstances","6 Years","11 Years",{"count":108,"type":20},50,[23],"The purpose of this randomized, controlled clinical study is to evaluate if application of 38% SDF increases the efficacy of local anesthesia during operative dentistry on permanent molars affected by molar-incisor hypoplasia (MIH). The goal is to determine if pre-operative application of SDF results in improved local anesthesia and decrease in procedural pain in MIH affected teeth, thereby addressing an important challenge in routine clinical practice and contributing to the development of a treatment protocol for MIH affected molars.",[112,27],"Molar Incisor Hypomineralization",[114],"Silver diamine fluoride","2026-02-09",{"date":117,"type":39},"2026-02-12",{"date":119,"type":39},"2023-06-12",{"date":121,"type":20},"2027-12-31",{"name":123,"class":46},"University of Michigan",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":76,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":131,"targetDuration":4,"studyType":21,"phases":133,"briefSummary":134,"conditions":135,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":47},"100569474","phase-4-split-face-study-of-the-duration-of-local-anesthetics---fourth-arm-100569474","NCT06694714","Split Face Study of the Duration of Local Anesthetics - Fourth Arm","Characterizing and Comparing the Duration of Local Anesthetic in Dermatologic Surgery - Fourth Arm","Inclusion Criteria:\n\n* Male or female ≥ 18 years of age\n* Normal skin sensation at both nasal ala assessed by pinprick\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Previous adverse reaction to local anesthetic or any components of the local anesthetics being evaluated\n* Pregnant or breastfeeding volunteers (assessed by self-report)\n* Patients taking monoamineoxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types",{"count":132,"type":20},35,[80],"This is a research study to compare how long injectable pain medications (anesthetics) commonly used in dermatologic surgery are effective for. The investigators will investigate the role of anesthetic volume on the duration of action at highly vascular sites.",[27],"2026-01-20",{"date":138,"type":39},"2026-01-22",{"date":140,"type":39},"2025-01-21",{"date":142,"type":20},"2027-06-01",{"name":144,"class":46},"Weill Medical College of Cornell University",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":151,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":21,"phases":155,"briefSummary":156,"conditions":157,"keywords":161,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":47},"100619237","phase-4-bicarbonate-addition-to-lidocaine-epinephrine-in-surgery-under-walant-100619237","NCT07342010","Bicarbonate Addition to Lidocaine-Epinephrine in Surgery Under WALANT","Evaluation of the Effect of Lidocaine With Adrenaline, With or Without Bicarbonate, on Early Postoperative Recovery in WALLANT-type Outpatient Hand and Foot Surgery: A Prospective, Randomised, Double-blind, Single-centre Non-inferiority Study.","ROPIWA-2","Inclusion Criteria:\n\n* Adults (≥18 years) eligible for ambulatory surgery under WALANT for Hand surgery (including carpal tunnel release, trigger finger release, or Dupuytren's disease surgery) and foot surgery (including hallux valgus or hallux rigidus.)\n* Provision of free and informed consent.\n* Signed informed consent form.\n* Affiliation with or beneficiary of a health insurance system\n\nExclusion Criteria:\n\n* Ischemic vascular disorders, including severe Raynaud's disease, Buerger's disease, or diabetic microangiopathy.\n* Scleroderma.\n* Known allergy to lidocaine or potential cross-reactivity with other amide-type local anesthetics.\n* Severe hepatic impairment.\n* Acute porphyria.\n* Intravascular administration of local anesthesia.\n* Local anesthetic infiltration at the level of the extremities.\n* Coronary artery disease.\n* Ventricular arrhythmias.\n* Severe arterial hypertension.\n* Obstructive cardiomyopathy.\n* Hyperthyroidism.\n* Hypovolemia.\n* Participation in an interventional clinical research study classified as category 1 (RIPH category 1).\n* Ongoing exclusion period related to participation in another clinical study.\n* Legal protection status (guardianship, trusteeship, or judicial protection).\n* Inability to provide informed consent.\n* Inability to receive or understand adequate study information.\n* Pregnancy, labor, or breastfeeding. Women of childbearing potential will undergo a urine pregnancy test prior to inclusion.",{"count":154,"type":20},150,[80],"Distal upper limb and distal lower limb surgery performed under local anesthesia using the WALANT technique (Wide Awake Local Anesthesia No Tourniquet) has become standard practice in ambulatory orthopedic surgery. Current infiltration mixtures used by orthopedic surgeons include lidocaine-epinephrine with the addition of 8.4% bicarbonate to reduce injection-related pain and improve analgesia duration. However, the clinical benefit of bicarbonate addition remains insufficiently supported by evidence and may increase preparation complexity and risk, including potential solution crystallization.\n\nThe aim of the ROPIWA-2 trial is to investigate whether omission of bicarbonate from the local infiltration mixture is noninferior to bicarbonate addition with respect to early postoperative quality of recovery on postoperative day 1. We hypothesize that removing bicarbonate does not impair postoperative quality of recovery after ambulatory hand and foot surgery under WALANT. Expected benefits include confirmation of a simpler, ready-to-use anesthetic solution that is easier and safer to use, without reducing patient comfort or recovery. The expected risks are those normally associated with this type of procedure.",[27,158,159,160],"Hand Surgery","Foot Surgery","Walant Surgery",[162,163,164,165],"lidocaine,","bicarbonates,","Quality of recovery","Walant","2026-01-06",{"date":168,"type":39},"2026-01-15",{"date":170,"type":20},"2026-02-01",{"date":172,"type":20},"2027-02-01",{"name":174,"class":46},"Centre Hospitalier Universitaire de Nīmes",{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":76,"sex":16,"minAge":181,"maxAge":4,"enrollmentInfo":182,"targetDuration":4,"studyType":21,"phases":184,"briefSummary":185,"conditions":186,"keywords":188,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":202},"100416696","a-pilot-study-of-local-anesthesia-for-inguinal-hernia-surgery-in-older-adults-100416696","NCT04706026","A Pilot Study of Local Anesthesia for Inguinal Hernia Surgery in Older Adults","Inclusion Criteria:\n\n* Age greater than or equal to 60 years\n* Presenting to clinic with a unilateral inguinal hernia that is not incarcerated\n* Considered suitable for either general or local anesthesia\n* Willing to complete all study requirements, including follow-up continuing until six months after surgery\n* English speaking\n\nExclusion Criteria:\n\n* The hernia that the patient is being evaluated for has undergone prior repair\n* Any contraindications to general anesthesia\n* Allergies to local anesthesia\n* Evidence of hernia incarceration or strangulation\n* Active local or systemic infection that would preclude the use of mesh for hernia repair\n* Need for concurrent surgical repair at the time of hernia repair\n* English is not the patient's primary language\n* Enrollment in other research studies\n* Clinical judgement of surgeon or anesthesiology\n* Current pregnancy\n* Unwilling to provide consent\n* Current active illegal drug use\n* Current alcoholism\n* Claustrophobia\n* Unable to tolerate lying in supine position for greater than 30 minutes","60 Years",{"count":183,"type":20},80,[23],"The purpose of this study is to collect data about local versus general anesthesia for inguinal hernia repair in Veterans aged 60 years for planning a larger, multisite randomized clinical trial. Approximately 80 participants will be enrolled and can expect to be on study for 6 months.",[187,27],"Inguinal Hernia",[189,190,191,192],"Elderly","Outcome","Inguinal hernia","Local anesthesia","2026-01-05",{"date":195,"type":39},"2026-01-07",{"date":197,"type":39},"2024-10-23",{"date":199,"type":20},"2027-03-01",{"name":201,"class":46},"University of Wisconsin, Madison",3,{"id":204,"slug":205,"hasResults":11,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":4,"eligibilityCriteria":209,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":210,"enrollmentInfo":211,"targetDuration":4,"studyType":21,"phases":213,"briefSummary":214,"conditions":215,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":222,"leadSponsor":224,"locationsCount":47},"100618911","comparing-different-doses-of-corticosteroids-in-local-infiltration-analgesia-lia-for-total-knee-arthroplasty-100618911","NCT07337772","Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty","Prospective Randomized Controlled Trial Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty","Inclusion Criteria:\n\n1. Male or female participants aged 18 years or older;\n2. Undergoing primary unilateral total knee arthroplasty (TKA)for unilateral knee osteoarthritis(OA)at ourhospital;\n3. Preoperative American Society of Anesthesiologists(ASA)physical status classification of 1-3;\n4. Ability to provide informed consent and sign a written informed consent form.\n\nExclusion Criteria:\n\n1. Previous surgery on the operative knee or a history of infection in the operative knee;\n2. Non-osteoarthritis conditions (including rheumatoid arthritis, traumatic arthritis, septic arthritis, and hemophilic arthritis);\n3. Severe osteoarthritis (including flexion contracture \\>30° or varus\u002Fvalgus deformity \\>30°);\n4. Allergy to the relevant study drugs;\n5. Presence of neuromuscular dysfunction in the ipsilateral limb;\n6. Dependence on anesthetic drugs (defined as weekly use of opioids exceeding 100 mg morphine equivalents or local anesthetics for preoperative pain control for more than 3 months);\n7. Poor systemic condition, including but not limited to: glycated hemoglobin (HbA1c) level \\>12%; blood pressure \\>170\u002F110 mmHg (1 mmHg = 0.133 kPa); history of myocardial infarction, stroke, transient ischemic attack, acute congestive heart failure, or any acute coronary event within 6 months; dialysis or renal transplantation; pregnancy or lactation.","100 Years",{"count":212,"type":20},120,[23],"This study aims to compare the efficacy of different doses of glucocorticoids in local infiltration analgesia (LIA) during total knee arthroplasty (TKA) through a prospective single-center randomized controlled trial, and to explore the safety and feasibility of high-dose glucocorticoids. Through this research, the investigators hope to provide an optimized solution for post-TKA pain management, improve patients' postoperative recovery and quality of life, and offer scientific evidence for pain management following TKA.",[216,217,27],"Adrenal Cortex Hormones","Arthroplasty, Replacement, Knee","2026-01-04",{"date":220,"type":39},"2026-01-13",{"date":170,"type":20},{"date":223,"type":20},"2028-11-01",{"name":225,"class":46},"First Affiliated Hospital of Fujian Medical University",{"id":227,"slug":228,"hasResults":11,"nctId":229,"briefTitle":230,"officialTitle":231,"acronym":4,"eligibilityCriteria":232,"healthyVolunteers":76,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":233,"targetDuration":4,"studyType":21,"phases":235,"briefSummary":236,"conditions":237,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":47},"100547287","phase-4-investigating-the-effect-of-pericapsular-nerve-group-peng-block-on-postoperative-pain-after-peri-acetabular-osteotomy-100547287","NCT06406010","Investigating the Effect of Pericapsular Nerve Group (PENG) Block on Postoperative Pain After Peri-acetabular Osteotomy","A Blinded Randomized Study Investigating the Effect of Pericapsular Nerve Group (PENG) Block on Postoperative Pain After Peri-acetabular Osteotomy","Inclusion Criteria:\n\n1. Patients ≥ 18 years old\n2. Informed consent\n3. Scheduled for periacetabular osteotomy under general anesthesia with intubation\n4. American Society of Anesthesiologists (ASA) physical status classification I to III\n5. Can read and understand Danish\n\nExclusion Criteria:\n\n1. Known allergy to ropivacaine\n2. Daily use of opioids, gabapentin or tricyclic antidepressant (regardless of dose) within the last four weeks prior to surgery\n3. Contraindications to Celocoxib, NSAIDs or paracetamol",{"count":234,"type":20},90,[80],"The aim of this study is to determine the effect of PENG blockade on postoperative pain after either ropivacaine 5 mg\u002FmL or saline (placebo) in patients undergoing PAO. The hypothesis of this study is that PENG block with ropivacaine reduces postoperative pain compared to placebo (saline).",[27],"2025-08-19",{"date":240,"type":39},"2025-08-26",{"date":242,"type":39},"2024-08-19",{"date":244,"type":20},"2026-03-01",{"name":246,"class":46},"Matias Vested",{"id":248,"slug":249,"hasResults":11,"nctId":250,"briefTitle":251,"officialTitle":252,"acronym":253,"eligibilityCriteria":254,"healthyVolunteers":11,"sex":255,"minAge":17,"maxAge":256,"enrollmentInfo":257,"targetDuration":4,"studyType":21,"phases":259,"briefSummary":260,"conditions":261,"keywords":266,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":4},"100599049","eit-evaluation-of-pulmonary-ventilation-with-different-ropivacaine-concentrations-in-intercostal-nerve-blockade-100599049","NCT07079436","EIT Evaluation of Pulmonary Ventilation With Different Ropivacaine Concentrations in Intercostal Nerve Blockade","Electrical Impedance Tomography (EIT) to Evaluate the Effect of Different Concentrations of Ropivacaine on Pulmonary Ventilation Function During Intercostal Nerve Blockade","EIT","Inclusion Criteria:\n\n* Patients scheduled for elective breast quadrantectomy;\n* Aged 18-80 years;\n* American Society of Anesthesiologists (ASA) physical status I-II;\n* Body mass index (BMI) \\\u003C35 kg\u002Fm².\n\nExclusion Criteria:\n\n* Contraindications for nerve block: infection at the puncture site, local anesthetic allergy, coagulation dysfunction or bleeding risk;\n* Patients with unilateral diaphragmatic paralysis;\n* Patients with severe ventilatory or gas exchange dysfunction;\n* Complicated with acute or chronic pulmonary and bronchial diseases, sleep apnea syndrome;\n* Mental disorders;\n* Patients who refuse to participate;\n* Patients whom the researchers consider unsuitable for the clinical trial, with reasons to be specified.","FEMALE","80 Years",{"count":258,"type":20},72,[23],"This study aims to find out how different strengths of the anesthetic drug ropivacaine affect lung breathing function when used in intercostal nerve block (a type of local anesthesia) for breast quadrantectomy surgery. Researchers will use a non-invasive imaging technique called electrical impedance tomography (EIT) to monitor lung ventilation in real time.\n\nWhy is this study being done? Intercostal nerve block is a common anesthesia method for breast surgeries, but the ideal strength of ropivacaine that balances effective pain relief with safety for lung function is not fully clear. EIT can help measure how each drug strength affects breathing by showing changes in lung airflow.\n\nWhat will happen in the study? Participants: 72 adults scheduled for breast quadrantectomy, aged 18-80, will be randomly assigned to receive one of three ropivacaine strengths (0.25%, 0.375%, or 0.5%) during intercostal nerve block.\n\nProcedures: After anesthesia, EIT will monitor lung ventilation before and after the block. Researchers will measure:\n\nHow much each lung side contributes to breathing during quiet and deep breaths. How quickly the anesthesia works, pain levels during surgery, and any side effects (like difficulty breathing or allergic reactions).\n\nWho can join? Adults having elective breast quadrantectomy. ASA physical status I-II (generally healthy to mildly ill). BMI \\\u003C35 kg\u002Fm². No history of nerve block allergies, breathing problems, or certain lung diseases.\n\nWhat are the possible benefits? The study may help doctors choose the best ropivacaine strength to ensure good pain control while minimizing risks to lung function, especially for same-day surgery patients.\n\nWhat are the risks? Potential risks include rare side effects from the anesthetic (like allergic reactions or low blood pressure) or temporary breathing changes, which will be closely monitored.\n\nHow is the study designed? This is a double-blind, randomized trial (neither patients nor doctors know which drug strength is used) at Fudan University Shanghai Cancer Center.",[262,263,27,264,265],"Intercostal Nerve Block","Pulmonary Ventilation","Breast Neoplasms","Surgical Procedures, Operative",[267,262,268,269,270,264],"Ropivacaine","Pulmonary Ventilation Function","Electrical Impedance Tomography","Anesthetic Concentration","2025-07-22",{"date":273,"type":39},"2025-07-23",{"date":275,"type":20},"2025-08-10",{"date":277,"type":20},"2025-12-31",{"name":279,"class":46},"Fudan University",{"id":281,"slug":282,"hasResults":11,"nctId":283,"briefTitle":284,"officialTitle":285,"acronym":4,"eligibilityCriteria":286,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":287,"targetDuration":4,"studyType":21,"phases":289,"briefSummary":290,"conditions":291,"keywords":292,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":47},"100460108","esp-block-versus-wound-infiltration-for-laminectomy-100460108","NCT05271331","ESP Block Versus Wound Infiltration for Laminectomy","ESP Block Versus Wound Infiltration for Laminectomy: a Randomized Controlled Trial","Inclusion Criteria:\n\n-Planned 1 or 2 level surgical laminectomy\n\nExclusion Criteria:\n\n* Allergy to local anesthetics\n* Refusal of consent\n* Uncompensated cardiopathies, nephropathies, liver disease or peripheral neuropathies\n* Hemopathies that predispose to bleeding\n* Gastrointestinal ulcer or bleeding\n* Local infection\n* Psychiatric or neurological disorders (except those attributed to primary disease for which intervention is planned) History of abuse (or use in the 24 hours prior to surgery) Alcohol addiction ASA \\> 3",{"count":288,"type":20},112,[23],"Spinal surgery is often burdened by perioperative pain and its treatment presently represents a challenge for anesthetists. An inadequate intra and postoperative analgesic therapy leads to a delay in the mobilization of the patients, prolonged hospital stay and thromboembolic complications, as well as the onset of chronic pain syndromes . Effective pain treatment can help improve surgical outcome for patients undergoing spinal surgery. From the pathophysiological point of view pain in vertebral surgery can originate from different anatomical structures: vertebrae, discs, ligaments, dura mater, facet joints, muscles and skin-subcutis. The terminal innervation of these tissues originate from the dorsal branches of the spinal nerves, and this represents a target a multimodal approach to perioperative analgesia in vertebral surgery. Systemically administered drugs such as NSAIDs, opioids, ketamine, intravenous lidocaine could benefit from the addition of locoregional therapies such as neuraxial blocks (anesthesia peridural or subarachnoid) or as shown more recently by other anesthesia techniques locoregional ultrasound-guided In recent years the anesthesiological interest has focused on the Erector Spinae Plane Block (ESPB). First described by Forero et al, it is a paraspinal interfascial block targeting the dorsal and ventral branches of the spinal nerves just after their emergence from the spinal cord. In the ultrasound-guided technique the local anesthetic is injected between the deep fascia of the muscle itself and the transverse processes of the vertebrae at the level interested. The aim of this study is to evaluate the efficacy of ESPB when compared to wound infiltration in patients undergoing laminectomy",[28,29,27,59],[293,294,295],"ESP block","Laminectomy","Wound infiltration","2025-06-20",{"date":298,"type":39},"2025-06-26",{"date":300,"type":39},"2022-05-23",{"date":302,"type":20},"2026-05-20",{"name":304,"class":46},"University of Padova",{"id":306,"slug":307,"hasResults":11,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":311,"eligibilityCriteria":312,"healthyVolunteers":76,"sex":255,"minAge":17,"maxAge":313,"enrollmentInfo":314,"targetDuration":4,"studyType":21,"phases":316,"briefSummary":317,"conditions":318,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":47},"100589892","empathy-through-pain-control-lidocaine-paracervical-block-for-iud-placements-100589892","NCT06960317","Empathy Through Pain Control: Lidocaine Paracervical Block for IUD Placements","Expanding the Use of Paracervical Block for IUD Placements and Adding a Compassionate Care Assessment","EPIC","Inclusion Criteria:\n\n1. Ability to provide informed consent\n2. Women IUD placement for contraception or heavy menstrual bleeding\n3. Ages 18-50\n4. English-speaking\n5. Participants must not have a past medical history of substance use disorders, pain disorders, use of prescription pain medications or are found to be pregnant\n\nExclusion Criteria:\n\n1. No history of vaginal delivery\n2. Current use of prescription pain medication prior to procedure. Over-the-counter medications such as those containing ibuprofen, aspirin, acetaminophen, or naproxen are allowed.\n3. Diagnosed chronic pain condition\n4. Current pregnancy\n5. Known allergic reactions to components of the local anesthetic\n6. History of an IUD placement\n7. Current substance use or history of substance use\n8. Known contraindications to IUD, such as unexplained vaginal bleeding","50 Years",{"count":315,"type":20},204,[23],"The goal of this research study is to learn more about how different uses of a numbing medication might affect pain levels while getting an IUD placed. The investigators are also studying participants opinions of their clinicians' empathy.\n\nThe investigators are inviting patients who arrive at their clinic visit seeking an IUD.\n\nUsually, at University of California, San Diego (UCSD), for patients who have never delivered a baby, clinicians use a buffered paracervical block for before IUD placement. The purpose of this research study is to investigate whether a \"buffered\" (2 cc of sodium bicarbonate, 18 cc of 1% lidocaine) paracervical block (numbing medication given on both sides of the cervix) is effective in reducing pain during IUD placement in individuals with prior C-sections, the difference between buffered and unbuffered for nulliparous patients, and whether a medicated gel reduces pain with the paracervical block.",[319,320,27],"Contraception","Pain, Acute","2025-06-10",{"date":323,"type":39},"2025-06-13",{"date":325,"type":39},"2025-06-04",{"date":327,"type":20},"2028-06-30",{"name":329,"class":46},"University of California, San Diego",{"id":331,"slug":332,"hasResults":11,"nctId":333,"briefTitle":334,"officialTitle":334,"acronym":335,"eligibilityCriteria":336,"healthyVolunteers":76,"sex":255,"minAge":17,"maxAge":313,"enrollmentInfo":337,"targetDuration":4,"studyType":21,"phases":339,"briefSummary":340,"conditions":341,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":348,"locationsCount":4},"100590945","empathy-through-pain-control-buffered-compared-to-unbuffered-1-lidocaine-during-iud-placement-100590945","NCT06974019","Empathy Through Pain Control: Buffered Compared to Unbuffered 1% Lidocaine During IUD Placement","EPIC2","Inclusion Criteria:\n\n1. Ability to provide informed consent\n2. Women IUD placement for contraception or heavy menstrual bleeding\n3. Ages 18-50\n4. English-speaking\n5. Participants must not have a past medical history of substance use disorders, pain disorders, use of prescription pain medications or are found to be pregnant\n6. Nulliparous (never given birth)\n\nExclusion Criteria:\n\n1. History of ever giving birth\n2. Current use of prescription pain medication prior to procedure. Over-the-counter medications such as those containing ibuprofen, aspirin, acetaminophen, or naproxen are allowed.\n3. Diagnosed chronic pain condition\n4. Current pregnancy\n5. Known allergic reactions to components of the local anesthetic\n6. History of an IUD placement\n7. Current substance use or history of substance use\n8. Known contraindications to IUD, such as unexplained vaginal bleeding",{"count":338,"type":20},68,[23],"The goal of this research study is to learn more about how different uses of a numbing medication might affect pain levels while getting an IUD placed. The investigators are also studying patients' opinions of their clinicians' empathy.\n\nThe investigators are inviting patients who have never given birth who arrive at their clinic visit seeking an IUD.\n\nUsually, at University of California, San Diego (UCSD), for patients who have never delivered, clinicians numb both the sides of the cervix with a lidocaine-based paracervical block. The purpose of this research study is to compare perceptions of pain between buffered (2 cc of sodium bicarbonate, 18 cc of 1% lidocaine) vs. unbuffered paracervical block (20 cc 1% lidocaine) during IUD placement for nulliparous women.",[319,320,27],"2025-05-07",{"date":344,"type":39},"2025-05-15",{"date":346,"type":20},"2025-06-01",{"date":327,"type":20},{"name":329,"class":46},{"id":350,"slug":351,"hasResults":11,"nctId":352,"briefTitle":353,"officialTitle":354,"acronym":355,"eligibilityCriteria":356,"healthyVolunteers":76,"sex":255,"minAge":17,"maxAge":313,"enrollmentInfo":357,"targetDuration":4,"studyType":21,"phases":358,"briefSummary":359,"conditions":360,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":361,"startDateStruct":362,"completionDateStruct":363,"leadSponsor":364,"locationsCount":4},"100590946","empathy-through-pain-control-lidocaine-gel-vs-placebo-prior-to-iud-placement-100590946","NCT06974032","Empathy Through Pain Control: Lidocaine Gel vs. Placebo Prior to IUD Placement","Expanding the Use of Paracervical Block for IUD Placements and Adding a Compassionate Care Assessment- Aim 3","EPIC3","Inclusion Criteria:\n\n1. Ability to provide informed consent\n2. Women presenting for IUD placement for contraception or heavy menstrual bleeding\n3. Ages 18-50\n4. English-speaking\n5. Participants must not have a past medical history of substance use disorders, pain disorders, use of prescription pain medications or are found to be pregnant\n6. Nulliparous (never given birth)\n\nExclusion Criteria:\n\n1. History of ever giving birth\n2. Current use of prescription pain medication prior to procedure. Over-the-counter medications such as those containing ibuprofen, aspirin, acetaminophen, or naproxen are allowed.\n3. Diagnosed chronic pain condition\n4. Current pregnancy\n5. Known allergic reactions to components of the local anesthetic\n6. History of an IUD placement\n7. Current substance use or history of substance use\n8. Known contraindications to IUD, such as unexplained vaginal bleeding",{"count":338,"type":20},[23],"The goal of this research study is to learn more about how different uses of a numbing medication might affect pain levels while getting an IUD placed. The investigators are also studying patients' opinions of their clinicians' empathy.\n\nThe investigators are inviting patients who have never given birth who arrive at their clinic visit seeking an IUD.\n\nUsually, at University of California, San Diego (UCSD), for patients who have never delivered, clinicians numb both the sides of the cervix with a lidocaine-based paracervical block. The purpose of this research study is to compare perceptions of pain between lidocaine-infused gel and non-medicated gel inserted into the vagina before paracervical block and IUD placement for nulliparous women.",[319,320,27],{"date":344,"type":39},{"date":346,"type":20},{"date":327,"type":20},{"name":329,"class":46},{"id":366,"slug":367,"hasResults":11,"nctId":368,"briefTitle":369,"officialTitle":369,"acronym":4,"eligibilityCriteria":370,"healthyVolunteers":11,"sex":255,"minAge":17,"maxAge":371,"enrollmentInfo":372,"targetDuration":4,"studyType":21,"phases":373,"briefSummary":374,"conditions":375,"keywords":377,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":380,"lastUpdatePostDateStruct":381,"startDateStruct":383,"completionDateStruct":385,"leadSponsor":387,"locationsCount":47},"100520370","the-use-of-electrical-stimulation-for-determination-of-epidural-catheter-placement-100520370","NCT06055686","The Use of Electrical Stimulation for Determination of Epidural Catheter Placement","Inclusion Criteria:\n\n* Pregnant female requesting epidural for labor analgesia.\n* Must meet standard inclusion criteria for safe epidural placement.\n* Platelet count over 70,000, INR under 1.3.\n\nExclusion Criteria:\n\n* Unable to safely place epidural catheter due to commonly accepted patient factors.","40 Years",{"count":108,"type":20},[23],"The aim of this study is to address the problem of epidural failure. The investigators theorize epidural failure can be due to inappropriate catheter movement and this may be related to the length of which the epidural catheter is inserted. The investigators will use electrical stimulation to determine if the catheter moved in the sacral direction with insertion.",[376,27],"Obstetric Pain",[378,379],"Electrical Epidural Stimulation Test","Epidural Failure","2025-04-30",{"date":382,"type":39},"2025-05-01",{"date":384,"type":20},"2025-11",{"date":386,"type":20},"2026-11",{"name":388,"class":46},"Stanford University",{"id":390,"slug":391,"hasResults":11,"nctId":392,"briefTitle":393,"officialTitle":393,"acronym":4,"eligibilityCriteria":394,"healthyVolunteers":11,"sex":255,"minAge":17,"maxAge":4,"enrollmentInfo":395,"targetDuration":4,"studyType":21,"phases":397,"briefSummary":398,"conditions":399,"keywords":400,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":380,"lastUpdatePostDateStruct":401,"startDateStruct":402,"completionDateStruct":403,"leadSponsor":405,"locationsCount":4},"100437994","electrical-epidural-stimulation-test-for-detecting-epidural-catheter-reactivation-in-obstetric-population-100437994","NCT04983511","Electrical Epidural Stimulation Test for Detecting Epidural Catheter Reactivation in Obstetric Population","Inclusion Criteria:\n\n* Females, 18 years and older\n* American Society of Anesthesiologists physical status I or II\n* Status post natural labor\u002Fbirth process or C-section\n* Has epidural or CSE catheter\n* Upcoming procedure requiring epidural\u002FCSE anesthesia for pain management\n\nExclusion Criteria:\n\n* Contraindication to regional anesthesia\n* Allergy or hypersensitivity to lidocaine, bupivacaine, or fentanyl\n* Use of sedatives or opioids\n* Abnormal vertebrae anatomy\n* Neurological disorder with lumbar involvement\n* Implanted electronic devices\n* Did not receive epidural or CSE anesthesia",{"count":396,"type":20},40,[23],"Following labor, epidural or combined spinal-epidural (CSE) catheters are kept in place and deactivated. However, many women opt for procedures such as tubal ligation, which may require epidural anesthesia as a method of pain relief. Our study aims to confirm the ability to predict reactivation of epidural catheter in postpartum females through the electrical epidural stimulation test (EST) which was first described by the PI of this study approximately 20 years ago.",[376,27],[378],{"date":382,"type":39},{"date":384,"type":20},{"date":404,"type":20},"2026-12",{"name":388,"class":46},{"id":407,"slug":408,"hasResults":11,"nctId":409,"briefTitle":410,"officialTitle":411,"acronym":4,"eligibilityCriteria":412,"healthyVolunteers":11,"sex":255,"minAge":17,"maxAge":4,"enrollmentInfo":413,"targetDuration":4,"studyType":21,"phases":414,"briefSummary":415,"conditions":416,"keywords":417,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":380,"lastUpdatePostDateStruct":418,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":423,"locationsCount":47},"100370900","obstetric-placement-study-using-est-100370900","NCT04109365","Obstetric Placement Study Using EST","Electrical Epidural Stimulation Test for Confirmation of Epidural Catheter Placement in Labouring Women","Inclusion Criteria:\n\n* Females, 18 years and older\n* American Society of Anesthesiologists physical status I or II\n* Full-term pregnancy with request for epidural early in labour (i.e. Regular labor or C-Section)\n\nExclusion Criteria:\n\n* Contraindication to regional anesthesia\n* Allergy or hypersensitivity to lidocaine, bupivacaine, or fentanyl\n* Use of sedatives or opioids\n* Abnormal vertebrae anatomy\n* Neurological disorder with lumbar involvement\n* Implanted electronic devices",{"count":396,"type":20},[23],"Combined spinal-epidural (CSE) is an established technique for providing labour analgesia to obstetric patients which provides rapid onset but unsustained analgesia. The epidural catheter can be used to extend and provide continuous pain relief, however during single-segment needle-through-needle CSE, the catheter is untested. This study aims to confirm placement of epidural catheters of anesthesia through the epidural stimulation test (EST) which was first described by the PI of the study for confirming placement of epidural catheters approximately 20 years ago.",[376,27],[378],{"date":382,"type":39},{"date":420,"type":39},"2020-12-15",{"date":422,"type":20},"2025-12",{"name":388,"class":46},{"id":425,"slug":426,"hasResults":11,"nctId":427,"briefTitle":428,"officialTitle":429,"acronym":430,"eligibilityCriteria":431,"healthyVolunteers":11,"sex":16,"minAge":432,"maxAge":181,"enrollmentInfo":433,"targetDuration":4,"studyType":21,"phases":434,"briefSummary":436,"conditions":437,"keywords":438,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":440,"lastUpdatePostDateStruct":441,"startDateStruct":443,"completionDateStruct":445,"leadSponsor":447,"locationsCount":47},"100582761","phase-3-preoperative-block-for-anterior-cervical-spine-surgery-100582761","NCT06867510","Preoperative Block for Anterior Cervical Spine Surgery","Preoperative Ultrasound-Guided Intermediate Cervical Plexus Block Versus Preoperative Cervical Erector Spinae Plane Block for Anterior Cervical Spine Surgery: A Randomized Controlled Study","ESPB\u002FICPB","Inclusion Criteria:\n\n* Both sex\n* Age: between 21 and 60 years\n* Physical status: belongs to American Society of Anesthesiologists (ASA) I, II\n* Body mass index (BMI): from 25 to 30 kg\u002Fm2\n* Type of surgery: elective anterior cervical spine surgery under general anesthesia\n\nExclusion Criteria:\n\n* Refusal of participation.\n* local infection at the puncture site.\n* Mental or physical disability.\n* History of allergy to study drugs (bupivacaine, fentanyl).\n* Hematological disorders including coagulation abnormalities.\n* Severe hepatic or kidney impairment.\n* Chronic pain.","21 Years",{"count":234,"type":20},[435],"PHASE3","The purpose of this clinical trial study is to compare the analgesic effects of ultrasound-guided intermediate cervical plexus block Versus cervical erector spinae block in patients undergoing anterior cervical spine surgery.\n\n* The main questions it aims to answer are:\n\n  * The primary outcome will be recording postoperative pain intensity using Numerical Rating Scale (NRS).\n  * The secondary outcomes will be measuring the performance time, onset of the sensory block, intraoperative fentanyl consumption, time to the first call for rescue analgesia (nalbuphine), postoperative total nalbuphine consumption, and postoperative complications such as nausea, vomiting, hypotension, and bradycardia.\n* We will compare two blocks to a placebo.\n* Participants will:\n\n  * undergo ultrasound-guided intermediate cervical plexus block or cervical erector spinae block or a placebo\n  * Be assessed for pain after 2 h, 4 h, 6 h, 12 h, and 24 h postoperatively",[27],[439],"Regional anesthesia in cervical spine surgery","2025-03-07",{"date":442,"type":39},"2025-03-10",{"date":444,"type":20},"2025-04-01",{"date":446,"type":20},"2026-08-01",{"name":448,"class":46},"Tanta University",{"id":450,"slug":451,"hasResults":11,"nctId":452,"briefTitle":453,"officialTitle":453,"acronym":454,"eligibilityCriteria":455,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":456,"targetDuration":4,"studyType":458,"phases":4,"briefSummary":459,"conditions":460,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":466,"leadSponsor":468,"locationsCount":47},"100565360","interest-of-soft-point-anesthesia-in-association-with-locoregional-anesthesia-in-arthroscopic-shoulder-surgery-100565360","NCT06641167","Interest of Soft Point Anesthesia in Association With Locoregional Anesthesia in Arthroscopic Shoulder Surgery","CAESAR","Inclusion Criteria:\n\n* Patient aged 18 years or older\n* Patient informed about the study and who has not opposed the use of their personal medical data\n* Patient scheduled for arthroscopic shoulder surgery\n\nExclusion Criteria:\n\n* Allergy to local anesthetics or epinephrine\n* Contraindications to Interscalene Block (e.g., respiratory disease, pneumothorax, pneumonectomy, phrenic or recurrent laryngeal nerve paralysis)\n* Coagulation disorder\n* Patients unable to understand the study information and objectives: dementia, psychosis, consciousness disorders, non-French-speaking patients\n* Patients under legal protection measures (guardianship, curatorship) or deprived of liberty by judicial or administrative decision",{"count":457,"type":20},96,"OBSERVATIONAL","This is a prospective, single-center, observational study. The inclusion period is set at 12 months.",[27],"2024-10-11",{"date":463,"type":39},"2024-10-15",{"date":465,"type":20},"2024-12-01",{"date":467,"type":20},"2025-12-01",{"name":469,"class":46},"GCS Ramsay Santé pour l'Enseignement et la Recherche",{"id":471,"slug":472,"hasResults":11,"nctId":473,"briefTitle":474,"officialTitle":475,"acronym":4,"eligibilityCriteria":476,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":477,"targetDuration":4,"studyType":21,"phases":478,"briefSummary":479,"conditions":480,"keywords":482,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":484,"lastUpdatePostDateStruct":485,"startDateStruct":487,"completionDateStruct":489,"leadSponsor":491,"locationsCount":47},"100557576","phase-4-modified-tips-block-for-total-knee-arthroplasty-100557576","NCT06539910","Modified TIPS Block for Total Knee Arthroplasty","Modified Triple Injection Peri-Sartorius (TIPS) Block for Postoperative Analgesia After Total Knee Arthroplasty (TKA)","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status I-III\n\nExclusion Criteria:\n\n* BMI \\> 35 kg\u002Fm2 Pre-existing neurological deficit Any disability of the non-operated limb preventing fair mobilization Known contraindications to peripheral nerve block (coagulopathy or infection at the site of injection) Chronic opioid users\u002Fabusers",{"count":234,"type":20},[80],"The is carried out to compare triple injection peri-sartorial block to a modified block including an extra local anesthetic injection deep to the adductor longs muscle via a medial to lateral approach regarding the peri-operative analgesia following total knee arthroplasty (TKA)",[481,27],"Knee Arthropathy",[483],"Analgesia, arthroplasty, knee replacement, nerve block, peri-sartorial block, triple injection, visual analogue scale","2024-08-02",{"date":486,"type":39},"2024-08-06",{"date":488,"type":20},"2024-08",{"date":490,"type":20},"2025-03",{"name":492,"class":46},"Alexandria University",{"id":494,"slug":495,"hasResults":11,"nctId":496,"briefTitle":497,"officialTitle":498,"acronym":4,"eligibilityCriteria":499,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":500,"enrollmentInfo":501,"targetDuration":4,"studyType":21,"phases":503,"briefSummary":504,"conditions":505,"keywords":511,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":521,"lastUpdatePostDateStruct":522,"startDateStruct":524,"completionDateStruct":526,"leadSponsor":527,"locationsCount":47},"100556058","evaluation-of-the-effectiveness-of-two-methods-of-regional-anesthesia-during-s-icd-implantation-procedure-100556058","NCT06520150","Evaluation of the Effectiveness of Two Methods of Regional Anesthesia During S-ICD Implantation Procedure.","Evaluation of the Effectiveness of Two Methods of Regional Anesthesia During Subcutaneous Implantable Cardioverter-defibrillator (SICD) Implantation Procedure.","Inclusion Criteria:\n\n* patients aged 18-90 years requiring S-ICD implantation for cardiac indications,\n* high risk of anesthesia (ASA II or higher), patients giving informed consent to participate in the study.\n\nExclusion Criteria:\n\n* absolute contraindications to regional anesthesia such as generalized coagulation disorders, inflammation at the site of anesthesia, allergy to the drugs used for regional anesthesia\n* lack of consent of the patient for the conducted procedure,\n* inability to cooperate with the patient - such as severe mental retardation, unregulated mental illness with motor agitation, advanced neurodegenerative diseases such as Parkinson's disease\u002FAlzheimer's,\n* inability to give informed consent to participate in the study.","90 Years",{"count":502,"type":20},32,[23],"Our study consists of a combination of regional blockade ('local' anesthesia) of the anterior and lateral chest wall in the form of a thin needle prick and the supply of local anesthetic drugs to the area of the relevant chest wall structures to exclude all stimuli, including pain from the operative site. A short-acting analgesic and sedative drug will be administered intravenously throughout the procedure - in a dose that allows the required contact between the patient and the anesthetist. If necessary, the dose of the drug may be increased to maintain pain comfort throughout the procedure.\n\nThe anesthetic team will be with the patient throughout the procedure to ensure comfort and safety.",[506,507,28,508,509,27,510],"Chest Pain","Pain, Procedural","Analgesia","Regional Anesthesia Morbidity","ICD",[512,513,514,515,516,517,518,519,520],"Superficial Serratus Anterior Plane Block (SSAP)","Superficial Parasternal Intercostal Plane Block (SPIP)","Pectoserratus Plane Blocks (PSP)","Regional anaesthesia","Subcutaneous implantable defibrillator (S-ICD)","thorax blockade","less invasive","implantation","pain treatment","2024-07-23",{"date":523,"type":39},"2024-07-25",{"date":525,"type":39},"2024-06-16",{"date":467,"type":20},{"name":528,"class":46},"4th Military Clinical Hospital with Polyclinic, Poland",{"id":530,"slug":531,"hasResults":11,"nctId":532,"briefTitle":533,"officialTitle":534,"acronym":535,"eligibilityCriteria":536,"healthyVolunteers":11,"sex":16,"minAge":537,"maxAge":4,"enrollmentInfo":538,"targetDuration":4,"studyType":458,"phases":4,"briefSummary":540,"conditions":541,"keywords":543,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":547,"lastUpdatePostDateStruct":548,"startDateStruct":550,"completionDateStruct":552,"leadSponsor":554,"locationsCount":47},"100512385","prediction-models-for-cardiovascular-and-neurocognitive-disease-risk-in-the-general-population-100512385","NCT05951764","Prediction Models for Cardiovascular and Neurocognitive Disease Risk in the General Population","Screening for Biomarkers of Cardiovascular and\u002For Neurological Fragility: A Longitudinal Prospective Cohort Study Based on the Population Under General Anesthesia","CME","Inclusion Criteria:\n\n* Patients \\> 45 years old\n* Eligible for outpatient or scheduled surgery or interventional procedures under general anesthesia or locoregional anesthesia with sedation.\n* Patient having expressed no objection to participation in this research.\n* Patient who is not subject to a legal protection measure\n\nExclusion Criteria:\n\n* Patients under 45 years of age.\n* Patient opposed to participation in the protocol\n* Pregnant woman\n* Patient under judicial protection\n* Patient not affiliated to a social health system","45 Years",{"count":539,"type":20},396,"More accurate and earlier identification of people at risk of cardiovascular disease (CVD) and neurodegenerative diseases (memory, cognition, dementia) through the appropriate use of biomarkers could lead to earlier initiation of preventive therapies and potentially avoid sometimes fatal events and complications.\n\nBiomarkers are useful for determining the risk of disease, but also for establishing a diagnosis.\n\nHigh inter-individual variability hinders the establishment of general laws that can be- used in predictive medicine.\n\nIn addition to the lack of validation, other limitations are the low participation rate in screening campaigns (regardless of disease) and the relative difficulty, accuracy, cost and time taken to perform the measurements.\n\nThe perioperative period is a very good time to screen for cardiovascular and neurodegenerative pathologies for several reasons:\n\n* Patients come to their anesthesia consultation and to the operating room because they have a direct visible benefit.\n* the physiological data collected intraoperatively during systematic monitoring are very \"rich\" and of very good quality because they are not very noisy\n* The induction of general anesthesia or the onset of locoregional anesthesia and its maintenance represents a strong and reproducible physiological \"test\" for the cardiovascular and cerebral systems.\n* The patients are regularly re-examined postoperatively for the follow-up of their pathology and the possible complications are recorded in their file, allowing a short and medium term follow-up.\n\nThe project aims to validate a biomarker predictive of cardiovascular complications, the pulse wave velocity, and a biomarker predictive of cognitive disorders, the power of the Alpha wave on the electroencephalogram, from the data usually collected during each anesthesia and during the perioperative period. The objective is to build a predictive model of cardiovascular and neurodegenerative risks, possibly combined, on a survival analysis.",[27,542],"Anesthesia",[544,545,546],"Predictive medicine","Cardiovascular biomarkers","Neurocognitive Biomarkers","2024-04-29",{"date":549,"type":39},"2024-04-30",{"date":551,"type":20},"2024-05",{"date":553,"type":20},"2032-05",{"name":555,"class":46},"Assistance Publique - Hôpitaux de Paris",{"id":557,"slug":558,"hasResults":11,"nctId":559,"briefTitle":560,"officialTitle":561,"acronym":4,"eligibilityCriteria":562,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":563,"targetDuration":4,"studyType":21,"phases":565,"briefSummary":566,"conditions":567,"keywords":570,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":574,"lastUpdatePostDateStruct":575,"startDateStruct":577,"completionDateStruct":579,"leadSponsor":581,"locationsCount":47},"100427703","phase-4-erector-spinae-plane-block-catheters-and-intrathecal-morphine-for-hepatic-resection-100427703","NCT04849455","Erector Spinae Plane Block Catheters and Intrathecal Morphine for Hepatic Resection","Erector Spinae Plane Block Catheters: The Role in Acute Postoperative Pain After Hepatic Resection With Intrathecal Morphine","Inclusion Criteria:\n\n* undergoing hepatic resection\n* Admitting service requests APS consult\n* \\>18 years old and able to provide consent\n\nExclusion criteria:\n\n* pregnancy\n* incarceration\n* inability to communicate with the investigators and hospital staff\n* severe hepatic disease\n* chronic high-dose opioid use (defined as daily use for more than 4 weeks prior to surgery of at least the equivalent of 20 mg oxycodone);\n* BMI \\> 40 kg\u002Fm2\n* allergy to study medications (lidocaine, ropivacaine)",{"count":564,"type":20},70,[80],"To determine whether the addition of erector spinae plane (ESP) catheters to existing multimodal analgesic regimen with intrathecal morphine provides superior postoperative analgesia in patients undergoing hepatic resection compared with patients not receiving ESP catheters.",[568,569,542,27],"Hepatic Resection","Acute Pain",[571,572,573],"acute postoperative pain","erector spinae plane block","liver resection","2022-06-06",{"date":576,"type":39},"2022-06-07",{"date":578,"type":39},"2021-05-24",{"date":580,"type":20},"2023-05-01",{"name":329,"class":46}]