[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anesthesia-morbidity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anesthesia-morbidity":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,41,75,105],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100621096","can-the-face-index-an-anthropometric-measurement-predict-difficult-laryngoscopy-and-intubation-100621096",false,"NCT07366177","Can the \"Face Index\"; an Anthropometric Measurement, Predict Difficult Laryngoscopy and Intubation?","Inclusion Criteria:\n\nAll adult patients over the age of 18 who have given written consent to undergo elective and\u002For emergency surgery under general anesthesia and be intubated in the operating rooms of our hospital's main building and annex building\n\nExclusion Criteria:\n\nPatients with a prior history of difficult airway\u002Fdifficult intubation, those who have undergone facial, neck, or airway surgery, those with deformities or scars in the facial and neck area due to burns or injuries, those with previous or recent tracheostomy, those with facial deformities due to any cause (congenital or acquired pathologies), and those with communication problems and who are uncooperative during measurements will be excluded from the study. Children and pregnant patients will not be included.","ALL","18 Years",{"count":18,"type":19},1000,"ESTIMATED","OBSERVATIONAL","Patient safety is the cornerstone of anesthetic practice, and maintaining adequate respiration represents its most critical initial step. In situations where spontaneous breathing cannot be sustained-such as during general anesthesia-the airway must be mechanically secured. While simple face masks may be sufficient in some cases, endotracheal intubation remains the most reliable method for airway control in conditions associated with respiratory depression.\n\nAirway management may be challenging due to various patient-related anatomical factors, including facial and mandibular structure, obesity, limited mouth opening, facial hair, sunken cheeks, wide facial morphology, and a short or muscular neck. These challenges are collectively described as difficult ventilation and difficult intubation (cannot ventilate-cannot intubate), which may occur unexpectedly or be anticipated. A difficult airway is defined as difficulty encountered by a trained anesthesiologist in face mask ventilation, tracheal intubation, or both.\n\nSeveral predictors of difficult airway are widely accepted, such as thyromental and sternomental distances, neck circumference, Mallampati classification, upper lip bite test, mouth opening, and interincisor distance. Thorough preoperative airway evaluation is mandatory, as difficult mask ventilation and failed intubation remain major contributors to anesthesia-related morbidity and mortality. Although numerous studies have examined these predictors, research focusing on facial morphology and anthropometric indices-particularly the face index-is extremely limited.\n\nFacial morphology varies considerably among individuals and can be evaluated anthropometrically using simple, noninvasive tools such as a digital caliper. Anthropometric analysis is commonly applied in forensic medicine and reconstructive surgery but has rarely been incorporated into airway assessment.\n\nThis study aims to introduce face index analysis as a novel predictor of difficult airway alongside conventional methods. By evaluating measurements such as trichion-gnathion distance, total facial index, upper facial index, and nasal index, the study investigates whether airway difficulty can be predicted using a single index value. All measurements are standard, noninvasive, and routinely performed during preoperative assessment.",[23,24,25,26],"Anesthesia Intubation Complication","Laryngoscopy","Intubation; Difficult or Failed","Anesthesia Morbidity",[28],"Difficult airway, face index, anesthesia","NOT_YET_RECRUITING","2026-01-18",{"date":32,"type":33},"2026-01-26","ACTUAL",{"date":35,"type":19},"2026-03",{"date":37,"type":19},"2027-03",{"name":39,"class":40},"Ordu University","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":59,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100538192","cpap-in-patients-with-severe-obesity-after-anesthesia-100538192","NCT06287632","CPAP in Patients With Severe Obesity After Anesthesia","Assessment of Cardiopulmonary Function in Response to Continuous Positive Airway Pressure in Patients With Severe Obesity After Anesthesia","Inclusion Criteria:\n\n1. Adult patients (≥ 18 years old) scheduled for elective non-cardiothoracic surgery requiring general anesthesia with an endotracheal tube\n2. Planned admission to the post-anesthesia care unit (PACU) after surgery\n3. BMI ≥ 40 kg\u002Fm2\n4. At the time of baseline measurements in the PACU, patients meet the following criteria:\n\n   * Receiving ≤ 6 liters of supplemental nasal cannula oxygen\n   * Alert as defined by a Richmond Agitation Sedation Scale of 0 or -1\n   * Oriented to person, place, and time\n\nExclusion Criteria:\n\n1. Pregnancy, suspected pregnancy or less than six weeks postpartum Known or current pneumothorax\n2. Hemodynamic instability at the time of study assessment in the PACU defined as:\n\n   * systolic blood pressure \\\u003C90 mmHg or \\>180 mmHg\n   * mean blood pressure \\\u003C60 or \\>130 mmHg\n   * Any use of intravenous vasoactive agent\n   * heart rate \\\u003C 50 or \\> 120 beats per minute\n3. Respiratory insufficiency in PACU defined as:\n\n   * Respiratory rate \\> 30\n   * Oxygen saturation \\\u003C 92%\n   * Receiving \\> 6 liters of supplemental oxygen\n4. Known chronic lung disease requiring supplemental oxygen at home\n5. Known systolic heart dysfunction (left ventricular ejection fraction ≤ 30%)\n6. Contraindication for esophageal catheter placement:\n\n   * Known esophageal varices\n   * Known bacterial sinusitis\n   * Recent esophageal, nasopharyngeal, or laryngeal trauma or surgery\n   * Known coagulopathy: including history of thrombocytopenia defined as platelet count \\\u003C50,000; presence of hemophilia; known genetic disorder of coagulation (e.g.,deficits of protein C, protein S, von Willebrand factor) or oral and subcutaneous anticoagulation treatment (e.g., heparin, warfarin, and or other oral anticoagulants)\n7. Contraindication for electrical impedance tomograph belt placement:\n\n   * Pacemaker and\u002For internal cardiac defibrillator\n   * Chest skin injury\n8. Concern for study inclusion by the perioperative nurse or anesthesia team",{"count":49,"type":19},60,"INTERVENTIONAL",[52],"NA","The goal of this study is to compare two continuous positive airway pressure (CPAP) settings on heart and lung function in patients with severe obesity after anesthesia. The main questions it aims to answer are:\n\n1. Does a recruitment maneuver and CPAP set to intrathoracic pressure (ITP) improve cardiopulmonary function compared to standard CPAP settings in patients with severe obesity after anesthesia?\n2. Does the location of adipose tissue influence the response to CPAP settings in patients with severe obesity after anesthesia?\n\nParticipants will undergo monitoring of their intrathoracic pressure using an esophageal catheter. In the recovery area after anesthesia, participants will receive two CPAP settings, each for 20 minutes.\n\n* Intervention 1: Recruitment maneuver and CPAP will set to the level of intrathoracic pressure\n* Intervention 2: CPAP set to home settings (if OSA is present) or between 8-10 cmH20 (if OSA is not present).",[55,26,56,57,58],"Obesity, Abdominal","Apnea, Obstructive Sleep","Atelectases, Postoperative Pulmonary","Ventilator Lung",[60,61,62,63,64,65],"clinical trial","crossover studies","continuous positive airway pressure","electrical impedance tomography","esophageal pressure monitoring","transthoracic echocardiography","2025-11-17",{"date":68,"type":33},"2025-11-18",{"date":70,"type":19},"2026-06",{"date":72,"type":19},"2027-06",{"name":74,"class":40},"Massachusetts General Hospital",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":50,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":104},"100515434","trajectories-of-recovery-after-intravenous-propofol-versus-inhaled-volatile-anesthesia-trial-100515434","NCT05991453","Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial","THRIVE","Inclusion Criteria\n\nEach patient must meet all of the following criteria:\n\n1. Aged 18 years or older\n2. Undergoing elective non-cardiac surgery expected to last ≥ 60 min requiring general anesthesia with a tracheal tube or laryngeal mask airway (or similar supra-glottic device)\n\nExclusion Criteria\n\nPatients will not be enrolled if any of the following criteria are met:\n\n1. Inability to provide informed consent in English (at all study sites) or Spanish (at sites where Spanish consent is provided as an option)\n2. Pregnancy (based on patient report or positive test on the day of surgery)\n3. Surgical procedure requiring general, regional, neuraxial anesthesia administered by an anesthesia clinician (anesthesiologist, CRNA, anesthesiology assistant) occurring within 30 days prior to or planned to occur within 30 days after surgery date\n4. Contraindication to propofol TIVA or INVA (for example, documented allergy to propofol, history of severe postoperative nausea or vomiting, concern for or history of malignant hyperthermia) based on self-report\n5. Surgical procedures requiring a specific general anesthesia technique (for example, TIVA required for neuromonitoring).\n6. Locally approved, written protocol mandating a particular anesthetic technique\n7. History of possible or definite intraoperative awareness during general anesthesia based on patient self-report\n8. Planned postoperative intubation\n9. Current incarceration",{"count":83,"type":19},13000,[52],"The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (ii) whether TIVA confers no more than a small (0.2 %) increased risk of intraoperative awareness than INVA in patients undergoing both outpatient and inpatient surgeries",[87,88,89,90,91,92,93,26],"Surgery-Complications","Anesthesia Complication","Anesthesia Awareness","Anesthesia","Surgery","Quality of Life","Pain, Postoperative","RECRUITING","2025-07-30",{"date":97,"type":33},"2025-08-05",{"date":99,"type":33},"2023-09-13",{"date":101,"type":19},"2028-07-31",{"name":103,"class":40},"Washington University School of Medicine",20,{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":113,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":114,"targetDuration":116,"studyType":20,"phases":4,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":132},"100506068","registry-of-anesthesia-and-perioperative-medicine-100506068","NCT05869578","Registry of Anesthesia and Perioperative Medicine","Registry of Patients Subjected to the Perioperative Care of the Anesthesia Service of Clinica Alemana of Santiago Chile","RAMP","Inclusion Criteria:\n\n* All individuals\n* Individuals agreeing to participate in the study by signing a consent\n\nExclusion Criteria:\n\n* The subjects who had insufficient data in their files",true,{"count":115,"type":19},10000,"1 Year","To assess mortality and morbidity associated to anesthesia interventions",[119,120,26,121,88,122],"Perioperative Complication","Perioperative\u002FPostoperative Complications","Anesthesia; Adverse Effect","Anesthesia; Reaction","2023-05-19",{"date":125,"type":33},"2023-05-22",{"date":127,"type":19},"2023-06-01",{"date":129,"type":19},"2045-01-01",{"name":131,"class":40},"Clinica Alemana de Santiago",1]